Therapies for Gestational Diabetes and their Implications for Maternal and Offspring Health: Evidence from Human and Animal Studies
Publication date: Available online 5 February 2018 Source:Pharmacological Research Author(s): Gabriel M. Brawerman, Vernon W. Dolinsky Obesity prior to and during pregnancy is associated with an increased risk of complications during pregnancy. One of the most common complications of pregnancy is gestational diabetes mellitus (GDM), a condition characterized by mild hyperglycemia and insulin resistance that is diagnosed in the third trimester of pregnancy. GDM predisposes both mothers and their children to increased obesity and cardiometabolic disorders, namely type 2 diabetes and cardiovascular disease. Current treatm...
Source: Pharmacological Research - February 6, 2018 Category: Drugs & Pharmacology Source Type: research

982: Blood glucose patterns and treatment response in women with gestational diabetes treated with glyburide
Given its mechanism of action, glyburide is thought to be more effective in treating postprandial hyperglycemia. We investigated whether pre-treamtent glucose patterns were associated with differences in glycemic control or fetal growth in women with GDM who are treated with glyburide. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 1, 2018 Category: OBGYN Authors: Maisa Feghali, Elizabeth O'neill, Steve Caritis, Janet Catov, Christina Scifres Tags: Poster Session V Source Type: research

988: Glyburide versus insulin for the prevention of perinatal complications of Gestational Diabetes Mellitus: a pragmatic, non-inferiority, randomized trial
To compare oral glyburide and subcutaneous insulin for prevention of perinatal complications in women with gestational diabetes mellitus (GDM) (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 1, 2018 Category: OBGYN Authors: Philippe Deruelle, Alexandra Letourneau, Christophe Vayssi ère, Helene Legardeur, Patrick Rozenberg, Guillaume Girard, Emmanuel Simon, Gael Beucher, Eric Verspyck, Raoul Desbriere, Loic Sentilhes, Florence Bretelle, Jean Bouyer, Marie-Victoire Senat, “ Tags: Poster Session V Source Type: research

993: Adverse pregnancy outcomes with glyburide vs insulin among patients with gestational diabetes established by the International Association of Diabetes and Pregnancy Study Group (IADPSG)
To address whether maternal use of glyburide is associated with greater incidence of adverse neonatal and maternal outcomes among patients with gestational diabetes mellitus (GDM) established by the International Association of Diabetes and Pregnancy Study Group (IADPSG) compared to insulin use. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 1, 2018 Category: OBGYN Authors: Anna Leung, Garrett Yu, Laura Smith Tags: Poster Session V Source Type: research

Electron microscopy/energy dispersive X-ray spectroscopy of drug distribution in solid dispersions and interpretation by multifractal geometry
Publication date: 20 February 2018 Source:Journal of Pharmaceutical and Biomedical Analysis, Volume 150 Author(s): Renata Abreu-Villela, Camille Adler, Isidoro Caraballo, Martin Kuentz Much contemporary research of poorly water-soluble drugs focuses on amorphous solid dispersions (SDs) for oral drug delivery. Recently, a multifractal formalism has been introduced to describe the distribution of an inorganic carrier in SDs. The present work attempts to directly image model drugs by means of scanning electron microscopy and energy dispersive X-ray spectroscopy. The compounds amlodipine, felodipine, glyburide, and indom...
Source: Journal of Pharmaceutical and Biomedical Analysis - December 23, 2017 Category: Drugs & Pharmacology Source Type: research

Very tight vs. tight control: what should be the criteria for pharmacologic therapy dose adjustment in diabetes in pregnancy? Evidence from randomized controlled trials
ConclusionsWhen evaluating RCTs which included criteria for pharmacologic GDM therapy dose adjustment, the most common criterion for diagnosis was the two‐step test, and the most common used therapies were insulin and metformin. Regarding glucose monitoring, the most common frequency was four times per day, fasting and two hours after each main meal, using as target glucose values 95 and 120 mg/dL, respectively. Importantly, we found six different criteria for pharmacologic GDM therapy dose adjustment, with the majority using very tight criteria of either one or two values per week higher than the target values, of whic...
Source: Acta Obstetricia et Gynecologica Scandinavica - December 14, 2017 Category: OBGYN Authors: Claudia Caissutti, Gabriele Saccone, Andrea Ciardulli, Vincenzo Berghella Tags: Systematic Review Source Type: research

Very tight versus tight control: what should be the criteria for pharmacologic therapy dose adjustment in diabetes in pregnancy? Evidence from randomized controlled trials
ConclusionsWhen evaluating RCTs which included criteria for pharmacologic GDM therapy dose adjustment, the most common criterion for diagnosis was the two‐step test, and the most common used therapies were insulin and metformin. Regarding glucose monitoring, the most common frequency was four times per day, fasting and two hours after each main meal, using as target glucose values 95 and 120 mg/dL, respectively. Importantly, we found six different criteria for pharmacologic GDM therapy dose adjustment, with the majority using very tight criteria of either one or two values per week higher than the target values, of whic...
Source: Acta Obstetricia et Gynecologica Scandinavica - December 14, 2017 Category: OBGYN Authors: Claudia Caissutti, Gabriele Saccone, Andrea Ciardulli, Vincenzo Berghella Tags: Systematic Review Source Type: research

Crystalline structure of pulverized dental calculus induces cell death in oral epithelial cells
ConclusionDental calculus induces pyroptotic cell death in human oral epithelial cells and the crystalline structure plays a major role in this process. Oral epithelial cell death induced by dental calculus might be important for the etiology of periodontitis. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - November 20, 2017 Category: Dentistry Authors: S. M. Ziauddin, A. Yoshimura, J. L. Montenegro Raudales, Y. Ozaki, K. Higuchi, T. Ukai, T. Kaneko, T. Miyazaki, E. Latz, Y. Hara Tags: ORIGINAL ARTICLE Source Type: research

