Relationship between serum uric acid and sarcopenia in geriatric heart failure patients with preserved ejection fraction
CONCLUSIONS: In summary, the prevalence of sarcopenia is positively related to serum UA levels among the elderly diagnosed with HFpEF. Due to the cross-sectional nature of the study design, additional investigations are necessary to validate our findings and identify the optimal range for UA reduction.PMID:38670208 | DOI:10.1016/j.exger.2024.112445 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 26, 2024 Category: Geriatrics Authors: Miao Lu Yansong Li Yiting Pan Yinzhang Ding Kai Wang Di Xu Source Type: research
Serine protease inhibitor, SerpinA3n regulates cardiac remodeling after myocardial infarction
Cardiovasc Res. 2024 Apr 26:cvae075. doi: 10.1093/cvr/cvae075. Online ahead of print.ABSTRACTFollowing myocardial infarction, the heart repairs itself via a fibrotic repair response. The degree of fibrosis is determined by the balance between deposition of extracellular matrix by activated fibroblasts and breakdown of nascent scar tissue by proteases that are secreted predominantly by inflammatory cells. Excessive proteolytic activity and matrix turnover has been observed in human heart failure and protease inhibitors in the injured heart regulate matrix breakdown. Serine protease inhibitors (Serpins) represent the largest...
Source: Cell Research - April 26, 2024 Category: Cytology Authors: Qihao Sun Wei Chen Rimao Wu Bo Tao Ping Wang Baiming Sun Juan F Alvarez Feiyang Ma David Ceja Galindo Sean P Maroney Anthony J Saviola Kirk C Hansen Shen Li Arjun Deb Source Type: research
Ultrasound ‑targeted microbubble destruction technology delivering β‑klotho to the heart enhances FGF21 sensitivity and attenuates heart remodeling post‑myocardial infarction
Int J Mol Med. 2024 Jun;53(6):54. doi: 10.3892/ijmm.2024.5378. Epub 2024 Apr 26.ABSTRACTFibroblast growth factor (FGF)21 is a peptide hormone that improves mitochondrial function and energy metabolism, and the deficiency of its co‑receptor β‑klotho (KLB) causes decreased FGF21 sensitivity. The present study examined whether the cardiac delivery of plasmids containing the KLB gene via ultrasound‑targeted microbubble destruction (UTMD) enhances the efficacy of FGF21 against heart failure post‑acute myocardial infarction (AMI). For this purpose, the levels of FGF21 in patients and rats with heart dysfunction post‑i...
Source: Molecular Medicine - April 26, 2024 Category: Molecular Biology Authors: Chaofu Yue Rong Li Chunyan Li Taoxian Yang Xian Huang Rong Lei Yongjun Yan Yuan Liu Qiaolin Li Qinyong Yan Dingrong Zuo Shisheng Liu Mei Yang Source Type: research
Ultrasound ‑targeted microbubble destruction technology delivering β‑klotho to the heart enhances FGF21 sensitivity and attenuates heart remodeling post‑myocardial infarction
Int J Mol Med. 2024 Jun;53(6):54. doi: 10.3892/ijmm.2024.5378. Epub 2024 Apr 26.ABSTRACTFibroblast growth factor (FGF)21 is a peptide hormone that improves mitochondrial function and energy metabolism, and the deficiency of its co‑receptor β‑klotho (KLB) causes decreased FGF21 sensitivity. The present study examined whether the cardiac delivery of plasmids containing the KLB gene via ultrasound‑targeted microbubble destruction (UTMD) enhances the efficacy of FGF21 against heart failure post‑acute myocardial infarction (AMI). For this purpose, the levels of FGF21 in patients and rats with heart dysfunction post‑i...
Source: International Journal of Molecular Medicine - April 26, 2024 Category: Molecular Biology Authors: Chaofu Yue Rong Li Chunyan Li Taoxian Yang Xian Huang Rong Lei Yongjun Yan Yuan Liu Qiaolin Li Qinyong Yan Dingrong Zuo Shisheng Liu Mei Yang Source Type: research
Modeling heart failure with preserved ejection fraction in female mice: an elusive target
Am J Physiol Heart Circ Physiol. 2024 Apr 26. doi: 10.1152/ajpheart.00139.2024. Online ahead of print.NO ABSTRACTPMID:38668704 | DOI:10.1152/ajpheart.00139.2024 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 26, 2024 Category: Physiology Authors: Taben M Hale Erik A Blackwood Source Type: research
Serine protease inhibitor, SerpinA3n regulates cardiac remodeling after myocardial infarction
Cardiovasc Res. 2024 Apr 26:cvae075. doi: 10.1093/cvr/cvae075. Online ahead of print.ABSTRACTFollowing myocardial infarction, the heart repairs itself via a fibrotic repair response. The degree of fibrosis is determined by the balance between deposition of extracellular matrix by activated fibroblasts and breakdown of nascent scar tissue by proteases that are secreted predominantly by inflammatory cells. Excessive proteolytic activity and matrix turnover has been observed in human heart failure and protease inhibitors in the injured heart regulate matrix breakdown. Serine protease inhibitors (Serpins) represent the largest...
Source: Cell Research - April 26, 2024 Category: Cytology Authors: Qihao Sun Wei Chen Rimao Wu Bo Tao Ping Wang Baiming Sun Juan F Alvarez Feiyang Ma David Ceja Galindo Sean P Maroney Anthony J Saviola Kirk C Hansen Shen Li Arjun Deb Source Type: research
Efficacy of catheter ablation for atrial fibrillation in heart failure: a meta ‐analysis of randomized controlled trials
AbstractThe study aims to evaluate whether rhythm control by catheter ablation is superior to medical therapy for the patients with atrial fibrillation (AF) and heart failure (HF). The literatures were searched by using PubMed, Cochrane Library, Embase, and Web of Science databases up to 12 October 2023. The randomized controlled trials (RCTs) comparing rhythm control using catheter ablation vs. medical therapy in AF patients with HF were pooled. The primary outcomes included all-cause mortality, HF re-hospitalization, and stroke, and the secondary outcomes included left ventricular ejection fraction (LVEF), atrial tachyar...
