The difference in determinant factor of six-minute walking distance between sarcopenic and non-sarcopenic elderly patients with heart failure.
Abstract BACKGROUND: The purpose of this study was to identify the factors determining exercise capacity in elderly patients with heart failure (HF) with and without sarcopenia. METHODS: We studied 186 consecutive patients with HF who met the criteria of being>60 years, with no physical disability. During hospitalization, we measured the 6-min walking distance (6MWD) and other physical functional parameters and evaluated echocardiographic and laboratory measurements indicating the severity of HF. First, we divided patients into two groups (the sarcopenia group and the nonsarcopenia group) according to the ...
Source: Journal of Cardiology - August 3, 2019 Category: Cardiology Authors: Kono Y, Izawa H, Aoyagi Y, Ishikawa A, Sugiura T, Mori E, Ueda S, Fujiwara W, Hayashi M, Saitoh E Tags: J Cardiol Source Type: research

The true population and diversity of ATTR cardiac amyloidosis revealed by new diagnostic tools.
PMID: 31375325 [PubMed - as supplied by publisher] (Source: Journal of Cardiology)
Source: Journal of Cardiology - July 30, 2019 Category: Cardiology Authors: Endo J Tags: J Cardiol Source Type: research

Real-world outcomes of rivaroxaban treatment in patients with nonvalvular atrial fibrillation and worsening renal function.
CONCLUSIONS: No association between WRF and occurrence of any bleeding, major bleeding, and stroke/systemic embolism/myocardial infarction was observed in patients with AF on rivaroxaban treatment during 1-year follow-up in real-world clinical practice. Clinicaltrials.gov: NCT01582737. PMID: 31371191 [PubMed - as supplied by publisher] (Source: Journal of Cardiology)
Source: Journal of Cardiology - July 29, 2019 Category: Cardiology Authors: Nakagawara J, Ikeda T, Ogawa S, Kitazono T, Minematsu K, Miyamoto S, Murakawa Y, Takeichi M, Kidani Y, Okayama Y, Sunaya T, Sato S, Yamanaka S Tags: J Cardiol Source Type: research

Innocent bystander or criminal? Influence of respiratory dysfunction on risk of atrial fibrillation.
PMID: 31353169 [PubMed - as supplied by publisher] (Source: Journal of Cardiology)
Source: Journal of Cardiology - July 25, 2019 Category: Cardiology Authors: Okumura Y, Nagashima K Tags: J Cardiol Source Type: research

Public location and survival from out-of-hospital cardiac arrest in the public-access defibrillation era in Japan.
CONCLUSIONS: In Japan, where public-access AEDs are well-disseminated, the PAD program worked effectively for adult OHCA of medical origin occurring in public locations. Notably, the proportions of PAD differed substantially according to specific public locations. PMID: 31350130 [PubMed - as supplied by publisher] (Source: Journal of Cardiology)
Source: Journal of Cardiology - July 23, 2019 Category: Cardiology Authors: Kobayashi D, Sado J, Kiyohara K, Kitamura T, Kiguchi T, Nishiyama C, Okabayashi S, Shimamoto T, Matsuyama T, Kawamura T, Iwami T Tags: J Cardiol Source Type: research

Design and rationale of the STroke secondary prevention with catheter ABLation and EDoxaban clinical trial in patients with non-valvular atrial fibrillation: The STABLED study.
CONCLUSION: This study will investigate the effectiveness and safety of CA and basic anticoagulation treatment with edoxaban for patients with NVAF who have suffered a recent ischemic stroke. The aim is to determine the best evidence for an optimal treatment strategy for patients with NVAF and recent stroke. TRIAL REGISTRATION: UMIN000031424/NCT03777631. PMID: 31337525 [PubMed - as supplied by publisher] (Source: Journal of Cardiology)
Source: Journal of Cardiology - July 20, 2019 Category: Cardiology Authors: Sakamoto Y, Nishiyama Y, Iwasaki YK, Daida H, Toyoda K, Kitagawa K, Okumura K, Kusano K, Hagiwara N, Fujimoto S, Miyamoto S, Otsuka T, Iguchi Y, Kanamaru T, Yamamoto T, Kaburagi J, Kimura T, Matsumoto T, Kimura K, Shimizu W, STABLED Study Investigators Tags: J Cardiol Source Type: research

Possible association of papillary muscle hypertrophy with the genesis of J-waves.
Abstract BACKGROUND: Although J-waves have been known to be associated with vulnerability to ventricular fibrillation, their electrophysiologic mechanism remains to be elucidated. The papillary muscles (PMs) of the left ventricle (LV) have been recognized as the target site of radiofrequency ablation for ventricular arrhythmias. However, the relationship between PM hypertrophy and J-waves has not been investigated. OBJECTIVE: To investigate the electrocardiographic characteristics, including the J-waves, in patients with solitary PM hypertrophy. METHODS: We studied 101 patients with PM hypertrophy withou...
Source: Journal of Cardiology - July 18, 2019 Category: Cardiology Authors: Ebata Y, Nakagawa M, Kondo H, Ezaki K, Miyazaki H, Shinohara T, Teshima Y, Yufu K, Takahashi N Tags: J Cardiol Source Type: research

