SETD2-mediated epigenetic regulation of noncanonical Wnt5A during osteoclastogenesis
To define the role of SETD2 in the WNT5a signaling in the context of osteoclastogenesis, we exploited two different models: in vitro osteoclast differentiation, and K/BxN serum-induced arthritis model. We foun... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - October 18, 2021 Category: Research Authors: Moonmoon Deb, Dipranjan Laha, Jyotirindra Maity and Hiranmoy Das Tags: Research Source Type: research

Association of peripheral blood DNA methylation level with Alzheimer ’s disease progression
Identifying biomarkers associated with Alzheimer ’s disease (AD) progression may enable patient enrichment and improve clinical trial designs. Epigenome-wide association studies have revealed correlations betwe... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - October 15, 2021 Category: Research Authors: Qingqin S. Li, Aparna Vasanthakumar, Justin W. Davis, Kenneth B. Idler, Kwangsik Nho, Jeffrey F. Waring and Andrew J. Saykin Tags: Research Source Type: research

DNA methylation-based profiling reveals distinct clusters with survival heterogeneity in high-grade serous ovarian cancer
High-grade serous ovarian cancer (HGSOC) is the most common type of epigenetically heterogeneous ovarian cancer. Methylation typing has previously been used in many tumour types but not in HGSOC. Methylation t... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - October 13, 2021 Category: Research Authors: Jieyu Wang, Jun Li, Ruifang Chen, Huiran Yue, Wenzhi Li, Beibei Wu, Yang Bai, Guohua Zhu and Xin Lu Tags: Research Source Type: research

Epigenetic targeting of the ACE2 and NRP1 viral receptors limits SARS-CoV-2 infectivity
SARS-CoV-2 uses the angiotensin-converting enzyme 2 (ACE2) and neuropilin-1 (NRP1) receptors for entry into cells, and the serine protease TMPRSS2 for S protein priming. Inhibition of protease activity or the ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - October 11, 2021 Category: Research Authors: Maria Laura Saiz, Marta L. De Diego, Dar ío López-García, Viviana Corte-Iglesias, Aroa Baragaño Raneros, Ivan Astola, Victor Asensi, Carlos López-Larrea and Beatriz Suarez-Alvarez Tags: Research Source Type: research

Race/ethnicity-associated blood DNA methylation differences between Japanese and European American women: an exploratory study
Racial/ethnic disparities in health reflect a combination of genetic and environmental causes, and DNA methylation may be an important mediator. We compared in an exploratory manner the blood DNA methylome of ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - October 11, 2021 Category: Research Authors: Min-Ae Song, Anna Eames Seffernick, Kellie J. Archer, Kellie M. Mori, Song-Yi Park, Linda Chang, Thomas Ernst, Maarit Tiirikainen, Karolina Peplowska, Lynne R. Wilkens, Lo ïc Le Marchand and Unhee Lim Tags: Research Source Type: research

Distinguishable DNA methylation defines disease susceptibility influenced by race and ethnicity
(Source: Clinical Epigenetics)
Source: Clinical Epigenetics - October 11, 2021 Category: Research Authors: Jairo A. Pinzon Cortes and Assam El-Osta Tags: Editorial Source Type: research

DNA methylation signatures of incident coronary heart disease: findings from epigenome-wide association studies
Coronary heart disease (CHD) is a type of cardiovascular disease (CVD) that affects the coronary arteries, which provide oxygenated blood to the heart. It is a major cause of mortality worldwide. Various predi... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - October 9, 2021 Category: Research Authors: Yujing Xia, Alison Brewer and Jordana T. Bell Tags: Review Source Type: research

Diagnosis of pulmonary nodules by DNA methylation analysis in bronchoalveolar lavage fluids
Lung cancer is the leading cause of cancer-related mortality. The alteration of DNA methylation plays a major role in the development of lung cancer. Methylation biomarkers become a possible method for lung ca... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - October 7, 2021 Category: Research Authors: Lei Li, Zhujia Ye, Sai Yang, Hao Yang, Jing Jin, Yingying Zhu, Jinsheng Tao, Siyu Chen, Jiehan Xu, Yanying Liu, Weihe Liang, Bo Wang, Mengzhu Yang, Qiaoyun Huang, Zhiwei Chen, Weimin Li & hellip; Tags: Research Source Type: research

