Biomedical Informatics Approaches to Identifying Drug–Drug Interactions: Application to Insulin Secretagogues
Conclusions: The self-controlled case series design has the potential to be widely applicable to screening for drug–drug interactions that lead to adverse outcomes identifiable in healthcare databases. Coupling pharmacokinetic prediction with pharmacoepidemiologic screening did not notably improve the ability to identify drug–drug interactions in this case. (Source: Epidemiology)
Source: Epidemiology - April 5, 2017 Category: Epidemiology Tags: Pharmacoepidemiology Source Type: research
Neuroprotective strategies and the underlying molecular basis of cerebrovascular stroke.
Abstract
Stroke is a leading cause of disability in the US. Although there has been significant progress in the area of medical and surgical thrombolytic technologies, neuroprotective agents to prevent secondary cerebral injury and to minimize disability remain limited. Only limited success has been reported in preclinical and clinical trials evaluating a variety of compounds. In this review, the authors discuss the most up-to-date information regarding the underlying molecular biology of stroke as well as strategies that aim to mitigate this complex signaling cascade. Results of historical research trials...
Source: Neurosurgical Focus - April 1, 2017 Category: Neurosurgery Authors: Karsy M, Brock A, Guan J, Taussky P, Kalani MY, Park MS Tags: Neurosurg Focus Source Type: research
Uptake of Community Pharmacist-Delivered MedsCheck Diabetes Medication Review Service in Ontario between 2010 and 2014
Conclusions Over the first 3.5 years of the program, approximately 50.0% of Ontarians with diabetes received an MCD. Follow-up assessments were low (2.7% to 4.1% of the population). Ongoing evaluation of the program is required to ensure that continuity of care is being provided to this population. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - March 23, 2017 Category: Endocrinology Source Type: research
All-Cause and Cardiovascular Mortality following Treatment with Metformin or Glyburide in Patients with Type 2 Diabetes Mellitus.
CONCLUSION: Treatment with glyburide is associated with increased all-cause and cardiovascular mortality in patients with T2DM.
PMID: 28287807 [PubMed - in process] (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - February 28, 2017 Category: Middle East Health Authors: Raee MR, Nargesi AA, Heidari B, Mansournia MA, Larry M, Rabizadeh S, Zarifkar M, Esteghamati A, Nakhjavani M Tags: Arch Iran Med Source Type: research
Glyburide Versus Metformin and Their Combination for the Treatment of Gestational Diabetes Mellitus: A Randomized Controlled Study
CONCLUSIONS
Glyburide and metformin are comparable oral treatments for GDM regarding glucose control and adverse effects. Their combination demonstrates a high efficacy rate with a significantly reduced need for insulin, with a possible advantage for metformin over glyburide as first-line therapy. (Source: Diabetes Care)
Source: Diabetes Care - February 20, 2017 Category: Endocrinology Authors: Nachum, Z.; Zafran, N.; Salim, R.; Hissin, N.; Hasanein, J.; Gam Ze Letova, Y.; Suleiman, A.; Yefet, E. Tags: Clinical Care/Education/Nutrition/Psychosocial Research Source Type: research
