Beta Blockers in Contemporary Cardiology: Is It Better to Cast Them Out?
Korean Circ J. 2024 Apr;54(4):165-171. doi: 10.4070/kcj.2023.0209.ABSTRACTBeta blockers are one of the commonest prescription drugs in medicine and they have been thought to revolutionize the treatment of heart failure (HF) with reduced ejection fraction (HFrEF) in the last century. In addition to HFrEF, they are prescribed for a variety of diseases in cardiology from hypertension to HF, angina, and stable coronary artery disease (CAD). The increased prescription of beta blockers in conditions like HF with preserved ejection fraction (HFpEF), and stable CAD may be doing more harm than good as per the data we have so far. T...
Source: Korean Circulation Journal - April 24, 2024 Category: Cardiology Authors: Javaid Ahmad Dar John Roshan Jacob Source Type: research
Lower Atrial Fibrillation Risk With Sodium-Glucose Cotransporter 2 Inhibitors Than With Dipeptidyl Peptidase-4 Inhibitors in Individuals With Type 2 Diabetes: A Nationwide Cohort Study
CONCLUSIONS: In this nationwide cohort study of individuals with type 2 diabetes, treatment with SGLT2i was associated with a lower risk of AF compared with treatment with DPP-4i.PMID:38654455 | DOI:10.4070/kcj.2023.0234 (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - April 24, 2024 Category: Cardiology Authors: Min Kim Kyoung Hwa Ha Junyoung Lee Sangshin Park Kyeong Seok Oh Dae-Hwan Bae Ju Hee Lee Sang Min Kim Woong Gil Choi Kyung-Kuk Hwang Dong-Woon Kim Myeong-Chan Cho Dae Jung Kim Jang-Whan Bae Source Type: research
Management of Cardiovascular Diseases by Short-Chain Fatty Acid Postbiotics
Curr Nutr Rep. 2024 Apr 24. doi: 10.1007/s13668-024-00531-1. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Global health concerns persist in the realm of cardiovascular diseases (CVDs), necessitating innovative strategies for both prevention and treatment. This narrative review aims to explore the potential of short-chain fatty acids (SCFAs)-namely, acetate, propionate, and butyrate-as agents in the realm of postbiotics for the management of CVDs.RECENT FINDINGS: We commence our discussion by elucidating the concept of postbiotics and their pivotal significance in mitigating various aspects of cardiovascular diseases. T...
Source: Atherosclerosis - April 24, 2024 Category: Cardiology Authors: Seyed Sadeq Mousavi Ghahfarrokhi Mohamadsadegh Mohamadzadeh Nasrin Samadi Mohammad Reza Fazeli Sara Khaki Bahman Khameneh Ramin Khameneh Bagheri Source Type: research
Thoracic impedance monitoring in heart failure: from theory to practice
Expert Rev Med Devices. 2024 Apr 24. doi: 10.1080/17434440.2024.2347412. Online ahead of print.NO ABSTRACTPMID:38655906 | DOI:10.1080/17434440.2024.2347412 (Source: Expert Review of Medical Devices)
Source: Expert Review of Medical Devices - April 24, 2024 Category: Medical Devices Authors: Ahmed Maraey Paul Chacko George V Moukarbel Source Type: research
Heart failure potentially affects the cortical structure of the brain
CONCLUSIONS: HF was potentially associated with changes in cortical thickness and in the surface area of the caudal middle frontal lobule, insula lobule, precuneus lobule and superior parietal lobule.PMID:38656892 | DOI:10.18632/aging.205762 (Source: Aging)
Source: Aging - April 24, 2024 Category: Biomedical Science Authors: Yinqin Hu Tianyun Shi Zhaohui Xu Meng Zhang Jiahui Yang Zhirui Liu Qiqi Wan Yongming Liu Source Type: research
Is it NICE to measure natriuretic peptides after a hospitalization for heart failure?
(Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - April 24, 2024 Category: Cardiology Authors: Matteo Pagnesi,
Marianna Adamo,
Marco Metra Tags: Invited Editorial Source Type: research
Cytotoxicity and toxicoproteomics analysis of thiazolidinedione exposure in human ‐derived cardiomyocytes
AbstractThiazolidinediones (TZDs) (e.g. pioglitazone and rosiglitazone), known insulin sensitiser agents for type II diabetes mellitus, exhibit controversial effects on cardiac tissue. Despite consensus on their association with increased heart failure risk, limiting TZD use in diabetes management, the underlying mechanisms remain uncharacterised. Herein, we report a comprehensive in vitro investigation utilising a novel toxicoproteomics pipeline coupled with cytotoxicity assays in human adult cardiomyocytes to elucidate mechanistic insights into TZD cardiotoxicity. The cytotoxicity assay findings showed a significant loss...
