DNA methylation changes that precede onset of dysplasia in advanced sessile serrated adenomas
Sessile serrated adenomas (SSAs) are common polyps which give rise to 20 –30% of colorectal cancer (CRC). SSAs display clinicopathologic features which present challenges in surveillance, including overrepresen... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - June 14, 2019 Category: Research Authors: Cheng Liu, Lochlan J. Fennell, Mark L. Bettington, Neal I. Walker, Joel Dwine, Barbara A. Leggett and Vicki L. J. Whitehall Tags: Research Source Type: research

DNA methylation profiling allows for characterization of atrial and ventricular cardiac tissues and hiPSC-CMs
Cardiac disease modelling using human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) requires thorough insight into cardiac cell type differentiation processes. However, current methods to dis... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - June 11, 2019 Category: Research Authors: Kirstin Hoff, Marta Lemme, Anne-Karin Kahlert, Kerstin Runde, Enrique Audain, Dorit Schuster, Jens Scheewe, Tim Attmann, Thomas Pickardt, Almuth Caliebe, Reiner Siebert, Hans-Heiner Kramer, Hendrik Milting, Arne Hansen, Ole Ammerpohl and Marc-Phillip Hitz Tags: Research Source Type: research

Early-life exposure to severe famine is associated with higher methylation level in the IGF2 gene and higher total cholesterol in late adulthood: the Genomic Research of the Chinese Famine (GRECF) study
To evaluate the association of early-life exposure to the Chinese Great Famine (1959 –1961) with DNA methylation in IGF2 and its subsequent influence on blood lipid levels in late adulthood among participants of t... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - June 10, 2019 Category: Research Authors: Luqi Shen, Changwei Li, Zhenghe Wang, Ruiyuan Zhang, Ye Shen, Toni Miles, Jingkai Wei and Zhiyong Zou Tags: Research Source Type: research

Smoking-associated AHRR demethylation in cord blood DNA: impact of CD235a+ nucleated red blood cells
Numerous studies have demonstrated that DNA methylation levels in the aryl hydrocarbon receptor repressor (AHRR) gene measured in cord blood are significantly associated with prenatal tobacco smoke exposure and c... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - June 10, 2019 Category: Research Authors: Matthew A. Bergens, Gary S. Pittman, Isabel J. B. Thompson, Michelle R. Campbell, Xuting Wang, Cathrine Hoyo and Douglas A. Bell Tags: Research Source Type: research

Neuronal methylome reveals CREB-associated neuro-axonal impairment in multiple sclerosis
Due to limited access to brain tissue, the precise mechanisms underlying neuro-axonal dysfunction in neurological disorders such as multiple sclerosis (MS) are largely unknown. In that context, profiling DNA m... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 30, 2019 Category: Research Authors: Lara Kular, Maria Needhamsen, Milena Z. Adzemovic, Tatiana Kramarova, David Gomez-Cabrero, Ewoud Ewing, Eliane Piket, Jesper Tegn ér, Stephan Beck, Fredrik Piehl, Lou Brundin and Maja Jagodic Tags: Research Source Type: research

Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status
Oncogenic K-Ras signaling highly relies on the canonical Ras/MEK/ERK pathway to contribute to pancreatic cancer progression. However, numerous efforts of MEK inhibitors have failed to provide an optimal antitu... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 29, 2019 Category: Research Authors: Min-Wu Chao, Li-Hsun Chang, Huang-Ju Tu, Chao-Di Chang, Mei-Jung Lai, Yi-Ying Chen, Jing-Ping Liou, Che-Ming Teng and Shiow-Lin Pan Tags: Research Source Type: research

Promoter methylation changes and vascular dysfunction in pre-eclamptic umbilical vein
Hypertension is one of primary clinical presentations of pre-eclampsia. The occurrence and progress of hypertension are closely related to vascular dysfunction. However, information is limited regarding the pa... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 28, 2019 Category: Research Authors: Qinqin Gao, Xiaorong Fan, Ting Xu, Huan Li, Yun He, Yuxian Yang, Jie Chen, Hongmei Ding, Jianying Tao and Zhice Xu Tags: Research Source Type: research

