Log in to search using one of your social media accounts:

 

The era of biofunctional biomaterials in orthopedics: what does the future hold?
Authors: Rehman M, Madni A, Webster TJ Abstract INTRODUCTION: Titanium-based materials do not fulfill all the requirements of orthopedic implants due to a mismatch in mechanical properties with bone which are prone to change during the course of bone growth. Biofunctional biomaterials are a new class of materials that show bioactivity and adaptability at any stage of bone growth. Areas covered: Different biofunctional biomaterials have evolved over time that can enhance calcium phosphate (CaP) precipitation, stimulate osteogenic differentiation, and can control osteoblast gene expression. These materials include me...
Source: Expert Review of Medical Devices - January 21, 2018 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

A comprehensive review of endoscopic ultrasound core biopsy needles.
Authors: James TW, Baron TH Abstract INTRODUCTION: Endoscopic ultrasound (EUS)-guided tissue acquisition by-fine needle biopsy (EUS-FNB) developed over the last two decades as an attempt to overcome the limitations of fine needle aspiration (FNA). There are now three commercially available second-generation FNB needles with different tip designs. Areas covered: In this review the roles of EUS-FNA and FNB, the history and evolution of the EUS core biopsy needle are addressed followed by a presentation of currently available needles. Literature search was conducted using MEDLINE, Controlled Trials Register, US Patent...
Source: Expert Review of Medical Devices - January 18, 2018 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Tissue expanders with a focus on extremity reconstruction.
We describe their uses, advantages, disadvantages, and clinical outcomes. The majority of articles reviewed include case series with level IV evidence. Outcome data was collected for studies after 1990 using PubMed database. Expert Commentary: An overall reduction in cost, time-to-wound closure, hospital length-of-stay, and infection rate may be expected with most tissue expanders. However, further studies comparing outcomes and cost-effectiveness of various expanders may be beneficial. Surgeons should be aware of the wide array of tissue expanders that are commercially available to individualize treatment based on thoroug...
Source: Expert Review of Medical Devices - January 13, 2018 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Corrigendum.
Authors: PMID: 29327615 [PubMed - as supplied by publisher] (Source: Expert Review of Medical Devices)
Source: Expert Review of Medical Devices - January 13, 2018 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Virtual reality in cognitive and motor rehabilitation: facts, fiction and fallacies.
Authors: Tieri G, Morone G, Paolucci S, Iosa M Abstract INTRODUCTION: Over recent decades many researchers and clinicians have started to use Virtual Reality (VR) as a new technology for implementing innovative rehabilitation treatments in cognitive and motor domains. However, the expression 'VR' has often also been improperly used to refer to video games. Further, VR efficacy, often confused with that of video-game exercises, is still debated. Areas covered: In this review, we provide the scientific rationale for the advantages of using VR systems in rehabilitation and investigate whether the VR could really be a ...
Source: Expert Review of Medical Devices - January 11, 2018 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Technology of irreversible electroporation and review of its clinical data on liver cancers.
Authors: Cohen EI, Field D, Lynskey GE, Kim AY Abstract INTRODUCTION: Irreversible electroporation (IRE) has developed as a novel percutaneous ablative technique over the past decade and its utility in the treatment of primary and metastatic liver disease has progressed rapidly. Areas Covered: After discussing the principles behind the technology and the practical steps in its use, this article offers a detailed analysis of the recent published work that evaluates its safety and efficacy. The strengths and weaknesses of other ablative techniques, including radiofrequency ablation, microwave ablation and cryoablatio...
Source: Expert Review of Medical Devices - January 9, 2018 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Does the novel delivery system for the STENTYS self-apposing coronary stent increase the risk of stent edge dissections? Optical coherence tomography post stent findings.
CONCLUSIONS: Detailed OCT assessment of stent edge dissections was possible, which revealed no large differences using the Xposition delivery device as compared with conventional delivery device, however large studies are warranted. PMID: 29284310 [PubMed - as supplied by publisher] (Source: Expert Review of Medical Devices)
Source: Expert Review of Medical Devices - December 30, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Next-generation sequencing: from conventional applications to breakthrough genomic analyses and precision oncology.
