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Issues and Events
(Source: Diabetes Care)
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Tags: Issues and Events Source Type: research

Erratum. Application of Zone Model Predictive Control Artificial Pancreas During Extended Use of Infusion Set and Sensor: A Randomized Crossover-Controlled Home-Use Trial. Diabetes Care 2017;40:1096-1102
(Source: Diabetes Care)
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Forlenza, G. P.; Deshpande, S.; Ly, T. T.; Howsmon, D. P.; Cameron, F.; Baysal, N.; Mauritzen, E.; Marcal, T.; Towers, L.; Bequette, B. W.; Huyett, L. M.; Pinsker, J. E.; Gondhalekar, R.; Doyle, F. J.; Maahs, D. M.; Buckingham, B. A.; Dassau, E. Tags: Errata Source Type: research

Erratum. Cardiovascular Disease and Type 2 Diabetes: Has the Dawn of a New Era Arrived? Diabetes Care 2017;40:813-820
(Source: Diabetes Care)
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Abdul-Ghani, M.; DeFronzo, R. A.; Del Prato, S.; Chilton, R.; Singh, R.; Ryder, R. E. J. Tags: Errata Source Type: research

Prognostic Impact of Diabetes on Long-term Survival Outcomes in Patients With Heart Failure: A Meta-analysis
CONCLUSIONS This updated meta-analysis shows that the presence of diabetes per se adversely affects long-term survival and risk of hospitalization in patients with acute and chronic HF. (Source: Diabetes Care)
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Dauriz, M.; Mantovani, A.; Bonapace, S.; Verlato, G.; Zoppini, G.; Bonora, E.; Targher, G. Tags: Complications-Macrovascular-Atherosclerotic Cardiovascular Disease and Human Diabetes Meta-analyses Source Type: research

Association Between Adherence to Pharmacotherapy and Outcomes in Type 2 Diabetes: A Meta-analysis
CONCLUSIONS We identified no trials reporting on outcomes by adherence, suggesting a systematic failure to include this information. Pooled estimates from available observational studies suggest that good medication adherence is associated with reduced risk of all-cause mortality and hospitalization in people with type 2 diabetes, although bias cannot be excluded as an explanation for these findings. (Source: Diabetes Care)
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Khunti, K.; Seidu, S.; Kunutsor, S.; Davies, M. Tags: Complications-Macrovascular-Atherosclerotic Cardiovascular Disease and Human Diabetes Meta-analyses Source Type: research

Does Cardiorespiratory Fitness Attenuate the Adverse Effects of Severe/Morbid Obesity on Cardiometabolic Risk and Insulin Resistance in Children? A Pooled Analysis
OBJECTIVE To investigate 1) differences in cardiometabolic risk and HOMA of insulin resistance (HOMA-IR) across BMI categories (underweight to morbid obesity), 2) whether fit children have lower cardiometabolic risk/HOMA-IR than unfit children in each BMI category, and 3) differences in cardiometabolic risk/HOMA-IR in normal-weight unfit children and obese fit children. RESEARCH DESIGN AND METHODS A pooled study including cross-sectional data from three projects (n = 1,247 children aged 8–11 years). Cardiometabolic risk was assessed using the sum of the sex- and age-specific z scores for triglycerides, HDL cholester...
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Nyström, C. D.; Henriksson, P.; Martinez-Vizcaino, V.; Medrano, M.; Cadenas-Sanchez, C.; Arias-Palencia, N. M.; Löf, M.; Ruiz, J. R.; Labayen, I.; Sanchez-Lopez, M.; Ortega, F. B. Tags: Pediatrics-Obesity and Type 2 Diabetes Cardiovascular and Metabolic Risk Source Type: research

Influences of Breakfast on Clock Gene Expression and Postprandial Glycemia in Healthy Individuals and Individuals With Diabetes: A Randomized Clinical Trial
OBJECTIVE The circadian clock regulates glucose metabolism by mediating the activity of metabolic enzymes, hormones, and transport systems. Breakfast skipping and night eating have been associated with high HbA1c and postprandial hyperglycemia after lunch and dinner. Our aim was to explore the acute effect of breakfast consumption or omission on glucose homeostasis and clock gene expression in healthy individuals and individuals with type 2 diabetes. RESEARCH DESIGN AND METHODS In a crossover design, 18 healthy volunteers and 18 volunteers with 14.5 ± 1.5 years diabetes, BMI 30.7 ± 1.1 kg/m2, and HbA1c 7.6 &...
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Jakubowicz, D.; Wainstein, J.; Landau, Z.; Raz, I.; Ahren, B.; Chapnik, N.; Ganz, T.; Menaged, M.; Barnea, M.; Bar-Dayan, Y.; Froy, O. Tags: Nutrition-Clinical Cardiovascular and Metabolic Risk Source Type: research