DNA methylation profiling identifies two distinct subgroups in breast cancers with low hormone receptor expression, mainly associated with HER2 amplification status
Current clinical guidelines suggest that breast cancers with low hormone receptor expression (LowHR) in 1 –10% of tumor cells should be regarded as hormone receptor positive. However, clinical data show that th... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - October 3, 2021 Category: Research Authors: Philipp Jurmeister, Karsten Weber, Sonia Villegas, Thomas Karn, Michael Untch, Anne Thieme, Volkmar M üller, Eliane Taube, Peter Fasching, Wolfgang D. Schmitt, Frederik Marmé, Elmar Stickeler, Bruno V. Sinn, Paul Jank, Christian Schem, Frederick Klausch Tags: Research Source Type: research

Investigating the DNA methylation profile of e-cigarette use
Little evidence exists on the health effects of e-cigarette use. DNA methylation may serve as a biomarker for exposure and could be predictive of future health risk. We aimed to investigate the DNA methylation... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - September 28, 2021 Category: Research Authors: Rebecca C. Richmond, Carlos Sillero-Rejon, Jasmine N. Khouja, Claire Prince, Alexander Board, Gemma Sharp, Matthew Suderman, Caroline L. Relton, Marcus Munaf ò and Suzanne H. Gage Tags: Research Source Type: research

Prenatal and postnatal traffic pollution exposure, DNA methylation in Shank3 and MeCP2 promoter regions, H3K4me3 and H3K27me3 and sociability in rats ’ offspring
Road traffic air pollution is linked with an increased risk of autistic spectrum disorder (ASD). The aim of this study is to assess the effect of exposure to prenatal or postnatal traffic-related air pollution... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - September 26, 2021 Category: Research Authors: Qinfeng Zhou, Yu Tian, Chenlu Xu, Juling Wang and Yongtang Jin Tags: Research Source Type: research

Combined effects of progesterone and SOCS3 DNA methylation on T2DM: a case –control study
This study aims to investigate the independent and combined effects of progesterone and suppressor of cytokine signaling (SOCS)-3 DNA methylation on type 2 diabetes mellitus (T2DM) among men and postmenopausal wo... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - September 26, 2021 Category: Research Authors: Lulu Wang, Zhenxing Mao, Xiaotian Liu, Dandan Wei, Pengling Liu, Luting Nie, Keliang Fan, Ning Kang, Yu Song, Qingqing Xu, Juan Wang, Mian Wang, Wei Liao, Tao Jing, Wenjie Li, Chongjian Wang & hellip; Tags: Research Source Type: research

Histone H3 lysine 27 acetylation profile undergoes two global shifts in undernourished children and suggests altered one-carbon metabolism
Stunting is a condition in which a child does not reach their full growth potential due to chronic undernutrition. It arises during the first 2 years of a child ’s life and is associated with developmental defi... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - September 26, 2021 Category: Research Authors: Kristyna Kupkova, Savera J. Shetty, Rashidul Haque, William A. Petri Jr. and David T. Auble Tags: Research Source Type: research

Integrative genomics analysis of nasal intestinal-type adenocarcinomas demonstrates the major role of CACNA1C and paves the way for a simple diagnostic tool in male woodworkers
Nasal intestinal-type adenocarcinomas (ITAC) are strongly related to chronic wood dust exposure: The intestinal phenotype relies on CDX2 overexpression but underlying molecular mechanisms remain unknown. Our o... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - September 25, 2021 Category: Research Authors: Patrice Gallet, Abderrahim Oussalah, Celso Pouget, Gunnar Dittmar, Celine Chery, Guillaume Gauchotte, Roger Jankowski, Jean Louis Gueant and R émi Houlgatte Tags: Research Source Type: research

Correction to: Evaluation of global and intragenic hypomethylation in colorectal adenomas improves patient stratification and colorectal cancer risk prediction
(Source: Clinical Epigenetics)
Source: Clinical Epigenetics - September 21, 2021 Category: Research Authors: Carla Debernardi, Laura Libera, Enrico Berrino, Nora Sahnane, Anna Maria Chiaravalli, Cristiana Laudi, Mattia Berselli, Anna Sapino, Fausto Sessa, Tiziana Venesio and Daniela Furlan Tags: Correction Source Type: research