HAS-BLED score as a predictor of bleeding complications from catheter ablation of atrial fibrillation: A subanalysis of the Japanese Anti-Coagulation Regimen Exploration in AF Catheter Ablation Registries.
Abstract BACKGROUND: The ATRIA, Outcomes Registry for Better Informed Treatment (ORBIT), and modified (m) HAS-BLED (excluding a labile international normalized ratio element from the HAS-BLED score) scores are currently used to predict the bleeding risk in atrial fibrillation (AF) patients receiving oral anticoagulant treatment. We assessed the usefulness of these scores in estimating the catheter ablation (CA)-related bleeding risk in AF patients from the Japanese Anti-Coagulation Regimen Exploration in AF Catheter Ablation Registry (JACRE). METHODS: We investigated 1322 consecutive patients enrolled in the ...
Source: Journal of Cardiology - July 18, 2019 Category: Cardiology Authors: Inoue K, Hirao K, Aonuma K, Kumagai K, Kimura M, Miyauchi Y, Tsushima E, Okumura K, JACRE Investigators Tags: J Cardiol Source Type: research

Multiparametric approach to congestion for predicting long-term survival in heart failure.
CONCLUSIONS: BNP, ePVS, BIVA, and BUN/Cr at admission provide independent and complementary prognostic information in patients with HF and, when combined, explain the 40% risk of death in these patients independent from the acute or chronic HF condition. PMID: 31326239 [PubMed - as supplied by publisher] (Source: Journal of Cardiology)
Source: Journal of Cardiology - July 17, 2019 Category: Cardiology Authors: Massari F, Scicchitano P, Iacoviello M, Passantino A, Guida P, Sanasi M, Piscopo A, Romito R, Valle R, Caldarola P, Ciccone MM Tags: J Cardiol Source Type: research

MicroRNAs: Emerging biomarkers for atrial fibrillation.
Abstract Atrial fibrillation (AF) causes severe cardiac dysrhythmia among patients with cardiovascular diseases. AF increases the risk of stroke and heart failure and is a growing public health concern. AF is also associated with various disease conditions such as hypertension, coronary artery disease, aging, and diabetes mellitus. The mechanism underlying AF is not completely understood due to its complexity. However, experimental and clinical data have revealed that the prevalence of this disease is associated with atrial arrhythmogenic remodeling. Currently, there are no biomarkers that are available for the ea...
Source: Journal of Cardiology - July 16, 2019 Category: Cardiology Authors: Komal S, Yin JJ, Wang SH, Huang CZ, Tao HL, Dong JZ, Han SN, Zhang LR Tags: J Cardiol Source Type: research

Association of slow flow with clinical factors in intravascular ultrasound-guided percutaneous coronary intervention for patients with left main trunk-acute myocardial infarction.
Abstract BACKGROUND: Slow flow can be fatal in primary percutaneous coronary interventions for left main trunk (LMT)-acute myocardial infarction (AMI), however, risk factors for slow flow in LMT-AMI have not been well investigated. Intravascular ultrasound (IVUS) may help to stratify the high-risk lesion for slow flow in LMT-AMI. METHODS: A total of 51 LMT-AMI were included as the study population, and were divided into the slow-flow group (n=22) and the non-slow-flow group (n=29). Slow flow was defined as either transient or persistent Thrombolysis in Myocardial Infarction (TIMI) flow grade ≤2. RESUL...
Source: Journal of Cardiology - July 16, 2019 Category: Cardiology Authors: Yamamoto K, Sakakura K, Akashi N, Watanabe Y, Seguchi M, Taniguchi Y, Wada H, Momomura SI, Fujita H Tags: J Cardiol Source Type: research

Integrated diagnostic approach to wild-type transthyretin cardiac amyloidosis with the use of high-sensitivity cardiac troponin T measurement and 99mTc-pyrophosphate scintigraphy.
Abstract BACKGROUND: The diagnosis of wild-type transthyretin cardiac amyloidosis (ATTRwt) is frequently missed or delayed because of the limited specificity of manifestations. We investigated the utility of combined assessment of high-sensitivity cardiac troponin T (hs-cTnT) measurement and 99mTc-pyrophosphate (99mTc-PYP) scintigraphy as diagnostic modalities in ATTRwt. METHODS: We divided 39 consecutive ATTRwt patients into two groups depending on whether serum hs-cTnT measurement and 99mTc-PYP scintigraphy were adopted as diagnostic tools: group A patients (n=8) who were diagnosed before the introduction o...
Source: Journal of Cardiology - July 16, 2019 Category: Cardiology Authors: Ochi Y, Kubo T, Nakashima Y, Baba Y, Hirota T, Yamasaki N, Yamashita T, Ueda M, Ando Y, Kitaoka H Tags: J Cardiol Source Type: research