Longitudinal Change in Fasting Blood Glucose and Myocardial Infarction Risk in a Population Without Diabetes
CONCLUSIONS We found that discrete FBG trajectories were significantly associated with subsequent risk of MI in individuals without diabetes. These observations suggest that long-term trajectories of FBG may be important for risk prediction of MI and possibly other macrovascular diseases. (Source: Diabetes Care)
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Jin, C.; Chen, S.; Vaidya, A.; Wu, Y.; Wu, Z.; Hu, F. B.; Kris-Etherton, P.; Wu, S.; Gao, X. Tags: Epidemiology-Cardiovascular Disease Cardiovascular and Metabolic Risk Source Type: research

Effects of Liraglutide on Weight Loss, Fat Distribution, and {beta}-Cell Function in Obese Subjects With Prediabetes or Early Type 2 Diabetes
CONCLUSIONS Liraglutide effects on visceral obesity and β-cell function might provide a rationale for using this molecule in obese subjects in an early phase of glucose metabolism dysregulation natural history. (Source: Diabetes Care)
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Santilli, F.; Simeone, P. G.; Guagnano, M. T.; Leo, M.; Maccarone, M. T.; Di Castelnuovo, A.; Sborgia, C.; Bonadonna, R. C.; Angelucci, E.; Federico, V.; Cianfarani, S.; Manzoli, L.; Davi, G.; Tartaro, A.; Consoli, A. Tags: Clinical Therapeutics/New Technology-Non-Insulin Injectables Pathophysiology/Complications Source Type: research

Identification of Novel Circulating Biomarkers Predicting Rapid Decline in Renal Function in Type 2 Diabetes: The Fremantle Diabetes Study Phase II
OBJECTIVE To assess the ability of plasma apolipoprotein (apo) A-IV (apoA4), apo C-III, CD5 antigen-like (CD5L), complement C1q subcomponent subunit B (C1QB), complement factor H–related protein 2, and insulin-like growth factor binding protein 3 (IBP3) to predict rapid decline in estimated glomerular filtration rate (eGFR) in type 2 diabetes. RESEARCH DESIGN AND METHODS Mass spectrometry was used to measure baseline biomarkers in 345 community-based patients (mean age 67.0 years, 51.9% males) from the Fremantle Diabetes Study Phase II (FDS2). Multiple logistic regression was used to determine clinical predictors of...
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Peters, K. E.; Davis, W. A.; Ito, J.; Winfield, K.; Stoll, T.; Bringans, S. D.; Lipscombe, R. J.; Davis, T. M. E. Tags: Complications-Nephropathy-Clinical and Translational Research Pathophysiology/Complications Source Type: research

The Role of Hyperglycemia, Insulin Resistance, and Blood Pressure in Diabetes-Associated Differences in Cognitive Performance--The Maastricht Study
OBJECTIVE To study to what extent differences in cognitive performance between individuals with different glucose metabolism status are potentially attributable to hyperglycemia, insulin resistance, and blood pressure–related variables. RESEARCH DESIGN AND METHODS We used cross-sectional data from 2,531 participants from the Maastricht Study (mean age ± SD, 60 ± 8 years; 52% men; n = 666 with type 2 diabetes), all of whom completed a neuropsychological test battery. Hyperglycemia was assessed by a composite index of fasting glucose, postload glucose, glycated hemoglobin (HbA1c), and tissue advanced gly...
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Geijselaers, S. L. C.; Sep, S. J. S.; Claessens, D.; Schram, M. T.; van Boxtel, M. P. J.; Henry, R. M. A.; Verhey, F. R. J.; Kroon, A. A.; Dagnelie, P. C.; Schalkwijk, C. G.; van der Kallen, C. J. H.; Biessels, G. J.; Stehouwer, C. D. A. Tags: Epidemiology-Diabetes Complications Pathophysiology/Complications Source Type: research

Pioglitazone Improves Left Ventricular Diastolic Function in Subjects With Diabetes
OBJECTIVE To examine the effect of pioglitazone on myocardial insulin sensitivity and left ventricular (LV) function in patients with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS Twelve subjects with T2D and 12 with normal glucose tolerance received a euglycemic insulin clamp. Myocardial glucose uptake (MGU) and myocardial perfusion were measured with [18F]fluoro-2-deoxy-d-glucose and [15O]H2O positron emission tomography before and after 24 weeks of pioglitazone treatment. Myocardial function and transmitral early diastolic relation/atrial contraction (E/A) flow ratio were measured with magnetic resonance imaging. ...
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Clarke, G. D.; Solis-Herrera, C.; Molina-Wilkins, M.; Martinez, S.; Merovci, A.; Cersosimo, E.; Chilton, R. J.; Iozzo, P.; Gastaldelli, A.; Abdul-Ghani, M.; DeFronzo, R. A. Tags: Epidemiology-Diabetes Complications Pathophysiology/Complications Source Type: research

