Comparative Analysis of Quality of Life of Family Caregivers of Patients With Heart Failure and Cancer Who Receive Palliative Care
CONCLUSIONS: Overall, healthcare professionals should focus on improving social support and caregiver role adoption and provide greater attention to the QoL of caregivers of patients with cancer.PMID:38687116 | DOI:10.1097/JCN.0000000000001097 (Source: The Journal of Cardiovascular Nursing)
Source: The Journal of Cardiovascular Nursing - April 30, 2024 Category: Nursing Authors: Mauricio Arias-Rojas Edith Arredondo Holg ín Sonia Carre ño-Moreno Source Type: research
Perceived Control, Functional Status, Depressive Symptoms, and Anxiety: Mediating and Moderating Influences on Health-Related Quality of Life in Patients With Heart Failure
CONCLUSION: Functional status moderated the indirect effects of perceived control on HRQoL through DS and anxiety in patients with heart failure. Efforts to improve HRQoL by targeting perceived control may be more effective when considering DS and anxiety in patients with low to moderate levels of functional status.PMID:38687114 | DOI:10.1097/JCN.0000000000001100 (Source: The Journal of Cardiovascular Nursing)
Source: The Journal of Cardiovascular Nursing - April 30, 2024 Category: Nursing Authors: Ashmita Thapa JungHee Kang Misook L Chung Jia-Rong Wu Abigail Latimer Terry A Lennie Chin-Yen Lin Jessica Harman Thompson Geunyeong Cha Debra K Moser Source Type: research
Does Serum Uric Acid to Creatinine Ratio Predict Mortality Risk in Patients With Heart Failure?
CONCLUSION: A high SUA/Cr ratio was an independent risk factor for the mortality risk of HF.PMID:38686683 | DOI:10.14503/THIJ-23-8210 (Source: Texas Heart Institute Journal)
Source: Texas Heart Institute Journal - April 30, 2024 Category: Cardiology Authors: Xiaoqing Xi Jinfeng Cai Chen Zhang Xuefei Wang Source Type: research
Delta-SVV as a Predictor for Circulating Blood Volume Evaluation during Intraoperative Period: A Prospective Cohort Study
CONCLUSION: In conclusion, SVV measured by FloTrac / Vigileo could guile fluid therapy precisely by predicting the blood volume of patients during the intraoperative period, as it has a strong linear correlation with the blood volume of patients who underwent general anesthesia, meaning anesthesiologist could calculate the exact fluid volume for patients' infusion. Further studies with large cohorts and centers would be needed to validate its efficiency.PMID:38687861 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 30, 2024 Category: Complementary Medicine Authors: Bei Wang Yiqi Wu Zhiyong He Jianghui Xu Source Type: research
Rectifying METTL4-Mediated N < sup > 6 < /sup > -Methyladenine Excess in Mitochondrial DNA Alleviates Heart Failure
CONCLUSIONS: Our findings identify a pivotal role of cardiomyocyte mtDNA 6mA and the corresponding methyltransferase, METTL4, in the pathogenesis of mitochondrial dysfunction and HF. Targeted suppression of METTL4 to rectify mtDNA 6mA excess emerges as a promising strategy for developing mitochondria-focused HF interventions.PMID:38686562 | DOI:10.1161/CIRCULATIONAHA.123.068358 (Source: Circulation)
Source: Circulation - April 30, 2024 Category: Cardiology Authors: Fuyang Zhang Ling Zhang Guangyu Hu Xiyao Chen Hui Liu Congye Li Xiong Guo Chong Huang Fangfang Sun Tongzheng Li Zhe Cui Yongzhen Guo Wenjun Yan Yunlong Xia Zhiyuan Liu Zhen Lin Weixun Duan Linhe Lu Xinyi Wang Zhengyang Wang Shan Wang Ling Tao Source Type: research
SIRT6 in Regulation of Mitochondrial Damage and Associated Cardiac Dysfunctions: A Possible Therapeutic Target for CVDs
Cardiovasc Toxicol. 2024 Apr 30. doi: 10.1007/s12012-024-09858-1. Online ahead of print.ABSTRACTCardiovascular diseases (CVDs) can be described as a global health emergency imploring possible prevention strategies. Although the pathogenesis of CVDs has been extensively studied, the role of mitochondrial dysfunction in CVD development has yet to be investigated. Diabetic cardiomyopathy, ischemic-reperfusion injury, and heart failure are some of the CVDs resulting from mitochondrial dysfunction Recent evidence from the research states that any dysfunction of mitochondria has an impact on metabolic alteration, eventually caus...
