Epigenetic measures of ageing predict the prevalence and incidence of leading causes of death and disease burden
Individuals of the same chronological age display different rates of biological ageing. A number of measures of biological age have been proposed which harness age-related changes in DNA methylation profiles. ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 31, 2020 Category: Research Authors: Robert F. Hillary, Anna J. Stevenson, Daniel L. McCartney, Archie Campbell, Rosie M. Walker, David M. Howard, Craig W. Ritchie, Steve Horvath, Caroline Hayward, Andrew M. McIntosh, David J. Porteous, Ian J. Deary, Kathryn L. Evans and Riccardo E. Marioni Tags: Research Source Type: research

Circulating unmethylated CHTOP and INS DNA fragments provide evidence of possible islet cell death in youth with obesity and diabetes
Identification of islet β cell death prior to the onset of type 1 diabetes (T1D) or type 2 diabetes (T2D) might allow for interventions to protect β cells and reduce diabetes risk. Circulating unmethylated DNA... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 31, 2020 Category: Research Authors: Farooq Syed, Sarah A. Tersey, Jean-Valery Turatsinze, Jamie L. Felton, Nicole Jiyun Kang, Jennifer B. Nelson, Emily K. Sims, Mathieu Defrance, Martin Bizet, Francois Fuks, Miriam Cnop, Marco Bugliani, Piero Marchetti, Anette-Gabriele Ziegler, Ezio Bonifac Tags: Research Source Type: research

AHRR cg05575921 methylation in relation to smoking and PM2.5 exposure among Taiwanese men and women
Polycyclic aromatic hydrocarbon (PAH)-rich substances like cigarette smoke and PM2.5 induce aryl hydrocarbon receptor (AHR)-mediated aryl hydrocarbon receptor repressor (AHRR) methylation. AHRR cg05575921 and coa... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 31, 2020 Category: Research Authors: Disline Manli Tantoh, Ming-Chi Wu, Chun-Chao Chuang, Pei-Hsin Chen, Yeu Sheng Tyan, Oswald Ndi Nfor, Wen-Yu Lu and Yung-Po Liaw Tags: Research Source Type: research

Novel candidate genes for ECT response prediction —a pilot study analyzing the DNA methylome of depressed patients receiving electroconvulsive therapy
Major depressive disorder (MDD) represents a serious global health concern. The urge for efficient MDD treatment strategies is presently hindered by the incomplete knowledge of its underlying pathomechanism. D... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 29, 2020 Category: Research Authors: Nicole Moschny, Tristan Zindler, Kirsten Jahn, Marie Dorda, Colin F. Davenport, Lutz Wiehlmann, Hannah B. Maier, Franziska Eberle, Stefan Bleich, Alexandra Neyazi and Helge Frieling Tags: Research Source Type: research

Characterisation of an inflammation-related epigenetic score and its association with cognitive ability
Chronic systemic inflammation has been associated with incident dementia, but its association with age-related cognitive decline is less clear. The acute responses of many inflammatory biomarkers mean they may... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 27, 2020 Category: Research Authors: Anna J. Stevenson, Daniel L. McCartney, Robert F. Hillary, Archie Campbell, Stewart W. Morris, Mairead L. Bermingham, Rosie M. Walker, Kathryn L. Evans, Thibaud S. Boutin, Caroline Hayward, Allan F. McRae, Barry W. McColl, Tara L. Spires-Jones, Andrew M. Tags: Research Source Type: research

Integrated epigenetic biomarkers in circulating cell-free DNA as a robust classifier for pancreatic cancer
The high lethal rate of pancreatic cancer is partly due to a lack of efficient biomarkers for screening and early diagnosis. We attempted to develop effective and noninvasive methods using 5-methylcytosine (5m... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 23, 2020 Category: Research Authors: Feng Cao, Ailin Wei, Xinlei Hu, Yijing He, Jun Zhang, Lin Xia, Kailing Tu, Jue Yuan, Ziheng Guo, Hongying Liu, Dan Xie and Ang Li Tags: Research Source Type: research