Use of speckle tracking to assess heart failure with preserved ejection fraction.
Abstract Heart failure with preserved ejection fraction (HFpEF) currently represents approximately 50% of heart failure (HF) cases in the USA and is increasingly recognized as a leading cause of morbidity and mortality. Recent data suggest that the prevalence of HFpEF relative to HF with reduced ejection fraction (HFrEF) is increasing at a rate of 1% per year. With an aging population and increasing risk factors such as hypertension, obesity, and diabetes mellitus, HFpEF will soon be the most prevalent HF phenotype. Two-dimensional speckle-tracking echocardiography (STE) has been used to diagnose HFpEF specificall...
Source: Journal of Cardiology - July 11, 2019 Category: Cardiology Authors: Hiebert JB, Vacek J, Shah Z, Rahman F, Pierce JD Tags: J Cardiol Source Type: research

Reconsideration of the cut-off value of angiotensin-converting enzyme for screening of sarcoidosis in Japanese patients.
The objective of this study was to reconsider the cut-off value of ACE. METHODS: We studied 79 Japanese patients who were diagnosed as having sarcoidosis at our hospital. We excluded patients who had taken steroids or ACE inhibitors and patients with renal impairment. We respectively evaluated ACE values and performed receiver operating characteristic (ROC) analysis from a comparison with data for 299 normal Japanese subjects who showed ACE values in the current Japanese standard normal range (7.0-25.0IU/L). RESULTS: Patients with sarcoidosis had higher ACE values than those in normal subjects (ACE: 20.3IU/L [IQR...
Source: Journal of Cardiology - July 9, 2019 Category: Cardiology Authors: Baba Y, Kubo T, Yamanaka S, Ochi Y, Hirota T, Yamasaki N, Ohnishi H, Kubota T, Yokoyama A, Kitaoka H Tags: J Cardiol Source Type: research

Association between the activities of daily living and clinical outcomes in patients with heart failure.
PMID: 31300269 [PubMed - as supplied by publisher] (Source: Journal of Cardiology)
Source: Journal of Cardiology - July 9, 2019 Category: Cardiology Authors: Li HQ, Wang N, Chen Y Tags: J Cardiol Source Type: research

Prognosis and risk stratification in cardiac sarcoidosis patients with preserved left ventricular ejection fraction.
Abstract BACKGROUND: Although recent reports showed that left ventricular ejection fraction (LVEF) is a prognostic factor in patients with cardiac sarcoidosis (CS), advances in diagnostic imaging have enabled us to detect CS patients with preserved LVEF in the early stage of the disorder. In the present study, we examined the prognosis and risk stratification in CS patients with preserved LVEF. METHODS AND RESULTS: We retrospectively examined 91 consecutive CS patients at our hospital from October 1998 to December 2015 (age, 57±11 years; male/female, 25/66) for the relationship between LVEF and major a...
Source: Journal of Cardiology - July 2, 2019 Category: Cardiology Authors: Chiba T, Nakano M, Hasebe Y, Kimura Y, Fukasawa K, Miki K, Morosawa S, Takanami K, Ota H, Fukuda K, Shimokawa H Tags: J Cardiol Source Type: research

Effects of Mokuboito, a Japanese Kampo medicine, on symptoms in patients hospitalized for acute decompensated heart failure - A prospective randomized pilot study.
CONCLUSIONS: Oral administration of Mokuboito significantly improved ADHF-related symptoms. Our observations might provide the basis for a novel therapeutic strategy in hospitalized patients with ADHF. PMID: 31272834 [PubMed - as supplied by publisher] (Source: Journal of Cardiology)
Source: Journal of Cardiology - July 2, 2019 Category: Cardiology Authors: Ezaki H, Ayaori M, Sato H, Maeno Y, Taniwaki M, Miyake T, Sakurada M Tags: J Cardiol Source Type: research

Atrial high-rate episodes and atrial cardiomyopathy on the future stroke.
PMID: 31262612 [PubMed - as supplied by publisher] (Source: Journal of Cardiology)
Source: Journal of Cardiology - June 28, 2019 Category: Cardiology Authors: Nakano M, Kondo Y, Nakano M, Kajiyama T, Kobayashi Y Tags: J Cardiol Source Type: research

