AKR1D1 and CYP7B1 mutations in patients with inborn errors of bile acid metabolism: Possibly underdiagnosed diseases
This study aimed to analyze the types and treatment outcomes of IEBAM in Taiwanese infants and document the allele frequency of CYP7B1 hot spot mutations in the population. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - July 20, 2019 Category: Perinatology & Neonatology Authors: Ju-Yin Chen, Jia-Feng Wu, Akihiko Kimura, Hiroshi Nittono, Bang-Yu Liou, Chee-Seng Lee, Ho-Sheng Chen, Yu-Chun Chiu, Yen-Hsuan Ni, Steven Shinn-Forng Peng, Wang-Tso Lee, I-Jung Tsai, Mei-Hwei Chang, Huey-Ling Chen Tags: Original Article Source Type: research

Modifying risk factors of chronicity in children with immune thrombocytopenia: Still underway
Immune thrombocytopenia (ITP) in children is one of the most commonly encountered benign hematologic diseases in daily practice for general pediatricians and pediatric hematologists. In general settings, clinical presentations include an incidental finding in an asymptomatic child, abrupt petechiae/ecchymoses, mucocutaneous bleeding, rarely seen life-threatening bleeding, etc.1 During the evaluation phase, an experienced personnel collects detailed history and performs physical examination, complete blood count with differential, and review of peripheral blood smear. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - July 18, 2019 Category: Perinatology & Neonatology Authors: Tsung-Yen Chang Tags: Editorial Source Type: research

Epidemiological characteristics of human cytomegalovirus infection and glycoprotein H genotype in Chinese children
In this study, systematic surveillance was conducted on the prevalence of HCMV infections and HCMV gH genotypes in children. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - July 16, 2019 Category: Perinatology & Neonatology Authors: Wei Li, Lifang Liu, Ran Tao, Xiaoyu Zheng, Huamei Li, Shiqiang Shang Tags: Original Article Source Type: research

Selection of lipid emulsions for protection against parenteral nutrition-associated liver disease
In the past decades, considerable progress has been made in intensive care and survival rate of premature infants. Administration of parenteral nutrition (PN) has improved the nutritional status of premature infants in their early life, especially for infants with extremely low birth weight. Lipid emulsions (LEs) are recognized as essential components of non-protein energy supplement of PN. In addition to their high caloric value and low osmolality, the use of LE prevents the complications of using glucose as sole non-protein energy source; these complications include fatty acid deficiency, hyperglycemia, and hepatic steat...
Source: Pediatrics and Neonatology - July 16, 2019 Category: Perinatology & Neonatology Authors: Ren-Huei Fu Tags: Editorial Source Type: research

Concomitant pediatric abdominal and pulmonary tuberculosis
A 10-year-old boy was referred from a local clinic to our institute due to abdominal fullness and ascites. He gained 4  kg in 4 months, despite reduced appetite. After admission, chest radiograph revealed bilateral pleural effusion with atelectasis and increased infiltration of bilateral lower lobes (Fig. 1A). Tachypnea and fever developed (Fig. 1B). Paracentesis yielded straw-colored ascites with leukocyte count of 1410 cells/mm3. with a relative lymphocytic pleocytosis (98%). Abdominal computer tomography (CT) scan showed massive ascites, thickening of omentum and peritoneum, associated with lymphaden...
Source: Pediatrics and Neonatology - July 11, 2019 Category: Perinatology & Neonatology Authors: Hsin-Ching Kuo, Solomon Chih-Cheng Chen, Hsin-Kai Lin, Shu-Ti Chia, Joseph-Hang Leung Tags: Images Source Type: research

Inflammation in the neonatal period and intrauterine growth restriction aggravate bronchopulmonary dysplasia
To investigate the hematological features of infants with bronchopulmonary dysplasia (BPD) and their relationships with clinical severity. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - July 10, 2019 Category: Perinatology & Neonatology Authors: Hiroaki Kurata, Masayuki Ochiai, Hirosuke Inoue, Takeshi Kusuda, Junko Fujiyoshi, Masako Ichiyama, Yoshifumi Wakata, Hidetoshi Takada Tags: Original Article Source Type: research