DNA 5-hydroxymethylcytosine in pediatric central nervous system tumors may impact tumor classification and is a positive prognostic marker
Nucleotide-specific 5-hydroxymethylcytosine (5hmC) remains understudied in pediatric central nervous system (CNS) tumors. 5hmC is abundant in the brain, and alterations to 5hmC in adult CNS tumors have been re... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - September 19, 2021 Category: Research Authors: Nasim Azizgolshani, Curtis L. Petersen, Youdinghuan Chen, Joshua J. Levy, Lucas A. Salas, Laurent Perreard, Lananh N. Nguyen and Brock C. Christensen Tags: Research Source Type: research

Impact of vitamin C supplementation on placental DNA methylation changes related to maternal smoking: association with gene expression and respiratory outcomes
Maternal smoking during pregnancy (MSDP) affects development of multiple organ systems including the placenta, lung, brain, and vasculature. In particular, children exposed to MSDP show lifelong deficits in pu... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - September 19, 2021 Category: Research Authors: Lyndsey E. Shorey-Kendrick, Cindy T. McEvoy, Shannon M. O ’Sullivan, Kristin Milner, Brittany Vuylsteke, Robert S. Tepper, David M. Haas, Byung Park, Lina Gao, Annette Vu, Cynthia D. Morris and Eliot R. Spindel Tags: Research Source Type: research

Hi-C profiling of cancer spheroids identifies 3D-growth-specific chromatin interactions in breast cancer endocrine resistance
Organoids or spheroids have emerged as a physiologically relevant in vitro preclinical model to study patient-specific diseases. A recent study used spheroids of MCF10 cells to model breast cancer progression ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - September 17, 2021 Category: Research Authors: Jingwei Li, Kun Fang, Lavanya Choppavarapu, Ke Yang, Yini Yang, Junbai Wang, Ruifeng Cao, Ismail Jatoi and Victor X. Jin Tags: Research Source Type: research

Impact of molecular surgical margin analysis on the prediction of pancreatic cancer recurrences after pancreaticoduodenectomy
Pancreatic cancer is one of the lethal cancers among solid malignancies. Pathological diagnosis of surgical margins is sometimes unreliable due to tissue shrinkage, invisible field cancerization and skipped le... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - September 16, 2021 Category: Research Authors: Yuki Sunagawa, Masamichi Hayashi, Suguru Yamada, Hiroshi Tanabe, Keisuke Kurimoto, Nobutake Tanaka, Fuminori Sonohara, Yoshikuni Inokawa, Hideki Takami, Mitsuro Kanda, Chie Tanaka, Goro Nakayama, Masahiko Koike and Yasuhiro Kodera Tags: Research Source Type: research

METTL3-dependent MALAT1 delocalization drives c-Myc induction in thymic epithelial tumors
Thymic epithelial tumors (TETs) are rare neoplasms, originating from epithelial thymic cells. The oncogenic potential of these rare neoplasms is still largely undefined, and a deeper molecular characterization... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - September 16, 2021 Category: Research Authors: Alessia Iaiza, Claudia Tito, Zaira Ianniello, Federica Ganci, Valentina Laquintana, Enzo Gallo, Andrea Sacconi, Silvia Masciarelli, Luciana De Angelis, Sara Aversa, Daniele Diso, Marco Anile, Vincenzo Petrozza, Francesco Facciolo, Enrico Melis, Edoardo Pe Tags: Research Source Type: research

Targeting the methyltransferase SETD8 impairs tumor cell survival and overcomes drug resistance independently of p53 status in multiple myeloma
Multiple myeloma (MM) is a malignancy of plasma cells that largely remains incurable. The search for new therapeutic targets is therefore essential. In addition to a wide panel of genetic mutations, epigenetic... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - September 16, 2021 Category: Research Authors: Laurie Herviou, Sara Ovejero, Fanny Izard, Ouissem Karmous-Gadacha, Claire Gourzones, Celine Bellanger, Eva De Smedt, Anqi Ma, Laure Vincent, Guillaume Cartron, Jian Jin, Elke De Bruyne, Charlotte Grimaud, Eric Julien and J érôme Moreaux Tags: Research Source Type: research