Assisted reproductive technology represents a possible risk factor for development of epimutation-mediated imprinting disorders for mothers aged ≥ 30 years
The proportion of assisted reproductive technology (ART)-conceived livebirths of patients with imprinting disorders (IDs) is higher than that of the general population. Whether this is due to ART or confoundin... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 22, 2020 Category: Research Authors: Kaori Hara-Isono, Keiko Matsubara, Masashi Mikami, Takahiro Arima, Tsutomu Ogata, Maki Fukami and Masayo Kagami Tags: Research Source Type: research

Alternative methylation of intron motifs is associated with cancer-related gene expression in both canine mammary tumor and human breast cancer
Canine mammary tumor (CMT) has long been considered as a good animal model for human breast cancer (HBC) due to their pathological and biological similarities. However, only a few aspects of the epigenome have... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 21, 2020 Category: Research Authors: A-Reum Nam, Kang-Hoon Lee, Hyeon-Ji Hwang, Johannes J. Schabort, Jae-Hoon An, Sung-Ho Won and Je-Yoel Cho Tags: Research Source Type: research

IGF1 gene is epigenetically activated in preterm infants with intrauterine growth restriction
IGF1 is a key molecule in the regulation of growth and metabolism. Low IGF1 secretion is known to cause growth restriction in childhood, as well as deregulated lipid metabolism, cardiovascular disease, and dia... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 16, 2020 Category: Research Authors: Masato Kantake, Naho Ikeda, Hirofumi Nakaoka, Natsuki Ohkawa, Toshitaka Tanaka, Kazuki Miyabayashi, Hiromichi Shoji and Toshiaki Shimizu Tags: Research Source Type: research

Gene –methylation interactions: discovering region-wise DNA methylation levels that modify SNP-associated disease risk
Current technology allows rapid assessment of DNA sequences and methylation levels at a single-site resolution for hundreds of thousands of sites in the human genome, in thousands of individuals simultaneously... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 16, 2020 Category: Research Authors: Julia Romanowska, Øystein A. Haaland, Astanand Jugessur, Miriam Gjerdevik, Zongli Xu, Jack Taylor, Allen J. Wilcox, Inge Jonassen, Rolv T. Lie and Håkon K. Gjessing Tags: Methodology Source Type: research

H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts
H3K27ac histone acetylome changes contribute to the phenotypic response in heart diseases, particularly in end-stage heart failure. However, such epigenetic alterations have not been systematically investigate... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 14, 2020 Category: Research Authors: Jiayi Pei, Magdalena Harakalova, Thomas A. Treibel, R Thomas Lumbers, Bastiaan J. Boukens, Igor R. Efimov, Jip T. van Dinter, Arantxa Gonz ález, Begoña López, Hamid El Azzouzi, Noortje van den Dungen, Christian G. M. van Dijk, Merle M. Krebber, Hester Tags: Research Source Type: research

Correction to: Current status of development of methylation biomarkers for in vitro diagnostic IVD applications
An amendment to this paper has been published and can be accessed via the original article. (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 14, 2020 Category: Research Authors: Olga Taryma-Le śniak, Katarzyna Ewa Sokolowska and Tomasz Kazimierz Wojdacz Tags: Correction Source Type: research

Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging
DNA methylation (DNAm) age constitutes a powerful tool to assess the molecular age and overall health status of biological samples. Recently, it has been shown that tissue-specific DNAm age predictors may pres... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 13, 2020 Category: Research Authors: Mariana Boroni, Alessandra Zonari, Carolina Reis de Oliveira, Kallie Alkatib, Edgar Andres Ochoa Cruz, Lear E. Brace and Juliana Lott de Carvalho Tags: Research Source Type: research

Concentrations of persistent organic pollutants in maternal plasma and epigenome-wide placental DNA methylation
Prenatal maternal plasma persistent organic pollutant (POP) concentrations have been associated with neonatal outcomes. However, the underlying mechanisms remain unknown. Placental epigenetic mechanisms may be... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 11, 2020 Category: Research Authors: Marion Ouidir, Pauline Mendola, Germaine M. Buck Louis, Kurunthachalam Kannan, Cuilin Zhang and Fasil Tekola-Ayele Tags: Research Source Type: research

The role of DNA methylation in the pathogenesis of type 2 diabetes mellitus
Diabetes mellitus (DM) is a chronic condition characterised by β cell dysfunction and persistent hyperglycaemia. The disorder can be due to the absence of adequate pancreatic insulin production or a weak cellu... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 11, 2020 Category: Research Authors: Sanabil Ali Hassan Ahmed, Suraiya Anjum Ansari, Eric P. K. Mensah-Brown and Bright Starling Emerald Tags: Review Source Type: research