Authors: Ziogas DE, Kyrochristos ID, Roukos DH PMID: 29284319 [PubMed - as supplied by publisher] (Source: Expert Review of Medical Devices)
Source: Expert Review of Medical Devices - December 30, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Implementation of smart technology to improve medication adherence in patients with cardiovascular disease: Is it effective?
Authors: Treskes R, Van der Velde E, Schoones JW, Schalij MJ Abstract INTRODUCTION: Medication adherence is of key importance in the treatment of cardiovascular disease. Studies consistently show that a substantial proportion of patients is non-adherent. Areas covered: For this review, telemedicine solutions that can potentially improve medication adherence in patients with cardiovascular disease were reviewed. A total of 475 PubMed papers were reviewed, of which 74 were assessed. Expert commentary: Papers showed that evidence regarding telemedicine solutions is mostly conflictive. Simple SMS reminders might work f...
Source: Expert Review of Medical Devices - December 24, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Open source modular ptosis crutch for the treatment of myasthenia gravis.
Authors: Saidi T, Sivarasu S, Douglas TS Abstract INTRODUCTION: Pharmacologic treatment of Myasthenia Gravis presents challenges due to poor tolerability in some patients. Conventional ptosis crutches have limitations such as interference with blinking which causes ocular surface drying, and frequent irritation of the eyes. To address this problem, a modular and adjustable ptosis crutch for elevating the upper eyelid in Myasthenia Gravis patients has been proposed as a non-surgical and low-cost solution. Areas covered: This paper reviews the literature on the challenges in the treatment of Myasthenia Gravis globall...
Source: Expert Review of Medical Devices - December 24, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

XEN Gel Implant: a new surgical approach in glaucoma.
Authors: Chaudhary A, Salinas L, Guidotti J, Mermoud A, Mansouri K Abstract INTRODUCTION: Glaucoma is a leading cause of blindness worldwide. Intraocular pressure (IOP) lowering is the only effective treatment strategy. Traditional glaucoma surgeries are generally considered to be unpredictable and associated with a high rate of complications. This has led to the development of a novel XEN Gel Implant, a type of minimally invasive glaucoma surgery (MIGS), lowering the IOP without extensive surgical dissection. Areas Covered: A literature search was undertaken on PubMed using the terms XEN glaucoma, gelatin microste...
Source: Expert Review of Medical Devices - December 21, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Burst and high frequency stimulation: Underlying mechanism of action.
Authors: Vanneste S, Ahmed S, Yearwood T, De Ridder D Abstract INTRODUCTION: Paresthesia-free spinal cord stimulation (SCS) techniques, such as burst and high-frequency (HF) SCS, have been developed and demonstrated to be successful for treating chronic pain, albeit via different mechanisms of action. The goal of this review is to discuss the mechanisms of action for pain suppression at both the cellular and systems levels for burst and HF SCS. In addition, we also discuss the neuromodulation devices that mimic these paradigms. Areas covered: The authors performed a literature review to unravel the mechanisms of ac...
Source: Expert Review of Medical Devices - December 20, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Prostate cancer high dose-rate brachytherapy: review of evidence and current perspectives.
Authors: Dutta SW, Alonso CE, Libby B, Showalter TN Abstract INTRODUCTION: Patients with intermediate to high risk disease (prostate specific antigen (PSA) ≥ 10, Gleason score ≥7, or clinical stage ≥ T2b) suffer from poorer long-term biochemical control (freedom from an increasing prostate specific antigen level) when treated with external beam radiation (EBRT) alone. In order to improve biochemical control while limiting long-term complications, brachytherapy has been incorporated into radiotherapy treatment, either alone or in combination with EBRT. Areas covered: Current literature regarding the use of ...
Source: Expert Review of Medical Devices - December 20, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Renal risk stratification in left ventricular assist device therapy.