Elevated Postoperative Endogenous GLP-1 Levels Mediate Effects of Roux-en-Y Gastric Bypass on Neural Responsivity to Food Cues
OBJECTIVE It has been suggested that weight reduction and improvements in satiety after Roux-en-Y gastric bypass (RYGB) are partly mediated via postoperative neuroendocrine changes. Glucagon-like peptide-1 (GLP-1) is a gut hormone secreted after food ingestion and is associated with appetite and weight reduction, mediated via effects on the central nervous system (CNS). Secretion of GLP-1 is greatly enhanced after RYGB. We hypothesized that postoperative elevated GLP-1 levels contribute to the improved satiety regulation after RYGB via effects on the CNS. RESEARCH DESIGN AND METHODS Effects of the GLP-1 receptor antagonis...
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: ten Kulve, J. S.; Veltman, D. J.; Gerdes, V. E. A.; van Bloemendaal, L.; Barkhof, F.; Deacon, C. F.; Holst, J. J.; Drent, M. L.; Diamant, M.; IJzerman, R. G. Tags: Integrated Physiology-Central Nervous System Regulation of Metabolism Emerging Technologies and Therapeutics Source Type: research

Diabetes, Prediabetes, and Brain Volumes and Subclinical Cerebrovascular Disease on MRI: The Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS)
OBJECTIVE To examine the associations of prediabetes, diabetes, and diabetes severity (as assessed by HbA1c and diabetes duration) with brain volumes and vascular pathology on brain MRI and to assess whether the associations of diabetes with brain volumes are mediated by brain vascular pathology. RESEARCH DESIGN AND METHODS Cross-sectional study of 1,713 participants in the Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS) (mean age 75 years, 60% female, 27% black, 30% prediabetes, and 35% diabetes) who underwent 3T brain MRI scans in 2011–2013. Participants were categorized by diabetes-HbA1c statu...
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Schneider, A. L. C.; Selvin, E.; Sharrett, A. R.; Griswold, M.; Coresh, J.; Jack, C. R.; Knopman, D.; Mosley, T.; Gottesman, R. F. Tags: Epidemiology-Aging Epidemiology/Health Services Research Source Type: research

Pharmacologic Differences of Sulfonylureas and the Risk of Adverse Cardiovascular and Hypoglycemic Events
CONCLUSIONS The nonspecific, long-acting sulfonylureas glyburide and glimepiride do not have an increased risk of cardiovascular adverse events compared with the specific, short-acting sulfonylureas gliclazide, glipizide, and tolbutamide. However, nonspecific, long-acting sulfonylureas glyburide and glimepiride have an increased risk of severe hypoglycemia. (Source: Diabetes Care)
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Douros, A.; Yin, H.; Yu, O. H. Y.; Filion, K. B.; Azoulay, L.; Suissa, S. Tags: Epidemiology-Cardiovascular Disease Epidemiology/Health Services Research Source Type: research

Antihyperglycemic Medications: A Claims-Based Estimate of First-line Therapy Use Prior to Initialization of Second-line Medications
OBJECTIVE The American Diabetes Association recommends metformin as first-line therapy for type 2 diabetes. However, nonadherence to antihyperglycemic medication is common, and a clinician could confuse nonadherence with pharmacologic failure, potentially leading to premature prescribing of second-line therapies. We measured metformin use prior to second-line therapy initialization. RESEARCH DESIGN AND METHODS This retrospective cross-sectional study used unidentifiable member claims data from individuals covered from 2010 to 2015 by Aetna, a U.S. health benefits company. Beneficiaries with two physician claims or one hos...
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Tseng, Y.-J.; Steinberg, G.; Fox, K. P.; Armstrong, J.; Mandl, K. D. Tags: Epidemiology-Other Epidemiology/Health Services Research Source Type: research

Dysglycemia and Index60 as Prediagnostic End Points for Type 1 Diabetes Prevention Trials
OBJECTIVE We assessed dysglycemia and a T1D Diagnostic Index60 (Index60) ≥1.00 (on the basis of fasting C-peptide, 60-min glucose, and 60-min C-peptide levels) as prediagnostic end points for type 1 diabetes among Type 1 Diabetes TrialNet Pathway to Prevention Study participants. RESEARCH DESIGN AND METHODS Two cohorts were analyzed: 1) baseline normoglycemic oral glucose tolerance tests (OGTTs) with an incident dysglycemic OGTT and 2) baseline Index60
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Nathan, B. M.; Boulware, D.; Geyer, S.; Atkinson, M. A.; Colman, P.; Goland, R.; Russell, W.; Wentworth, J. M.; Wilson, D. M.; Evans-Molina, C.; Wherrett, D.; Skyler, J. S.; Moran, A.; Sosenko, J. M.; the Type 1 Diabetes TrialNet and Diabetes Prevention T Tags: Epidemiology-Type 1 Diabetes Epidemiology/Health Services Research Source Type: research

