Comparison of Insulin, Metformin, and Glyburide on Perinatal Complications of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis
Conclusions: This review suggests that metformin can decrease the incidence of perinatal complications, and it should be considered as a generally safe alternative to insulin.Gynecol Obstet Invest (Source: Gynecologic and Obstetric Investigation)
Source: Gynecologic and Obstetric Investigation - May 12, 2021 Category: OBGYN Source Type: research

Cancers, Vol. 13, Pages 2344: Photosensitizing Medications and Skin Cancer: A Comprehensive Review
unyoung Cho (1) The incidence of skin cancer is increasing in the United States (US) despite scientific advances in our understanding of skin cancer risk factors and treatments. In vitro and in vivo studies have provided evidence that suggests that certain photosensitizing medications (PSMs) increase skin cancer risk. This review summarizes current epidemiological evidence on the association between common PSMs and skin cancer. (2) A comprehensive literature search was conducted to identify meta-analyses, observational studies and clinical trials that report on skin cancer events in PSM users. The associated risks of k...
Source: Cancers - May 12, 2021 Category: Cancer & Oncology Authors: Elisabeth A. George Navya Baranwal Jae H. Kang Abrar A. Qureshi Aaron M. Drucker Eunyoung Cho Tags: Review Source Type: research

siGCD: a web server to explore survival interaction of genes, cells and drugs in human cancers
Brief Bioinform. 2021 Apr 5:bbab058. doi: 10.1093/bib/bbab058. Online ahead of print.ABSTRACTIt is pivotal and remains challenge for cancer precision treatment to identify the survival outcome interactions between genes, cells and drugs. Here, we present siGCD, a web-based tool for analysis and visualization of the survival interaction of Genes, Cells and Drugs in human cancers. siGCD utilizes the cancer heterogeneity to simulate the manipulated gene expression, cell infiltration and drug treatment, which overcomes the data and experimental limitations. To illustrate the performance of siGCD, we identified the survival int...
Source: Briefings in Bioinformatics - April 6, 2021 Category: Bioinformatics Authors: XiuLiang Cui Lu Han Yang Liu Ying Li Wen Sun Bin Song Wenxia Zhou Yongxiang Zhang Hongyang Wang Source Type: research

siGCD: a web server to explore survival interaction of genes, cells and drugs in human cancers
Brief Bioinform. 2021 Apr 5:bbab058. doi: 10.1093/bib/bbab058. Online ahead of print.ABSTRACTIt is pivotal and remains challenge for cancer precision treatment to identify the survival outcome interactions between genes, cells and drugs. Here, we present siGCD, a web-based tool for analysis and visualization of the survival interaction of Genes, Cells and Drugs in human cancers. siGCD utilizes the cancer heterogeneity to simulate the manipulated gene expression, cell infiltration and drug treatment, which overcomes the data and experimental limitations. To illustrate the performance of siGCD, we identified the survival int...
Source: Briefings in Bioinformatics - April 6, 2021 Category: Bioinformatics Authors: XiuLiang Cui Lu Han Yang Liu Ying Li Wen Sun Bin Song Wenxia Zhou Yongxiang Zhang Hongyang Wang Source Type: research

siGCD: a web server to explore survival interaction of genes, cells and drugs in human cancers
Brief Bioinform. 2021 Apr 5:bbab058. doi: 10.1093/bib/bbab058. Online ahead of print.ABSTRACTIt is pivotal and remains challenge for cancer precision treatment to identify the survival outcome interactions between genes, cells and drugs. Here, we present siGCD, a web-based tool for analysis and visualization of the survival interaction of Genes, Cells and Drugs in human cancers. siGCD utilizes the cancer heterogeneity to simulate the manipulated gene expression, cell infiltration and drug treatment, which overcomes the data and experimental limitations. To illustrate the performance of siGCD, we identified the survival int...
Source: Briefings in Bioinformatics - April 6, 2021 Category: Bioinformatics Authors: XiuLiang Cui Lu Han Yang Liu Ying Li Wen Sun Bin Song Wenxia Zhou Yongxiang Zhang Hongyang Wang Source Type: research

BIIB093 (intravenous glibenclamide) for the prevention of severe cerebral edema
CONCLUSION: Studies analyzing the GAMES-Pilot and GAMES-PR trials suggest that glibenclamide has a moderate, however, measurable effect on intermediate biomarkers and clinical endpoints. Meaningful conclusions are limited by the small sample size of patients studied.PMID:33767884 | PMC:PMC7982107 | DOI:10.25259/SNI_933_2020 (Source: Surgical Neurology International)
Source: Surgical Neurology International - March 26, 2021 Category: Neurosurgery Authors: Daniel W Griepp Jason Lee Christina M Moawad Cyrus Davati Juliana Runnels Brian Fiani Source Type: research