Cardiorespiratory fitness is a strong and consistent predictor of morbidity and mortality among adults: an overview of meta-analyses representing over 20.9 million observations from 199 unique cohort studies
Conclusion
We found consistent evidence that high CRF is strongly associated with lower risk for a variety of mortality and incident chronic conditions in general and clinical populations. (Source: British Journal of Sports Medicine)
Source: British Journal of Sports Medicine - May 2, 2024 Category: Sports Medicine Authors: Lang, J. J., Prince, S. A., Merucci, K., Cadenas-Sanchez, C., Chaput, J.-P., Fraser, B. J., Manyanga, T., McGrath, R., Ortega, F. B., Singh, B., Tomkinson, G. R. Tags: Open access, BJSM Reviews with MCQs, BJSM Systematic review Source Type: research
Deciphering mortality risk of diabetes medications in heart failure patients with diabetes mellitus under triple guideline-directed medical therapy
Scientific evidence regarding the impact of different combinations of diabetes medications in heart failure patients with diabetes mellitus (HFwDM) remains limited. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 2, 2024 Category: Cardiology Authors: İnci Tuğçe Çöllüoğlu, Ahmet Çelik, Naim Ata, Dilek Ural, Anıl Şahin, Mustafa Mahir Ulgu, Emine Arzu Kanık, Şuayip Birinci, Mehmet Birhan Yılmaz Source Type: research
Digital health technologies in enhancing patient and caregiver engagement in heart failure management: Opportunities and challenges
The management of heart failure has undergone significant evolution, advancing from the initial utilization of digitalis and diuretics to the contemporary practice of personalized medicine and sophisticated device therapy. Despite these advancements, the persistent challenge of high hospitalization and readmission rates underscores an urgent need for innovative solutions. This manuscript explores how the integration of digital health technologies into interventional cardiology marks a paradigm shift in the management of heart failure. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 2, 2024 Category: Cardiology Authors: Arif Albulushi, Dawoud I. Al Kindi, Nader Moawwad, Adel M. Kamel, Asif Khan, Mohamed A. Moustafa, Ahmed Al Kalbani Source Type: research
Adult and neonatal models of chemogenetic heart failure caused by oxidative stress
(Source: Journal of Clinical Investigation)
Source: Journal of Clinical Investigation - May 1, 2024 Category: Biomedical Science Authors: Fotios Spyropoulos, Apabrita Ayan Das, Markus Waldeck-Weiermair, Shambhu Yadav, Arvind K. Pandey, Ruby Guo, Taylor A. Covington, Venkata Thulabandu, Kosmas Kosmas, Benjamin Steinhorn, Mark A. Perrella, Xiaoli Liu, Helen Christou, Thomas Michel Source Type: research
Semaglutide in Patients with HFpEF and Obesity
This study enrolled adult patients with obesity (BMI ≥30 kg/m2), HFpEF (left ventricular ejection fraction ≥45%; and New York Heart Association functional class II, III, or IV), a Kansas City Cardiomyopathy Questionnaire clinical summary score (KCCQ-CSS) of less than 90 points, a six-minute walk distance of at least 100 m; and clinical or laboratory evidence of volume-overloaded HF. About 500 participants, median age of 69, were randomized to receive semaglutide 2.4 mg subcutaneously weekly, versus placebo for 52 weeks. In patients randomized to receive semaglutide, there was an improvement in self-reported HF symptoms...