Authors: Topkara VK, Givens RC Abstract INTRODUCTION: Left ventricular assist device (LVAD) therapy has greatly reduced mortality for patients with advanced heart failure (HF), both as a bridge to heart transplantation and as destination therapy. However, among other comorbidities, LVAD recipients face a risk of renal dysfunction, related to either the residual effects of HF or to LVAD support, which complicates the management of these patients and increases the risk of an adverse clinical outcome, including death. Areas covered: The authors summarize the current understanding of pre-LVAD predictors of post-LVAD re...
Source: Expert Review of Medical Devices - December 20, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Differential effects of public and private funding in the medical device industry.
Authors: Kang HD, Ku DN Abstract INTRODUCTION: Funding for scientific advancement comes from two dominant sources: public funds used to generate knowledge, and private sector funds in the pursuit of commercial products. It is unclear how to compare the outputs of these two financial mechanisms because both sectors are motivated by common goods but are also governed by divergent forces. Employment within a geographic region may be a metric of mutual value that can be applied equally to assess the societal impacts of two financing sources. Areas covered: The authors focused on the medical device industry, which is a ...
Source: Expert Review of Medical Devices - December 20, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

The Bolton Treo endograft for treatment of abdominal aortic aneurysms: Just another trimodular platform?
This article discusses the technical features and clinical performance of Treo as well as the interesting hemodynamic consequences of its design. Expert commentary: The Treo aortic stent-graft provides accurate deployment, secure proximal seal and fixation as well as efficient conformability in angulated necks. Early results drawn from single-center studies are promising with acceptable technical and clinical success. Moreover, the custom-made solution provided with the Treo platform is one of the most intriguing challenges in current endovascular era and is expected to broaden significantly the armamentarium of endovascul...
Source: Expert Review of Medical Devices - December 20, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Off-the-shelf tissue engineered heart valves for in situ regeneration: current state, challenges and future directions.
Authors: Motta SE, Lintas V, Fioretta ES, Hoerstrup SP, Emmert MY Abstract INTRODUCTION: Transcatheter aortic valve replacement (TAVR) is continuously evolving and is expected to surpass surgical valve implantation in the near future. Combining durable valve substitutes with minimally invasive implantation techniques might increase the clinical relevance of this therapeutic option for younger patient populations. Tissue engineering offers the possibility to create tissue-engineered heart valves (TEHVs) with regenerative and self-repair capacities which may overcome the pitfalls of current TAVR prostheses. Areas cov...
Source: Expert Review of Medical Devices - December 20, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Designing medical technology for resilience: Integrating health economics and human factors approaches.
Authors: Borsci S, Uchegbu I, Buckle P, Ni Z, Walne S, Hanna GB Abstract INTRODUCTION: The slow adoption of innovation into healthcare calls into question the manner of evidence generation for medical technology. This paper identifies potential reasons for this including a lack of attention to human factors, poor evaluation of economic benefits, lack of understanding of the existing healthcare system and a failure to recognise the need to generate resilient products. Areas covered. Recognising a cross-disciplinary need to enhance evidence generation early in a technology's life cycle, the present paper proposes a n...
Source: Expert Review of Medical Devices - December 17, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Computer assisted surgery in preoperative planning of acetabular fracture surgery: State of the art.
Authors: Courvoisier A, Boudissa M, Chabanas M, Tonetti J Abstract INTRODUCTION: The development of imaging modalities and computer technology provides a new approach in acetabular surgery. Areas covered: This review describes the role of computer-assisted surgery (CAS) in understanding of the fracture patterns, in the virtual preoperative planning of the surgery and in the use of custom-made plates in acetabular fractures with or without 3D printing technologies. A Pubmed internet research of the English literature of the last 20 years was carried out about studies concerning computer-assisted surgery in acetabula...
Source: Expert Review of Medical Devices - December 7, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

What does the future hold for novel intravascular imaging devices: a focus on morphological and physiological assessment of plaque.
Authors: Katagiri Y, Tenekecioglu E, Serruys PW, Collet C, Katsikis A, Asano T, Miyazaki Y, Piek JJ, Wykrzykowska JJ, Bourantas C, Onuma Y Abstract INTRODUCTION: It is well recognized that a lesion that does not cause a hemodynamically significant stenosis can trigger a sudden cardiac event through plaque rupture. As a diagnostic tool, intravascular imaging was developed to circumvent limitations of coronary angiography; however, none of the intravascular imaging devices are individually able to provide complete assessment of the plaque morphology, geometry, physiology and biology. Therefore, over the past few year...