Identification of dynamic glucocorticoid-induced methylation changes at the FKBP5 locus
Epigenetic mechanisms may play a major role in the biological embedding of early-life stress (ELS). One proposed mechanism is that glucocorticoid (GC) release following ELS exposure induces long-lasting altera... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 23, 2019 Category: Research Authors: Tobias Wiechmann, Simone R öh, Susann Sauer, Darina Czamara, Janine Arloth, Maik Ködel, Madita Beintner, Lisanne Knop, Andreas Menke, Elisabeth B. Binder and Nadine Provençal Tags: Research Source Type: research

DNA methylation changes related to nutritional deprivation: a genome-wide analysis of population and in vitro data
DNA methylation has recently been identified as a mediator between in utero famine exposure and a range of metabolic and psychiatric traits. However, genome-wide analyses are scarce and cross-sectional analyse... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 16, 2019 Category: Research Authors: Yujie He, Lot D. de Witte, Lotte C. Houtepen, Danny M. Nispeling, Zhida Xu, Qiong Yu, Yaqin Yu, Elly M. Hol, Ren é S. Kahn and Marco P. Boks Tags: Research Source Type: research

Epigenetics in cancer therapy and nanomedicine
The emergence of nanotechnology applied to medicine has revolutionized the treatment of human cancer. As in the case of classic drugs for the treatment of cancer, epigenetic drugs have evolved in terms of thei... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 16, 2019 Category: Research Authors: Annalisa Roberti, Adolfo F. Valdes, Ram ón Torrecillas, Mario F. Fraga and Agustin F. Fernandez Tags: Review Source Type: research

Prenatal epigenetics diets play protective roles against environmental pollution
It is thought that germ cells and preimplantation embryos during development are most susceptible to endogenous and exogenous environmental factors because the epigenome in those cells is undergoing dramatic e... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 16, 2019 Category: Research Authors: Shizhao Li, Min Chen, Yuanyuan Li and Trygve O. Tollefsbol Tags: Review Source Type: research

Functional roles of lncRNAs and its potential mechanisms in neuropathic pain
Neuropathic pain (NP) is ranked as one of the major forms of chronic pain and emerges as a direct consequence of a lesion or disease affecting the somatosensory nervous system. Despite great advances into the ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 15, 2019 Category: Research Authors: Simin Tang, Jun Zhou, Huan Jing, Meijuan Liao, Sen Lin, Zhenxing Huang, Teng Huang, Jiying Zhong and HanbingWang Tags: Review Source Type: research

Circadian rhythms in the three-dimensional genome: implications of chromatin interactions for cyclic transcription
Circadian rhythms orchestrate crucial physiological functions and behavioral aspects around a day in almost all living forms. The circadian clock is a time tracking system that permits organisms to predict and... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 15, 2019 Category: Research Authors: Ignacio Pacheco-Bernal, Fernando Becerril-P érez and Lorena Aguilar-Arnal Tags: Review Source Type: research

Circulating cell-free DNA use for diagnosing cholangiocarcinoma
(Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 14, 2019 Category: Research Authors: Steven Sorscher Tags: Letter to the Editor Source Type: research

Novel predictive epigenetic signature for temozolomide in non-G-CIMP glioblastomas
To identify novel epigenetic signatures that could provide predictive information that is complementary to promoter methylation status of the O-6-methylguanine-DNA methyltransferase (MGMT) gene for predicting ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 14, 2019 Category: Research Authors: An-An Yin, Ya-Long He, Amandine Etcheverry, Yu-He Liu, Marc Aubry, Jill Barnholtz-Sloan, Bo-Lin Liu, Jean Mosser, Zi-Fan Lu and Xiang Zhang Tags: Research Source Type: research

Prognostic implications and interaction of L1 methylation and p53 expression statuses in advanced gastric cancer
TP53 is frequently mutated across various tissue types of cancers. In normal cells, long interspersed nuclear element-1 (LINE-1, L1) is mostly repressed by DNA methylation in its 5 ′ untranslated region but is act... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 14, 2019 Category: Research Authors: Yun-Joo Shin, Younghoon Kim, Xianyu Wen, Nam-Yun Cho, Sun Lee, Woo Ho Kim and Gyeong Hoon Kang Tags: Research Source Type: research