How much do we know about constipation after surgery for anorectal malformation?
To evaluate the occurrence of constipation after anorectal malformations (ARM) repair and the results of laxative treatment. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - July 8, 2019 Category: Perinatology & Neonatology Authors: Paul Chia-Yu Chang, Yih-Cherng Duh, Yu-Wei Fu, Yao-Jen Hsu, Chin-Hung Wei, Hsuan Huang Tags: Original Article Source Type: research

Gender-differential associations between attention deficit and hyperactivity symptoms and youth health risk behaviors
Attention deficit and hyperactivity disorder (ADHD) is one of the common developmental disorders that generally receives clinical attention at learning ages, and some symptoms may persist in young adulthood.1 Past research has demonstrated a consistent association between ADHD and youth health risk behaviors (e.g., cigarette smoking), which often develop during adolescence and contribute to early morbidity and mortality among young adults.2 However, ADHD symptoms are not routinely screened in adolescents and emerging adults during their visits to healthcare providers. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - July 8, 2019 Category: Perinatology & Neonatology Authors: Kai-Jyun Jhang, Yu-Fang Lin, Meng-Che Tsai, Carol Strong, Yi-Ching Lin, Yi-Ping Hsieh, Chung-Ying Lin Tags: Short Communication Source Type: research

Neurodevelopmental outcomes at 2 and 5 years of age in very-low-birth-weight preterm infants born between 2002 and 2009: A prospective cohort study in Taiwan
Neurodevelopmental outcome in preterm infants has been of great importance in recent decades. We determined the prevalence of abnormal neurodevelopmental outcomes and associated risk factors of very-low-birth-weight (VLBW) preterm infants at 2 and 5 years of age. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - July 3, 2019 Category: Perinatology & Neonatology Authors: Chia-Ying Lin, Chyong-Hsin Hsu, Jui-Hsing Chang, Taiwan Premature Infant Follow-up Network Tags: Original Article Source Type: research

The analgesic effect of non-pharmacological interventions to reduce procedural pain in preterm neonates
Thank you very much for informing us about the comments for our study from the readers.1,2 The first concern was that the infants included in our study were given the pain reducing treatments which were of no evidence- based and were already shown to be ineffective.  Actually, most of the previous studies in this aspect were conducted in full-term babies or healthy preterms, and the preterms included were quite few. However, in this study, we chose sick premature neonates who were unable to breastfeed or receive skin-to-skin care; some of them received nasal p rong continuous positive airway pressure or nasal intermit...
Source: Pediatrics and Neonatology - July 3, 2019 Category: Perinatology & Neonatology Authors: Kao-Hsian Hsieh, Shu-Jen Chen, Pei-Chen Tsao, Chih-Chien Wang, Ching-Feng Huang, Chien-Ming Lin, Ya-Ling Chou, Wei-Yu Chen, I-Ching Chan Tags: Letter to the Editor Source Type: research

Vitamin B12 deficiency anemia in an exclusively breastfed infant born to an ileum-resected mother
Vitamin B12 (cobalamin) is essential for folate metabolism and DNA synthesis. It acts as a cofactor for two key enzymatic reactions, methylation of homocysteine to methionine and conversion of methylmalonyl coenzyme A (CoA) to succinyl CoA.1 Deficiency of vitamin B12 results in an accumulation of homocysteine and methylmalonic acid, resulting in hematologic and neurologic manifestations.1 Although vitamin B12 deficiency is rare in developed countries, it is important to recognize this condition because early treatment can prevent potentially devastating neurologic sequelae. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - June 29, 2019 Category: Perinatology & Neonatology Authors: Akihiro Tamura, Nanako Nino, Nobuyuki Yamamoto, Akiyoshi Naito, Kousaku Matsubara, Naoko Nakatani, Takayuki Ichikawa, Sayaka Nakamura, Atsuro Saito, Aiko Kozaki, Kenji Kishimoto, Toshiaki Ishida, Yosuke Shigematsu, Daiichiro Hasegawa, Yoshiyuki Kosaka Tags: Short Communication Source Type: research