Very tight versus tight control: which should be the criteria for pharmacologic therapy dose adjustment in diabetes in pregnancy? Evidence from randomized controlled trials
ConclusionsWhen evaluating RCTs which included criteria for pharmacologic GDM therapy dose adjustment, the most common criteria for diagnosis was the two step test, and the most common used therapies were insulin and metformin. Regarding glucose monitoring, the most common frequency was four times per day, fasting and 2 hours after each main meal, using as target glucose values 95mg/dL and 120mg/dL, respectively. Importantly, we found six different criteria for pharmacologic GDM therapy dose adjustment, with the majority using very tight criteria of either 1 or 2 values per week higher than the target values, of which two ...
Source: Acta Obstetricia et Gynecologica Scandinavica - November 10, 2017 Category: OBGYN Authors: Claudia Caissutti, Gabriele Saccone, Andrea Ciardulli, Vincenzo Berghella Tags: Systematic review Source Type: research

Comparative risk of serious hypoglycemia with oral antidiabetic monotherapy: A retrospective cohort study
ConclusionsSulfonylureas were associated with the highest rates of serious hypoglycemia. Among all study drugs, the highest rate was seen with glyburide. Pioglitazone was associated with a lower adjusted hazard for serious hypoglycemia vs metformin, while rosiglitazone and nateglinide had hazards similar to that of metformin. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - November 6, 2017 Category: Drugs & Pharmacology Authors: Charles E. Leonard, Xu Han, Colleen M. Brensinger, Warren B. Bilker, Serena Cardillo, James H. Flory, Sean Hennessy Tags: ORIGINAL REPORT Source Type: research

Antidiabetic drug glyburide modulates depressive-like behavior comorbid with insulin resistance
Abundant reports indicated that depression was often comorbid with type 2 diabetes and even metabolic syndrome. Considering they might share common biological origins, it was tentatively attributed to the chro... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 30, 2017 Category: Neurology Authors: Wen-Jun Su, Wei Peng, Hong Gong, Yun-Zi Liu, Yi Zhang, Yong-Jie Lian, Zhi-Yong Cao, Ran Wu, Lin-Lin Liu, Bo Wang, Yun-Xia Wang and Chun-Lei Jiang Tags: Research Source Type: research

Pharmacologic Differences of Sulfonylureas and the Risk of Adverse Cardiovascular and Hypoglycemic Events
CONCLUSIONS The nonspecific, long-acting sulfonylureas glyburide and glimepiride do not have an increased risk of cardiovascular adverse events compared with the specific, short-acting sulfonylureas gliclazide, glipizide, and tolbutamide. However, nonspecific, long-acting sulfonylureas glyburide and glimepiride have an increased risk of severe hypoglycemia. (Source: Diabetes Care)
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Douros, A.; Yin, H.; Yu, O. H. Y.; Filion, K. B.; Azoulay, L.; Suissa, S. Tags: Epidemiology-Cardiovascular Disease Epidemiology/Health Services Research Source Type: research

Irisin protects against neuronal injury induced by oxygen-glucose deprivation in part depends on the inhibition of ROS-NLRP3 inflammatory signaling pathway
Publication date: November 2017 Source:Molecular Immunology, Volume 91 Author(s): Juan Peng, Xian Deng, Wei Huang, Ji-hua Yu, Jian-xiong Wang, Jie-ping Wang, Shi-bin Yang, Xi Liu, Li Wang, Yun Zhang, Xiang-Yu Zhou, Hui Yang, Yan-Zheng He, Fang-yuan Xu Recent studies found that irisin, a newly discovered skeletal muscle-derived myokine during exercise, is also synthesized in various tissues of different species and protects against neuronal injury in cerebral ischemia. The NOD-like receptor pyrin 3 (NLRP3) inflammasome play an important role in detecting cellular damage and mediating inflammatory responses t...
Source: Molecular Immunology - October 1, 2017 Category: Allergy & Immunology Source Type: research

Patchouli Alcohol Isolated from Pogostemon Cablin Mediates Endothelium-Independent Vasorelaxation by Blockade of Ca2+ Channels in Rat Isolated Thoracic Aorta
Conclusion PA may act as a Ca2+ antagonist to exert an intensively vasorelaxant effects through endothelium-independent pathway, and its mechanisms underlying the vasoactivities seem to be associated with the blockade of extracellular Ca2+ influx through VDCCs and ROCCs in vascular smooth muscle cells (VSMCs) membrane and intracellular Ca2+ releases through IP3R- and RYR-mediated Ca2+ channels in sarcolemma. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 29, 2017 Category: Drugs & Pharmacology Source Type: research

Sentinel Modular Program for Propensity Score–Matched Cohort Analyses: Application to Glyburide, Glipizide, and Serious Hypoglycemia
Sentinel is a program sponsored by the US Food and Drug Administration to monitor the safety of medical products. We conducted a cohort assessment to evaluate the ability of the Sentinel Propensity Score Matching Tool to reproduce in an expedited fashion the known association between glyburide (vs. glipizide) and serious hypoglycemia. Thirteen data partners who contribute to the Sentinel Distributed Database participated in this analysis. A pretested and customizable analytic program was run at each individual site. De-identified summary results from each data partner were returned and aggregated at the Sentinel Operations...
Source: Epidemiology - September 28, 2017 Category: Epidemiology Tags: Methods Source Type: research