ZBTB12 DNA methylation is associated with coagulation- and inflammation-related blood cell parameters: findings from the Moli-family cohort
Zinc finger and BTB domain-containing protein 12 (ZBTB12) is a predicted transcription factor with potential role in hematopoietic development. Recent evidence linked low methylation level of ZBTB12 exon1 to myoc... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 10, 2019 Category: Research Authors: Fabrizia Noro, Francesco Gianfagna, Alessandro Gialluisi, Amalia De Curtis, Augusto Di Castelnuovo, Emanuela Napoleone, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Marc F. Hoylaerts, Licia Iacoviello and Benedetta Izzi Tags: Research Source Type: research

Prenatal adverse environment is associated with epigenetic age deceleration at birth and hypomethylation at the hypoxia-responsive EP300 gene
Obstetric complications have long been retrospectively associated with a wide range of short- and long-term health consequences, including neurodevelopmental alterations such as those observed in schizophrenia... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 9, 2019 Category: Research Authors: Helena Palma-Gudiel, Elisenda Eixarch, F átima Crispi, Sebastián Morán, Anthony S. Zannas and Lourdes Fañanás Tags: Research Source Type: research

UHRF1 depletion and HDAC inhibition reactivate epigenetically silenced genes in colorectal cancer cells
In this study, we examined the involvem... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 7, 2019 Category: Research Authors: Takeshi Niinuma, Hiroshi Kitajima, Masahiro Kai, Eiichiro Yamamoto, Akira Yorozu, Kazuya Ishiguro, Hajime Sasaki, Gota Sudo, Mutsumi Toyota, Tomo Hatahira, Reo Maruyama, Takashi Tokino, Hiroshi Nakase, Tamotsu Sugai and Hiromu Suzuki Tags: Research Source Type: research

Epigenetic silencing of miR-340-5p in multiple myeloma: mechanisms and prognostic impact
miR-340-5p, localized to 5q35, is a tumor suppressor miRNA implicated in multiple cancers. As a CpG island is present at the putative promoter region of its host gene, RNF130, we hypothesized that the intronic mi... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 7, 2019 Category: Research Authors: Zhenhai Li, Kwan Yeung Wong, George A. Calin, Wee-Joo Chng, Godfrey Chi-fung Chan and Chor Sang Chim Tags: Research Source Type: research

Casp8 hypomethylation and neural tube defects in association with polycyclic aromatic hydrocarbon exposure
Epidemiological studies have found that prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) is associated with increased risk for neural tube defects (NTDs). Aberrant DNA methylation, excessive apopto... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 7, 2019 Category: Research Authors: Yun Huang, Aiguo Ren, Linlin Wang, Lei Jin, Shanshan Lin, Zhiwen Li and Jasmine A. McDonald Tags: Research Source Type: research

Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells
DNA methyltransferases (DNMTs) are epigenetic enzymes involved in embryonic development, cell differentiation, epithelial to mesenchymal transition, and control of gene expression, whose overexpression or enha... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 6, 2019 Category: Research Authors: Clemens Zwergel, Michael Schnekenburger, Federica Sarno, Cecilia Battistelli, Maria Cristina Manara, Giulia Stazi, Roberta Mazzone, Rossella Fioravanti, Christina Gros, Fr édéric Ausseil, Cristina Florean, Angela Nebbioso, Raffaele Strippoli, Toshikazu Tags: Research Source Type: research

Methylation at cg05575921 of a smoking-related gene (AHRR) in non-smoking Taiwanese adults residing in areas with different PM2.5 concentrations
DNA methylation is associated with cancer, metabolic, neurological, and autoimmune disorders. Hypomethylation of aryl hydrocarbon receptor repressor (AHRR) especially at cg05575921 is associated with smoking a... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 6, 2019 Category: Research Authors: Disline Manli Tantoh, Kuan-Jung Lee, Oswald Ndi Nfor, Yi-Chia Liaw, Chin Lin, Hou-Wei Chu, Pei-Hsin Chen, Shu-Yi Hsu, Wen-Hsiu Liu, Chen-Chang Ho, Chia-Chi Lung, Ming-Fang Wu, Yi-Ching Liaw, Tonmoy Debnath and Yung-Po Liaw Tags: Research Source Type: research

DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer
Genetic aberrations in DNA repair genes are linked to cancer, but less is reported about epigenetic regulation of DNA repair and functional consequences. We investigated the intragenic methylation loss at the ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 3, 2019 Category: Research Authors: Christoph Weigel, Jittiporn Chaisaingmongkol, Yassen Assenov, Christine Kuhmann, Volker Winkler, Irene Santi, Olga Bogatyrova, Simone Kaucher, Justo L. Bermejo, Suet Y. Leung, Tsun L. Chan, Felix Lasitschka, Manfred H. Bohrer, Alexander Marx, Roland Heyny Tags: Research Source Type: research

Epigenome-wide association study for lifetime estrogen exposure identifies an epigenetic signature associated with breast cancer risk
It is well established that estrogens and other hormonal factors influence breast cancer susceptibility. We hypothesized that a woman ’s total lifetime estrogen exposure accumulates changes in DNA methylation, ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 30, 2019 Category: Research Authors: Annelie Johansson, Domenico Palli, Giovanna Masala, Sara Grioni, Claudia Agnoli, Rosario Tumino, Maria Concetta Giurdanella, Francesca Fasanelli, Carlotta Sacerdote, Salvatore Panico, Amalia Mattiello, Silvia Polidoro, Michael E. Jones, Minouk J. Schoemak Tags: Research Source Type: research

Gene domain-specific DNA methylation episignatures highlight distinct molecular entities of ADNP syndrome
ADNP syndrome is a rare Mendelian disorder characterized by global developmental delay, intellectual disability, and autism. It is caused by truncating mutations in ADNP, which is involved in chromatin regulation... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 27, 2019 Category: Research Authors: Eric G. Bend, Erfan Aref-Eshghi, David B. Everman, R. Curtis Rogers, Sara S. Cathey, Eloise J. Prijoles, Michael J. Lyons, Heather Davis, Katie Clarkson, Karen W. Gripp, Dong Li, Elizabeth Bhoj, Elaine Zackai, Paul Mark, Hakon Hakonarson, Laurie A. Demmer Tags: Research Source Type: research

Loss of Msh2 and a single-radiation hit induce common, genome-wide, and persistent epigenetic changes in the intestine
Mismatch repair (MMR)-deficiency increases the risk of colorectal tumorigenesis. To determine whether the tumors develop on a normal or disturbed epigenetic background and how radiation affects this, we quanti... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 27, 2019 Category: Research Authors: Maria Herberg, Susann Siebert, Marianne Quaas, Torsten Thalheim, Karen Rother, Michelle Hussong, Janine Altm üller, Christiane Kerner, Joerg Galle, Michal R. Schweiger and Gabriela Aust Tags: Research Source Type: research

Hyperglycemia affects global 5-methylcytosine and 5-hydroxymethylcytosine in blood genomic DNA through upregulation of SIRT6 and TETs
Accumulating evidence suggests that epigenetic changes play key roles in the pathogenesis of type 2 diabetes mellitus (T2DM). However, the dynamic regulation of 5-methylcytosine (5mC) and 5-hydroxymethylcytosi... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 15, 2019 Category: Research Authors: Er-Feng Yuan, Ying Yang, Lin Cheng, Xujing Deng, Shao-Min Chen, Xin Zhou and Song-Mei Liu Tags: Research Source Type: research

DNA methylome profiling of granulosa cells reveals altered methylation in genes regulating vital ovarian functions in polycystic ovary syndrome
Women with polycystic ovary syndrome (PCOS) manifest a host of ovarian defects like impaired folliculogenesis, anovulation, and poor oocyte quality, which grossly affect their reproductive health. Addressing t... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 11, 2019 Category: Research Authors: Pooja Sagvekar, Pankaj Kumar, Vijay Mangoli, Sadhana Desai and Srabani Mukherjee Tags: Research Source Type: research

The epigenetic clock as a predictor of disease and mortality risk: a systematic review and meta-analysis
Ageing is one of the principal risk factors for many chronic diseases. However, there is considerable between-person variation in the rate of ageing and individual differences in their susceptibility to diseas... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 11, 2019 Category: Research Authors: Peter D. Fransquet, Jo Wrigglesworth, Robyn L. Woods, Michael E. Ernst and Joanne Ryan Tags: Review Source Type: research