The clinical features and therapy of community-acquired gram negative bacteremia in children less than three years old
Community-acquired Gram-Negative (GN) bacteremia caused more morbidity and mortality recently in children. The increasing drug resistance was also an important issue. However, published reference was few about children. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - June 27, 2019 Category: Perinatology & Neonatology Authors: Kuang-Che Kuo, Yi-Chun Yeh, I-Min Chiu, Kuo-Su Tang, Chih-Min Su, Ying-Hsien Huang Tags: Original Article Source Type: research

Clinical and genetic characteristics of three Chinese patients with glycogen storage disease type Ⅸα
Glycogen storage disease (GSD) Ⅸ is caused by a deficiency of phosphorylase kinase (PHK, EC.2.7.1.38), which plays a critical role in regulating the release of glucose from glycogen, resulting in the storage of glycogen.1 PHK is composed of four subunits, namely, α, β, γ and δ. Each of the subunits is tissue-specific and en coded by different genes. Subunit α has two isoforms, GSD Ⅸα1 and Ⅸα2 (MIM #306000), both of which are encoded by the PHKA2 gene (MIM *300798), these isoforms are involved in liver glycogenosis. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - June 24, 2019 Category: Perinatology & Neonatology Authors: Fengxia Yang, Yi Xu, Chunxiao Fang, Limei Tan, Qianqian Tan, Yong Zhou Tags: Short Communication Source Type: research

A case of diagnosis of Lyme disease in the absence of a tick bite
A 6-year-old girl was presented with a rash on the left side of her face (Fig.  1a). Her primary care pediatrician assumed this to be allergic dermatitis and treated it with topical steroids, but there was no improvement. Over the next 1.5 months, the rash spread to the back of the head (Fig. 1b). The patient also had systemic manifestations, including low-grade fever (up to 37.7 °C) and malaise. Because the patient lived in an endemic area, the rash was deemed suspicious for erythema migrans associated with Lyme disease. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - June 24, 2019 Category: Perinatology & Neonatology Authors: Nataliya Banadyha, Igor Rogalskyy, Roman Komorovsky Tags: Images Source Type: research

Standard-dose gentamicin does not increase risk of patent ductus arteriosus
Rates of patent ductus arteriosus (PDA) and infection are high in preterm infants. Preterm infants with infection are more likely to develop symptomatic PDA, a potentially fatal disease. Clinically, gentamicin is widely used for early-onset infection in neonates including preterm infants. A recent study demonstrated that standard-dose gentamicin itself, not infection, increased risk of PDA in mice, suggesting that gentamicin should be avoided in neonates with a risk of PDA. This claim has been insufficiently investigated in subsequent in-vivo experiments. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - June 22, 2019 Category: Perinatology & Neonatology Authors: Ayana Kishibuchi, Toru Akaike, Susumu Minamisawa Tags: Original Article Source Type: research

Chlamydia pneumonia – induced mucositis
A 16-year-old healthy male presented to the emergency department with a 5-day history of upper respiratory symptoms, persistent fever, and blisters present within the oral cavity. Two days before presentation, he also developed severe bilateral conjunctivitis with watery discharge. There were no other symptoms such as respiratory distress, skin rash, and genital lesions. He was not sexually active and denied taking any medications recently. His vitals were within normal limits. However, he appeared to be in distress that was secondary to pain. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - June 22, 2019 Category: Perinatology & Neonatology Authors: Krishna Kishore Umapathi, Jagdeep Tuli, Sruthi Menon Tags: Letter to the Editor Source Type: research

Impact of urine osmolality/urine sodium on the timing of diuretic phase and non-invasive ventilation support: Differences from late preterm to term neonates
Extracellular fluid retained in the lungs lead to respiratory distress in both late preterm (LP) and term neonates. The relationship between urine parameters toward the diuresis and the duration of ventilation postnatally is unknown. To find the correlation between the diuretic phase with urine parameters in the first 4 days after birth and the duration of non-invasive ventilation (NIV). (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - June 18, 2019 Category: Perinatology & Neonatology Authors: Yu-Hsuan Chien, Yi-Ling Chen, Li-Yi Tsai, Shu-Chi Mu Tags: Original Article Source Type: research

