Long Term Outcomes of IV Glyburide In Patients 70 Years of Age or Under: Subgroup Analysis from the Phase II GAMES-RP Study of Patients with Large Hemispheric Infarction (S29.008)
Conclusions:This post-hoc analysis suggests that patients under 70, who may be at highest risk for poor outcomes secondary to edema after large hemispheric infarction, may have improved survival, better functional outcome and improved quality of life following treatment with IV glyburide. A prospective study is required in this population in order to definitively establish that IV glyburide can improve outcome.Study Supported by: Remedy Pharmaceuticals, NCT: 01794182Disclosure: Dr. Sheth has received personal compensation in an editorial capacity Current Treatment Options in Neurology. Dr. Sheth has received research suppo...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Sheth, K., Cheung, K., Elm, J., Hinson, H., Molyneaux, B., Beslow, L., Sze, G., Ostwaldt, A.-C., Kimberly, W. Tags: Cerebrovascular Disease and Interventional Neurology: Critical Care and Hemorrhage Source Type: research

Glucose elicits cephalic-phase insulin release in mice by activating KATP channels in taste cells
The taste of sugar elicits cephalic-phase insulin release (CPIR), which limits the rise in blood glucose associated with meals. Little is known, however, about the gustatory mechanisms that trigger CPIR. We asked whether oral stimulation with any of the following taste stimuli elicited CPIR in mice: glucose, sucrose, maltose, fructose, Polycose, saccharin, sucralose, AceK, SC45647, or a nonmetabolizable sugar analog. The only taste stimuli that elicited CPIR were glucose and the glucose-containing saccharides (sucrose, maltose, Polycose). When we mixed an α-glucosidase inhibitor (acarbose) with the latter three sacch...
Source: AJP: Regulatory, Integrative and Comparative Physiology - April 7, 2017 Category: Physiology Authors: Glendinning, J. I., Frim, Y. G., Hochman, A., Lubitz, G. S., Basile, A. J., Sclafani, A. Tags: Research Article Source Type: research

Biomedical Informatics Approaches to Identifying Drug–Drug Interactions: Application to Insulin Secretagogues
Conclusions: The self-controlled case series design has the potential to be widely applicable to screening for drug–drug interactions that lead to adverse outcomes identifiable in healthcare databases. Coupling pharmacokinetic prediction with pharmacoepidemiologic screening did not notably improve the ability to identify drug–drug interactions in this case. (Source: Epidemiology)
Source: Epidemiology - April 5, 2017 Category: Epidemiology Tags: Pharmacoepidemiology Source Type: research

Neuroprotective strategies and the underlying molecular basis of cerebrovascular stroke.
Abstract Stroke is a leading cause of disability in the US. Although there has been significant progress in the area of medical and surgical thrombolytic technologies, neuroprotective agents to prevent secondary cerebral injury and to minimize disability remain limited. Only limited success has been reported in preclinical and clinical trials evaluating a variety of compounds. In this review, the authors discuss the most up-to-date information regarding the underlying molecular biology of stroke as well as strategies that aim to mitigate this complex signaling cascade. Results of historical research trials...
Source: Neurosurgical Focus - April 1, 2017 Category: Neurosurgery Authors: Karsy M, Brock A, Guan J, Taussky P, Kalani MY, Park MS Tags: Neurosurg Focus Source Type: research

Uptake of Community Pharmacist-Delivered MedsCheck Diabetes Medication Review Service in Ontario between 2010 and 2014
Conclusions Over the first 3.5 years of the program, approximately 50.0% of Ontarians with diabetes received an MCD. Follow-up assessments were low (2.7% to 4.1% of the population). Ongoing evaluation of the program is required to ensure that continuity of care is being provided to this population. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - March 23, 2017 Category: Endocrinology Source Type: research