Source: Expert Review of Medical Devices - December 3, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

The risk of right ventricular failure with current continuous-flow left ventricular assist devices.
Authors: Loforte A, Grigioni F, Marinelli G Abstract INTRODUCTION: Right ventricular failure (RVF) still results as the major cause of morbidity and mortality after left ventricular assist device (LVAD) implantation. Despite overall improved outcomes and lower rates of RVF with the use of the newer, continuous-flow (CF) LVADs over pulsatile-flow devices, and development of clinical prediction scores to facilitate preoperative identification of patients at risk for RVF after implantation, RVF occurs in 13% to 40% of continuous-flow device. Areas covered: In this article, a review has been carried out on the current ...
Source: Expert Review of Medical Devices - November 29, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Capillaroscopy in pregnancy.
Authors: Thevissen K, Gyselaers W Abstract INTRODUCTION: In pregnancy, the circulatory system undergoes profound adaptation to meet the requirements in blood supply for the mother and the foetus. With the development of new techniques, research of the microcirculatory changes, important for e.g. pre-eclampsia, becomes available. This expert review gives an overview of the current evidence in the field of capillaroscopy. The aim of this review is to summarize the available techniques in the assessment of the microcirculation during pregnancy. Areas covered: A literature search was done, using the strategy: (microcir...
Source: Expert Review of Medical Devices - November 24, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Smartphone accelerometers for the detection of heart rate.
Authors: Landreani F, Caiani EG Abstract INTRODUCTION: Micro-electro-mechanical systems technology, now embedded into smartphones, potentially allows measuring heart mechanical activity by positioning the phone on the body and acquiring vibrational signals, without the need for additional peripherals or interfaces. However, lack of standardization in experimental protocol, processing methodology and validation procedures, together with the wide range of available smartphones on the market, impact on the comparability of results and their general validity. The aim of this review is to provide information on the stat...
Source: Expert Review of Medical Devices - November 24, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Existing issues and valid concerns in continuous-flow ventricular assist devices.
Authors: Hetzer R, Delmo Walter EM Abstract INTRODUCTION: Through concerted endeavours in the fields of surgery, medicine, and biomedical engineering, patronized by government and industry, ventricular assist devices have become an established surgical treatment to support the failing heart, which could easily and simply surpass the frequency of heart transplantation. Be it as it may, complications and adverse events have unfolded, and these facilitated the way to newer biomedically-engineered pump designs in search of the perfect support for a failing heart. Areas covered: This review focuses on the evolution of t...
Source: Expert Review of Medical Devices - November 24, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

On the new regulation of medical devices in Europe.
Authors: Migliore A PMID: 29157016 [PubMed - as supplied by publisher] (Source: Expert Review of Medical Devices)
Source: Expert Review of Medical Devices - November 23, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

A state-of-art review of low intensity extracorporeal shock wave therapy and lithotripter machines for the treatment of erectile dysfunction.
Authors: Chung E, Wang J Abstract Introduction Current treatment for erectile dysfunction (ED) mostly attempts to improve erectile function with limited impact on altering the underlying pathophysiology of ED. Recent animal experiments have supported the notion that low intensity extracorporeal shockwave therapy (LIESWT) significantly improves penile hemodynamics and might induce structural changes that regenerate penile tissue. Areas covered This review article provides an overview of the basic mechanics and clinical studies pertaining to LIESWT and its use in the field of ED. We identify several key aspects of LI...
Source: Expert Review of Medical Devices - November 10, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Corrigendum.
Authors: PMID: 29034797 [PubMed - as supplied by publisher] (Source: Expert Review of Medical Devices)
Source: Expert Review of Medical Devices - October 18, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Utilization of Robotic-Arm Assisted Total Knee Arthroplasty for Soft Tissue Protection.
