Cardiovascular outcomes and molecular targets for the cardiac effects of Sodium-Glucose Cotransporter 2 Inhibitors: A systematic review
Biomed Pharmacother. 2024 Apr 27;175:116650. doi: 10.1016/j.biopha.2024.116650. Online ahead of print.ABSTRACTSodium-glucose cotransporter 2 inhibitors (SGLT2i), a new class of glucose-lowering drugs traditionally used to control blood glucose levels in patients with type 2 diabetes mellitus, have been proven to reduce major adverse cardiovascular events, including cardiovascular death, in patients with heart failure irrespective of ejection fraction and independently of the hypoglycemic effect. Because of their favorable effects on the kidney and cardiovascular outcomes, their use has been expanded in all patients with an...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 28, 2024 Category: Drugs & Pharmacology Authors: Rosalinda Madonna Filippo Biondi Mattia Alberti Sandra Ghelardoni Letizia Mattii Alberto D'Alleva Source Type: research
Overexpression of soluble epoxide hydrolase reduces post-ischemic recovery of cardiac contractile function
Biochem Pharmacol. 2024 Apr 26:116237. doi: 10.1016/j.bcp.2024.116237. Online ahead of print.ABSTRACTCytochromes P450 can metabolize endogenous fatty acids, such as arachidonic acid, to bioactive lipids such as epoxyeicosatrienoic acids (EETs) that have beneficial effects. EETs protect hearts against ischemic damage, heart failure or fibrosis; however, their effects are limited by hydrolysis to less active dihydroxy oxylipins by soluble epoxide hydrolase (sEH), encoded by the epoxide hydrolase 2 gene (EPHX2, EC 3.3.2.10). Pharmacological inhibition or genetic disruption of sEH/EPHX2 have been widely studied for their impac...
Source: Biochemical Pharmacology - April 28, 2024 Category: Drugs & Pharmacology Authors: Matthew L Edin Artiom Gruzdev J Alyce Bradbury Joan P Graves Ginger W Muse David R Goulding Fred B Lih Laura M DeGraff Darryl C Zeldin Source Type: research
Cardiac hypertrophy that affects hyperthyroidism occurs independently of the NLRP3 inflammasome
Pflugers Arch. 2024 Apr 29. doi: 10.1007/s00424-024-02965-6. Online ahead of print.ABSTRACTCardiac hypertrophy (CH) is an adaptive response to maintain cardiac function; however, persistent stress responses lead to contractile dysfunction and heart failure. Although inflammation is involved in these processes, the mechanisms that control cardiac inflammation and hypertrophy still need to be clarified. The NLRP3 inflammasome is a cytosolic multiprotein complex that mediates IL-1β production. The priming step of NLRP3 is essential for increasing the expression of its components and occurs following NF-κB activation. Hypert...
Source: Pflugers Archiv : European Journal of Physiology - April 28, 2024 Category: Physiology Authors: Aline Cristina Parletta Gabriela Cavazza Cerri Claudia Ribeiro Borba Gasparini Karine Panico Denival Nascimento Vieira-Junior Larissa Maria Zacarias-Rodrigues Nathalia Senger Amanda de Almeida Silva Marina Fevereiro Gabriela Placon á Diniz Maria Cl áudi Source Type: research
[Translated article] Retrospective study of home antibiotic infusion therapy using elastomeric infusion pumps
CONCLUSIONS: Outpatient antimicrobial therapy in elastomeric infusion pumps is an alternative in patients requiring prolonged intravenous treatment, and age is not a conditioning factor for inclusion in these programs. However, the presence of certain comorbidities can negatively affect the clinical course and mortality of patients.PMID:38679534 | DOI:10.1016/j.farma.2024.03.011 (Source: Farmacia Hospitalaria)
Source: Farmacia Hospitalaria - April 28, 2024 Category: Drugs & Pharmacology Authors: Sara Ferro Rodr íguez Yelco Chantres Legaspi Eva Mar ía Romay Lema Blanca Ayuso Garc ía Paloma Castellano Copa Pedro Pein ó Camba Andrea Barcia Losada Cristina Rodr íguez Díaz Source Type: research
Cardiovascular outcomes and molecular targets for the cardiac effects of Sodium-Glucose Cotransporter 2 Inhibitors: A systematic review
Biomed Pharmacother. 2024 Apr 27;175:116650. doi: 10.1016/j.biopha.2024.116650. Online ahead of print.ABSTRACTSodium-glucose cotransporter 2 inhibitors (SGLT2i), a new class of glucose-lowering drugs traditionally used to control blood glucose levels in patients with type 2 diabetes mellitus, have been proven to reduce major adverse cardiovascular events, including cardiovascular death, in patients with heart failure irrespective of ejection fraction and independently of the hypoglycemic effect. Because of their favorable effects on the kidney and cardiovascular outcomes, their use has been expanded in all patients with an...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 28, 2024 Category: Drugs & Pharmacology Authors: Rosalinda Madonna Filippo Biondi Mattia Alberti Sandra Ghelardoni Letizia Mattii Alberto D'Alleva Source Type: research
Overexpression of soluble epoxide hydrolase reduces post-ischemic recovery of cardiac contractile function
Biochem Pharmacol. 2024 Apr 26:116237. doi: 10.1016/j.bcp.2024.116237. Online ahead of print.ABSTRACTCytochromes P450 can metabolize endogenous fatty acids, such as arachidonic acid, to bioactive lipids such as epoxyeicosatrienoic acids (EETs) that have beneficial effects. EETs protect hearts against ischemic damage, heart failure or fibrosis; however, their effects are limited by hydrolysis to less active dihydroxy oxylipins by soluble epoxide hydrolase (sEH), encoded by the epoxide hydrolase 2 gene (EPHX2, EC 3.3.2.10). Pharmacological inhibition or genetic disruption of sEH/EPHX2 have been widely studied for their impac...