All-Cause and Cardiovascular Mortality following Treatment with Metformin or Glyburide in Patients with Type 2 Diabetes Mellitus.
CONCLUSION: Treatment with glyburide is associated with increased all-cause and cardiovascular mortality in patients with T2DM. PMID: 28287807 [PubMed - in process] (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - February 28, 2017 Category: Middle East Health Authors: Raee MR, Nargesi AA, Heidari B, Mansournia MA, Larry M, Rabizadeh S, Zarifkar M, Esteghamati A, Nakhjavani M Tags: Arch Iran Med Source Type: research

Glyburide Versus Metformin and Their Combination for the Treatment of Gestational Diabetes Mellitus: A Randomized Controlled Study
CONCLUSIONS Glyburide and metformin are comparable oral treatments for GDM regarding glucose control and adverse effects. Their combination demonstrates a high efficacy rate with a significantly reduced need for insulin, with a possible advantage for metformin over glyburide as first-line therapy. (Source: Diabetes Care)
Source: Diabetes Care - February 20, 2017 Category: Endocrinology Authors: Nachum, Z.; Zafran, N.; Salim, R.; Hissin, N.; Hasanein, J.; Gam Ze Letova, Y.; Suleiman, A.; Yefet, E. Tags: Clinical Care/Education/Nutrition/Psychosocial Research Source Type: research

NLRP3 (Nucleotide Oligomerization Domain-Like Receptor Family, Pyrin Domain Containing 3)-Caspase-1 Inflammasome Degrades Contractile Proteins: Implications for Aortic Biomechanical Dysfunction and Aneurysm and Dissection Formation.
CONCLUSIONS: Inflammasome-caspase-1-mediated degradation of SMC contractile proteins may contribute to aortic biomechanical dysfunction and AAD development. This cascade may be a therapeutic target in AAD formation. In addition, glyburide may have protective effects against AAD development. PMID: 28153878 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 1, 2017 Category: Cardiology Authors: Wu D, Ren P, Zheng Y, Zhang L, Xu G, Xie W, Lloyd EE, Zhang S, Zhang Q, Curci JA, Coselli JS, Milewicz DM, Shen YH, LeMaire SA Tags: Arterioscler Thromb Vasc Biol Source Type: research

Glucose elicits cephalic-phase insulin release in mice by activating K(ATP) channels in taste cells.
Abstract The taste of sugar elicits cephalic-phase insulin release (CPIR), which limits the rise in blood glucose associated with meals. Little is known, however, about the orosensory mechanisms that trigger CPIR. We asked whether oral stimulation with any of the following taste stimuli elicited CPIR in mice: glucose, sucrose, maltose, fructose, Polycose, saccharin, sucralose, AceK, SC45647 or a non-metabolizable sugar analog. The only taste stimuli that elicited CPIR were glucose and the glucose-containing saccharides (sucrose, maltose, Polycose). When we mixed an alpha-glucosidase inhibitor (acarbose) wi...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - January 31, 2017 Category: Physiology Authors: Glendinning JI, Frim YG, Hochman A, Lubitz GS, Basile AJ, Sclafani A Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Antidiabetic agents and cardiovascular outcomes in patients with heart diseases.
This article reviews evidence of benefits and risk of antidiabetic agents in cardiovascular (CV) outcomes, with a focus on medications approved by the FDA since 2008. Peer-reviewed articles were identified from MEDLINE and Current Content database (both 1966 to October 1, 2016) using the search terms insulin, metformin, rosiglitazone, pioglitazone, glyburide, glipizide, glimepiride, acarbose, miglitol, albiglutide, exenatide, liraglutide, lixisenatide, dulaglutide, pramlintide, meglitinide, alogliptin, linagliptin, saxagliptin, sitagliptin, canagliflozin, dapagliflozin, empagliflozin, colesevalam, bromocriptine, mortality,...
Source: Current Medical Research and Opinion - January 19, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Sulfonylurea receptor-associated channels: Involvement in disease and therapeutic implications
The sulfonylurea receptors (SURs) 1 (SUR1) and 2 (SUR2) are members of the adenosine triphosphate (ATP) binding cassette transporters superfamily. Unlike other members of this superfamily, these receptors are not involved in transport but associate with pore-forming subunits to form cation channels. Both SUR1 and SUR2 associate with inward rectifying potassium (K+) (Kir) channels (Kir6) subunits to form functional ATP-sensitive K+ channels (KATP).1 These channels are molecular sensors that provide a link between cellular energy state and electrical excitability; they are tonically inhibited by ATP, and their activation in ...
Source: Neurology - January 15, 2017 Category: Neurology Authors: Benarroch, E. E. Tags: CLINICAL IMPLICATIONS OF NEUROSCIENCE RESEARCH Source Type: research