Impact of transcatheter aortic valve replacement on hemodynamic status in patients with aortic stenosis and mitral stenosis: Doppler echocardiographic study.
CONCLUSIONS: NYHA functional class and hemodynamic status of MS improved after TAVR in patients with severe AS and MS. TAVR might provide therapeutic efficacy for selected symptomatic severe AS patients with MS. PMID: 31256928 [PubMed - as supplied by publisher] (Source: Journal of Cardiology)
Source: Journal of Cardiology - June 27, 2019 Category: Cardiology Authors: Kato N, Shibayama K, Omori N, Hoshina M, Makihara Y, Okumura H, Tabata M, Obunai K, Hirao K, Pellikka PA, Watanabe H Tags: J Cardiol Source Type: research

What echocardiographic indices are predictive of patent ductus arteriosus surgical closure in early preterm infants? A prospective multicenter cohort study.
CONCLUSIONS: Considering the measurement's easiness and independence of body size, PDA diameter and LPAedv may serve as useful indices for assessing the need for PDA surgery in early preterm infants. PMID: 31256929 [PubMed - as supplied by publisher] (Source: Journal of Cardiology)
Source: Journal of Cardiology - June 27, 2019 Category: Cardiology Authors: Toyoshima K, Isayama T, Kobayashi T, Su C, Mikami M, Yokoyama T, Iwami H, Nagasawa H, Kawasaki H, Amari S, Nakayama A, Ikeda T, Okada N, Yamamoto Y, Masutani S, Patent ductus arteriosus, Left Atrial Size Evaluation in preterm infants (PLASE) study group i Tags: J Cardiol Source Type: research

Efficacy of cryoablation for paroxysmal and persistent atrial fibrillation in patients with structural heart disease.
PMID: 31256930 [PubMed - as supplied by publisher] (Source: Journal of Cardiology)
Source: Journal of Cardiology - June 27, 2019 Category: Cardiology Authors: Spartalis M, Iliopoulos DC, Spartalis E, Athanasiou A, Paschou SA, Livanis E, Voudris V, Siasos G Tags: J Cardiol Source Type: research

Diagnostic and prognostic significance of cardiovascular vortex formation.
Abstract Various forms of vortex formation in the cardiovascular system convey valuable information regarding the function of heart and great vessels. The vortex ring that forms during systole in the aortic sinus is the first that was recognized and the asymmetric transmitral vortex ring that forms in the left ventricle during diastole has been most commonly used for diagnosis and follow up of heart failure patients. Adverse vortex interaction in the heart can also occur due to valvular regurgitation and may have energetic consequences to the heart. Furthermore, vortices do exist in other chambers such as the righ...
Source: Journal of Cardiology - June 26, 2019 Category: Cardiology Authors: Kheradvar A, Rickers C, Morisawa D, Kim M, Hong GR, Pedrizzetti G Tags: J Cardiol Source Type: research

Unprecedented crisis-Heart failure hospitalizations in current or future Japan.
PMID: 31255459 [PubMed - as supplied by publisher] (Source: Journal of Cardiology)
Source: Journal of Cardiology - June 26, 2019 Category: Cardiology Authors: Ejiri K, Noriyasu T, Nakamura K, Ito H Tags: J Cardiol Source Type: research

Author's reply.
PMID: 31255460 [PubMed - as supplied by publisher] (Source: Journal of Cardiology)
Source: Journal of Cardiology - June 26, 2019 Category: Cardiology Authors: Perego GB, Tondo C Tags: J Cardiol Source Type: research

High-grade patent foramen ovale is a risk factor of unprovoked decompression sickness in recreational divers.
This study sought to evaluate the risk factors of unprovoked DCS in recreational divers. METHODS: A total of 489 consecutive divers were screened for PFO between January 2006 and January 2014 by means of transcranial Doppler. All patients were prospectively included in the study registry. Survival analysis techniques were used to assess for risk factors for unprovoked DCS. Age, sex, BMI, PFO presence, and grade were analyzed. The total sum of dives was used as a measure of time. RESULTS: The group performed a total of 169,411 dives (mean 346±636). Thirty-six (7%) of the divers suffered from an unprovoked D...
Source: Journal of Cardiology - June 26, 2019 Category: Cardiology Authors: Honěk J, Šrámek M, Šefc L, Januška J, Fiedler J, Horváth M, Tomek A, Novotný Š, Honěk T, Veselka J Tags: J Cardiol Source Type: research

Correlation between asymptomatic gastroesophageal excessive transmural injury after pulmonary vein isolation and a bonus freeze protocol using the second-generation 28-mm cryoballoon for paroxysmal atrial fibrillation.
CONCLUSIONS: In the patients with a bonus-freeze protocol using the 2G-CB, gastroesophageal ETIs were detected more often than in those with the non-bonus freeze protocol. In contrast, freedom from atrial fibrillation after the 2G-CB based PVI was comparable when applying either a bonus or non-bonus freeze protocol. PMID: 31255462 [PubMed - as supplied by publisher] (Source: Journal of Cardiology)
Source: Journal of Cardiology - June 26, 2019 Category: Cardiology Authors: Yoshiga Y, Okamoto T, Shimizu A, Ueyama T, Ono M, Mito T, Fukuda M, Ishiguchi H, Omuro T, Kobayashi S, Goto A, Nishikawa J, Sakaida I, Yano M Tags: J Cardiol Source Type: research