Authors: Sultan AA, Piuzzi N, Khlopas A, Chughtai M, Sodhi N, Mont MA Abstract Despite the well-established success of total knee arthroplasty (TKA), iatrogenic ligamentous and soft tissue injuries are infrequent, but potential complications that can have devastating impact on clinical outcomes. These injuries are often related to technical errors and excessive soft tissue manipulation, particularly during bony resections. Recently, robotic-arm assisted TKA was introduced and demonstrated promising results with potential technical advantages over manual surgery in implant positioning and mechanical accuracy. Furthe...
Source: Expert Review of Medical Devices - October 15, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Use of Amplatzer occluders for treatment of aorto-pulmonary fistulas - case and review of the literature.
We present the case of a patient with a very rare complication following proximal aortic surgery treated using a unique strategy. A huge pseudoaneurysm around an ascending aortic prosthesis ruptured into the right pulmonary artery. A hybrid treatment strategy consisting of percutaneous closure of the fistula followed by cardiosurgery was chosen due to the patient's poor haemodynamic condition. We also review current clinical experience of endovascular treatment of aortopulmonary fistulas by searching case reports in PubMed. Expert commentary: Closure of the APF using an Amplatzer occluder via the antegrade venous approach ...
Source: Expert Review of Medical Devices - October 14, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Computational Methods for the Aortic Heart Valve and its Replacements.
Authors: Zakerzadeh R, Hsu MC, Sacks MS Abstract INTRODUCTION: Replacement with a prosthetic device remains a major treatment option for the patients suffering from heart valve disease, with prevalence growing resulting from an ageing population. While the most popular replacement heart valve continues to be the bioprosthetic heart valve (BHV), its durability remains limited. There is thus a continued need to develop a general understanding of the underlying mechanisms limiting BHV durability to facilitate development of a more durable prosthesis. In this regard, computational models can play a pivotal role as they...
Source: Expert Review of Medical Devices - October 7, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Biosensing in Multiple Sclerosis.
Authors: Yousef A, Jonzzon S, Suleiman L, Arjona J, Graves JS Abstract INTRODUCTION: The goal of using wearable biosensors in multiple sclerosis (MS) is to provide outcome metrics with higher sensitivity to deficits and better inter-test and inter-rater reliability than standard neurological exam bedside maneuvers. A wearable biosensor not only has the potential to enhance physical exams, but also offers the promise of remote evaluations of the patient either at home or with local non-specialist providers. Areas Covered: We performed a structured literature review on the use of wearable biosensors in studies of mul...
Source: Expert Review of Medical Devices - October 5, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Endoscope-i: an innovation in mobile endoscopic technology transforming the delivery of patient care in otolaryngology.
This article gives a detailed overview of the endoscope-i system together with its applications. A review and comparison of alternative devices on the market offering smartphone adapted endoscopic viewing systems is also presented. Expert Commentary: The endoscope-i fulfils unmet needs by providing a compact, highly portable, simple to use endoscopic viewing system which is cost-effective and which makes use of smartphone technology most clinicians have in their pocket. The system allows real-time feedback to the patient and has the potential to transform the way that healthcare is delivered in ENT as well as having applic...
Source: Expert Review of Medical Devices - October 4, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Use of Minimally Invasive Spine Surgical Instruments for the Treatment of Bone Tumors.
Authors: Reeves RA, DeWolf MC, Shaughnessy PJ, Ames JB, Henderson ER Abstract INTRODUCTION: Orthopedic oncologists often encounter patients with minor bony lesions that are difficult to access surgically and therefore require large exposures out of proportion to the severity of disease that confer significant patient morbidity. Minimally invasive surgical techniques offer the advantage of smaller incisions, shorter operative times, decreased tissue damage, and decreased costs. A variety of surgical procedures have emerged using minimally invasive technologies, particularly in the field of spine surgery. AREAS C...
Source: Expert Review of Medical Devices - October 1, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Motion sensors in multiple sclerosis: narrative review and update of applications.