Anonymous reporting of medical errors from The Egyptian Neonatal Safety Training Network
ENSTN is the first database to collect incidents and medical errors in NICU in Egypt. To ensure confidential and anonymous reporting system, identify the nature of medical errors and grade of harm as well as the risk factors. To promote patient safety culture and aid to decrease mortality and morbidity due to medical errors in NICU. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - June 12, 2019 Category: Perinatology & Neonatology Authors: Safaa ELMeneza, Mariam AbuShady Tags: Original Article Source Type: research

Posterior mediastinal lipoblastoma: A rare cause of acute respiratory compromise
Mediastinal syndromes are a group of disorders involving, principally, the mediastinum and characterized by infiltration, entrapment, or compression of nearby organs.1 Children are particularly sensitive to mediastinal lesions because of their limited chest volume.2 Here, we report a  case of an infant with a posterior mediastinal lipoblastoma triggering an unexpected life-threatening emergency. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - June 10, 2019 Category: Perinatology & Neonatology Authors: Yen-Hsiu Wang, Zen-Kong Dai, I-Chen Chen Tags: Letter to the Editor Source Type: research

Long-term outcomes of enzyme replacement therapy for Taiwanese patients with Mucopolysaccharidosis I
Mucopolysaccharidosis (MPS) I is an autosomal recessive lysosomal storage disorder resulting from a deficiency in the lysosomal enzyme α-l-iduronidase, leading to the accumulation of the glycosaminoglycans (GAGs) dermatan sulfate (DS) and heparan sulfate (HS) in cells throughout the body. The clinical characteristics of MPS I include cognitive impairment (severe form), coarse facial features, corneal clouding, respiratory disorder s, cardiac diseases, hepatomegaly, umbilical and inguinal hernias, skeletal abnormalities, and joint contractures. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - June 10, 2019 Category: Perinatology & Neonatology Authors: Hsiang-Yu Lin, Chung-Lin Lee, Chih-Kuang Chuang, Shuan-Pei Lin Tags: Short Communication Source Type: research

Hepatic extravasation complicated by umbilical venous catheterization in neonates: A 5-year, single-center experience
Care of newborns in the neonatal intensive care unit generally involves umbilical venous catheterization (UVC) for central vein access to enable medical needs. The study aimed to evaluate the sonographic appearance, risk factors, and outcomes of UVC-related hepatic extravasation (HE) in neonates. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - June 8, 2019 Category: Perinatology & Neonatology Authors: Hsin-Jen Chen, Hsun-Chin Chao, Ming-Chou Chiang, Shih-Ming Chu Tags: Original Article Source Type: research

What happened to the principle of equipoise in the planning, designing and conducting of placebo-controlled trials for neonatal procedural pain?
We refer to the recent study published by Hsieh and colleagues1 comparing the effects of 10% glucose and expressed breast milk (EBM) on pain scores during heel lance in preterm infants. The enrolled infants underwent four heel lance procedures while receiving EBM, 10% glucose, water, or no intervention. Results demonstrated significantly lower pain scores for the EBM and 10% glucose groups than for the water and no intervention groups. However, all infants obviously experienced moderate pain (e.g., Premature Infant Pain Profile scores higher than 6) during the first 30  s after heel lance irrespective of the allocated...
Source: Pediatrics and Neonatology - June 8, 2019 Category: Perinatology & Neonatology Authors: Mariana Bueno, Denise Harrison Tags: Letter to the Editor Source Type: research

Editorial Board
(Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - June 1, 2019 Category: Perinatology & Neonatology Source Type: research

Self-efficacy profile in daily activities: Children at risk and with developmental coordination disorder
The objectives of this study were: 1) to compare the perceptions of self-efficacy in the daily activities (self-care, schoolwork, and leisure) of boys and girls with DCD, or in children at risk for DCD (r-DCD) and in typical children (TD); 2) to investigate if a self-efficacy assessment could be a support tool in the establishment of children with the DCD profile. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - May 27, 2019 Category: Perinatology & Neonatology Authors: G.C. Nobre, N.C. Valentini, M.H.S. Ramalho, R.F. Sartori Tags: Original Article Source Type: research

