Very tight versus tight control: what should be the criteria for pharmacologic therapy dose adjustment in diabetes in pregnancy? Evidence from randomized controlled trials

ConclusionsWhen evaluating RCTs which included criteria for pharmacologic GDM therapy dose adjustment, the most common criterion for diagnosis was the two‐step test, and the most common used therapies were insulin and metformin. Regarding glucose monitoring, the most common frequency was four times per day, fasting and two hours after each main meal, using as target glucose values 95 and 120 mg/dL, respectively. Importantly, we found six different criteria for pharmacologic GDM therapy dose adjustment, with the majority using very tight criteria of either one or two values per week higher than the target values, of which two‐thirds used only one value, and one‐third used two values.

Source: Acta Obstetricia et Gynecologica Scandinavica - December 14, 2017 Category: OBGYN Authors: Claudia Caissutti, Gabriele Saccone, Andrea Ciardulli, Vincenzo Berghella Tags: Systematic Review Source Type: research