Novel parent-of-origin-specific differentially methylated loci on chromosome 16
Congenital malformations associated with maternal uniparental disomy of chromosome 16, upd(16)mat, resemble those observed in newborns with the lethal developmental lung disease, alveolar capillary dysplasia w... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 8, 2019 Category: Research Authors: Katharina V. Schulze, Przemyslaw Szafranski, Harry Lesmana, Robert J. Hopkin, Aaron Hamvas, Jennifer A. Wambach, Marwan Shinawi, Gladys Zapata, Claudia M. B. Carvalho, Qian Liu, Justyna A. Karolak, James R. Lupski, Neil A. Hanchard and Pawe ł Stankiewicz Tags: Research Source Type: research

Promoter methylation of ADAMTS1 and BNC1 as potential biomarkers for early detection of pancreatic cancer in blood
Despite improvements in cancer management, most pancreatic cancers are still diagnosed at an advanced stage. We have recently identified promoter DNA methylation of the genes ADAMTS1 and BNC1 as potential blood b... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 5, 2019 Category: Research Authors: Maryam A. L. Eissa, Lane Lerner, Eihab Abdelfatah, Nakul Shankar, Joseph K. Canner, Nesrin M. Hasan, Vesal Yaghoobi, Barry Huang, Zachary Kerner, Felipe Takaesu, Christopher Wolfgang, Ruby Kwak, Michael Ruiz, Matthew Tam, Thomas R. Pisanic II, Christine A Tags: Research Source Type: research

Integrative analysis of DNA methylation in discordant twins unveils distinct architectures of systemic sclerosis subsets
Systemic sclerosis (SSc) is a rare autoimmune fibrosing disease with an incompletely understood genetic and non-genetic etiology. Defining its etiology is important to allow the development of effective predic... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 4, 2019 Category: Research Authors: Paula S. Ramos, Kip D. Zimmerman, Sandra Haddad, Carl D. Langefeld, Thomas A. Medsger Jr and Carol A. Feghali-Bostwick Tags: Research Source Type: research

Association of leukocyte DNA methylation changes with dietary folate and alcohol intake in the EPIC study
There is increasing evidence that folate, an important component of one-carbon metabolism, modulates the epigenome. Alcohol, which can disrupt folate absorption, is also known to affect the epigenome. We inves... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 2, 2019 Category: Research Authors: F. Perrier, V. Viallon, S. Ambatipudi, A. Ghantous, C. Cuenin, H. Hernandez-Vargas, V. Chaj ès, L. Baglietto, M. Matejcic, H. Moreno-Macias, T. Kühn, H. Boeing, A. Karakatsani, A. Kotanidou, A. Trichopoulou, S. Sieri & hellip; Tags: Methodology Source Type: research

Prenatal maternal antidepressants, anxiety, and depression and offspring DNA methylation: epigenome-wide associations at birth and persistence into early childhood
Maternal mood disorders and their treatment during pregnancy may have effects on the offspring epigenome. We aim to evaluate associations of maternal prenatal antidepressant use, anxiety, and depression with c... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 29, 2019 Category: Research Authors: Andres Cardenas, Sabrina Faleschini, Andrea Cortes Hidalgo, Sheryl L. Rifas-Shiman, Andrea A. Baccarelli, Dawn L. DeMeo, Augusto A. Litonjua, Alexander Neumann, Janine F. Felix, Vincent W. V. Jaddoe, Hanan El Marroun, Henning Tiemeier, Emily Oken, Marie-F Tags: Research Source Type: research

Exploring targets of TET2-mediated methylation reprogramming as potential discriminators of prostate cancer progression
Global DNA methylation alterations are hallmarks of cancer. The tumor-suppressive TET enzymes, which are involved in DNA demethylation, are decreased in prostate cancer (PCa); in particular, TET2 is specifical... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 27, 2019 Category: Research Authors: Shivani Kamdar, Ruth Isserlin, Theodorus Van der Kwast, Alexandre R. Zlotta, Gary D. Bader, Neil E. Fleshner and Bharati Bapat Tags: Research Source Type: research