A prospective observational survey on landiolol in atrial fibrillation/atrial flutter patients with chronic heart failure - AF-CHF landiolol survey.
CONCLUSIONS: In a real-world setting in Japan, landiolol for the treatment of atrial fibrillation or atrial flutter with heart failure was acceptable without new safety concerns, and most patients achieved effective heart rate control during their arrhythmias. PMID: 31255463 [PubMed - as supplied by publisher] (Source: Journal of Cardiology)
Source: Journal of Cardiology - June 26, 2019 Category: Cardiology Authors: Yamashita T, Nakasu Y, Mizutani H, Sumitani K Tags: J Cardiol Source Type: research

University hospitals, general hospitals, private clinics: Place-based differences in patient characteristics and outcomes of AF-A SAKURA AF Registry Substudy.
AKURA AF Registry Investigators Abstract BACKGROUND: Relations between characteristics and outcomes of patients in Japan with atrial fibrillation (AF) and the type of medical facility providing their outpatient care are unclear. METHODS AND RESULTS: We compared patient characteristics and outcomes between 2 university hospitals (n=1178), 20 general hospitals (n=1308), and 41 private clinics (n=751) (follow-up: 39.3 months) in the prospective SAKURA AF Registry. Private clinic patients were significantly older than university hospital and general hospital patients (73.4±9.2 vs. 70.3±9.8 and 72.6±8.9 years; p
Source: Journal of Cardiology - June 25, 2019 Category: Cardiology Authors: Kogawa R, Okumura Y, Yokoyama K, Matsumoto N, Tachibana E, Kuronuma K, Oiwa K, Nishida T, Matsumoto M, Kojima T, Hanada S, Nomoto K, Sonoda K, Arima K, Takahashi F, Kotani T, Ohkubo K, Fukushima S, Itou S, Kondo K, Chiku M, Ohno Y, Onikura M, Hirayama A, Tags: J Cardiol Source Type: research

The relationship between decreased pulmonary function and atrial fibrillation in general population: Findings from Ansung-Ansan cohort of the Korean Genome and Epidemiology Study.
Abstract BACKGROUND: Decreased pulmonary function is a possible risk factor for atrial fibrillation (AF). However, data on this relationship in Asian populations are scant. The aim of this study was to evaluate the relationship between decreased pulmonary function and the incidence of AF in a prospective cohort of Koreans aged 40-69 years. METHODS: We assessed AF in 9631 Korean people enrolled in the community-based cohort who were followed for up to 12 years. AF at baseline was identified by electrocardiography (ECG) performed during the baseline visit and/or the self-reported history of physician-determined...
Source: Journal of Cardiology - June 25, 2019 Category: Cardiology Authors: Kim BS, Park JK, Lee Y, Shin JH, Lim YH, Park HC, Kim CK, Shin J Tags: J Cardiol Source Type: research

Effect of combination of non-slip element balloon and drug-coating balloon for in-stent restenosis lesions (ELEGANT study).
CONCLUSION: Eight-month angiographic outcomes were similar between NSE and non-compliant balloon pre-dilatation with DCB for treatment of ISR lesions. However, NSE pre-dilatation has advantages such as reduction of balloon slippage and geographical miss during the procedure. PMID: 31248751 [PubMed - as supplied by publisher] (Source: Journal of Cardiology)
Source: Journal of Cardiology - June 24, 2019 Category: Cardiology Authors: Aoki J, Nakazawa G, Ando K, Nakamura S, Tobaru T, Sakurada M, Okada H, Hibi K, Zen K, Habara S, Fujii K, Habara M, Ako J, Asano T, Ozaki S, Fusazaki T, Kozuma K, ELEGANT Investigators Tags: J Cardiol Source Type: research

Post-procedural tricuspid regurgitation predicts long-term survival in patients undergoing percutaneous mitral valve repair.
This study aimed to compare pre- and post-procedural TR and investigated the impact of post-procedural TR and major clinical risk factors on long-term survival in patients undergoing PMVR. METHODS: In this retrospective observational cohort study, data from 213 consecutive patients at a tertiary care center undergoing PMVR from 2010 to 2016 were analyzed. Two different groups, dichotomized according to the degree of TR (none/mild and moderate/severe) were compared. Multivariable analyses were performed assessing predictors for long-term survival adjusting for major risk factors. RESULTS: Following PMVR TR was sig...
Source: Journal of Cardiology - June 22, 2019 Category: Cardiology Authors: Bannehr M, Kahn U, Okamoto M, Kaneko H, Hähnel V, Neuß M, Haase-Fielitz A, Butter C Tags: J Cardiol Source Type: research