Gastrointestinal hemodynamic changes during therapeutic hypothermia and after rewarming in neonatal hypoxic-Ischemic encephalopathy
The objective of this study was to assess gastrointestinal (GI) blood flow and left ventricle output (LVO) in infants with hypoxic-ischemic encephalopathy during whole body TH and after rewarming. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - May 17, 2019 Category: Perinatology & Neonatology Authors: Pankaj Sakhuja, Kiran More, Joseph Y. Ting, Jesal Sheth, Annie Lapointe, Amish Jain, Patrick J. McNamara, Aideen M. Moore Tags: Original Article Source Type: research

Vitamin D and health - The missing vitamin in humans
Severe vitamin D deficiency may cause rickets in infants or children and osteomalacia in adults, though it is now uncommon in developed countries. However, subclinical vitamin D deficiency is more prevalent, and it is associated with osteoporosis and higher incidence of falls or fractures. It was reported that 96% children with rickets were breastfed, since breast milk contains inadequate vitamin D. The American Academy of Pediatrics 2008 recommended infants who were exclusively or partially breastfed required 400  international units vitamin D daily from the first few days of life. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - May 14, 2019 Category: Perinatology & Neonatology Authors: Szu-Wen Chang, Hung-Chang Lee Tags: Review Article Source Type: research

Prevention of Group B streptococcus infection
Group B streptococcus (GBS), also known as Streptococcus agalactiae (S. agalactiae), is a bacterium surrounded by a polysaccharide capsule. Based on the serological reaction against the polysaccharide capsule or as determined by a multiplex polymerase chain reaction assay, GBS strains can be divided into 10 distinct serotypes (Ia, Ib, and II to IX). Multilocus sequence typing is also used to classify GBS strains. More than 750 sequence types (STs) have been identified, and most human isolates are clustered into six major clonal complexes. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - May 14, 2019 Category: Perinatology & Neonatology Authors: Nan-Chang Chiu Tags: Editorial Source Type: research

Neonatal percutaneous central venous catheters: Equations for the inserted length and locations of the insertion sites
The use of percutaneous central venous catheters (PCVCs) for central venous access is a routine and essential part of neonatal intensive care, particularly in the care of extremely preterm infants. It has been suggested that insertion of PCVCs is associated with sepsis, embolism, intravascular thrombosis, or pericardial effusion with tamponade.1,2 Besides, a case of ruptured PCVC has been reported as well.3 Repositioned PCVC or repeated mechanical stress might be related to the rupture of PCVCs. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - May 14, 2019 Category: Perinatology & Neonatology Authors: Ming-Chou Chiang Tags: Editorial Source Type: research

Hypothermic reaction after infection in an infant with pyruvate dehydrogenase complex deficiency
Pyruvate dehydrogenase complex (PDC) deficiency is a rare genetic mitochondrial disorder that impairs the activity of PDC, the rate-limiting enzyme in aerobic glucose oxidation, thereby being integral to cellular energetics.1 Defects in PCD activity may also decrease the availability of acetyl-CoA for the tricarboxylic acid cycle, resulting in lactic acidosis and cellular energy failure, which is indicated by progressive neurological and neuromuscular deterioration.2 Reviews of molecular genetics reported that most patients with PDC deficiency lack the PDC-E1 alpha component, encoded by the PDHA1 gene located on the Xp22.1...
Source: Pediatrics and Neonatology - May 4, 2019 Category: Perinatology & Neonatology Authors: Hideaki Yagasaki, Tetsuo Ohyama, Hiromune Narusawa, Takaya Nakane Tags: Letter to the Editor Source Type: research

Impact of maternal intrapartum antibiotics on the initial oral microbiome of neonates
Prior studies have proposed that maternal intrapartum antibiotic exposure shapes the gut microbiota and, subsequently the child's health. However, the effect of maternal intrapartum antibiotic exposure and its influence on the development of the neonatal oral microbiota in early infancy has not yet been reported. The aim of this study was to compare the initial oral microbiota immediately after birth of healthy infants with and without intrapartum antibiotic exposure. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - May 2, 2019 Category: Perinatology & Neonatology Authors: Hongping Li, Bin Xiao, Yong Zhang, Shanqiu Xiao, Jun Luo, Weimin Huang Tags: Original Article Source Type: research