Prenatal risk factors and neonatal DNA methylation in very preterm infants
Prenatal risk factors are related to poor health and developmental outcomes for infants, potentially via epigenetic mechanisms. We tested associations between person-centered prenatal risk profiles, cumulative... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - September 10, 2021 Category: Research Authors: Marie Camerota, Stefan Graw, Todd M. Everson, Elisabeth C. McGowan, Julie A. Hofheimer, T. Michael O ’Shea, Brian S. Carter, Jennifer B. Helderman, Jennifer Check, Charles R. Neal, Steven L. Pastyrnak, Lynne M. Smith, Lynne M. Dansereau, Sheri A. DellaG Tags: Research Source Type: research

Cellular reprogramming and epigenetic rejuvenation
Ageing is an inevitable condition that afflicts all humans. Recent achievements, such as the generation of induced pluripotent stem cells, have delivered preliminary evidence that slowing down and reversing th... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - September 6, 2021 Category: Research Authors: Daniel J. Simpson, Nelly N. Olova and Tamir Chandra Tags: Review Source Type: research

Dynamics of epigenetic regulator gene BCOR mutation and response predictive value for hypomethylating agents in patients with myelodysplastic syndrome
BCOR (BCL6 corepressor) is an epigenetic regulator gene involved in the specification of cell differentiation and body structure development. Recurrent somatic BCOR mutations have been identified in myelodyspl... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 30, 2021 Category: Research Authors: Xiao Li, Feng Xu, Zheng Zhang, Juan Guo, Qi He, Lu-Xi Song, Dong Wu, Li-Yu Zhou, Ji-Ying Su, Chao Xiao, Chun-Kang Chang and Ling-Yun Wu Tags: Research Source Type: research

Longitudinal analysis of individual cfDNA methylome patterns in metastatic prostate cancer
Disease progression and therapeutic resistance are hallmarks of advanced stage prostate cancer (PCa), which remains a major cause of cancer-related mortality around the world. Longitudinal studies, coupled wit... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 28, 2021 Category: Research Authors: Romina Silva, Bruce Moran, Anne-Marie Baird, Colm J. O ’Rourke, Stephen P. Finn, Ray McDermott, William Watson, William M. Gallagher, Donal J. Brennan and Antoinette S. Perry Tags: Research Source Type: research

Transcriptional epigenetic regulation of Fkbp1/Pax9 genes is associated with impaired sensitivity to platinum treatment in ovarian cancer
In an effort to contribute to overcoming the platinum resistance exhibited by most solid tumors, we performed an array of epigenetic approaches, integrating next-generation methodologies and public clinical da... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 28, 2021 Category: Research Authors: Javier Andr és Soto, Carlos Rodríguez-Antolín, Olga Vera, Olga Pernía, Isabel Esteban-Rodríguez, Maria Dolores Diestro, Javier Benitez, Fátima Sánchez-Cabo, Rafael Alvarez, Javier De Castro and Inmaculada Ibanez de Cáceres Tags: Research Source Type: research

DNA methyltransferase inhibitors combination therapy for the treatment of solid tumor: mechanism and clinical application
DNA methylation, an epigenetic modification, regulates gene transcription and maintains genome stability. DNA methyltransferase (DNMT) inhibitors can activate silenced genes at low doses and cause cytotoxicity... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 27, 2021 Category: Research Authors: Chunhong Hu, Xiaohan Liu, Yue Zeng, Junqi Liu and Fang Wu Tags: Review Source Type: research

Betamethasone administration during pregnancy is associated with placental epigenetic changes with implications for inflammation
Glucocorticoids (GCs) play a pivotal role in fetal programming. Antenatal treatment with synthetic GCs (sGCs) in individuals in danger of preterm labor is common practice. Adverse short- and long-term effects ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 26, 2021 Category: Research Authors: Darina Czamara, Linda Dieckmann, Simone R öh, Sarah Kraemer, Rebecca C. Rancourt, Sara Sammallahti, Eero Kajantie, Hannele Laivuori, Johan G. Eriksson, Katri Räikkönen, Wolfgang Henrich, Andreas Plagemann, Elisabeth B. Binder, Thorsten Braun and Sonja Tags: Research Source Type: research