A randomized unblinded trial to compare effects of intensive versus conventional lipid-lowering therapy in patients undergoing renal artery stenting.
Abstract BACKGROUND: Although current guidelines recommend the use of statins for severe atherosclerotic renal artery stenosis (ARAS), the renal protection of intensive lipid-lowering therapy in patients with ARAS who underwent stent placement remains uncertain. The aim of this study was to compare the renal-protective effect of intensive lipid lowering with that of conventional lipid lowering in patients with ARAS undergoing stent placement. METHODS: A total 150 patients with severe ARAS undergoing stent placement were randomly (1:1) assigned to receive intensive lipid lowering [target low-density lipoprotei...
Source: Journal of Cardiology - June 21, 2019 Category: Cardiology Authors: Peng M, Dong H, Jiang X, Che W, Zou Y, Zhang Y, Liu L Tags: J Cardiol Source Type: research

Author's reply: A decline in activities of daily living due to acute heart failure is an independent risk factor of hospitalization for heart failure and mortality.
PMID: 31235419 [PubMed - as supplied by publisher] (Source: Journal of Cardiology)
Source: Journal of Cardiology - June 21, 2019 Category: Cardiology Authors: Takabayashi K Tags: J Cardiol Source Type: research

Efficacy and safety of exercise rehabilitation in patients with hypertrophic cardiomyopathy.
CONCLUSIONS: Exercise rehabilitation appears to be applicable and safe in HCM. It mainly benefits patients suffering from significant functional limitation. Larger prospective studies are needed to validate these findings and better characterize patients expected to benefit from these programs. PMID: 31235420 [PubMed - as supplied by publisher] (Source: Journal of Cardiology)
Source: Journal of Cardiology - June 21, 2019 Category: Cardiology Authors: Wasserstrum Y, Barbarova I, Lotan D, Kuperstein R, Shechter M, Freimark D, Segal G, Klempfner R, Arad M Tags: J Cardiol Source Type: research

Factors related to physical functioning decline after cardiac surgery in older patients: A multicenter retrospective study.
This study aimed to investigate the factors related to physical functioning decline after cardiac surgery in older patients. METHODS: The final study sample consisted of 523 older (≥65 years) patients (age 74.2±6.1 years, 66% male) who underwent cardiac surgery at 8 Japanese institutions. We excluded patients who were unable to walk independently or had a slow gait speed (
Source: Journal of Cardiology - June 20, 2019 Category: Cardiology Authors: Itagaki A, Saitoh M, Okamura D, Kawamura T, Otsuka S, Tahara M, Mori Y, Kamisaka K, Ochi Y, Yuguchi S, Kato M, Morisawa T, Takahashi T Tags: J Cardiol Source Type: research

microRNAs in bicuspid aortic valve associated aortopathy: Recent advances and future perspectives.
Abstract The risk of acute aortic events in patients with bicuspid aortic valve (BAV) constitutes a medical concern in terms of timing and surgical decision. During the past years, there has been a growing interest in the potential of microRNAs (miRNAs) as crucial epigenetic factors in multiple cellular processes associated with BAV aortopathy. Nevertheless, there are still challenges that need to be overcome before miRNAs could enter clinical practice, and further validation studies in larger and well-defined BAV cohorts are now required. This review aims at providing a comprehensive overview of the available dat...
Source: Journal of Cardiology - June 20, 2019 Category: Cardiology Authors: Pulignani S, Borghini A, Andreassi MG Tags: J Cardiol Source Type: research

The standing of percutaneous pulmonary valve implantation compared to surgery in a non-preselected cohort with dysfunctional right ventricular outflow tract - Reasons for failure and contraindications.
Abstract BACKGROUND: Percutaneous pulmonary valve implantation (PPVI) numbers are rising but are still minor compared to surgery due to several contraindications. We sought to analyze the impact of PPVI compared to standard surgery in an unselected cohort with dysfunctional right ventricular outflow tract (RVOT). Reasons for PPVI failure and possible contraindications were explored. METHODS: Between 2010 and 2015 all consecutive patients who underwent surgery or intervention for a dysfunctional RVOT were investigated. RESULTS: A total of 382 cases was identified - 246 patients underwent successful valve ...
Source: Journal of Cardiology - June 20, 2019 Category: Cardiology Authors: Haas NA, Vcasna R, Laser KT, Blanz U, Herrmann FE, Jakob A, Fischer M, Kanaan M, Lehner A Tags: J Cardiol Source Type: research