Control of viral infections by epigenetic-targeted therapy
Epigenetics is defined as the science that studies the modifications of gene expression that are not owed to mutations or changes in the genetic sequence. Recently, strong evidences are pinpointing toward a so... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 27, 2019 Category: Research Authors: Zeina Nehme, S ébastien Pasquereau and Georges Herbein Tags: Review Source Type: research

Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer ’s disease
Alzheimer ’s disease is a progressive neurodegenerative disorder that is hypothesized to involve epigenetic dysfunction. Previous studies of DNA modifications in Alzheimer’s disease have been unable to distingu... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 21, 2019 Category: Research Authors: Adam R. Smith, Rebecca G. Smith, Ehsan Pishva, Eilis Hannon, Janou A. Y. Roubroeks, Joe Burrage, Claire Troakes, Safa Al-Sarraj, Carolyn Sloan, Jonathan Mill, Daniel L. van den Hove and Katie Lunnon Tags: Research Source Type: research

Genome-wide methylation profiling of Beckwith-Wiedemann syndrome patients without molecular confirmation after routine diagnostics
Beckwith-Wiedemann syndrome (BWS) is caused due to the disturbance of imprinted genes at chromosome 11p15. The molecular confirmation of this syndrome is possible in approximately 85% of the cases, whereas in ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 21, 2019 Category: Research Authors: I. M. Krzyzewska, M. Alders, S. M. Maas, J. Bliek, A. Venema, P. Henneman, F. I. Rezwan, K. v. d. Lip, A. N. Mul, D. J. G. Mackay and M. M. A. M. Mannens Tags: Research Source Type: research

Increased methylation upstream of the MEG3 promotor is observed in acute myeloid leukemia patients with better overall survival
The delta-like non-canonical Notch ligand 1 (DLK1)-maternally expressed 3(MEG3) locus (DLK1-MEG3 locus) plays a critical role in the maintenance and differentiation of hematopoietic stem cells. Accumulating evide... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 15, 2019 Category: Research Authors: Zachariah Payne Sellers, Lukasz Bolkun, Janusz Kloczko, Marzena Liliana Wojtaszewska, Krzysztof Lewandowski, Marcin Moniuszko, Mariusz Z. Ratajczak and Gabriela Schneider Tags: Research Source Type: research

Early detection of colorectal cancer based on presence of methylated syndecan-2 (SDC2) in stool DNA
Colorectal cancer (CRC) screening can effectively reduce disease-related mortality by detecting CRC at earlier stages. We have previously demonstrated that the presence of SDC2 methylation in stool DNA is signifi... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 15, 2019 Category: Research Authors: Yoon Dae Han, Tae Jeong Oh, Tae-Ha Chung, Hui Won Jang, Youn Nam Kim, Sungwhan An and Nam Kyu Kim Tags: Research Source Type: research

Genetic regulation of methylation in human endometrium and blood and gene targets for reproductive diseases
Major challenges in understanding the functional consequences of genetic risk factors for human disease are which tissues and cell types are affected and the limited availability of suitable tissue. The aim of... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 14, 2019 Category: Research Authors: Sally Mortlock, Restuadi Restuadi, Rupert Levien, Jane E. Girling, Sarah J. Holdsworth-Carson, Martin Healey, Zhihong Zhu, Ting Qi, Yang Wu, Samuel W. Lukowski, Peter A. W. Rogers, Jian Yang, Allan F. McRae, Jenny N. Fung and Grant W. Montgomery Tags: Research Source Type: research

Impact of chemotherapy for breast cancer on leukocyte DNA methylation landscape and cognitive function: a prospective study
Little is known about the effects of chemotherapeutic drugs on DNA methylation status of leukocytes, which may be predictive of treatment benefits and toxicities. Based on a prospective national study, we char... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 12, 2019 Category: Research Authors: Song Yao, Qiang Hu, Sarah Kerns, Li Yan, Adedayo A. Onitilo, Jamal Misleh, Kelley Young, Lianlian Lei, Javier Bautista, Mostafa Mohamed, Supriya G. Mohile, Christine B. Ambrosone, Song Liu and Michelle C. Janelsins Tags: Research Source Type: research