Parental concern of feeding difficulty predicts poor growth status in their child
Parents often express concerns about feeding difficulties in their child. We hypothesized that these parental concerns were associated with adverse growth status in early childhood. We aimed to determine the prevalence of such concerns and whether these concerns were associated with adverse growth status in early childhood. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - May 2, 2019 Category: Perinatology & Neonatology Authors: Way Seah Lee, Chun Wei Tee, Aaron GS. Tan, Shin Yee Wong, Kee Seang Chew, Hon Kit Cheang, Tammy Lim, Lucy CS. Lum, Marion Margaret Aw Tags: Original Article Source Type: research

Tachycardia induced cardiomyopathy in an infant with atrial flutter: A challenging but reversible cause of heart failure
A one-month-old asymptomatic full-term infant was referred for tachycardia, featuring 216 beats per minute as per routine examination. Apart from the tachycardia, a mild systolic murmur (grade 1/6) at the left sternal border and liver enlargement (3 –4 cm under the costal margin) were observed. The blood pressure was 97/33 mmHg, whereas the full blood count, C-reactive protein, acid base balance, biochemical profile, and thyroid function tests were within the normal limits. Furthermore, the blood cultures and screening for metabolic disease s were negative. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - April 27, 2019 Category: Perinatology & Neonatology Authors: Maria Papadopoulou, Despoina Tramma, Konstantinos Thomaidis, Kyriaki Papadopoulou-Legbelou Tags: Letter to the Editor Source Type: research

Factors associated with non- and under-vaccination among children aged 12 –23 months in Malawi. A multinomial analysis of the population-based sample
Non- and under-vaccination among children in Malawi have received little attention. Between 2010 and 2016, the proportion of children who received full immunization before their first birthday dropped from 81% to 76% in Malawi. This signifies that a certain fraction of children are either non-vaccinated or under-vaccinated. Thus, the present study attempted to examine the predictors of non- and under-vaccination among children aged 12 –23 months in Malawi. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - April 27, 2019 Category: Perinatology & Neonatology Authors: Peter Austin Morton Ntenda Tags: Original Article Source Type: research

Perianal streptococcal dermatitis
A previously healthy 3-year-old boy presented with rectal pain and refusal to sit and defecate over the past 24  h. He had no fever. The perianal region showed a painful circumferential bright erythema with well-demarcated margins (diameter 4 cm) covered with light exudate (Fig. 1). An anal fissure was noted. He had chronic obstipation. There were no close contacts with tonsillitis or impetigo. The rapid a ntigen detection test for group A Streptococcus (GAS) of the perianal lesion showed a positive result (Healgen GAS Rapid Test – Cassette). (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - April 26, 2019 Category: Perinatology & Neonatology Authors: Maria Jo ão Palha, Sara Limão, Mafalda Casinhas Santos, Florbela Cunha Tags: Images Source Type: research

Pediatric gastric perforation beyond neonatal period: 8-year experience with 20 patients
To describe the characteristics, treatments, and prognosis of pediatric gastric perforation patients beyond neonatal period. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - April 13, 2019 Category: Perinatology & Neonatology Authors: Kai Wang, Siyu Cai, Lejian He, Chunhui Peng, Wenbo Pang, Zengmeng Wang, Dongyang Wu, Yajun Chen Tags: Original Article Source Type: research

Cutaneous markers of occult spinal dysraphism
A female infant was born at 40 weeks' gestational age after an uncomplicated pregnancy with normal prenatal ultrasound findings. After birth, the newborn was found to have a midline sacrococcygeal soft tissue protrusion, a deviated gluteal cleft, and a left paraspinal hypopigmented macula (Fig.  1). The rest of the examination was normal. A spinal magnetic resonance imaging (MRI) performed when the infant was 5 days’ old confirmed the presence of spinal cord tethering, sacrococcygeal lipomyelocele, and dermal sinus tract in continuity with the protrusion (Fig. 2). (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - April 13, 2019 Category: Perinatology & Neonatology Authors: Rita Ramos, Rita Guerreiro, Catarina Couto, Andreia Amorim, Margarida Cabral, Anselmo Costa Tags: Images Source Type: research