Incidence, Demographics, and Clinical Characteristics of Diabetes of the Exocrine Pancreas (Type 3c): A Retrospective Cohort Study
This study was conducted to describe the incidence of diabetes following pancreatic disease, assess how these patients are classified by clinicians, and compare clinical characteristics with type 1 and type 2 diabetes. RESEARCH DESIGN AND METHODS Primary care records in England (n = 2,360,631) were searched for incident cases of adult-onset diabetes between 1 January 2005 and 31 March 2016. We examined demographics, diabetes classification, glycemic control, and insulin use in those with and without pancreatic disease (subcategorized into acute pancreatitis or chronic pancreatic disease) before diabetes diagnosis. Regress...
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Woodmansey, C.; McGovern, A. P.; McCullough, K. A.; Whyte, M. B.; Munro, N. M.; Correa, A. C.; Gatenby, P. A. C.; Jones, S. A.; de Lusignan, S. Tags: Epidemiology-Clinical-Diagnosis and Screening Epidemiology/Health Services Research Source Type: research

Acute Kidney Injury in Patients on SGLT2 Inhibitors: A Propensity-Matched Analysis
OBJECTIVE Sodium-glucose cotransporter-2 (SGLT2) inhibitors are new medications that improve cardiovascular and renal outcomes in patients with type 2 diabetes (T2D). However, the Food and Drug Administration has issued alerts regarding increased acute kidney injury (AKI) risk with canagliflozin and dapagliflozin. We aimed to assess the real-world risk of AKI in new SGLT2 inhibitor users in two large health care utilization cohorts of patients with T2D. RESEARCH DESIGN AND METHODS We used longitudinal data from the Mount Sinai chronic kidney disease registry and the Geisinger Health System cohort. We selected SGLT inhibit...
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Nadkarni, G. N.; Ferrandino, R.; Chang, A.; Surapaneni, A.; Chauhan, K.; Poojary, P.; Saha, A.; Ferket, B.; Grams, M. E.; Coca, S. G. Tags: Epidemiology-Other Epidemiology/Health Services Research Source Type: research

Understanding the Gap Between Efficacy in Randomized Controlled Trials and Effectiveness in Real-World Use of GLP-1 RA and DPP-4 Therapies in Patients With Type 2 Diabetes
CONCLUSIONS Poor medication adherence is primarily why RW effectiveness is significantly less than RCT efficacy, suggesting an urgent need to effectively address adherence among patients with type 2 diabetes. (Source: Diabetes Care)
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Carls, G. S.; Tuttle, E.; Tan, R.-D.; Huynh, J.; Yee, J.; Edelman, S. V.; Polonsky, W. H. Tags: Epidemiology/Health Services Research Source Type: research

Cut Points for Identifying Clinically Significant Diabetes Distress in Adolescents With Type 1 Diabetes Using the PAID-T: Results From Diabetes MILES Youth-Australia
OBJECTIVE To establish cut point(s) for the Problem Areas in Diabetes–teen version (PAID-T) scale to identify adolescents with clinically meaningful, elevated diabetes distress. RESEARCH DESIGN AND METHODS Data were available from the Diabetes Management and Impact for Long-term Empowerment and Success (MILES) Youth–Australia Study, a national survey assessing various psychosocial indicators among self-selected National Diabetes Services Scheme registrants. Participants in the current study (n = 537) were (mean ± SD) 16 ± 2 years old, had type 1 diabetes for 6 ± 4 years, and 62% (n = 334) ...
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Hagger, V.; Hendrieckx, C.; Cameron, F.; Pouwer, F.; Skinner, T. C.; Speight, J. Tags: Psychosocial, Behavioral Medicine Clinical Care/Education/Nutrition/Psychosocial Research Source Type: research

What End Users and Stakeholders Want From Automated Insulin Delivery Systems
CONCLUSIONS Incorporating stakeholder perspectives on use of automated insulin delivery systems will improve the adoption of devices, quality of life, and likelihood of optimal health. Efforts to build trust in systems, optimize user-system interactions, and provide clear guidance about device capabilities and limitations may help potential users achieve optimal glycemic outcomes. (Source: Diabetes Care)
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Naranjo, D.; Suttiratana, S. C.; Iturralde, E.; Barnard, K. D.; Weissberg-Benchell, J.; Laffel, L.; Hood, K. K. Tags: Clinical Therapeutics/New Technology-Insulin Delivery Systems Clinical Care/Education/Nutrition/Psychosocial Research Source Type: research

Effect of a Behavioral Intervention Strategy for Adoption and Maintenance of a Physically Active Lifestyle: The Italian Diabetes and Exercise Study 2 (IDES_2): A Randomized Controlled Trial
CONCLUSIONS This behavioral intervention is effective in the short term for increasing LPA and MVPA and reducing SED-time. Significant improvements in cardiometabolic risk profiles were observed in subjects experiencing the most pronounced changes in PA and SED-time, even if below the recommended level. (Source: Diabetes Care)
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Balducci, S.; DErrico, V.; Haxhi, J.; Sacchetti, M.; Orlando, G.; Cardelli, P.; Vitale, M.; Bollanti, L.; Conti, F.; Zanuso, S.; Nicolucci, A.; Pugliese, G.; for the Italian Diabetes and Exercise Study 2 (IDES{-}_2) Investigators Tags: Exercise Clinical Care/Education/Nutrition/Psychosocial Research Source Type: research