Source: Journal of Applied Toxicology - April 24, 2024 Category: Toxicology Authors: Abdullah Al Sultan,
Zahra Rattray,
Nicholas J. W. Rattray Tags: RESEARCH ARTICLE Source Type: research
Follow the EMPULSE: In ‐hospital initiation of empagliflozin for heart failure across the spectrum of left ventricular ejection fraction
(Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - April 24, 2024 Category: Cardiology Authors: Tann Lien,
Kishan Srikanth,
Andrew P. Ambrosy Tags: Invited Editorial Source Type: research
Randomized investigation of the MitraClip device in heart failure: Design and rationale of the RESHAPE ‐HF2 trial design
ConclusionsThe RESHAPE-HF2 trial will provide sound evidence on the MitraClip device and its effects in HF patients with FMR. The recruitment was recently completed with 506 randomized patients. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - April 24, 2024 Category: Cardiology Authors: Stefan D. Anker,
Tim Friede,
Ralph Stephan von Bardeleben,
Javed Butler,
Kaneez Fatima,
Monika Diek,
Jutta Heinrich,
Gerd Hasenfu ß,
Wolfgang Schillinger,
Piotr Ponikowski Tags: Study Design Source Type: research
Clinical Pathology Conference: Case 4: An exophytic gingival mass of the right anterior mandible
An 83-year-old male presented to a community oral maxillofacial surgeon with a tender, pink, pedunculated exophytic tumor measuring 2 × 1.5 cm involving the right anterior mandible adjacent to tooth #27 (Figure 1A). His medical history was significant for hypertension, congestive heart failure, atrial fibrillation, and prostate cancer treated with radiation and androgen deprivation chemotherapy. The patient had been taking a miodarone, metoprolol, digoxin, rivaroxaban, furosemide, bicalutamide, and leuprorelin injections. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - April 24, 2024 Category: ENT & OMF Authors: Safia Durab, Ida A. Varghese, Laith Mahmood, Nadarajah Vigneswaran Source Type: research
A large, multi-center survey assessing health, social support, literacy, and self-management resources in patients with heart failure
Most patients with heart failure (HF) have multimorbidity which may cause difficulties with self-management. Understanding the resources patients draw upon to effectively manage their health is fundamental to ... (Source: BMC Public Health)
Source: BMC Public Health - April 24, 2024 Category: Consumer Health News Authors: Alanna M. Chamberlain, Erinn M. Hade, Irina V. Haller, Benjamin D. Horne, Catherine P. Benziger, Brent C. Lampert, Kismet D. Rasmusson, Kimberly Boddicker, Sheila M. Manemann and V éronique L. Roger Tags: Research Source Type: research
Evaluating the link between DIO3-FA27 promoter methylation, biochemical indices, and heart failure progression
Heart failure (HF) is a disease that poses a serious threat to individual health, and DNA methylation is an important mechanism in epigenetics, and its role in the occurrence and development of the disease has... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 24, 2024 Category: Research Authors: Yan Qi, Xiangchao Meng, Jing Li, Aoyue He, Jie Hao, Xu Zhao, Ruonan Zhao, Rongrong Chen and Rongqiang Zhang Tags: Research Source Type: research
Research advances on molecular mechanism and natural product therapy of iron metabolism in heart failure
AbstractThe progression of heart failure (HF) is complex and involves multiple regulatory pathways. Iron ions play a crucial supportive role as a cofactor for important proteins such as hemoglobin, myoglobin, oxidative respiratory chain, and DNA synthetase, in the myocardial energy metabolism process. In recent years, numerous studies have shown that HF is associated with iron dysmetabolism, and deficiencies in iron and overload of iron can both lead to the development of various myocarditis diseases, which ultimately progress to HF. Iron toxicity and iron metabolism may be key targets for the diagnosis, treatment, and pre...
Source: European Journal of Medical Research - April 24, 2024 Category: Research Source Type: research
Management of Cardiovascular Diseases by Short-Chain Fatty Acid Postbiotics
AbstractPurpose of ReviewGlobal health concerns persist in the realm of cardiovascular diseases (CVDs), necessitating innovative strategies for both prevention and treatment. This narrative review aims to explore the potential of short-chain fatty acids (SCFAs) —namely, acetate, propionate, and butyrate—as agents in the realm of postbiotics for the management of CVDs.Recent FindingsWe commence our discussion by elucidating the concept of postbiotics and their pivotal significance in mitigating various aspects of cardiovascular diseases. This review centers on a comprehensive examination of diverse SCFAs and their assoc...
Source: Current Nutrition Reports - April 24, 2024 Category: Nutrition Source Type: research
Brief report: Effect of cardiac multi-morbidity on COVID hospitalization outcomes
by Fouad Chouairi, Edward Jaffe, Abdul Mannan Khan Minhas, Marat Fudim
BackgroundThe COVID-19 pandemic has stretched healthcare resources thin and led to significant morbidity and mortality. There have been no studies utilizing national data to investigate the role of cardiac risk factors on outcomes of COVID hospitalizations. The aim of this study was to examine the effect of cardiac multimorbidity on healthcare utilization and outcomes among COVID hospitalizations during the first year of the pandemic. MethodsUsing the national inpatient sample (NIS), we identified all adult hospital admissions with a primary diagnosis o...
Source: PLoS One - April 24, 2024 Category: Biomedical Science Authors: Fouad Chouairi Source Type: research