Risk factors for postdischarge growth retardation among very-low-birth-weight infants: A nationwide registry study in Taiwan
This study examined the prevalence and the risk factors for postdischarge GR among VLBW infants in Taiwan. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - April 11, 2019 Category: Perinatology & Neonatology Authors: Wei-Li Liao, Ming-Chih Lin, Teh-Ming Wang, Chao-Huei Chen, Taiwan Premature Infant Follow-up Network Tags: Original Article Source Type: research

Cystic fibrosis complicated by cor pulmonale: The first case report in Taiwan
I read with great interest the article entitled Cystic Fibrosis Complicated by Cor Pulmonale: The First Case Report in Taiwan by Chen et  al.1 (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - April 8, 2019 Category: Perinatology & Neonatology Authors: Mohammad Ashkan Moslehi Tags: Letter to the Editor Source Type: research

Reply – Cystic fibrosis complicated by cor pulmonale: The first case report in Taiwan
Moslehi1 had some recommendations on our paper about “Cystic Fibrosis Complicated by Cor Pulmonale: The First Case Report in Taiwan.”2 He mentioned the possibility of neglected and/or undiagnosed severe cystic fibrosis (CF) patients in Asia and Taiwan and had some suggestions about prompting the CF condition among Asian countries and Taiwan.1 CF i s an autosomal recessive inherited disorder most commonly found in Caucasians and characterized by a defective chloride transport channel in the epithelial cells. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - April 8, 2019 Category: Perinatology & Neonatology Authors: Shyh-Dar Shyur Tags: Letter to the Editor Source Type: research

Basal serum cortisol concentration in very low birth weight infants
The aim of our study was to measure the basal serum cortisol concentration immediately after birth and to determine its association with perinatal factors and clinical outcomes in very low birth weight (VLBW) infants. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - April 5, 2019 Category: Perinatology & Neonatology Authors: Ji Hye Hwang, Byong Sop Lee, Chae Young Kim, Euiseok Jung, Ellen Ai-Rhan Kim, Ki-Soo Kim Tags: Original Article Source Type: research

The missing link between familial Mediterranean fever and recurrent aseptic meningitis
Yusef et  al. reported a case of familial Mediterranean fever (FMF) presenting with recurrent aseptic meningitis (RAM).1 There is no consensus on a possible association between the two conditions, and we have proposed criteria to assess the strength of evidence of case reports.2 In the present case, FMF was diagnosed based on a homozygous E148Q mutation on the MEFV gene. However, the pathogenicity of the E148Q mutation is uncertain, and the diagnosis of FMF requires clinical features that are missing in this case. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - April 3, 2019 Category: Perinatology & Neonatology Authors: J. Capron, G. Grateau, O. Steichen Tags: Letter to the Editor Source Type: research

Editorial Board
(Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - April 1, 2019 Category: Perinatology & Neonatology Source Type: research

The association of Trisomy 13 and 18 and hospital discharge outcomes among neonates in California: A retrospective cohort study
Despite Trisomy 13 and 18 being among the most fatal congenital anomalies, limited information exists about resource utilization and factors associated with length of stay (LOS) and total hospital charges (THC) for these anomalies. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - March 29, 2019 Category: Perinatology & Neonatology Authors: Edith Haghnazarian, Jiaqi Hu, Ashley Y. Song, Philippe S. Friedlich, Ashwini Lakshmanan Tags: Original Article Source Type: research

Purpuric rash and fever among hospitalized children aged 0 –18 years: Comparison between clinical, laboratory, therapeutic and outcome features of patients with bacterial versus viral etiology
We described all children aged 0 –18 years with PRF in southern Israel during the period 2005 ̶ 2016 and compared their microbiologic, laboratory, clinical and outcome characteristics in relation to various etiologies of this syndrome. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - March 25, 2019 Category: Perinatology & Neonatology Authors: Moran Gawie-Rotman, Guy Hazan, Yariv Fruchtman, Yuval Cavari, Eduard Ling, Isaac Lazar, Eugene Leibovitz Tags: Original Article Source Type: research