Cellular senescence in cardiac diseases.
Abstract Replicative capacity of somatic cells is limited. It indicates that aging also develops at the cellular level, and this is described as "cellular senescence". Senescent cells become flattened, enlarged, and irreversibly lose capacity for proliferation. Lack of specific and conclusive markers for cellular senescence makes it difficult to comprehensively define and understand this biological process especially in vivo. Molecules including p53, p21, p16Ink4a, p38MAPK, and γH2AX, telomere attrition, enhanced signals for SA-β-gal, etc. are widely used to detect senescent cells, but these a...
Source: Journal of Cardiology - June 12, 2019 Category: Cardiology Authors: Shimizu I, Minamino T Tags: J Cardiol Source Type: research

The risk of infective endocarditis following interventional pulmonary valve implantation: A meta-analysis.
CONCLUSIONS: At present, there is an important difference for the risk of IE after PPVI. To reduce the risk of post PPVI endocarditis, a careful valve selection in favor of the Sapien™ valves seems to be beneficial. PMID: 31113702 [PubMed - as supplied by publisher] (Source: Journal of Cardiology)
Source: Journal of Cardiology - May 18, 2019 Category: Cardiology Authors: Lehner A, Haas NA, Dietl M, Jakob A, Schulze-Neick I, Dalla Pozza R, Rodriguez SF, Fischer M Tags: J Cardiol Source Type: research

Mesenchymal stem/stromal cell therapy for pulmonary arterial hypertension: Comprehensive review of preclinical studies.
Abstract Pulmonary arterial hypertension (PAH) is a disease characterized by progressive pulmonary vascular remodeling, resulting in right-sided heart failure and premature death. Current available therapies for PAH have limited efficacy, and new therapeutic strategies need to be developed. Mesenchymal stem/stromal cells (MSCs) may offer a novel therapeutic approach to PAH. Since the first report in 2006, a number of preclinical studies have demonstrated a potential therapeutic effect of this approach, with attenuated hemodynamic and histological progression of PAH, in animal models of PAH. However, there remain s...
Source: Journal of Cardiology - May 17, 2019 Category: Cardiology Authors: Fukumitsu M, Suzuki K Tags: J Cardiol Source Type: research

Different effects of norepinephrine and nerve growth factor on atrial fibrillation vulnerability.
Abstract BACKGROUND: The sympathetic nerve plays an important role in atrial fibrillation (AF) vulnerability. Norepinephrine (NE) has a relationship with AF and nerve growth factor (NGF) injection can induce sympathetic innervation. However, the mechanisms of NE and NGF on AF vulnerability remain unclear. METHODS: Four groups of rabbits were studied: the control group, the NGF group, the NE group, and the NGF+valsartan+metoprolol group. After receiving drugs for 15 days, induced AF was observed, and left atrium (LA) tissues were obtained. Immunocytochemical staining of cardiac nerves and ionic remodeling were...
Source: Journal of Cardiology - May 15, 2019 Category: Cardiology Authors: Yang M, Zhang S, Liang J, Tang Y, Wang X, Huang C, Zhao Q Tags: J Cardiol Source Type: research

Association of calciprotein particles measured by a new method with coronary artery plaque in patients with coronary artery disease: A cross-sectional study.
Abstract BACKGROUND: Calciprotein particles (CPPs) have been suggested to be associated with the degree of coronary atherosclerosis, and have also been established as a molecular marker for clinical outcome in patients with chronic kidney disease (CKD). However, there are several concerns with regard to conventional measurement of CPPs. We therefore developed a new CPP measurement system that can detect both smaller and lower-density CPPs. METHODS: We analyzed 71 consecutive patients who underwent percutaneous coronary intervention for acute coronary syndrome (ACS, n=29) and/or stable angina pectoris (AP, n=4...
Source: Journal of Cardiology - May 15, 2019 Category: Cardiology Authors: Nakazato J, Hoshide S, Wake M, Miura Y, Kuro-O M, Kario K Tags: J Cardiol Source Type: research

De novo atrial fibrillation as an independent prognostic marker after ST-segment elevation myocardial infarction: Results from the RIMA registry.
We examined the 1-year prognostic value of AF in STEMI, distinguishing patients with prior AF from patients with de novo AF. METHODS: Between January 2004 and December 2015, 3173 STEMI patients were enrolled in the RIMA registry (Registre des Infarctus en Maine Anjou). They were divided into 3 groups: (1) AF-free patients; (2) patients with known prior AF; and (3) patients with de novo AF during hospitalization (including admission). We defined 3 primary outcomes at 1-year post-discharge: cardiovascular mortality, readmission for heart failure (HF), and stroke. Temporal onset of de novo AF was also studied. RESUL...
Source: Journal of Cardiology - May 9, 2019 Category: Cardiology Authors: Gourronc Y, Grall S, Ingremeau D, Desprets L, Prunier F, Furber A, Bière L Tags: J Cardiol Source Type: research