MOTION SENSORS IN MULTIPLE SCLEROSIS: NARRATIVE REVIEW AND UPDATE OF APPLICATIONS. Expert Rev Med Devices. 2017 Sep 28;: Authors: Sasaki JE, Sandroff B, Bamman M, Motl RW Abstract INTRODUCTION: The use of motion sensors for measuring physical activity in multiple sclerosis (MS) has evolved with increasing research particularly during the past decade. Areas covered: This manuscript reviews the literature regarding the application of motion sensors for measuring physical activity in MS. We first describe 'what is known' about their use in MS by examining the evidence generated between 1997 and 2012, incl...
Source: Expert Review of Medical Devices - September 30, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Orbital atherectomy for the treatment of severely calcified coronary lesions: evidence, technique, and best practices.
Authors: Shlofmitz E, Martinsen BJ, Lee M, Rao SV, Généreux P, Higgins J, Chambers JW, Kirtane AJ, Brilakis ES, Kandzari DE, Sharma SK, Shlofmitz R Abstract INTRODUCTION: The presence of severe coronary artery calcification is associated with higher rates of angiographic complications during percutaneous coronary intervention (PCI), as well as higher major adverse cardiac events compared with non-calcified lesions. Incorporating orbital atherectomy (OAS) for effective preparation of severely calcified lesions can help maximize the benefits of PCI by attaining maximal luminal gain (or stent expansion) ...
Source: Expert Review of Medical Devices - September 27, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Retrograde Magnetic Internal Lengthening Nail for Acute Femoral Deformity Correction and Limb Lengthening.
Authors: Fragomen AT, Rozbruch SR Abstract The Precice magnetic internal lengthening intramedullary nail is being used with great success in femur lengthening and deformity correction with a retrograde approach. Our personal history of limb lengthening and the Precice nail will be reviewed. Several technical aspects are discussed including design updates, pre operative planning, selection of nail length, the use of blocking screws and intra operative temporary external fixation, osteotomy practice, post operative management, and cost analysis. The phenomenal bone healing ability for the retrograde Precice nail afte...
Source: Expert Review of Medical Devices - September 14, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Orsiro cobalt-chromium sirolimus-eluting stent: present and future perspectives.
This article aims to review the currently available evidence on the clinical performance of the Orsiro BP-DES and its future perspectives. EXPERT COMMENTARY The Orsiro DES is a recent newer-generation BP-DES that combines a highly deliverable thin-strut cobalt-chromium stent platform and a unique hybrid concept with passive and active coatings designed to enhance tissue biocompatibility. In preclinical and intravascular imaging studies, the Orsiro BP-DES was shown to induce low inflammation and promote very early arterial healing. Recently, large randomized non-inferiority clinical trials have shown similar short- and mid-...
Source: Expert Review of Medical Devices - September 13, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Nonparametric Bootstrap Technique for Calibrating Surgical SmartForceps: Theory and Application.
Authors: Azimaee P, Jafari Jozani M, Maddahi Y, Zareinia K, Sutherland GR Abstract Knowledge of forces, exerted on the brain tissue during the performance of neurosurgical tasks, is critical for quality assurance, case rehearsal, and training purposes. Quantifying the interaction forces has been made possible by developing SmartForceps, a bipolar forceps retrofitted by a set of strain gauges. The forces are estimated using voltages read from strain gauges. We therefore need to quantify the force-voltage relationship to estimate the interaction forces during microsurgery. This problem has been addressed in the liter...
Source: Expert Review of Medical Devices - September 13, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Expert review on the VenaSeal ® system for endovenous cyano-acrylate adhesive ablation of incompetent saphenous trunks in patients with varicose veins.
Expert review on the VenaSeal® system for endovenous cyano-acrylate adhesive ablation of incompetent saphenous trunks in patients with varicose veins. Expert Rev Med Devices. 2017 Sep 11;: Authors: Lam YL, De Maeseneer M, Lawson J, de Borst GJ, Boersma D Abstract INTRODUCTION: The treatment of incompetent truncal veins has been innovated by the introduction of minimally invasive non-thermal non-tumescent (NTNT) techniques. One of these consists of the use of cyanoacrylate glue to occlude the vein lumen by means of the VenaSeal device. Areas covered: This expert-review aims to evaluate NTNT ablation...
Source: Expert Review of Medical Devices - September 13, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

The Law of Unintended Consequences: Current Design Challenges in Inferior Vena Cava Filters.