Epigenetic age is associated with baseline and 3-year change in frailty in the Canadian Longitudinal Study on Aging
The trajectory of frailty in older adults is important to public health; therefore, markers that may help predict this and other important outcomes could be beneficial. Epigenetic clocks have been developed an... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 23, 2021 Category: Research Authors: Chris P. Verschoor, David T. S. Lin, Michael S. Kobor, Oxana Mian, Jinhui Ma, Guillaume Pare and Gustavo Ybazeta Tags: Research Source Type: research

Pre-implantation alcohol exposure induces lasting sex-specific DNA methylation programming errors in the developing forebrain
Prenatal alcohol exposure is recognized for altering DNA methylation profiles of brain cells during development, and to be part of the molecular basis underpinning Fetal Alcohol Spectrum Disorder (FASD) etiolo... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 23, 2021 Category: Research Authors: L. M. Legault, K. Doiron, M. Breton-Larriv ée, A. Langford-Avelar, A. Lemieux, M. Caron, L. A. Jerome-Majewska, D. Sinnett and S. McGraw Tags: Research Source Type: research

Whole-genome methylation analysis of testicular germ cells from cryptozoospermic men points to recurrent and functionally relevant DNA methylation changes
Several studies have reported an association between male infertility and aberrant sperm DNA methylation patterns, in particular in imprinted genes. In a recent investigation based on whole methylome and deep ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 21, 2021 Category: Research Authors: Sara Di Persio, Elsa Leit ão, Marius Wöste, Tobias Tekath, Jann-Frederik Cremers, Martin Dugas, Xiaolin Li, Gerd Meyer zu Hörste, Sabine Kliesch, Sandra Laurentino, Nina Neuhaus and Bernhard Horsthemke Tags: Research Source Type: research

DNA methylome profiling reveals epigenetic regulation of lipoprotein-associated phospholipase A2 in human vulnerable atherosclerotic plaque
Atherosclerotic plaque vulnerability is a key feature of atheroprogression and precipitating acute cardiovascular events. Although the pivotal role of epigenetic regulation in atherosclerotic plaque destabiliz... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 21, 2021 Category: Research Authors: Jingjin Li, Xiaoping Zhang, Mengxi Yang, Hang Yang, Ning Xu, Xueqiang Fan, Gang Liu, Xintong Jiang, Jiasai Fan, Lifang Zhang, Hu Zhang, Ying Zhou, Rui Li, Si Gao, Jiangli Jin, Zening Jin & hellip; Tags: Research Source Type: research

Identifying causal models between genetically regulated methylation patterns and gene expression in healthy colon tissue
DNA methylation is involved in the regulation of gene expression and phenotypic variation, but the inter-relationship between genetic variation, DNA methylation and gene expression remains poorly understood. H... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 21, 2021 Category: Research Authors: Anna D íez-Villanueva, Mireia Jordà, Robert Carreras-Torres, Henar Alonso, David Cordero, Elisabet Guinó, Xavier Sanjuan, Cristina Santos, Ramón Salazar, Rebeca Sanz-Pamplona and Victor Moreno Tags: Research Source Type: research

DNA methylation patterns at and beyond the histological margin of early-stage invasive lung adenocarcinoma radiologically manifested as pure ground-glass opacity
Early-stage lung cancers radiologically manifested as ground-glass opacities (GGOs) have been increasingly identified, among which pure GGO (pGGO) has a good prognosis after local resection. However, the optim... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 19, 2021 Category: Research Authors: Ziqi Jia, Yadong Wang, Jianchao Xue, Xiaoying Yang, Zhongxing Bing, Chao Guo, Chao Gao, Zhenhuan Tian, Zhenzhen Zhang, Hualei Kong, Qiye He, Zhixi Su, Yiying Liu, Yang Song, Dianjing Liang, Naixin Liang & hellip; Tags: Research Source Type: research

A targeted multi-omics approach reveals paraoxonase-1 as a determinant of obesity-associated fatty liver disease
The multifactorial nature of non-alcoholic fatty liver disease cannot be explained solely by genetic factors. Recent evidence revealed that DNA methylation changes take place at proximal promoters within susce... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 13, 2021 Category: Research Authors: Sara Diels, Bart Cuypers, Asta Tvarijonaviciute, Bruno Derudas, Evelien Van Dijck, An Verrijken, Luc F. Van Gaal, Kris Laukens, Philippe Lefebvre, Jose J. Ceron, Sven Francque, Wim Vanden Berghe and Wim Van Hul Tags: Research Source Type: research