Source: The Hospitalist - May 1, 2024 Category: Hospital Management Authors: Ronda Whitaker Tags: Cardiology In the Literature Pharmacology Source Type: research
Elevated cardiovascular risk and acute events in hospitalized colon cancer survivors: A decade-apart study of two nationwide cohorts
CONCLUSION: Colon cancer survivors hospitalized 10 years apart in the United States showed an increased CVD risk with an increased risk of acute cardiovascular events (stroke 28%, PE 47%, arrhythmia 41%, and cardiac arrest 63%). It is vital to regularly screen colon cancer survivors with concomitant CVD risk factors to curtail long-term cardiovascular complications.PMID:38689632 | PMC:PMC11056864 | DOI:10.5306/wjco.v15.i4.548 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Rupak Desai Avilash Mondal Vivek Patel Sandeep Singh Shaylika Chauhan Akhil Jain Source Type: research
The role of IFI16 in regulating PANoptosis and implication in heart diseases
Cell Death Discov. 2024 May 1;10(1):204. doi: 10.1038/s41420-024-01978-5.ABSTRACTInterferon Gamma Inducible Protein 16 (IFI16) belongs to the HIN-200 protein family and is pivotal in immunological responses. Serving as a DNA sensor, IFI16 identifies viral and aberrant DNA, triggering immune and inflammatory responses. It is implicated in diverse cellular death mechanisms, such as pyroptosis, apoptosis, and necroptosis. Notably, these processes are integral to the emergent concept of PANoptosis, which encompasses cellular demise and inflammatory pathways. Current research implies a significant regulatory role for IFI16 in P...
Source: Atherosclerosis - May 1, 2024 Category: Cardiology Authors: Xindi Chang Bei Wang Yingli Zhao Bing Deng Ping Liu Yiru Wang Source Type: research
MicroRNA-181 in cardiovascular disease: Emerging biomarkers and therapeutic targets
FASEB J. 2024 May 15;38(9):e23635. doi: 10.1096/fj.202400306R.ABSTRACTCardiovascular disease (CVD) is the leading cause of death worldwide. MicroRNAs (MiRNAs) have attracted considerable attention for their roles in several cardiovascular disease states, including both the physiological and pathological processes. In this review, we will briefly describe microRNA-181 (miR-181) transcription and regulation and summarize recent findings on the roles of miR-181 family members as biomarkers or therapeutic targets in different cardiovascular-related conditions, including atherosclerosis, myocardial infarction, hypertension, and...
Source: Atherosclerosis - May 1, 2024 Category: Cardiology Authors: Bingjie Lv Shaolin He Peixin Li Shijiu Jiang Dazhu Li Jibin Lin Mark W Feinberg Source Type: research
Cardioprotective Potential of Sodium-Glucose Co-Transporter-2 Inhibitors in Cancer Patients Treated With Anthracyclines: An Observational Study
In conclusion, amidst cancer patients receiving anthracycline therapy without preexisting HF, SGLT2i use demonstrates both safety and effectiveness in reducing anthracycline-induced cardiotoxicity, with a decreased incidence of new-onset HF, HF exacerbation, and arrhythmias.PMID:38692401 | DOI:10.1016/j.amjcard.2024.04.032 (Source: Cancer Control)
Source: Cancer Control - May 1, 2024 Category: Cancer & Oncology Authors: Ayman R Fath Mostafa Aglan Amro Aglan Robert J Chilton Anatole Trakhtenbroit Odaye A Al-Shammary Oduro Oppong-Nkrumah Daniel J Lenihan Susan F Dent Prince Otchere Source Type: research
Ertugliflozin for Functional Mitral Regurgitation Associated With Heart Failure: EFFORT Trial
CONCLUSIONS: Among patients with functional MR associated with HF, ertugliflozin significantly improved LV global longitudinal strain and left atrial remodeling, and reduced functional MR. Sodium-glucose cotransporter 2 inhibitors may be considered for patients with functional MR.REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT04231331.PMID:38690659 | DOI:10.1161/CIRCULATIONAHA.124.069144 (Source: Circulation)
Source: Circulation - May 1, 2024 Category: Cardiology Authors: Duk-Hyun Kang Sung-Ji Park Sung-Hee Shin In-Chang Hwang Yeonyee Elizabeth Yoon Hyung-Kwan Kim Mijin Kim Min-Seok Kim Sung-Cheol Yun Jong-Min Song Seok-Min Kang Source Type: research
Left bundle branch pacing set to outshine biventricular pacing for cardiac resynchronization therapy?