Source: Biochemical Pharmacology - April 28, 2024 Category: Drugs & Pharmacology Authors: Matthew L Edin Artiom Gruzdev J Alyce Bradbury Joan P Graves Ginger W Muse David R Goulding Fred B Lih Laura M DeGraff Darryl C Zeldin Source Type: research
Evaluation of synchronized left ventricular pacing rate over biventricular pacing in cardiac resynchronization therapy
CONCLUSIONS: sLVP was associated with CRT response, and a higher sLVP rate (≧59.4 %) was important for good prognosis in patients with aCRT.PMID:38679318 | DOI:10.1016/j.jjcc.2024.04.007 (Source: Journal of Cardiology)
Source: Journal of Cardiology - April 28, 2024 Category: Cardiology Authors: Yuichiro Miyazaki Kohei Ishibashi Nobuhiko Ueda Satoshi Oka Akinori Wakamiya Keiko Shimamoto Kenzaburo Nakajima Tsukasa Kamakura Mitsuru Wada Yuko Inoue Koji Miyamoto Satoshi Nagase Takeshi Aiba Kengo Kusano Source Type: research
Cardiac hypertrophy that affects hyperthyroidism occurs independently of the NLRP3 inflammasome
Pflugers Arch. 2024 Apr 29. doi: 10.1007/s00424-024-02965-6. Online ahead of print.ABSTRACTCardiac hypertrophy (CH) is an adaptive response to maintain cardiac function; however, persistent stress responses lead to contractile dysfunction and heart failure. Although inflammation is involved in these processes, the mechanisms that control cardiac inflammation and hypertrophy still need to be clarified. The NLRP3 inflammasome is a cytosolic multiprotein complex that mediates IL-1β production. The priming step of NLRP3 is essential for increasing the expression of its components and occurs following NF-κB activation. Hypert...
Source: Pflugers Archiv : European Journal of Physiology - April 28, 2024 Category: Physiology Authors: Aline Cristina Parletta Gabriela Cavazza Cerri Claudia Ribeiro Borba Gasparini Karine Panico Denival Nascimento Vieira-Junior Larissa Maria Zacarias-Rodrigues Nathalia Senger Amanda de Almeida Silva Marina Fevereiro Gabriela Placon á Diniz Maria Cl áudi Source Type: research
Molecules, Vol. 29, Pages 2028: Target Cell Extraction and Spectrum & ndash;Effect Relationship Coupled with BP Neural Network Classification for Screening Potential Bioactive Components in Ginseng Extract with a Protective Effect against Myocardial Damage
This study offers a reference for quality control in red ginseng and preparations containing red ginseng for the management of cardiovascular diseases. It also provides ideas for screening active ingredients of the same type of multi-pharmacologically active traditional Chinese medicines. (Source: Molecules)
Source: Molecules - April 28, 2024 Category: Chemistry Authors: Junyi Li Min Lin Zexin Xie Liwenyu Chen Jin Qi Boyang Yu Tags: Article Source Type: research
Noninvasive Ambulatory Electrocardiographic Markers from Patients with COVID-19 Pneumonia: A Report of Three Cases
Medicina (Kaunas). 2024 Apr 19;60(4):655. doi: 10.3390/medicina60040655.ABSTRACTCoronavirus disease 2019 (COVID-19) has affected medical practice. More than 7,000,000 patients died worldwide after being infected with COVID-19; however, no specific laboratory markers have yet been established to predict death related to this disease. In contrast, electrocardiographic changes due to COVID-19 include QT prolongation and ST-T changes; however, there have not been studies on the ambulatory electrocardiographic markers of COVID-19. We encountered three patients diagnosed as having COVID-19 who did not have a prior history of sig...
