Insulin detemir versus glyburide in women with gestational diabetes mellitus
. (Source: Gynecological Endocrinology)
Source: Gynecological Endocrinology - September 5, 2016 Category: Endocrinology Authors: Ronit Koren Eran Ashwal Moshe Hod Yoel Toledano Source Type: research
Safety and efficacy of intravenous glyburide on brain swelling after large hemispheric infarction (GAMES-RP): a randomised, double-blind, placebo-controlled phase 2 trial
Publication date: Available online 23 August 2016 Source:The Lancet Neurology Author(s): Kevin N Sheth, Jordan J Elm, Bradley J Molyneaux, Holly Hinson, Lauren A Beslow, Gordon K Sze, Ann-Christin Ostwaldt, Gregory J del Zoppo, J Marc Simard, Sven Jacobson, W Taylor Kimberly Background Preclinical models of stroke have shown that intravenous glyburide reduces brain swelling and improves survival. We assessed whether intravenous glyburide (RP-1127; glibenclamide) would safely reduce brain swelling, decrease the need for decompressive craniectomy, and improve clinical outcomes in patients presenting with a large...
Source: The Lancet Neurology - August 23, 2016 Category: Neurology Source Type: research
Glyburide for cerebral oedema: could an old dog have a new trick?
Publication date: Available online 23 August 2016 Source:The Lancet Neurology Author(s): Graeme J Hankey (Source: The Lancet Neurology)
Source: The Lancet Neurology - August 23, 2016 Category: Neurology Source Type: research
[Articles] Safety and efficacy of intravenous glyburide on brain swelling after large hemispheric infarction (GAMES-RP): a randomised, double-blind, placebo-controlled phase 2 trial
Intravenous glyburide was well tolerated in patients with large hemispheric stroke at risk for cerebral oedema. There was no difference in the composite primary outcome. Further study is warranted to assess the potential clinical benefit of a reduction in swelling by intravenous glyburide. (Source: Lancet Neurology)
Source: Lancet Neurology - August 22, 2016 Category: Neurology Authors: Kevin N Sheth, Jordan J Elm, Bradley J Molyneaux, Holly Hinson, Lauren A Beslow, Gordon K Sze, Ann-Christin Ostwaldt, Gregory J del Zoppo, J Marc Simard, Sven Jacobson, W Taylor Kimberly Tags: Articles Source Type: research
[Comment] Glyburide for cerebral oedema: could an old dog have a new trick?
Swelling of a large brain infarct portends transtentorial herniation and death. Yet, there are few effective prevention and treatment options. Reactive medical treatments, including osmotic drugs (eg, glycerol and mannitol) and corticosteroids, do not improve survival and functional outcome.1 –3 Reactive decompressive craniectomy improves survival and functional outcome in some patients, but increases survival with major disability in others, and appropriate patient selection is difficult.4 (Source: Lancet Neurology)
Source: Lancet Neurology - August 22, 2016 Category: Neurology Authors: Graeme J Hankey Tags: Comment Source Type: research
VIDEOS ON DEMAND: Post-Stroke Edema: Is IV-glyburide effective?
No abstract available (Source: Neurology Today)
Source: Neurology Today - August 18, 2016 Category: Neurology Tags: Features Source Type: research
Pharmacokinetic and Pharmacodynamic Drug Interaction Study of Piragliatin, a Glucokinase Activator, and Glyburide, a Sulfonylurea, in Type 2 Diabetic Patients
Abstract
A glucokinase activator and a sulfonylurea might be coprescribed to synergize treatment success for type 2 diabetes (T2D). This clinical pharmacology study was designed to investigate the potential glucose‐lowering effect or pharmacodynamic (PD), pharmacokinetic (PK), and safety/tolerability interactions between piragliatin and glyburide in T2D patients already taking glyburide but not adequately controlled. This was an open‐label, multiple‐dose, 3‐period, single‐sequence crossover design: on days –1, 6, and 12, PD and PK samples were drawn with glyburide alone (period 0), piragliatin + glyburide (peri...