Patients with PWS and related syndromes display differentially methylated regions involved in neurodevelopmental and nutritional trajectory
Prader –Willi syndrome is a rare genetic neurodevelopmental disorder caused by a paternal deficiency of maternally imprinted gene expression located in the chromosome 15q11–q13 region. Previous studies have dem... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 13, 2021 Category: Research Authors: Juliette Salles, Sanaa Eddiry, Emmanuelle Lacassagne, Virginie Laurier, Catherine Molinas, Éric Bieth, Nicolas Franchitto, Jean-Pierre Salles and Maithé Tauber Tags: Research Source Type: research

Childhood-onset dystonia-causing KMT2B variants result in a distinctive genomic hypermethylation profile
Dystonia is a clinically and genetically heterogeneous movement disorder characterized by sustained or intermittent muscle contractions causing abnormal, often repetitive, movements and/or postures. Heterozygo... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 11, 2021 Category: Research Authors: Andrea Ciolfi, Aidin Foroutan, Alessandro Capuano, Lucia Pedace, Lorena Travaglini, Simone Pizzi, Marco Andreani, Evelina Miele, Federica Invernizzi, Chiara Reale, Celeste Panteghini, Maria Iascone, Marcello Niceta, Ralitza H. Gavrilova, Laura Schultz-Rog Tags: Research Source Type: research

Evaluation of global and intragenic hypomethylation in colorectal adenomas improves patient stratification and colorectal cancer risk prediction
Aberrant DNA hypomethylation of the long interspersed nuclear elements (LINE-1 or L1) has been recognized as an early event of colorectal transformation. Simultaneous genetic and epigenetic analysis of colorec... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 9, 2021 Category: Research Authors: Carla Debernardi, Laura Libera, Enrico Berrino, Nora Sahnane, Anna Maria Chiaravalli, Cristiana Laudi, Mattia Berselli, Anna Sapino, Fausto Sessa, Tiziana Venesio and Daniela Furlan Tags: Research Source Type: research

Childhood growth and development and DNA methylation age in mid-life
In the first study of its kind, we examine the association between growth and development in early life and DNAm age biomarkers in mid-life. (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 9, 2021 Category: Research Authors: Jane Maddock, Juan Castillo-Fernandez, Andrew Wong, George B. Ploubidis, Diana Kuh, Jordana T. Bell and Rebecca Hardy Tags: Research Source Type: research

PRC2: an epigenetic multiprotein complex with a key role in the development of rhabdomyosarcoma carcinogenesis
Skeletal muscle formation represents a complex of highly organized and specialized systems that are still not fully understood. Epigenetic systems underline embryonic development, maintenance of stemness, and ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 9, 2021 Category: Research Authors: Stefano Zoroddu, Irene Marchesi and Luigi Bagella Tags: Review Source Type: research

Differential DNA methylation and changing cell-type proportions as fibrotic stage progresses in NAFLD
Non-alcoholic fatty liver disease (NAFLD) is characterized by changes in cell composition that occur throughout disease pathogenesis, which includes the development of fibrosis in a subset of patients. DNA met... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 5, 2021 Category: Research Authors: Nicholas D. Johnson, Xiumei Wu, Christopher D. Still, Xin Chu, Anthony T. Petrick, Glenn S. Gerhard, Karen N. Conneely and Johanna K. DiStefano Tags: Research Source Type: research

Correction to: Genome-wide DNA methylome analysis identifies methylation signatures associated with survival and drug resistance of ovarian cancers
(Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 3, 2021 Category: Research Authors: David W. Chan, Wai-Yip Lam, Fushun Chen, Mingo M. H. Yung, Yau-Sang Chan, Wai-Sun Chan, Fangfang He, Stephanie S. Liu, Karen K. L. Chan, Benjamin Li and Hextan Y. S. Ngan Tags: Correction Source Type: research

Chromatin insulation dynamics in glioblastoma: challenges and future perspectives of precision oncology
Glioblastoma (GBM) is the most aggressive primary brain tumor, having a poor prognosis and a median overall survival of less than two years. Over the last decade, numerous findings regarding the distinct molec... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 31, 2021 Category: Research Authors: Borja Ses é, Miquel Ensenyat-Mendez, Sandra Iñiguez, Pere Llinàs-Arias and Diego M. Marzese Tags: Review Source Type: research