Source: Cardiovascular Toxicology - April 30, 2024 Category: Cardiology Authors: K P Divya Navjot Kanwar P V Anuranjana Gautam Kumar Fathima Beegum Krupa Thankam George Nitesh Kumar K Nandakumar Abhinav Kanwal Source Type: research
Efficacy of a Single Day Extracorporeal Membrane Oxygenation Training Course for Critical Care Air Transport Team Eligible Personnel
CONCLUSIONS: An abbreviated 1-day lecture and hands-on task-trainer-based ECMO course resulted in a high rate of successful skill demonstration and improvement of physicians' and nurses' knowledge assessments and confidence levels, similar to our previous live-tissue training program. When compared to our previous studies, the addition of telemedicine and patient transportation to this study did not affect the duration or performance of procedures.PMID:38687647 | DOI:10.1093/milmed/usae138 (Source: Military Medicine)
Source: Military Medicine - April 30, 2024 Category: International Medicine & Public Health Authors: R Madelaine Paredes Brannon Inman William T Davis Maria Castaneda Allyson A Mireles Darren S Baldwin Dylan C Rodriguez Kimberly L Medellin Patrick C Ng Joseph K Maddry Source Type: research
Regulation of cardiomyocyte t-tubule structure by preload and afterload: Roles in cardiac compensation and decompensation
In conclusion, modest augmentation of workload promotes compensatory increases in t-tubule density and Ca2+ cycling, whereas this adaptation is reversed in overloaded hearts during heart failure progression. KEY POINTS: Excised papillary muscle experiments demonstrated a bell-shaped relationship between cardiomyocyte t-tubule density and workload (preload or afterload), which was only present when muscles were electrically stimulated. The in vivo heart at baseline is positioned on the rising phase of this curve because moderate increases in preload (mice with brief aortic shunt surgery, patients with mitral valve regurgita...
Source: The Journal of Physiology - April 30, 2024 Category: Physiology Authors: Marianne Ruud Michael Frisk Arne Olav Melleby Per Andreas Norseng Belal A Mohamed Jia Li Jan Magnus Aronsen Ingunn E Setterberg Joanna Jakubiczka Isabelle van Hout Sean Coffey Xin Shen St åle Nygård Ida G Lunde Theis T ønnessen Peter P Jones Ivar Sjaas Source Type: research
A Structure-Based Pharmacophore Modelling Approach to Identify and Design New Neprilysin (NEP) Inhibitors: An in silico-based investigation
Arch Biochem Biophys. 2024 Apr 28:110019. doi: 10.1016/j.abb.2024.110019. Online ahead of print.ABSTRACTNeutral endopeptidase or neprilysin (NEP) cleaves the natriuretic peptides, bradykinin, endothelin, angiotensin II, amyloid β protein, substance P, etc., thus modulating their effects on heart, kidney, and other organs. NEP has a proven role in hypertension, heart disease, renal disease, Alzheimer's, diabetes, and some cancers. NEP inhibitor development has been in focus since the US FDA approved a combination therapy of angiotensin II type 1 receptor inhibitor (valsartan) and NEP inhibitor (sacubitril) for use in heart...