Visual function scale for identification of infants with low respiratory compliance
Precise estimation of respiratory function is essential to optimise neonatal respiratory care. However, current clinical scores have not been validated with quantitative measures of respiratory function. The aim of this study was to develop a physiological scoring system to predict low respiratory dynamic compliance of (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - March 21, 2019 Category: Perinatology & Neonatology Authors: Eimei Harada, Masahiro Kinoshita, Sachiko Iwata, Mamoru Saikusa, Kennosuke Tsuda, Ryota Shindou, Takeshi Sahashi, Shin Kato, Yasumasa Yamada, Shinji Saitoh, Osuke Iwata Tags: Original Article Source Type: research

Clinical significance of asymmetric skin folds in the medial thigh for the infantile screening of developmental dysplasia of the hip
The presence of asymmetric skin folds in the medial thigh (ASM) is often used as one of the screening items for developmental dysplasia of the hip (DDH). However, few studies have evaluated the clinical relevance of ASM in DDH. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - March 20, 2019 Category: Perinatology & Neonatology Authors: Michael Seungcheol Kang, Geun Won Han, Minjae Kam, Soo-Sung Park Tags: Original Article Source Type: research

How to predict serious bacterial infections in young febrile infants in the emergency department?
Fever is the most common reason for young infants (age (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - March 20, 2019 Category: Perinatology & Neonatology Authors: Ting-Yu Yen Tags: Editorial Source Type: research

Endoscopic balloon dilatation in pediatric patients with esophageal strictures: From the past to the future
Following its first successful use in re-opening an artery with stenosis by Dr. Andreas Gr üntzig in 1974,1 balloon catheter was applied to not only angioplasty but also dilatation of esophageal strictures under fluoroscope in two adults in 1981 and under fiberesophagoscope in seven patients, including a child with caustic stricture complicated twice with perforation in 1984.2,3 Balloon catheters can pass thorough severe, lengthy, irregular esophageal strictures with a bendable guide wire with subsequent balloon catheter dilatation for patients who had failed treatment with conventional bougienage techniques. (Source:...
Source: Pediatrics and Neonatology - March 20, 2019 Category: Perinatology & Neonatology Authors: Shiuh-Bin Fang Tags: Editorial Source Type: research

Single strain versus multispecies probiotic on necrotizing enterocolitis and faecal IgA levels in very low birth weight preterm neonates: A randomized clinical trial
The objective of this study was to compare single strain (Lactobacillus acidophilus boucardii) versus multispecies probiotics on NEC incidence and faecal secretory Immunoglobulin A (sIgA) levels in very low preterm newborns. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - March 18, 2019 Category: Perinatology & Neonatology Authors: Guadalupe G ómez–Rodríguez, Norma Amador-Licona, Leonel Daza-Benítez, Gloria Barbosa-Sabanero, Deyanira Carballo-Magdaleno, Rodrigo Aguilar-Padilla, Eduardo González-Ramirez Tags: Original Article Source Type: research

Dynamics of concomitant therapy in children with juvenile idiopathic arthritis treated with etanercept and methotrexate
Both the steroid- and NSAID-sparing effects of biologics in juvenile idiopathic arthritis (JIA) treatment are key aspects of the dynamics of patient ’s condition. The proper selection of biologics enables maximum treatment effectiveness and reduction of the dosage of concomitant therapy. Our aim was to study the dynamics of concomitant therapy during etanercept (ETA) and methotrexate (MTX) treatment in patients with JIA. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - March 15, 2019 Category: Perinatology & Neonatology Authors: Ekaterina Alexeeva, Tatyana Dvoryakovskaya, Rina Denisova, Tatyana Sleptsova, Kseniya Isaeva, Alexandra Chomahidze, Anna Fetisova, Anna Mamutova, Alina Alshevskaya, Victor Gladkikh, Andrey Moskalev Tags: Original Article Source Type: research