The MLH1 polymorphism rs1800734 and risk of endometrial cancer with microsatellite instability
Both colorectal (CRC, 15%) and endometrial cancers (EC, 30%) exhibit microsatellite instability (MSI) due to MLH1 hypermethylation and silencing. The MLH1 promoter polymorphism, rs1800734 is associated with MSI C... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 8, 2020 Category: Research Authors: Holly Russell, Katarzyna Kedzierska, Daniel D. Buchanan, Rachael Thomas, Emma Tham, Miriam Mints, Anne Ker änen, Graham G. Giles, Melissa C. Southey, Roger L. Milne, Ian Tomlinson, David Church, Amanda B. Spurdle, Tracy A. O’Mara and Annabelle Lewis Tags: Short report Source Type: research

Current status of development of methylation biomarkers for in vitro diagnostic IVD applications
A significant volume of research clearly shows that disease-related methylation changes can be used as biomarkers at all stages of clinical disease management, including risk assessment and predisposition scre... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 6, 2020 Category: Research Authors: Olga Taryma-Le śniak, Katarzyna Ewa Sokolowska and Tomasz Kazimierz Wojdacz Tags: Review Source Type: research

Reduced DNA methylation of the oxytocin receptor gene is associated with obsessive-compulsive disorder
Oxytocin is an important neuromodulator involved in cognition and socio-emotional processing that exerts its central activities via oxytocin receptors. Epigenetic alterations in the oxytocin receptor gene (OXTR) ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 6, 2020 Category: Research Authors: Chun Il Park, Hae Won Kim, Sumoa Jeon, Jee In Kang and Se Joo Kim Tags: Research Source Type: research

Wandering along the epigenetic timeline
Increasing life expectancy but also healthspan seems inaccessible as of yet but it may become a reality in the foreseeable future. To extend lifespan, it is essential to unveil molecular mechanisms involved in... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 2, 2020 Category: Research Authors: Cl émence Topart, Emilie Werner and Paola B. Arimondo Tags: Review Source Type: research

Ten-eleven translocation methyl-cytosine dioxygenase 2 deficiency exacerbates renal ischemia-reperfusion injury
Ten-eleven translocation (Tet) methyl-cytosine dioxygenases (including Tet1/2/3)-mediated 5mC oxidation and DNA demethylation play important roles in embryonic development and adult tissue homeostasis. The exp... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 2, 2020 Category: Research Authors: Huan Yan, Li Tan, Yuqi Liu, Ning Huang, Jing Cang and Hao Wang Tags: Research Source Type: research

meQTL and ncRNA functional analyses of 102 GWAS-SNPs associated with depression implicate HACE1 and SHANK2 genes
Little is known about how genetics and epigenetics interplay in depression. Evidence suggests that genetic variants may change vulnerability to depression by modulating DNA methylation (DNAm) and non-coding RN... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 2, 2020 Category: Research Authors: Diana M. Ciuculete, Sarah Voisin, Lara Kular, J örgen Jonsson, Mathias Rask-Andersen, Jessica Mwinyi and Helgi B. Schiöth Tags: Research Source Type: research

Identifying epigenetic biomarkers of established prognostic factors and survival in a clinical cohort of individuals with oropharyngeal cancer
Smoking status, alcohol consumption and HPV infection (acquired through sexual activity) are the predominant risk factors for oropharyngeal cancer and are thought to alter the prognosis of the disease. Here, w... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - June 29, 2020 Category: Research Authors: Ryan Langdon, Rebecca Richmond, Hannah R. Elliott, Tom Dudding, Nabila Kazmi, Chris Penfold, Kate Ingarfield, Karen Ho, Andrew Bretherick, Chris Haley, Yanni Zeng, Rosie M. Walker, Michael Pawlita, Tim Waterboer, Tom Gaunt, George Davey Smith & hellip; Tags: Research Source Type: research