Preoperative left atrial minimum volume as a surrogate marker of postoperative symptoms in senile patients with aortic stenosis who underwent surgical aortic valve replacement.
CONCLUSIONS: The preoperative echocardiographic LAVImin measurement is useful as a surrogate marker of symptomatic status after AVR in patients with AS. PMID: 31072724 [PubMed - as supplied by publisher] (Source: Journal of Cardiology)
Source: Journal of Cardiology - May 6, 2019 Category: Cardiology Authors: Morimoto J, Hozumi T, Takemoto K, Wada T, Maniwa N, Kashiwagi M, Shimamura K, Shiono Y, Kuroi A, Yamano T, Yamaguchi T, Matsuo Y, Kitabata H, Ino Y, Kubo T, Tanaka A, Nishimura Y, Akasaka T Tags: J Cardiol Source Type: research

Characteristics of ventricular tachycardia and long-term treatment outcome in patients with dilated cardiomyopathy complicated by lamin A/C gene mutations.
CONCLUSIONS: These results demonstrate that patients with LMNA-related cardiomyopathy are characterized by VTs refractory to RFCA probably because of the deep intramural focus at the basal ventricular septum, resulting in poor prognosis with progressive severe heart failure despite all available optimized therapies. Thus, we should consider heart transplantation in their early 50s when several VT events begin to occur. PMID: 31060954 [PubMed - as supplied by publisher] (Source: Journal of Cardiology)
Source: Journal of Cardiology - May 3, 2019 Category: Cardiology Authors: Hasebe Y, Fukuda K, Nakano M, Kumagai K, Karibe A, Fujishima F, Satake H, Kondo M, Wakayama Y, Shimokawa H Tags: J Cardiol Source Type: research

Red blood cell distribution width as a prognostic factor in patients undergoing transcatheter aortic valve implantation.
Abstract BACKGROUND: Red blood cell distribution width (RDW), which is routinely reported in complete blood counts, is a measure of the variability in size of circulating erythrocytes. RDW is an independent predictor of prognosis in patients with cardiovascular diseases. We evaluated the short- and long-term prognostic value of RDW in a large cohort of transcatheter aortic valve implantation (TAVI) patients. METHODS: The impact of RDW on outcome was determined prospectively in 1029 consecutive patients with severe aortic stenosis (AS) undergoing transfemoral TAVI. The cohort was divided into 2 groups accordin...
Source: Journal of Cardiology - May 3, 2019 Category: Cardiology Authors: Szekely Y, Finkelstein A, Bazan S, Halkin A, Abbas Younis M, Erez J, Keren G, Banai S, Arbel Y Tags: J Cardiol Source Type: research

Predicting postpartum cardiac events in pregnant women with complete atrioventricular block.
Abstract BACKGROUND: Women with complete atrioventricular block (CAVB) can tolerate hemodynamic changes during pregnancy; however, the incidence of cardiac events in women with CAVB may increase after delivery. The aim of this study was to investigate predictive factors for postpartum cardiac events in pregnant women with CAVB. METHODS AND RESULTS: Pregnant women with CAVB who received perinatal management at a tertiary cardiac center from 1981 to 2015 were retrospectively reviewed. Univariate and multivariate logistic analyses of postpartum cardiac events were performed. Postpartum cardiac event was defined ...
Source: Journal of Cardiology - May 3, 2019 Category: Cardiology Authors: Nakashima A, Miyoshi T, Aoki-Kamiya C, Nishio M, Horiuchi C, Tsuritani M, Iwanaga N, Katsuragi S, Neki R, Ikeda T, Yoshimatsu J Tags: J Cardiol Source Type: research

Corundum of stroke risk in atrial high rate episodes.
PMID: 31060957 [PubMed - as supplied by publisher] (Source: Journal of Cardiology)
Source: Journal of Cardiology - May 3, 2019 Category: Cardiology Authors: Ozcan EE, Gorenek B Tags: J Cardiol Source Type: research

Percutaneous coronary intervention strategies in patients with acute myocardial infarction and multivessel disease: Completeness, timing, lesion assessment, and patient status.
Abstract Approximately 50% of patients with acute myocardial infarction including ST segment elevation myocardial infarction and non-ST segment elevation myocardial infarction have multivessel (MV) coronary artery disease. Recently, the evidence for beneficial outcomes associated with MV percutaneous coronary intervention (PCI) compared with culprit-only PCI has increased. However, optimal timing of non-culprit revascularization, appropriate lesion assessment in non-culprit vessels, and the best treatment strategy for patients with cardiogenic shock remain unclear. This review summarizes current evidence and focus...
Source: Journal of Cardiology - April 30, 2019 Category: Cardiology Authors: Saito Y, Kobayashi Y Tags: J Cardiol Source Type: research

Is rhythm control superior to rate control in patients with heart failure and preserved ejection fraction?
PMID: 31029454 [PubMed - as supplied by publisher] (Source: Journal of Cardiology)
Source: Journal of Cardiology - April 24, 2019 Category: Cardiology Authors: Watanabe T Tags: J Cardiol Source Type: research