Authors: Magnowski A, Brown M, Schramm K, Lindquist J, Rochon PJ, Johnson DT, Kondo KL, Desai K, Lewandowski RJ, Ryu RK Abstract INTRODUCTION: Venous thromboembolic disease (VTD) encompassing deep vein thrombosis (DVT) and pulmonary embolism (PE) is a commonly encountered condition with potentially fatal sequelae. When unable to be adequately anticoagulated, patients require a mechanical means to prevent PE. This review discusses the history of inferior vena cava interruption and the development of inferior vena cava filters (IVCF). Areas covered: Milestone innovations in the mechanical treatment of VTD, their succ...
Source: Expert Review of Medical Devices - September 10, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Management of failing bioprosthesis in elderly patients who have undergone Transcatheter Aortic Valve Replacement.
Authors: Demir OM, Ruparelia N, Frame A, Sen S, Mikhail GW, Fertleman M, Malik IS Abstract INTRODUCTION: Transcatheter aortic valve replacement (TAVR) has revolutionized the treatment of symptomatic aortic stenosis. The number of TAVR procedures is expected to increase exponentially in the next decade. Therefore, patients will inevitably present with signs and symptoms attributable to TAVR bioprosthesis failure many years after an acutely successful procedure. Their management will become increasing important moving forward. Areas covered: The aim of this article is to review the causes of bioprosthesis failure and...
Source: Expert Review of Medical Devices - September 10, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Mobile ECMO - A Divine Technology or Bridge to Nowhere?
Authors: Merkle J, Djorjevic I, Sabashnikov A, Kuhn EW, Deppe AC, Eghbalzadeh K, Fattulayev J, Hohmann C, Zeriouh M, Kuhn-Régnier F, Choi YH, Mader N, Wahlers T Abstract INTRODUCTION: Extracorporeal life support emerged as a salvage option in patients with therapy-refractory severe hemodynamic or respiratory failure. However, this promising therapy option has been limited by the use of experienced teams in highly specialized tertiary-care centers. Thus, in order to provide this standard of care in local hospitals and due to increasing evidence on improved outcomes using ECMO devices and setting for patients ...
Source: Expert Review of Medical Devices - September 8, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Utilization of the Impella for Hemodynamic Support during Percutaneous Intervention and Cardiogenic Shock: An insight.
Authors: Nalluri N, Patel N, Saouma S, Anugu VR, Anugula D, Asti D, Mehta V, Kumar V, Atti V, Edla S, Grewal RK, Khan HM, Kanotra R, Maniatis G, Kandov R, Lafferty JC, Dyal M, Alfonso CE, Cohen MG Abstract Abstract/Summary Impella is a catheter-based micro-axial flow pump placed across the aortic valve, and it is currently the only percutaneous left ventricular assist device approved for high-risk percutaneous coronary intervention and cardiogenic shock. Even though several studies have repeatedly demonstrated the excellent hemodynamic profile of Impella in high-risk settings, it remains underutilized. Here we aim ...
Source: Expert Review of Medical Devices - September 3, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

A Comparison of the Different Features of Quadripolar Left Ventricular Pacing Leads to Deliver Cardiac Resynchronisation Therapy.
Authors: Antoniadis AP, Behar JM, Sieniewicz B, Gould J, Niederer S, Rinaldi CA Abstract Introduction Cardiac Resynchronization therapy (CRT) improves the quality of life and reduces morbidity and mortality of certain patients with heart failure. However, not all patients respond positively after CRT and about one third of cases do not experience benefit. Suboptimal biventricular pacing may account for this and quadripolar left ventricular (LV) leads have emerged in the last years to address issues relating to inadequate delivery of CRT. Areas Covered This review article concisely summarizes the main technical char...
Source: Expert Review of Medical Devices - August 25, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

A comparison of the different features of quadripolar left ventricular pacing leads to deliver cardiac resynchronization therapy.