Correction to: DNA methylation changes during preimplantation development reveal interspecies differences and reprogramming events at imprinted genes
An amendment to this paper has been published and can be accessed via the original article. (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - June 29, 2020 Category: Research Authors: Elena Ivanova, Sebastian Canovas, Soledad Garcia-Mart ínez, Raquel Romar, Jordana S. Lopes, Dimitrios Rizos, Maria J. Sanchez-Calabuig, Felix Krueger, Simon Andrews, Fernando Perez-Sanz, Gavin Kelsey and Pilar Coy Tags: Correction Source Type: research

Prognostic and predictive value of PD-L2 DNA methylation and mRNA expression in melanoma
PD-L1 (programmed cell death 1 ligand 1) expression in melanoma has been associated with a better response to anti-PD-1 (programmed cell death 1) therapy. However, patients with PD-L1-negative melanomas can re... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - June 26, 2020 Category: Research Authors: Friederike Hoffmann, Romina Zarbl, Dennis Niebel, Judith Sirokay, Anne Fr öhlich, Christian Posch, Tobias A. W. Holderried, Peter Brossart, Gonzalo Saavedra, Pia Kuster, Sebastian Strieth, Gerrit H. Gielen, Sandra S. Ring, Jörn Dietrich, Torsten Pietsch Tags: Research Source Type: research

Epigenome-wide DNA methylation analysis of small cell lung cancer cell lines suggests potential chemotherapy targets
Small cell lung cancer (SCLC) is an aggressive neuroendocrine lung cancer. SCLC progression and treatment resistance involve epigenetic processes. However, links between SCLC DNA methylation and drug response ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - June 25, 2020 Category: Research Authors: Julia Krushkal, Thomas Silvers, William C. Reinhold, Dmitriy Sonkin, Suleyman Vural, John Connelly, Sudhir Varma, Paul S. Meltzer, Mark Kunkel, Annamaria Rapisarda, David Evans, Yves Pommier and Beverly A. Teicher Tags: Research Source Type: research

Refinement of cg05575921 demethylation response in nascent smoking
The initiation of adolescent smoking is difficult to detect using carbon monoxide or cotinine assays. Previously, we and others have shown that the methylation of cg05575921 is an accurate predictor of adult s... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - June 24, 2020 Category: Research Authors: Kelsey Dawes, Allan Andersen, Emma Papworth, Brandon Hundley, Natasha Hutchens, Heba El Manawy, Ashley Becker, Luke Sampson, Willem Philibert, Frederick X. Gibbons, Meg Gerrard and Robert Philibert Tags: Research Source Type: research

DNA methylation for cervical cancer screening: a training set in China
Despite rapid improvements in DNA methylation tools for cervical cancer screening, few robust, exploratory studies have been performed using the combination of two host genes, EPB41L3 and JAM3, newly developed as... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - June 23, 2020 Category: Research Authors: Linghua Kong, Linhai Wang, Ziyun Wang, Xiaoping Xiao, Yan You, Huanwen Wu, Ming Wu, Pei Liu and Lei Li Tags: Research Source Type: research

Comprehensive evaluation of targeted multiplex bisulphite PCR sequencing for validation of DNA methylation biomarker panels
DNA methylation is a well-studied epigenetic mark that is frequently altered in diseases such as cancer, where specific changes are known to reflect the type and severity of the disease. Therefore, there is a ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - June 22, 2020 Category: Research Authors: Dilys Lam, Phuc-Loi Luu, Jenny Z. Song, Wenjia Qu, Gail P. Risbridger, Mitchell G. Lawrence, Jennifer Lu, Matt Trau, Darren Korbie, Susan J. Clark, Ruth Pidsley and Clare Stirzaker Tags: Methodology Source Type: research

Individual and joint contributions of genetic and methylation risk scores for enhancing lung cancer risk stratification: data from a population-based cohort in Germany
This study aimed to assess if and to what extent such risk stratification could be enhanced by additional considera... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - June 18, 2020 Category: Research Authors: Haixin Yu, Janhavi R. Raut, Ben Sch öttker, Bernd Holleczek, Yan Zhang and Hermann Brenner Tags: Research Source Type: research