Source: ESC Heart Failure - April 26, 2024 Category: Cardiology Authors: Zhongyin Zhang,
Yan Zheng,
Wenxiu He,
Jiahe Wei,
Pengzhan Li,
Guoqiang Zhong,
Zhiyuan Jiang Tags: Review Source Type: research
Interatrial shunting as a treatment for heart failure: Where do we stand?
(Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - April 26, 2024 Category: Cardiology Authors: Thomas M. Gorter,
Elke S. Hoendermis,
Dirk J. van Veldhuisen Tags: Invited Editorial Source Type: research
Me Versus Not Me: Assimilating to a Left Ventricular Assist Device Implant
Durable left ventricular assist device (dLVAD) is life-saving strategy for several patients with end-stage heart failure, offering them an opportunity for increased longevity as well as improved quality of life. The effectiveness of this life saving treatment is well documented throughout the literature.1 Research exploring the patient ’s subjective experience on dLVAD, including health related quality of life (hrQOL) and overlapping concepts of patients’ physical and social adaptations, and psychological symptoms remain insufficient. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 26, 2024 Category: Transplant Surgery Authors: Kelly Bryce, Juliane K. Vierecke Tags: Editorial Source Type: research
Factors affecting hospitalization and mortality in a retrospective study of elderly patients with heart failure
The objective of this study was to investigate factors that affect hospitalization an... (Source: BMC Cardiovascular Disorders)
Source: BMC Cardiovascular Disorders - April 26, 2024 Category: Cardiology Authors: Johan Bj örklund, Louise Pettersson and Björn Agvall Tags: Research Source Type: research
Improved all-cause mortality with left bundle branch area pacing compared to biventricular pacing in cardiac resynchronization therapy: a meta-analysis
ConclusionIn this meta-analysis, LBBAP was associated with a significant reduction in all-cause mortality as well as HF-related hospitalization when compared to BIVP. Additional data from large RCTs is warranted to corroborate these promising findings.Graphical abstractLBBP, left bundle branch area pacing; BIVP, biventricular pacing; RRR, relative risk reduction; ARR, absolute risk reduction; ms, milliseconds; LVEF, left ventricular ejection fraction; NYHA, New York Heart Association; min, minutes (Source: Journal of Interventional Cardiac Electrophysiology)
Source: Journal of Interventional Cardiac Electrophysiology - April 26, 2024 Category: Cardiology Source Type: research
Alcohol consumption and progression of heart failure in those at risk for or with pre-heart failure
People with heart risk factors such as high blood pressure, diabetes, obesity or high cholesterol, may develop extra strain on the heart over time because of these risk factors. We researched the association of low and moderate-high levels of alcohol intake, compared to no intake, with changes in the heart over time. We found that amongst participants with heart abnormalities, drinking the equivalent of more than a bottle of wine per week was associated with further negative changes in the heart or development of symptoms of heart failure. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - April 26, 2024 Category: Cardiology Authors: Bethany Wong, Ashe Moore, Ken McDonald, Mark Ledwidge Source Type: research
Effect of diabetes mellitus on global longitudinal strain
The global longitudinal strain (GLS) of the left ventricle (LV) is considered an effective measure for the evaluation of ventricular function, especially in the absence of systolic dysfunction or in its earliest forms, and it correlates strongly with LV ejection fraction (LVEF) (1 –3). Age, gender, and impaired LVEF have been identified as leading factors for higher GLS(2). Patients with diabetes mellitus (DM) have a higher risk of developing ventricular dysfunction and heart failure (HF)(4). We hypothesized that DM could be have a higher impact on GLS in patients with HF. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - April 26, 2024 Category: Cardiology Authors: Alberto Cordero, David Sirera, Jos é Méndez-Gallego, Ignacio Echeverría Tags: Brief report Source Type: research
Letter to the editor regarding ‘Autopsy findings in cases of fatal COVID‐19 vaccine‐induced myocarditis’
(Source: ESC Heart Failure)
Source: ESC Heart Failure - April 25, 2024 Category: Cardiology Authors: Hannah Van Wyk,
Mia Q. Zhu,
Danielle R. Stone,
Awnish Kumar Singh,
Sarah Bassiouni Tags: Letter to the Editor Source Type: research
Conceptual Approach to Body Fluids and Edema, Education Determines Clinical Outcomes in Heart Failure
Iran J Kidney Dis. 2024 Mar;18(2):65-67. doi: 10.5254/1aytkx77.ABSTRACTIn this brief communication, we reemphasize the importance of critical thinking in clinical practice using the example of edema. The common practice of thinking and inquiry by practicing clinicians has beneficial implications for healthcare by improving outcomes and patient care while alleviating the burden of misconceptions in practice. We provide an in-depth and interactive investigation of physiological concepts as a foundation for understanding body fluid dynamics. Finally, we offer a new classification of symptoms of heart failure. DOI: 10.52547/ij...
Source: Iranian Journal of Kidney Diseases - April 25, 2024 Category: Urology & Nephrology Authors: Mohammad A Shafiee Amireza Goli Pouyan Shaker Vishal Sharma Yasmin Shahideh Khrystyna Maryniak Behrooz Broumand Source Type: research