SOX2 promoter hypermethylation in non-smoking Taiwanese adults residing in air pollution areas
Both SOX2 promoter methylation and air pollution have been associated with lung cancer risk. However, little has been done to assess SOX2 promoter methylation in individuals living in air pollution areas. The ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 12, 2019 Category: Research Authors: Disline Manli Tantoh, Ming-Fang Wu, Chien-Chang Ho, Chia-Chi Lung, Kuan-Jung Lee, Oswald Ndi Nfor, Yi-Chia Liaw, Shu-Yi Hsu, Pei-Hsin Chen, Chin Lin, Hou-Wei Chu, Yi-Ching Liaw and Yung-Po Liaw Tags: Research Source Type: research

Correction to: Liver DNA methylation of FADS2 associates with FADS2 genotype
Following publication of the original article [1], the author reported the title of this article has been misspelled. (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 12, 2019 Category: Research Authors: Paula Walle, Ville M ännistö, Vanessa Derenji de Mello, Maija Vaittinen, Alexander Perfilyev, Kati Hanhineva, Charlotte Ling and Jussi Pihlajamäki Tags: Correction Source Type: research

The hyper-activation of transcriptional enhancers in breast cancer
Activation of transcription enhancers, especially super-enhancers, is one of the critical epigenetic features of tumorigenesis. However, very few studies have systematically identified the enhancers specific i... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 12, 2019 Category: Research Authors: Qing-Lan Li, Dan-Ya Wang, Lin-Gao Ju, Jie Yao, Chuan Gao, Pin-Ji Lei, Lian-Yun Li, Xiao-Lu Zhao and Min Wu Tags: Research Source Type: research

RFX1 downregulation contributes to TLR4 overexpression in CD14+ monocytes via epigenetic mechanisms in coronary artery disease
Toll-like receptor 4 (TLR4) expression is increased in activated monocytes, which play a critical role in the pathogenesis of coronary artery disease (CAD). However, the mechanism remains unclear. Regulatory f... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 11, 2019 Category: Research Authors: Pei Du, Keqin Gao, Yu Cao, Shuang Yang, Yang Wang, Ren Guo, Ming Zhao and Sujie Jia Tags: Research Source Type: research

Emerging roles of H3K9me3, SETDB1 and SETDB2 in therapy-induced cellular reprogramming
A multitude of recent studies has observed common epigenetic changes develop in tumour cells of multiple lineages following exposure to stresses such as hypoxia, chemotherapeutics, immunotherapy or targeted th... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 8, 2019 Category: Research Authors: Joachim Torrano, Abdullah Al Emran, Heinz Hammerlindl and Helmut Schaider Tags: Review Source Type: research

Genome-wide methylation profiling identified novel differentially hypermethylated biomarker MPPED2 in colorectal cancer
Epigenetic alternation is a common contributing factor to neoplastic transformation. Although previous studies have reported a cluster of aberrant promoter methylation changes associated with silencing of tumo... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 7, 2019 Category: Research Authors: Simeng Gu, Shujuan Lin, Ding Ye, Sangni Qian, Danjie Jiang, Xiaocong Zhang, Qilong Li, Jinhua Yang, Xiaojiang Ying, Zhenjun Li, Mengling Tang, Jianbing Wang, Mingjuan Jin and Kun Chen Tags: Research Source Type: research

Temple syndrome in a patient with variably methylated CpGs at the primary MEG3/DLK1:IG-DMR and severely hypomethylated CpGs at the secondary MEG3:TSS-DMR
The human chromosome 14q32.2 imprinted region harbors the primary MEG3/DLK1:IG-differentially methylated region (DMR) and secondary MEG3:TSS-DMR. The MEG3:TSS-DMR can remain unmethylated only in the presence of u... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 7, 2019 Category: Research Authors: Masayo Kagami, Atsuhiro Yanagisawa, Miyuki Ota, Kentaro Matsuoka, Akie Nakamura, Keiko Matsubara, Kazuhiko Nakabayashi, Shuji Takada, Maki Fukami and Tsutomu Ogata Tags: Short report Source Type: research