Genome wide DNA methylation analysis of alveolar capillary dysplasia lung tissue reveals aberrant methylation of genes involved in development including the FOXF1 locus
Alveolar capillary dysplasia with or without misalignment of the pulmonary veins (ACD/MPV) is a lethal congenital lung disorder associated with a variety of heterozygous genomic alterations in the FOXF1 gene or i... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 29, 2021 Category: Research Authors: Evelien Slot, Ruben Boers, Joachim Boers, Wilfred F. J. van IJcken, Dick Tibboel, Joost Gribnau, Robbert Rottier and Annelies de Klein Tags: Research Source Type: research

Interplay of Val66Met and BDNF methylation: effect on reward learning and cognitive performance in major depression
There is a growing interest in the role of brain-derived neurotrophic factor (BDNF) in major depressive disorder (MDD). BDNF potentially exhibits opposite effects in the pathways linked to anhedonia and reward... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 29, 2021 Category: Research Authors: J. Bakusic, E. Vrieze, M. Ghosh, D. A. Pizzagalli, B. Bekaert, S. Claes and L. Godderis Tags: Research Source Type: research

Spatial epi-proteomics enabled by histone post-translational modification analysis from low-abundance clinical samples
Increasing evidence linking epigenetic mechanisms and different diseases, including cancer, has prompted in the last 15 years the investigation of histone post-translational modifications (PTMs) in clinical sa... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 28, 2021 Category: Research Authors: Roberta Noberini, Evelyn Oliva Savoia, Stefania Brandini, Francesco Greco, Francesca Marra, Giovanni Bertalot, Giancarlo Pruneri, Liam A. McDonnell and Tiziana Bonaldi Tags: Methodology Source Type: research

Aorta-specific DNA methylation patterns in cell-free DNA from patients with bicuspid aortic valve-associated aortopathy
The dilation of the aorta that occurs as a consequence of a congenitally bicuspid aortic valve (BAV) is associated with a risk of dissection, aneurysm or rupture. With progressive aortopathy, surgery is often ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 28, 2021 Category: Research Authors: Ashna Maredia, David Guzzardi, Mohammad Aleinati, Fatima Iqbal, Arshroop Khaira, Aiswarya Madhu, Xuemei Wang, Alex J. Barker, Patrick M. McCarthy, Paul W. M. Fedak and Steven C. Greenway Tags: Research Source Type: research

Differential DNA methylation by early versus late parenteral nutrition in the PICU: a biological basis for its impact on emotional and behavioral problems documented 4 years later
The PEPaNIC multicenter randomized controlled trial (RCT) has shown that early administration of supplemental parenteral nutrition (early-PN) as compared with withholding PN for 1 week (late-PN) induced long-t... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 27, 2021 Category: Research Authors: An Jacobs, Fabian G üiza, Ines Verlinden, Karolijn Dulfer, Gonzalo Garcia Guerra, Koen Joosten, Sascha C. Verbruggen, Ilse Vanhorebeek and Greet Van den Berghe Tags: Research Source Type: research

Epigenetic reprogramming of cell identity: lessons from development for regenerative medicine
Epigenetic mechanisms are known to define cell-type identity and function. Hence, reprogramming of one cell type into another essentially requires a rewiring of the underlying epigenome. Cellular reprogramming... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 23, 2021 Category: Research Authors: Amitava Basu and Vijay K. Tiwari Tags: Review Source Type: research

Genome-wide DNA methylome analysis identifies methylation signatures associated with survival and drug resistance of ovarian cancers
In contrast to stable genetic events, epigenetic changes are highly plastic and play crucial roles in tumor evolution and development. Epithelial ovarian cancer (EOC) is a highly heterogeneous disease that is ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 22, 2021 Category: Research Authors: David W. Chan, Wai-Yip Lam, Fushun Chen, Mingo M. H. Yung, Yau-Sang Chan, Wai-Sun Chan, Fangfang He, Stephanie S. Liu, Karen K. L. Chan, Benjamin Li and Hextan Y. S. Ngan Tags: Research Source Type: research