Diabetes, Associated Clinical Spectrum, Long-term Prognosis, and Genotype/Phenotype Correlations in 201 Adult Patients With Hepatocyte Nuclear Factor 1B (HNF1B) Molecular Defects
OBJECTIVE Molecular defects of hepatocyte nuclear factor 1B (HNF1B) are associated with a multiorgan disease, including diabetes (maturity-onset diabetes of the young 5) and kidney abnormalities. The HNF1B syndrome is related to HNF1B mutations or to a 17q12 deletion spanning 15 genes, including HNF1B. Here, we described HNF1B-related diabetes and associated phenotypes and assessed genotype/phenotype correlations at diagnosis and in the long-term. RESEARCH DESIGN AND METHODS This multicenter retrospective cohort study included 201 patients, aged 18 years or older at follow-up, with HNF1B mutations (n = 101) or deletion (n...
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Dubois-Laforgue, D.; Cornu, E.; Saint-Martin, C.; Coste, J.; Bellanne-Chantelot, C.; Timsit, J.; for the Monogenic Diabetes Study Group of the Societe Francophone du Diabete Tags: Clinical Care/Education/Nutrition/Psychosocial Research Source Type: research

The Promise and Practice of Genetics on Diabetes Care: The Fog Rises to Reveal a Field of Genetic Complexity in HNF1B
(Source: Diabetes Care)
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Rich, S. S. Tags: Genetics-Type 1 Diabetes Commentary Source Type: research

Type 2 Diabetes in the Real World: The Elusive Nature of Glycemic Control
Despite U.S. Food and Drug Administration (FDA) approval of over 40 new treatment options for type 2 diabetes since 2005, the latest data from the National Health and Nutrition Examination Survey show that the proportion of patients achieving glycated hemoglobin (HbA1c)
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Edelman, S. V.; Polonsky, W. H. Tags: Epidemiology-Other Perspectives in Care Source Type: research

In This Issue of Diabetes Care
(Source: Diabetes Care)
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Tags: In This Issue Source Type: research

Response to Comment on Craig et al. Prevalence of Celiac Disease in 52,721 Youth With Type 1 Diabetes: International Comparison Across Three Continents. Diabetes Care 2017;40:1034-1040
(Source: Diabetes Care)
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Craig, M. E.; Prinz, N.; Boyle, C. T.; Campbell, F. M.; Jones, T. W.; Hofer, S. E.; Simmons, J. H.; Holman, N.; Tham, E.; Fröhlich-Reiterer, E.; DuBose, S.; Thornton, H.; King, B.; Maahs, D. M.; Holl, R. W.; Warner, J. T.; on behalf of the Austral Tags: Pediatrics-Type 1 Diabetes e-Letters: Comments and Responses Source Type: research

Comment on Craig et al. Prevalence of Celiac Disease in 52,721 Youth With Type 1 Diabetes: International Comparison Across Three Continents. Diabetes Care 2017;40:1034-1040
(Source: Diabetes Care)
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Maltoni, G.; Franceschi, R.; DAnnunzio, G.; Toni, S.; Rabbone, I.; Zucchini, S. Tags: Epidemiology-Type 1 Diabetes e-Letters: Comments and Responses Source Type: research

Response to Comment on Lachin et al. Association of Glycemic Variability in Type 1 Diabetes With Progression of Microvascular Outcomes in the Diabetes Control and Complications Trial. Diabetes Care 2017;40:777-783
(Source: Diabetes Care)
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Lachin, J. M.; Bebu, I.; Bergenstal, R. M.; Pop-Busui, R.; Service, F. J.; Zinman, B.; Nathan, D. M.; for the DCCT/EDIC Research Group Tags: Complications-Retinopathy e-Letters: Comments and Responses Source Type: research

Comment on Lachin et al. Association of Glycemic Variability in Type 1 Diabetes With Progression of Microvascular Outcomes in the Diabetes Control and Complications Trial. Diabetes Care 2017;40:777-783
(Source: Diabetes Care)
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Fleischer, J.; Cichosz, S. L.; Hansen, T. K. Tags: Complications-Neuropathy e-Letters: Comments and Responses Source Type: research

Response to Comment on Ely et al. A National Effort to Prevent Type 2 Diabetes: Participant-Level Evaluation of CDCs National Diabetes Prevention Program. Diabetes Care 2017;40:1331-1341
(Source: Diabetes Care)
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Ely, E. K.; Gruss, S. M.; Luman, E. T.; Albright, A. L. Tags: Epidemiology-Other e-Letters: Comments and Responses Source Type: research

