Human epididymis protein 4: Analysis of national health and nutrition examination survey data
The average risk of developing ovarian cancer in the United States is 1 in 78, with the majority of women diagnosed with advanced stage disease (stage III/IV) [1,2]. The benefits and risks associated with screening average-risk women have been studied to include serum blood draws or use of transvaginal ultrasound [3]. Cancer Antigen 125 (CA 125) has low sensitivity in early stages of ovarian cancer, and elevations are also seen in other conditions such as endometriosis or inflammatory conditions of the peritoneum [4,5]. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - March 17, 2024 Category: OBGYN Authors: Emily R. Penick, Thomas A. Beltran, Y. Sammy Choi, Karen L. Wilson Tags: Full length article Source Type: research

Non-invasive prediction model of histologic chorioamnionitis with preterm prelabour rupture of membranes
Preterm Prelabour Rupture of Membranes (PPROM) is defined as the rupture of membranes occurring prior to 37  weeks of gestation [1]. PPROM is associated with one-third of preterm births [2,3]. Compared with other preterm infants, those born following PPROM have higher perinatal mortality rates due to infection [4]. The etiology of PPROM is multifactorial and includes genital infection, inflammatory illn ess, vascular disease, and uterine over-distension [5]. These multiple factors contribute to PPROM, individually or in combination, however, an exaggerated inflammatory response or infection, which is largely subclinical,...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - March 14, 2024 Category: OBGYN Authors: Yan Hu, Zheng Ye, Nathan Obore, Xiaojun Guo, Hong Yu Tags: Full length article Source Type: research

Evaluation of Elastic Venous compression device dispensation in pregnant and post-partum women using the French National Health Insurance Claims Database: The ProFIL retrospective cohort study
During pregnancy, women are at an increased risk of Venous Thrombo-Embolism (VTE), including Deep Vein Thrombosis (DVT) or Pulmonary Embolism (PE) [1]. VTE risk is further increased in post-partum, being highest during the first 3  weeks after delivery and remaining elevated throughout the first 12 weeks [2]. Between 2013 and 2015, VTE was the fourth cause of death (8.8 %) among pregnant women in France [3] and accounted for 3.2 % of deaths worldwide [4]. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - March 14, 2024 Category: OBGYN Authors: Olivier Joassard, Anne-Laure Kerveillant, Claire Sellal, Erwana Coatantiec, Violaine Jabbour, Guillaume Desjeux, Ben Braithwaite, Antoine Elias, Arnaud Fauconnier Tags: Full length article Source Type: research

Major placenta previa among patients with and without previous cesarean section: Maternal characteristics, outcomes and risk factors
Currently, the common ultrasonographic (US) classification of the placenta previa (PP) includes just 2 main types: major PP (reaching or overlapping the internal os [IO]) and minor PP (within 2  cm from IO) [1]. In 2014, a multi-society meeting recommended 2 simple definitions: PP and low-lying placenta to describe major and minor PP [2]. There is evidence that this classification could be helpful in management decisions and also has some prognostic value, as morbidity and mortality incr ease with an increasing degree of PP [3]. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - March 13, 2024 Category: OBGYN Authors: Ayman H. Shaamash, Mehad H. AlQasem, Ahmed A. Mahfouz, Deama S. Al Ghamdi, Mamdoh A. Eskandar Tags: Full length article Source Type: research

Manually driven versus motor driven hysteroscopic tissue removal system for polypectomy: Long-term results
Multiple studies have investigated the effectiveness of several hysteroscopic techniques for polypectomy [1 –4]. Polyp recurrence occurs in 4.9 % [5]. This appears to be lower when using mechanical hysteroscopic tissue removal systems (TRS) compared to electrosurgical resection [6]. With increasing follow-up time, more polyp recurrences are observed [7]. Other risk factors for polyp recurrence are a l arger polyp size and the occurrence of symptoms such as abnormal uterine bleeding (AUB) during follow-up time. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - March 12, 2024 Category: OBGYN Authors: Margot Van Geyte, Alejandra de Frenne, Basiel Weyers, Steven Weyers, Huib van Vliet, Tjalina Hamerlynck, Steffi van Wessel Tags: Full length article Source Type: research

Inside Back Cover - Editors with images
(Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - March 10, 2024 Category: OBGYN Source Type: research

Homelessness in pregnancy
Homelessness has become a significant social and political issue across many countries in the Organization for Economic Co-operation and Development (OECD). The rise of housing insecurity has been particularly pronounced since the global financial crisis of 2008 and further exacerbated by the COVID-19 pandemic [1]. The enduring rise of house prices over the past two decades has additionally made it increasingly challenging for young people to buy their first home in many OECD countries [1]. Subsequently, compared with the general population, individuals aged between 20 and 29 have developed an increased reliance on private...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - March 9, 2024 Category: OBGYN Authors: L. Creswell, C. Leahy, E. McNamee, S.W. Lindow, M.P. O'Connell Tags: Full length article Source Type: research