Epigenetic silencing of AATK in acinar to ductal metaplasia in murine model of pancreatic cancer
Cancer subtype switching, which involves unclear cancer cell origin, cell fate decision, and transdifferentiation of cells within a confined tumor microenvironment, remains a major problem in pancreatic cancer... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - June 17, 2020 Category: Research Authors: Li-Yun Ding, Ya-Chin Hou, I-Ying Kuo, Ting-Yi Hsu, Tsung-Ching Tsai, Hsiu-Wei Chang, Wei-Yu Hsu, Chih-Chieh Tsao, Chung-Chen Tian, Po-Shun Wang, Hao-Chen Wang, Chung-Ta Lee, Yi-Ching Wang, Sheng-Hsiang Lin, Michael W. Hughes, Woei-Jer Chuang & hellip; Tags: Research Source Type: research

G9a regulates tumorigenicity and stemness through genome-wide DNA methylation reprogramming in non-small cell lung cancer
This study investigated the regulatory roles of G9A in tumorigenes... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - June 17, 2020 Category: Research Authors: Rajendra P. Pangeni, Lu Yang, Keqiang Zhang, Jinhui Wang, Wendong Li, Chao Guo, Xinwei Yun, Ting Sun, Jami Wang and Dan J. Raz Tags: Research Source Type: research

Contribution of gene mutations to Silver-Russell syndrome phenotype: multigene sequencing analysis in 92 etiology-unknown patients
Silver-Russell syndrome (SRS) is characterized by growth failure and dysmorphic features. Major (epi)genetic causes of SRS are loss of methylation on chromosome 11p15 (11p15 LOM) and maternal uniparental disom... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - June 16, 2020 Category: Research Authors: Takanobu Inoue, Akie Nakamura, Megumi Iwahashi-Odano, Kanako Tanase-Nakao, Keiko Matsubara, Junko Nishioka, Yoshihiro Maruo, Yukihiro Hasegawa, Hiroshi Suzumura, Seiji Sato, Yoshiyuki Kobayashi, Nobuyuki Murakami, Kazuhiko Nakabayashi, Kazuki Yamazawa, To Tags: Research Source Type: research

Harnessing peripheral DNA methylation differences in the Alzheimer ’s Disease Neuroimaging Initiative (ADNI) to reveal novel biomarkers of disease
Alzheimer ’s disease (AD) is a chronic progressive neurodegenerative disease impacting an estimated 44 million adults worldwide. The causal pathology of AD (accumulation of amyloid-beta and tau), precedes hallm... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - June 15, 2020 Category: Research Authors: Aparna Vasanthakumar, Justin W. Davis, Kenneth Idler, Jeffrey F. Waring, Elizabeth Asque, Bridget Riley-Gillis, Shaun Grosskurth, Gyan Srivastava, Sungeun Kim, Kwangsik Nho, Kelly N. H. Nudelman, Kelley Faber, Yu Sun, Tatiana M. Foroud, Karol Estrada, Lia Tags: Research Source Type: research

Methylome profiling of young adults with depression supports a link with immune response and psoriasis
Currently the leading cause of global disability, clinical depression is a heterogeneous condition characterised by low mood, anhedonia and cognitive impairments. Its growing incidence among young people, ofte... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - June 15, 2020 Category: Research Authors: Coral R. Lapsley, Rachelle Irwin, Margaret McLafferty, Sara Jayne Thursby, Siobhan M. O ’Neill, Anthony J. Bjourson, Colum P. Walsh and Elaine K. Murray Tags: Research Source Type: research

BTB/POZ zinc finger protein ZBTB16 inhibits breast cancer proliferation and metastasis through upregulating ZBTB28 and antagonizing BCL6/ZBTB27
Breast cancer remains in urgent need of reliable diagnostic and prognostic markers. Zinc finger and BTB/POZ domain-containing family proteins (ZBTBs) are important transcription factors functioning as oncogene... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - June 9, 2020 Category: Research Authors: Jin He, Mingjun Wu, Lei Xiong, Yijia Gong, Renjie Yu, Weiyan Peng, Lili Li, Li Li, Shaorong Tian, Yan Wang, Qian Tao and Tingxiu Xiang Tags: Research Source Type: research

Association between variation of circulating 25-OH vitamin D and methylation of secreted frizzled-related protein 2 in colorectal cancer
Colorectal cancer (CRC) results from the accumulation of epigenetic and genetic changes in colon cells during neoplasic transformation, which the activation of Wingless (Wnt) signaling pathway is a common mech... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - June 9, 2020 Category: Research Authors: Hatim Boughanem, Amanda Cabrera-Mulero, Pablo Hern ández-Alonso, Mercedes Clemente-Postigo, Felipe F. Casanueva, Francisco José Tinahones, Sonsoles Morcillo, Ana B. Crujeiras and Manuel Macias-Gonzalez Tags: Research Source Type: research