Comment on Ely et al. A National Effort to Prevent Type 2 Diabetes: Participant-Level Evaluation of CDCs National Diabetes Prevention Program. Diabetes Care 2017;40:1331-1341
(Source: Diabetes Care)
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Ritchie, N. D.; Kaufmann, P.; Sauder, K. A. Tags: Psychosocial, Behavioral Medicine e-Letters: Comments and Responses Source Type: research

Response to Comment on Lovshin et al. Dipeptidyl Peptidase 4 Inhibition Stimulates Distal Tubular Natriuresis and Increases in Circulating SDF-1{alpha}1-67 in Patients With Type 2 Diabetes. Diabetes Care 2017;40:1073-1081
(Source: Diabetes Care)
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Lovshin, J. A.; Lovblom, L. E.; Cherney, D. Z. I. Tags: Complications-Nephropathy-Clinical and Translational Research e-Letters: Comments and Responses Source Type: research

Comment on Lovshin et al. Dipeptidyl Peptidase 4 Inhibition Stimulates Distal Tubular Natriuresis and Increases in Circulating SDF-1{alpha}1-67 in Patients With Type 2 Diabetes. Diabetes Care 2017;40:1073-1081
(Source: Diabetes Care)
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: van Baar, M. J. B.; van Raalte, D. H.; Muskiet, M. H. A. Tags: Clinical Therapeutics/New Technology-Pharmacological Treatment of Complications e-Letters: Comments and Responses Source Type: research

Issues and Events
(Source: Diabetes Care)
Source: Diabetes Care - August 22, 2017 Category: Endocrinology Tags: Issues and Events Source Type: research

Erratum. Diabetic Retinopathy: A Position Statement by the American Diabetes Association. Diabetes Care 2017;40:412-418
(Source: Diabetes Care)
Source: Diabetes Care - August 22, 2017 Category: Endocrinology Authors: Solomon, S. D.; Chew, E.; Duh, E. J.; Sobrin, L.; Sun, J. K.; VanderBeek, B. L.; Wykoff, C. C.; Gardner, T. W. Tags: Erratum Source Type: research

Diabetes and Hypertension: A Position Statement by the American Diabetes Association
(Source: Diabetes Care)
Source: Diabetes Care - August 22, 2017 Category: Endocrinology Authors: de Boer, I. H.; Bangalore, S.; Benetos, A.; Davis, A. M.; Michos, E. D.; Muntner, P.; Rossing, P.; Zoungas, S.; Bakris, G. Tags: Complications-Macrovascular-Atherosclerotic Cardiovascular Disease and Human Diabetes Position Statement Source Type: research

Exercise Training Improves but Does Not Normalize Left Ventricular Systolic and Diastolic Function in Adolescents With Type 1 Diabetes
CONCLUSIONS These data demonstrate that in adolescents, the impairment in left ventricular function seen with type 1 diabetes can be improved, although not normalized, with regular intense physical activity. Importantly, diastolic dysfunction, a common mechanism causing heart failure in older subjects with diabetes, appears to be partially reversible in this age group. (Source: Diabetes Care)
Source: Diabetes Care - August 22, 2017 Category: Endocrinology Authors: Gusso, S.; Pinto, T.; Baldi, J. C.; Derraik, J. G. B.; Cutfield, W. S.; Hornung, T.; Hofman, P. L. Tags: Cardiovascular and Metabolic Risk Source Type: research

Skeletal Muscle Microvascular-Linked Improvements in Glycemic Control From Resistance Training in Individuals With Type 2 Diabetes
CONCLUSIONS RT improves OGC-stimulated muscle MBF and glycemic control concomitantly, suggesting that MBF plays a role in improved glycemic control from RT. (Source: Diabetes Care)
Source: Diabetes Care - August 22, 2017 Category: Endocrinology Authors: Russell, R. D.; Hu, D.; Greenaway, T.; Blackwood, S. J.; Dwyer, R. M.; Sharman, J. E.; Jones, G.; Squibb, K. A.; Brown, A. A.; Otahal, P.; Boman, M.; Al-Aubaidy, H.; Premilovac, D.; Roberts, C. K.; Hitchins, S.; Richards, S. M.; Rattigan, S.; Keske, M. A. Tags: Exercise Cardiovascular and Metabolic Risk Source Type: research

Diabetic Ketoacidosis at Diagnosis of Type 1 Diabetes Predicts Poor Long-term Glycemic Control
This study tested the hypothesis that diabetic ketoacidosis (DKA) at diagnosis of type 1 diabetes in children predicts poor long-term glycemic control independently of established risk factors. RESEARCH DESIGN AND METHODS This was a prospective cohort study of 3,364 Colorado residents diagnosed with type 1 diabetes before 18 years of age, in 1998–2012, and monitored for up to 15 years. Of those, 1,297 (39%) had DKA at diagnosis (blood glucose>250 mg/dL, and venous pH
Source: Diabetes Care - August 22, 2017 Category: Endocrinology Authors: Duca, L. M.; Wang, B.; Rewers, M.; Rewers, A. Tags: Pediatrics-Type 1 Diabetes Cardiovascular and Metabolic Risk Source Type: research