Authors: Antoniadis AP, Behar JM, Sieniewicz B, Gould J, Niederer S, Rinaldi CA Abstract INTRODUCTION: Cardiac Resynchronization therapy (CRT) improves the quality of life and reduces morbidity and mortality of certain patients with heart failure. However, not all patients respond positively after CRT and about one third of cases do not experience benefit. Suboptimal biventricular pacing may account for this and quadripolar left ventricular (LV) leads have emerged in the last years to address issues relating to inadequate delivery of CRT. Areas covered: This review article concisely summarizes the main technical ch...
Source: Expert Review of Medical Devices - August 25, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Effects of solid acellular Type-I/III collagen biomaterials on in vitro and in vivo chondrogenesis of mesenchymal stem cells.
Authors: Gao L, Orth P, Cucchiarini M, Madry H Abstract INTRODUCTION: Type-I/III collagen membranes are advocated for clinical use in articular cartilage repair as being able of inducing chondrogenesis, a technique termed autologous matrix-induced chondrogenesis (AMIC). Area covered: The current in vitro and translational in vivo evidence for chondrogenic effects of solid acellular type-I/III collagen biomaterials. Expert commentary: In vitro, mesenchymal stem cells (MSCs) adhere to the fibers of the type-I/III collagen membrane. No in vitro study provides evidence that a type-I/III collagen matrix alone may induce...
Source: Expert Review of Medical Devices - August 19, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

The use of flexible intramedullary nails in limb lengthening.
Authors: Popkov A, Foster P, Gubin A, Borzunov D, Popkov D Abstract INTRODUCTION: Lower and upper limb length discrepancy and deformity, congenital or acquired, are amongst the most common conditions in children for orthopaedic referral. Over the last twenty years, surgical techniques have evolved in an attempt to decrease Healing Index and minimise these complications. Areas covered: The flexible intramedullary nailing (FIN) is a minimally invasive intramedullary osteosynthesis. In combination with an external fixator, it is appropriated for pediatric bone lengthenings and lengthening of bones of small diameter in...
Source: Expert Review of Medical Devices - August 19, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Evaluation of the Svelte Medical Systems SLENDER IDS Sirolimus-Eluting Coronary Stent-On-A-Wire Integrated Delivery System for the treatment of coronary artery disease.
Authors: Verheye S Abstract INTRODUCTION: The SLENDER Integrated Delivery System (IDS™) is an 'all-in-one' fixed-wire coronary stenting device designed for direct stenting, precluding the need for conventional guidewires and predilatation balloons. It achieves ultra-low profiles (crossing profiles as low as 0.029" /0.737 mm), enabling the downsizing of catheters to facilitate TRI across wider subsets of patients. Areas covered: This paper aims to evaluate the SLENDER IDS for the treatment of coronary artery disease. Expert commentary: The system represents the first advance in coronary stent delivery sin...
Source: Expert Review of Medical Devices - August 12, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Locking intramedullary nails versus locking plates for the treatment of proximal humerus fractures.
Authors: Gracitelli M, Malavolta EA, Assunção JH, Ferreira Neto AA, Silva J, Hernandez AJ Abstract INTRODUCTION: Proximal humerus fractures (PHF) are common fractures and are the third most common type of fractures among older adults. The most commonly used implants include the locking plate and the locking intramedullary nail. Areas covered. The aim of this study is to perform a literature review of biomechanical and clinical studies that compare the locking plate and intramedullary nail for PHF osteosynthesis. Expert commentary. Twelve clinical studies and seven biomechanical studies were identified...
Source: Expert Review of Medical Devices - August 11, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Clinical implications of blood-material interaction and drug eluting stent polymers in review.
Authors: Mori H, Gupta A, Torii S, Harari E, Jinnouchi H, Virmani R, Finn AV Abstract INTRODUCTION: Despite advances in drug-eluting stent (DES) technology, stent thrombosis (ST) remains the most feared complication with high morbidity and mortality. Area covered: Stent related factors certainly play a role in the pathophysiology of ST and more recent data suggest coating technologies have the potential to favorable modify this risk though blood material interactions. Of the polymer coatings used in DES, fluorinated polymers in particular have shown significant promise in modifying the risk of ST through their pref...
Source: Expert Review of Medical Devices - August 5, 2017 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research