The signature of HBV-related liver disease in peripheral blood mononuclear cell DNA methylation
Hepatitis B virus (HBV)-related liver disease induces liver damage by hepatic immune and inflammatory response. The association between aberrant peripheral blood mononuclear cell (PBMC) DNA methylation and pro... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - June 8, 2020 Category: Research Authors: Kang Li, Ling Qin, Sanjie Jiang, Ang Li, Chi Zhang, Guihai Liu, Jianping Sun, Huanqing Sun, Yan Zhao, Ning Li and Yonghong Zhang Tags: Research Source Type: research

CTCF loss mediates unique DNA hypermethylation landscapes in human cancers
The chromatin insulator CCCTC-binding factor (CTCF) displays tissue-specific DNA binding sites that regulate transcription and chromatin organization. Despite evidence linking CTCF to the protection of epigene... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - June 5, 2020 Category: Research Authors: Nathan A. Damaschke, Joseph Gawdzik, Mele Avilla, Bing Yang, John Svaren, Avtar Roopra, Jian-Hua Luo, Yan P. Yu, Sunduz Keles and David F. Jarrard Tags: Research Source Type: research

Epigenome-wide association study in healthy individuals identifies significant associations with DNA methylation and PBMC extract VEGF-A concentration
Vascular endothelial growth factor A (VEGF-A) is a chemokine that induces proliferation and migration of vascular endothelial cells and is essential for both physiological and pathological angiogenesis. It is ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - June 5, 2020 Category: Research Authors: Vesna Gorenjak, Dwaine R. Vance, S ébastien Dade, Maria G. Stathopoulou, Lauren Doherty, Ting Xie, Helena Murray, Christine Masson, John Lamont, Peter Fitzgerald and Sophie Visvikis-Siest Tags: Research Source Type: research

Genome-wide analysis of DNA methylation identifies S100A13 as an epigenetic biomarker in individuals with chronic ( ≥ 30 years) type 2 diabetes without diabetic retinopathy
This study aimed to determine the epigenetic biomarkers of diabetic retinopathy (DR) in subjects with type 2 diabetes mellitus (T2DM). This retrospective study is based on the Shanghai Xinjing community preven... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - June 3, 2020 Category: Research Authors: Tao Li, Yi Xu, Yongyong Shi, Jianhua Chen, Senlin Lin, Jianfeng Zhu, Xian Xu, Lina Lu and Haidong Zou Tags: Research Source Type: research

Effect of short-term prescription opioids on DNA methylation of the OPRM1 promoter
A long-term opioid use has been associated with hypermethylation of the opioid receptor mu 1 (OPRM1) promoter. Very little is currently known about the early epigenetic response to therapeutic opioids. Here, we e... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - June 3, 2020 Category: Research Authors: Jose Vladimir Sandoval-Sierra, Francisco I. Salgado Garc ía, Jeffrey H. Brooks, Karen J. Derefinko and Khyobeni Mozhui Tags: Research Source Type: research

DNA methylation loci in placenta associated with birthweight and expression of genes relevant for early development and adult diseases
Birthweight marks an important milestone of health across the lifespan, including cardiometabolic disease risk in later life. The placenta, a transient organ at the maternal-fetal interface, regulates fetal gr... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - June 3, 2020 Category: Research Authors: Fasil Tekola-Ayele, Xuehuo Zeng, Marion Ouidir, Tsegaselassie Workalemahu, Cuilin Zhang, Fabien Delahaye and Ronald Wapner Tags: Research Source Type: research

Single-cell DNA methylation sequencing reveals epigenetic alterations in mouse oocytes superovulated with different dosages of gonadotropins
Epigenetic abnormalities caused by superovulation have recently attracted increasing attention. Superovulation with exogenous hormones may prevent oocytes from establishing an appropriate epigenetic state, and... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - June 1, 2020 Category: Research Authors: Ying Huo, Zhi Qiang Yan, Peng Yuan, Meng Qin, Ying Kuo, Rong Li, Li Ying Yan, Huai Liang Feng and Jie Qiao Tags: Research Source Type: research