Source: Clinical Pharmacology in Drug Development - June 27, 2016 Category: Drugs & Pharmacology Authors: S. Zhai, A. Georgy, Z. Liang, J. Zhi Tags: Brief Report Source Type: research
Computer-aided identification of potential TYK2 inhibitors from drug database
Publication date: 15 October 2016 Source:Journal of Molecular Structure, Volume 1122 Author(s): Wei Zhang, Jianzong Li, Zhixin Huang, Haiyang Wang, Hao Luo, Xin Wang, Nan Zhou, Chuanfang Wu, Jinku Bao TYK2 is a member of JAKs family protein tyrosine kinase activated in response to various cytokines. It plays a crucial role in transducing signals downstream of various cytokine receptors, which are involved in proinflammatory responses associated with immunological diseases. Thus, the study of selective TYK2 inhibitors is one of the most popular fields in anti-inflammation drug development. Herein, we a...
Source: Journal of Molecular Structure - June 9, 2016 Category: Molecular Biology Source Type: research
Oral Medications for Diabetes in Pregnancy: Use in a Rural Population
This article presents clinical strategies for using oral agents in the management of GDM based on a pragmatic approach taken in a group of rural Native American women. (Source: Diabetes Spectrum)
Source: Diabetes Spectrum - May 15, 2016 Category: Endocrinology Authors: Thorkelson, S. J.; Anderson, K. R. Tags: From Research to Practice Source Type: research
Pharmacokinetic and Pharmacodynamics drug Interaction Study of Piragliatin, a Glucokinase Activator, and Glyburide, a Sulfonylurea, in type 2 Diabetic Patients
This article is protected by copyright. All rights reserved (Source: Clinical Pharmacology in Drug Development)
Source: Clinical Pharmacology in Drug Development - April 30, 2016 Category: Drugs & Pharmacology Authors: S. Zhai, A. Georgy, Z. Liang, J. Zhi Tags: Brief Report Source Type: research
Trends in antidiabetic medication use in patients with type 2 diabetes mellitus and chronic kidney disease
The objective of this study was to assess antidiabetic medication use in patients with type 2 Diabetes Mellitus (T2DM) and CKD across years and according to CKD stages. (Source: Value in Health)
Source: Value in Health - April 30, 2016 Category: Global & Universal Authors: D. Gor, D. Touchette Source Type: research
Dose ‐response relationship between sulfonylureas and major adverse cardiovascular events in elderly patients with type 2 diabetes
ConclusionsAmong new users of sulfonylureas, there appears to be a dose‐response relationship between glyburide and MACE, but not for gliclazide. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - April 21, 2016 Category: Drugs & Pharmacology Authors: Ahmed S. Abdelmoneim, Dean T. Eurich, Ambikaipakan Senthilselvan, Weiyu Qiu, Scot H. Simpson Tags: Original Report Source Type: research
Dose‐response relationship between sulfonylureas and major adverse cardiovascular events in elderly patients with type 2 diabetes
ConclusionsAmong new users of sulfonylureas, there appears to be a dose‐response relationship between glyburide and MACE, but not for gliclazide. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - April 21, 2016 Category: Drugs & Pharmacology Authors: Ahmed S. Abdelmoneim, Dean T. Eurich, Ambikaipakan Senthilselvan, Weiyu Qiu, Scot H. Simpson Tags: Original Report Source Type: research
News from the AAN Annual Meeting: IV Glyburide Shows Promise in Reducing Edema After Ischemic Stroke
No abstract available (Source: Neurology Today)
Source: Neurology Today - April 21, 2016 Category: Neurology Tags: Features Source Type: research
Secular trends in antihyperglycaemic medication prescriptions in older adults with diabetes and chronic kidney disease: 2004–2013
ConclusionsIn patients with chronic kidney disease, there were trends towards safer antihyperglycaemic medication prescribing. A considerable number of patients, however, continue to receive medications that should be avoided. (Source: Diabetes, Obesity and Metabolism)
Source: Diabetes, Obesity and Metabolism - April 11, 2016 Category: Endocrinology Authors: K. K. Clemens, K. Liu, S. Shariff, G. Schernthaner, N. Tangri, A. X. Garg Tags: ORIGINAL ARTICLE Source Type: research