Prediction of adverse neonatal adaptation in fetuses with severe fetal growth restriction after 34  weeks of gestation
Intrauterine fetal growth is determined on the one hand by genetic parameters constituting growth potential, and on the other by other factors that may be fetal, maternal, and/or placental [1]. Fetal growth restriction (FGR) is a complication of pregnancy associated with adverse perinatal outcomes [2]. However, differentiating between the fetus that is constitutionally small (small for gestational age, SGA) and the fetus that fails to realize its growth potential due to an underlying pathological condition (FGR) remains a major challenge in clinical practice today [3]. (Source: European Journal of Obstetrics, Gynecology, a...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - March 8, 2024 Category: OBGYN Authors: C élia Ross, Philippe Deruelle, Mary Pontvianne, Lise Lecointre, Samuel Wieder, Pierre Kuhn, Massimo Lodi Tags: Full length article Source Type: research

Diagnostic accuracy validation study of the M6 model without initial serum progesterone (M6NP) in triage of pregnancy of unknown location
Emergency consultations are common in early pregnancy, mostly for vaginal bleeding or abdominal pain. Pregnancy of unknown location (PUL) is defined as a positive pregnancy test and the absence of intrauterine or ectopic pregnancy on transvaginal sonography (TVS) [1]. In France, guidelines require that patients with PUL undergo TVS and measurement of serum human chorionic gonadotrophin (hCG) every 48  h until a final outcome can be established between intrauterine pregnancy (IUP), ectopic pregnancy (EP) or failed pregnancy of unknown location (FPUL) [2,3], with the latter usually considered as a miscarriage. (Source: Eur...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - March 8, 2024 Category: OBGYN Authors: C élia Maheut, Henri Panjo, Perrine Capmas Tags: Full length article Source Type: research

Brain metastasis as a first clinical presentation of endometrial cancer: A case report
Dear Editor, (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - March 8, 2024 Category: OBGYN Authors: Dra žan Butorac, Ana-Meyra Potkonjak, Josip Kuharić, Goran Vujić Source Type: research

Characterizing of intra-amniotic inflammatory changes associated with chronic inflammation in the placenta marked by elevated amniotic fluid interferon gamma-induced protein 10 (IP-10) in pregnancies complicated by preterm prelabor rupture of membranes
Preterm delivery (PTD), which refers to delivery occurring before 37  weeks of gestation, is a significant contributor to perinatal mortality and morbidity, as extensively supported by research studies [1,2]. The World Health Organization estimates that approximately 13.4 million children worldwide are born preterm [2,3]. The incidence of PTD in developed countries ranges from 5 % to 12 % [2,4,5]. Preterm prelabor rupture of membranes (PPROM) represents a clinical phenotype of spontaneous PTD, characterized by the rupture of the fetal membranes prior to the onset of labor and before 37 weeks of gestation. (Source: ...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - March 7, 2024 Category: OBGYN Authors: Nina Aber šek, Panagiotis Tsiartas, Ondrej Soucek, Ctirad Andrys, Ivana Musilova, Bo Jacobsson, Marian Kacerovsky Tags: Full length article Source Type: research

Urinary symptoms and sexual function after hysterectomy secondary to cervical cancer: A prospective, cohort study
The global incidence of cervical cancer (CC) is about half million cases per year. Nine out of ten deaths per cervical cancer occur in underdeveloped regions, where the risk of dying from CC is three times higher than developed countries. [1]. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - March 6, 2024 Category: OBGYN Authors: Mariana Alves Firmeza, Nat ália Maria Vasconcelos Oliveira, Flávio Mendes Alves, Camila Teixeira Moreira Vasconcelos, José Ananias Vasconcelos Neto Tags: Full length article Source Type: research

Chemotherapy response score as a predictor of survival in ovarian cancer patients
Ovarian cancer is the main cause of mortality among gynecological cancer patients, accounting for more than 200,000 new cases annually at an international level and responsible for more than 150,000 deaths [1]. It is usually encountered in advanced stages, as symptomatology is primarily of an obstructive nature from the gastrointestinal system or the respiratory tract, depending on the site of metastases, the involvement of the bowel tract, and the severity of ascites [2]. The symptomatology in patients with early-stage disease may exceed rates of 50  % of those affected; however, it is usually subtle and may be overlook...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - March 6, 2024 Category: OBGYN Authors: Ioannis Rodolakis, Michalis Liontos, Vasilios Pergialiotis, Dimitrios Haidopoulos, Maria Kaparelou, Dimitrios Efthimios Vlachos, Meletios Athanasios Dimopoulos, Dimitrios Loutradis, Alexandros Rodolakis, Aristotelis Bamias, Nikolaos Thomakos Tags: Full length article Source Type: research

Letter to the editor on “Acupuncture modification treatment for female sexual dysfunction: Ameta-analysis”
Dear Editor, (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - March 5, 2024 Category: OBGYN Authors: E. Colonnello, H. Zhang, S. Liu, F. Wang, J. Guo, E.A. Jannini Source Type: research

Overview of the current situation of embryo donation in Belgian fertility centers
Embryo donation (ED) has been legally regulated in Belgium since 2007. The 2007 law on medically assisted reproduction regulates the various aspects of medically assisted reproduction, including the donation of gametes and supernumerary embryos [1]. After a cryopreservation period of maximum five years, patients have three options when they no longer wish to keep their embryos for their own reproduction, i.e. destruction, donation for research or donation to another patient or couple. This decision is included in a written contract between the patient(s) and the fertility center, which is signed before starting the treatme...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - March 3, 2024 Category: OBGYN Authors: Rita Puga-Leal, Guido Pennings, Herman Tournaye Tags: Full length article Source Type: research