Restoration of KMT2C/MLL3 in human colorectal cancer cells reinforces genome-wide H3K4me1 profiles and influences cell growth and gene expression
The histone 3 lysine 4 (H3K4) monomethylase KMT2C is mutated across several cancer types; however, the effects of mutations on epigenome organization, gene expression, and cell growth are not clear. A frequent... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 29, 2020 Category: Research Authors: Chatarina Larsson, Lina Cordeddu, Lee Siggens, Tatjana Pandzic, Snehangshu Kundu, Liqun He, Muhammad Akhtar Ali, Nu ša Pristovšek, Karin Hartman, Karl Ekwall and Tobias Sjöblom Tags: Research Source Type: research

Therapeutic strategies against hDOT1L as a potential drug target in MLL-rearranged leukemias
Therapeutic intervention of proteins participating in chromatin-mediated signaling with small-molecules is a novel option to reprogram expression networks for restraining disease states. Protein methyltransfer... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 25, 2020 Category: Research Authors: Shahid Banday, Zeenat Farooq, Shabir Ahmad Ganai and Mohammad Altaf Tags: Review Source Type: research

Transgenerational inheritance of fetal alcohol exposure adverse effects on immune gene interferon- ϒ
Alcohol exposures in utero have been shown to alter immune system functions in the offspring which persists into adulthood. However, it is not apparent why the in utero alcohol effect on the immune system pers... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 24, 2020 Category: Research Authors: Omkaram Gangisetty, Ajay Palagani and Dipak K. Sarkar Tags: Research Source Type: research

Novel visualized quantitative epigenetic imprinted gene biomarkers diagnose the malignancy of ten cancer types
Epigenetic alterations are involved in most cancers, but its application in cancer diagnosis is still limited. More practical and intuitive methods to detect the aberrant expressions from clinical samples usin... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 24, 2020 Category: Research Authors: Rulong Shen, Tong Cheng, Chuanliang Xu, Rex C. Yung, Jiandong Bao, Xing Li, Hongyu Yu, Shaohua Lu, Huixiong Xu, Hongxun Wu, Jian Zhou, Wenbo Bu, Xiaonan Wang, Han Si, Panying Shi, Pengcheng Zhao & hellip; Tags: Methodology Source Type: research

Symphony of epigenetic and metabolic regulation —interaction between the histone methyltransferase EZH2 and metabolism of tumor
Increasing evidence has suggested that epigenetic and metabolic alterations in cancer cells are highly intertwined. As the master epigenetic regulator, enhancer of zeste homolog 2 (EZH2) suppresses gene transc... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 24, 2020 Category: Research Authors: Tengrui Zhang, Yueqing Gong, Hui Meng, Chen Li and Lixiang Xue Tags: Review Source Type: research

Novel HDAC inhibitor MAKV-8 and imatinib synergistically kill chronic myeloid leukemia cells via inhibition of BCR-ABL/MYC-signaling: effect on imatinib resistance and stem cells
Chronic myeloid leukemia (CML) pathogenesis is mainly driven by the oncogenic breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1 (BCR-ABL) fusion protein. Since BCR-ABL displays abnorma... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 19, 2020 Category: Research Authors: Manon Lernoux, Michael Schnekenburger, H élène Losson, Koen Vermeulen, Hyunggu Hahn, Déborah Gérard, Jin-Young Lee, Aloran Mazumder, Muneer Ahamed, Christo Christov, Dong-Wook Kim, Mario Dicato, Guy Bormans, Byung Woo Han and Marc Diederich Tags: Research Source Type: research

Histone deacetylase 9 promoter hypomethylation associated with adipocyte dysfunction is a statin-related metabolic effect
Adipogenesis, the process whereby preadipocytes differentiate into mature adipocytes, is crucial for maintaining metabolic homeostasis. Cholesterol-lowering statins increase type 2 diabetes (T2D) risk possibly... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 14, 2020 Category: Research Authors: Amna Khamis, Raphael Boutry, Micka ël Canouil, Sumi Mathew, Stephane Lobbens, Hutokshi Crouch, Toby Andrew, Amar Abderrahmani, Filippo Tamanini and Philippe Froguel Tags: Research Source Type: research