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Motohiro Kimata Kenichi Hashimoto Naomi Harada Yusuke Kawamura Yoshifumi Kimizuka Yuji Fujikura Mayuko Kaneko Nobuaki Kiriu Yasumasa Sekine Natsumi Iwabuchi Tetsuro Kiyozumi Akihiko Kawana Susumu Matsukuma Yuji Tanaka Source Type: research
Interoceptive signals from the heart and coronary circulation in health and disease
Auton Neurosci. 2024 Apr 24;253:103180. doi: 10.1016/j.autneu.2024.103180. Online ahead of print.ABSTRACTThis review considers interoceptive signalling from the heart and coronary circulation. Vagal and cardiac sympathetic afferent sensory nerve endings are distributed throughout the atria, ventricles (mainly left), and coronary artery. A small proportion of cardiac receptors attached to thick myelinated vagal afferents are tonically active during the cardiac cycle. Dependent upon location, these mechanoreceptors detect fluctuations in atrial volume and coronary arterial perfusion. Atrial volume and coronary arterial signa...
Source: Autonomic Neuroscience - April 27, 2024 Category: Neuroscience Authors: Jonathan P Moore Source Type: research
Noninvasive Ambulatory Electrocardiographic Markers from Patients with COVID-19 Pneumonia: A Report of Three Cases
Medicina (Kaunas). 2024 Apr 19;60(4):655. doi: 10.3390/medicina60040655.ABSTRACTCoronavirus disease 2019 (COVID-19) has affected medical practice. More than 7,000,000 patients died worldwide after being infected with COVID-19; however, no specific laboratory markers have yet been established to predict death related to this disease. In contrast, electrocardiographic changes due to COVID-19 include QT prolongation and ST-T changes; however, there have not been studies on the ambulatory electrocardiographic markers of COVID-19. We encountered three patients diagnosed as having COVID-19 who did not have a prior history of sig...
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Motohiro Kimata Kenichi Hashimoto Naomi Harada Yusuke Kawamura Yoshifumi Kimizuka Yuji Fujikura Mayuko Kaneko Nobuaki Kiriu Yasumasa Sekine Natsumi Iwabuchi Tetsuro Kiyozumi Akihiko Kawana Susumu Matsukuma Yuji Tanaka Source Type: research
Interoceptive signals from the heart and coronary circulation in health and disease
Auton Neurosci. 2024 Apr 24;253:103180. doi: 10.1016/j.autneu.2024.103180. Online ahead of print.ABSTRACTThis review considers interoceptive signalling from the heart and coronary circulation. Vagal and cardiac sympathetic afferent sensory nerve endings are distributed throughout the atria, ventricles (mainly left), and coronary artery. A small proportion of cardiac receptors attached to thick myelinated vagal afferents are tonically active during the cardiac cycle. Dependent upon location, these mechanoreceptors detect fluctuations in atrial volume and coronary arterial perfusion. Atrial volume and coronary arterial signa...
Source: Autonomic Neuroscience - April 27, 2024 Category: Neuroscience Authors: Jonathan P Moore Source Type: research
Noninvasive Ambulatory Electrocardiographic Markers from Patients with COVID-19 Pneumonia: A Report of Three Cases
Medicina (Kaunas). 2024 Apr 19;60(4):655. doi: 10.3390/medicina60040655.ABSTRACTCoronavirus disease 2019 (COVID-19) has affected medical practice. More than 7,000,000 patients died worldwide after being infected with COVID-19; however, no specific laboratory markers have yet been established to predict death related to this disease. In contrast, electrocardiographic changes due to COVID-19 include QT prolongation and ST-T changes; however, there have not been studies on the ambulatory electrocardiographic markers of COVID-19. We encountered three patients diagnosed as having COVID-19 who did not have a prior history of sig...
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Motohiro Kimata Kenichi Hashimoto Naomi Harada Yusuke Kawamura Yoshifumi Kimizuka Yuji Fujikura Mayuko Kaneko Nobuaki Kiriu Yasumasa Sekine Natsumi Iwabuchi Tetsuro Kiyozumi Akihiko Kawana Susumu Matsukuma Yuji Tanaka Source Type: research
Diabetic Cardiomyopathy-From Basics through Diagnosis to Treatment
Biomedicines. 2024 Mar 29;12(4):765. doi: 10.3390/biomedicines12040765.ABSTRACTDiabetic cardiomyopathy (DCM) is the development of myocardial dysfunction in patients with diabetes despite the absence of comorbidities such as hypertension, atherosclerosis or valvular defect. The cardiovascular complications of poorly controlled diabetes are very well illustrated by the U.K. Prospective Diabetes Study (UKPDS), which showed a clear association between increasing levels of glycated hemoglobin and the development of heart failure (HF). The incidence of HF in patients with diabetes is projected to increase significantly, which i...
Source: Atherosclerosis - April 27, 2024 Category: Cardiology Authors: Ewa Radzioch Bart łomiej Dąbek Marta Balcerczyk-Lis Weronika Fr ąk Piotr Fularski Ewelina M łynarska Jacek Rysz Beata Franczyk Source Type: research