Computed Tomography Angiography Images of Coronary Artery Stenosis Provide a Better Prediction of Risk Than Traditional Risk Factors in Asymptomatic Individuals With Type 2 Diabetes: A Long-term Study of Clinical Outcomes
OBJECTIVE We investigated the efficacy of coronary computed tomography angiography (CCTA) in predicting the long-term risks in asymptomatic patients with type 2 diabetes and compared it with traditional risk factors. RESEARCH DESIGN AND METHODS We analyzed 933 patients with asymptomatic type 2 diabetes who underwent CCTA. Stenosis was considered obstructive (≥50%) in each coronary artery segment using CCTA. The extent and severity scores for coronary artery disease (CAD) were evaluated. The primary end point was major adverse cardiovascular events (MACE), including all-cause mortality, nonfatal myocardial infarction, a...
Source: Diabetes Care - August 22, 2017 Category: Endocrinology Authors: Lee, K. Y.; Hwang, B.-H.; Kim, T.-H.; Kim, C. J.; Kim, J.-J.; Choo, E.-H.; Choi, I. J.; Choi, Y.; Park, H.-W.; Koh, Y.-S.; Kim, P.-J.; Lee, J. M.; Kim, M.-J.; Jeon, D. S.; Cho, J.-H.; Jung, J. I.; Seung, K.-B.; Chang, K. Tags: Complications-Macrovascular-Atherosclerotic Cardiovascular Disease and Human Diabetes Cardiovascular and Metabolic Risk Source Type: research

The Prognostic Value of Fasting Plasma Glucose, Two-Hour Postload Glucose, and HbA1c in Patients With Coronary Artery Disease: A Report From EUROASPIRE IV: A Survey From the European Society of Cardiology
This study explored the prognostic value of these screening tests in patients with coronary artery disease (CAD). RESEARCH DESIGN AND METHODS FPG, 2h-PG, and HbA1c were used to screen 4,004 CAD patients without a history of diabetes (age 18–80 years) for dysglycemia. The prognostic value of these tests was studied after 2 years of follow-up. The primary end point included cardiovascular mortality, nonfatal myocardial infarction, stroke, or hospitalization for heart failure and a secondary end point of incident diabetes. RESULTS Complete information including all three glycemic parameters was available in 3,775 pati...
Source: Diabetes Care - August 22, 2017 Category: Endocrinology Authors: Shahim, B.; De Bacquer, D.; De Backer, G.; Gyberg, V.; Kotseva, K.; Mellbin, L.; Schnell, O.; Tuomilehto, J.; Wood, D.; Ryden, L. Tags: Epidemiology-Clinical-Diagnosis and Screening Cardiovascular and Metabolic Risk Source Type: research

Prevalence of and Risk Factors for Diabetic Peripheral Neuropathy in Youth With Type 1 and Type 2 Diabetes: SEARCH for Diabetes in Youth Study
CONCLUSIONS The high rates of DPN among youth with diabetes are a cause of concern and suggest a need for early screening and better risk factor management. Interventions in youth that address poor glycemic control and dyslipidemia may prevent or delay debilitating neuropathic complications. (Source: Diabetes Care)
Source: Diabetes Care - August 22, 2017 Category: Endocrinology Authors: Jaiswal, M.; Divers, J.; Dabelea, D.; Isom, S.; Bell, R. A.; Martin, C. L.; Pettitt, D. J.; Saydah, S.; Pihoker, C.; Standiford, D. A.; Dolan, L. M.; Marcovina, S.; Linder, B.; Liese, A. D.; Pop-Busui, R.; Feldman, E. L. Tags: Complications-Neuropathy Pathophysiology/Complications Source Type: research

A Team-Based Online Game Improves Blood Glucose Control in Veterans With Type 2 Diabetes: A Randomized Controlled Trial
CONCLUSIONS Patients with diabetes who were randomized to an online game delivering DSME demonstrated sustained and meaningful HbA1c improvements. Among patients with poorly controlled diabetes, the DSME game reduced HbA1c by a magnitude comparable to starting a new diabetes medication. Online games may be a scalable approach to improve outcomes among geographically dispersed patients with diabetes and other chronic diseases. (Source: Diabetes Care)
Source: Diabetes Care - August 22, 2017 Category: Endocrinology Authors: Kerfoot, B. P.; Gagnon, D. R.; McMahon, G. T.; Orlander, J. D.; Kurgansky, K. E.; Conlin, P. R. Tags: Diabetes Education Emerging Technologies and Therapeutics Source Type: research