Inhibition of hepatic cells pyroptosis attenuates CLP-induced acute liver injury.
Authors: Chen YL, Xu G, Liang X, Wei J, Luo J, Chen GN, Yan XD, Wen XP, Zhong M, Lv X Abstract Pyroptosis is a programmed cell death associated with caspase-1 and accompanied by the secretion of a large number of pro-inflammatory cytokines. In the acute stage of sepsis, the release of several pro-inflammatory cytokines aggravates hepatic cell death, and acute liver injury is aggravated with the progress of the disease, resulting in acute liver failure with a very high mortality rate. The present study investigated the effect of inhibiting hepatic cell pyroptosis on the septic acute liver injury. Septic acu...
Source: American Journal of Translational Research - January 13, 2017 Category: Research Tags: Am J Transl Res Source Type: research

Phosphatidylserine Outer Layer Translocation Is Implicated in IL-10 Secretion by Human Regulatory B Cells
This study showed that B10 cells have an increased PS exposure independently of any apoptotic state. B cells exposing PS differentiate more into B10 cells whereas PS blockage inhibits B10 cells generation. These results strongly suggest a link between PS exposure and B10 cells. (Source: PLoS One)
Source: PLoS One - January 9, 2017 Category: Biomedical Science Authors: Rachel Audo Source Type: research

oxLDL antibody inhibits MCP-1 release in monocytes/macrophages by regulating Ca(2+) /K(+) channel flow.
Abstract oxLDL peptide vaccine and its antibody adoptive transferring have shown a significantly preventive or therapeutic effect in atherosclerotic animal model. The molecular mechanism behind this is obscure. Here, we report that oxLDL induces MCP-1 release in monocytes/macrophages through their TLR-4 (Toll-like receptor 4) and ERK MAPK pathway and is calcium/potassium channel-dependent. Using blocking antibodies against CD36, TLR-4, SR-AI and LOX-1, only TLR-4 antibody was found to have an inhibitory effect and ERK MAPK-specific inhibitor (PD98059) was found to have a dramatic inhibitory effect compared...
Source: J Cell Mol Med - December 19, 2016 Category: Molecular Biology Authors: Su J, Zhou H, Liu X, Nilsson J, Fredrikson GN, Zhao M Tags: J Cell Mol Med Source Type: research

oxLDL antibody inhibits MCP ‐1 release in monocytes/macrophages by regulating Ca2+/K+ channel flow
Abstract oxLDL peptide vaccine and its antibody adoptive transferring have shown a significantly preventive or therapeutic effect in atherosclerotic animal model. The molecular mechanism behind this is obscure. Here, we report that oxLDL induces MCP‐1 release in monocytes/macrophages through their TLR‐4 (Toll‐like receptor 4) and ERK MAPK pathway and is calcium/potassium channel‐dependent. Using blocking antibodies against CD36, TLR‐4, SR‐AI and LOX‐1, only TLR‐4 antibody was found to have an inhibitory effect and ERK MAPK‐specific inhibitor (PD98059) was found to have a dramatic inhibitory effect compare...
Source: Journal of Cellular and Molecular Medicine - December 19, 2016 Category: Molecular Biology Authors: Jinyu Su, Hui Zhou, Xianyan Liu, Jan Nilsson, Gunilla Nordin Fredrikson, Ming Zhao Tags: Original Article Source Type: research