World J Cardiol. 2024 Apr 26;16(4):186-190. doi: 10.4330/wjc.v16.i4.186.ABSTRACTThe deleterious effects of long-term right ventricular pacing necessitated the search for alternative pacing sites which could prevent or alleviate pacing-induced cardiomyopathy. Until recently, biventricular pacing (BiVP) was the only modality which could mitigate or prevent pacing induced dysfunction. Further, BiVP could resynchronize the baseline electromechanical dssynchrony in heart failure and improve outcomes. However, the high non-response rate of around 20%-30% remains a major limitation. This non-response has been largely attributable...
Source: World Journal of Cardiology - May 1, 2024 Category: Cardiology Authors: Akash Batta Juniali Hatwal Source Type: research
Carnosol attenuates angiotensin II-induced cardiac remodeling and inflammation via directly binding to p38 and inhibiting p38 activation
Int Immunopharmacol. 2024 Apr 30;134:112143. doi: 10.1016/j.intimp.2024.112143. Online ahead of print.ABSTRACTChronic inflammation is a significant contributor to hypertensive heart failure. Carnosol (Car), primarily derived from the sage plant (Salvia carnosa), exhibits anti-inflammatory properties in a range of systems. Nevertheless, the influence of angiotensin II (Ang II) on cardiac remodeling remains uncharted. Car was shown to protect mice's hearts against Ang II-induced heart damage at dosages of 20 and 40 mg/kg/d. This protection was evident in a concentration-related decrease in the remodeling of the heart and dys...
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Diyun Xu Bozhi Ye Liming Lin Yanhong Jin Yuchen Jiang Zhaozheng Zheng Yanghao Chen Xue Han Wei Wang Gaojun Wu Zaishou Zhuang Peiren Shan Guang Liang Source Type: research
Significant Association of Serum Albumin With the Severity of Coronary Microvascular Dysfunction Using Dynamic CZT ‐SPECT
ConclusionLow SA concentration was associated with the severity of CMD in both global and regional MFR as well as MBF. (Source: Microcirculation)
Source: Microcirculation - May 1, 2024 Category: Research Authors: Shih ‐Chieh Chien,
Shan‐Ying Wang,
Cheng‐Ting Tsai,
Yu‐Chien Shiau,
Yen‐Wen Wu Tags: ORIGINAL ARTICLE Source Type: research
Precision cardiac monitoring: algorithmic real ‐time assessment of right ventricular function in pulmonary hypertension
(Source: ESC Heart Failure)
Source: ESC Heart Failure - May 1, 2024 Category: Cardiology Authors: Nils Kremer,
Felix Glocker,
Simon Sch äfer,
Zvonimir Rako,
Athiththan Yogeswaran,
Werner Seeger,
Hans‐Bernd Hopf,
Khodr Tello Tags: Letter to the Editor Source Type: research
Pharmacist intervention to improve adherence to medication among heart failure patients at North East Ethiopia hospital
AbstractHeart failure (HF) is a major and growing medical problem and its management is still challenging due to the coexistence of complications, co-morbidity, and medication non-adherence. HF patients who are adherent to their medication have fewer HF exacerbations, improved survival, and lower healthcare expenditure. Adherence to HF medication plays a pivotal role in attaining maximal therapeutic outcomes. The aim was to assess the medication adherence of heart failure patients at Debre Berhan Comprehensive Specialized Hospital (DBCSH). A pre-post interventional study was undertaken from July 1, 2022, to December 31, 20...
Source: Pharmacology Research and Perspectives - May 1, 2024 Category: Drugs & Pharmacology Authors: Abate Wondesen Tsige,
Tsegaye Ababiya Kotiso,
Kassahun Dires Ayenew,
Siraye Genzeb Ayele Tags: ORIGINAL ARTICLE Source Type: research