Visit-to-Visit Variations in Fasting Plasma Glucose and HbA1c Associated With an Increased Risk of Alzheimer Disease: Taiwan Diabetes Study
CONCLUSIONS FPG CV and HbA1c CV are independently associated with AD. The associations between glycemic variability and AD demonstrated in this study suggest a linked pathophysiological mechanism, which is worthy of further investigation. Further research is required to confirm our results and to evaluate whether FPG CV and HbA1c CV can be valuable therapeutic targets for patients with T2DM at risk. (Source: Diabetes Care)
Source: Diabetes Care - August 22, 2017 Category: Endocrinology Authors: Li, T.-C.; Yang, C.-P.; Tseng, S.-T.; Li, C.-I.; Liu, C.-S.; Lin, W.-Y.; Hwang, K.-L.; Yang, S.-Y.; Chiang, J.-H.; Lin, C.-C. Tags: Epidemiology-Other Epidemiology/Health Services Research Source Type: research

Cardiac Stress and Inflammatory Markers as Predictors of Heart Failure in Patients With Type 2 Diabetes: The ADVANCE Trial
CONCLUSIONS Only NT-proBNP strongly and consistently improved the prediction of heart failure in patients with type 2 diabetes beyond a wide range of clinical risk factors and biomarkers. (Source: Diabetes Care)
Source: Diabetes Care - August 22, 2017 Category: Endocrinology Authors: Ohkuma, T.; Jun, M.; Woodward, M.; Zoungas, S.; Cooper, M. E.; Grobbee, D. E.; Hamet, P.; Mancia, G.; Williams, B.; Welsh, P.; Sattar, N.; Shaw, J. E.; Rahimi, K.; Chalmers, J.; on behalf of the ADVANCE Collaborative Group Tags: Epidemiology/Health Services Research Source Type: research

Genetic and Environmental Interactions Modify the Risk of Diabetes-Related Autoimmunity by 6 Years of Age: The TEDDY Study
CONCLUSIONS These results show clear differences in the initiation of autoimmunity according to genetic factors and environmental exposures that give rise to IAA or GADA as the first appearing indication of autoimmunity. (Source: Diabetes Care)
Source: Diabetes Care - August 22, 2017 Category: Endocrinology Authors: Krischer, J. P.; Lynch, K. F.; Lernmark, A.; Hagopian, W. A.; Rewers, M. J.; She, J.-X.; Toppari, J.; Ziegler, A.-G.; Akolkar, B.; the TEDDY Study Group Tags: Epidemiology-Type 1 Diabetes Epidemiology/Health Services Research Source Type: research

Hemoglobin A1c Variability Predicts Symptoms of Depression in Elderly Individuals With Type 2 Diabetes
This study aimed to analyze the relationship of variability in hemoglobin A1c (HbA1c) over years with subsequent depressive symptoms. RESEARCH DESIGN AND METHODS Subjects (n = 837) were participants of the Israel Diabetes and Cognitive Decline (IDCD) study, which aimed to examine the relationship of characteristics of long-term type 2 diabetes with cognitive decline. All pertain to a diabetes registry established in 1998, which contains an average of 18 HbA1c measurements per subject. The results presented here are based on the IDCD baseline examination. Symptoms of depression were assessed using the 15-item version of th...
Source: Diabetes Care - August 22, 2017 Category: Endocrinology Authors: Ravona-Springer, R.; Heymann, A.; Schmeidler, J.; Moshier, E.; Guerrero-Berroa, E.; Soleimani, L.; Sano, M.; Leroith, D.; Preiss, R.; Tzukran, R.; Silverman, J. M.; Beeri, M. S. Tags: Epidemiology-Diabetes Complications Epidemiology/Health Services Research Source Type: research

Poor Reliability and Poor Adherence to Self-Monitoring of Blood Glucose Are Common in Women With Gestational Diabetes Mellitus and May Be Associated With Poor Pregnancy Outcomes
OBJECTIVE To evaluate the compliance with self-monitoring of blood glucose (SMBG) and the reliability of diabetes logbooks in women with gestational diabetes mellitus (GDM), as well as the associated determinants and outcomes. RESEARCH DESIGN AND METHODS We prospectively selected French-speaking women with newly diagnosed GDM who had been referred to our diabetes management program and understood SMBG principles. At the next follow-up visit, we collected SMBG results from glucose meters and logbooks. We analyzed pregnancy outcomes. RESULTS Data were analyzed over 13 ± 3 days in 91 women. Only 61.5% had performed &...
Source: Diabetes Care - August 22, 2017 Category: Endocrinology Authors: Cosson, E.; Baz, B.; Gary, F.; Pharisien, I.; Nguyen, M. T.; Sandre-Banon, D.; Jaber, Y.; Cussac-Pillegand, C.; Banu, I.; Carbillon, L.; Valensi, P. Tags: Clinical Care/Education/Nutrition/Psychosocial Research Source Type: research