Source: Archives of Biochemistry and Biophysics - April 30, 2024 Category: Biochemistry Authors: Shikha Thakur Apurba Sinhari Anil Bhanudas Gaikwad Hemant R Jadhav Source Type: research
Hyperkalemia Recurrence Following Medical Nutrition Therapy in Patients with Stage 3-4 Chronic Kidney Disease: The REVOLUTIONIZE I Real-World Study
CONCLUSION: Most patients with stage 3-4 CKD had hyperkalemia recurrence, and MNT alone was inadequate to prevent recurrence. These patients may require additional long-term treatment, such as novel potassium binders, to maintain normokalemia and prevent hyperkalemia recurrence following MNT. Infographic available for this article. INFOGRAPHIC.PMID:38687454 | DOI:10.1007/s12325-024-02835-8 (Source: Adv Data)
Source: Adv Data - April 30, 2024 Category: Epidemiology Authors: Christopher G Rowan Abiy Agiro K Arnold Chan Ellen Colman Katie White Pooja Desai Jamie P Dwyer Source Type: research
Comparative Analysis of Quality of Life of Family Caregivers of Patients With Heart Failure and Cancer Who Receive Palliative Care
CONCLUSIONS: Overall, healthcare professionals should focus on improving social support and caregiver role adoption and provide greater attention to the QoL of caregivers of patients with cancer.PMID:38687116 | DOI:10.1097/JCN.0000000000001097 (Source: The Journal of Cardiovascular Nursing)
Source: The Journal of Cardiovascular Nursing - April 30, 2024 Category: Nursing Authors: Mauricio Arias-Rojas Edith Arredondo Holg ín Sonia Carre ño-Moreno Source Type: research
Perceived Control, Functional Status, Depressive Symptoms, and Anxiety: Mediating and Moderating Influences on Health-Related Quality of Life in Patients With Heart Failure
CONCLUSION: Functional status moderated the indirect effects of perceived control on HRQoL through DS and anxiety in patients with heart failure. Efforts to improve HRQoL by targeting perceived control may be more effective when considering DS and anxiety in patients with low to moderate levels of functional status.PMID:38687114 | DOI:10.1097/JCN.0000000000001100 (Source: The Journal of Cardiovascular Nursing)
Source: The Journal of Cardiovascular Nursing - April 30, 2024 Category: Nursing Authors: Ashmita Thapa JungHee Kang Misook L Chung Jia-Rong Wu Abigail Latimer Terry A Lennie Chin-Yen Lin Jessica Harman Thompson Geunyeong Cha Debra K Moser Source Type: research
Does Serum Uric Acid to Creatinine Ratio Predict Mortality Risk in Patients With Heart Failure?
CONCLUSION: A high SUA/Cr ratio was an independent risk factor for the mortality risk of HF.PMID:38686683 | DOI:10.14503/THIJ-23-8210 (Source: Texas Heart Institute Journal)
Source: Texas Heart Institute Journal - April 30, 2024 Category: Cardiology Authors: Xiaoqing Xi Jinfeng Cai Chen Zhang Xuefei Wang Source Type: research
Efficacy of a Single Day Extracorporeal Membrane Oxygenation Training Course for Critical Care Air Transport Team Eligible Personnel
CONCLUSIONS: An abbreviated 1-day lecture and hands-on task-trainer-based ECMO course resulted in a high rate of successful skill demonstration and improvement of physicians' and nurses' knowledge assessments and confidence levels, similar to our previous live-tissue training program. When compared to our previous studies, the addition of telemedicine and patient transportation to this study did not affect the duration or performance of procedures.PMID:38687647 | DOI:10.1093/milmed/usae138 (Source: Military Medicine)
Source: Military Medicine - April 30, 2024 Category: International Medicine & Public Health Authors: R Madelaine Paredes Brannon Inman William T Davis Maria Castaneda Allyson A Mireles Darren S Baldwin Dylan C Rodriguez Kimberly L Medellin Patrick C Ng Joseph K Maddry Source Type: research
Delta-SVV as a Predictor for Circulating Blood Volume Evaluation during Intraoperative Period: A Prospective Cohort Study
CONCLUSION: In conclusion, SVV measured by FloTrac / Vigileo could guile fluid therapy precisely by predicting the blood volume of patients during the intraoperative period, as it has a strong linear correlation with the blood volume of patients who underwent general anesthesia, meaning anesthesiologist could calculate the exact fluid volume for patients' infusion. Further studies with large cohorts and centers would be needed to validate its efficiency.PMID:38687861 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 30, 2024 Category: Complementary Medicine Authors: Bei Wang Yiqi Wu Zhiyong He Jianghui Xu Source Type: research
