CGM Metrics Predict Imminent Progression to Type 1 Diabetes: Autoimmunity Screening for Kids (ASK) Study
CONCLUSIONSTA140>10% is associated with a high risk of progression to clinical diabetes within the next year in autoantibody-positive children. CGM should be included in the ongoing monitoring of high-risk children and could be used as potential entry criterion for prevention trials. (Source: Diabetes Care)
Source: Diabetes Care - December 8, 2021 Category: Endocrinology Source Type: research
Lifestyle Changes and Long-term Weight Gain in Women With and Without a History of Gestational Diabetes Mellitus: A Prospective Study of 54,062 Women in the Nurses ’ Health Study II
CONCLUSIONSImprovements in diet quality and PA were related to less weight gain in midlife among parous women, and the benefit of such improvements on weight management was particularly pronounced among women with a history of GDM. (Source: Diabetes Care)
Source: Diabetes Care - December 8, 2021 Category: Endocrinology Source Type: research
Differentiating Diabetic Ketoacidosis and Hyperglycemic Ketosis Due to Cannabis Hyperemesis Syndrome in Adults With Type 1 Diabetes
CONCLUSIONSIn patients who present with DKA and higher pH, especially pH ≥7.4, cannabis use should be considered in the differential diagnosis. (Source: Diabetes Care)
Source: Diabetes Care - December 8, 2021 Category: Endocrinology Source Type: research
Alterations in Biomarkers Related to Glycemia, Lipid Metabolism, and Inflammation up to 20 Years Before Diagnosis of Type 1 Diabetes in Adults: Findings From the AMORIS Cohort
CONCLUSIONSAlterations in biomarker levels related to glycemia, lipid metabolism, and inflammation are associated with clinically diagnosed type 1 diabetes risk, and these may be elevated many years preceding diagnosis. (Source: Diabetes Care)
Source: Diabetes Care - December 7, 2021 Category: Endocrinology Source Type: research
Trends in Prevalence and Awareness of Prediabetes Among Adults in the U.S., 2005 –2020
Previous studies on trends in the prevalence of prediabetes among U.S. adults were based on either fasting plasma glucose (FPG) and 2-h plasma glucose (2-h PG) definition (1) or FPG and hemoglobin A1c (HbA1c) definition (2) and observed inconsistent results. The trend in prevalence of prediabetes among U.S. adults based on all three glycemic measures is unknown. (Source: Diabetes Care)
Source: Diabetes Care - December 6, 2021 Category: Endocrinology Source Type: research
Universal Subsidized Continuous Glucose Monitoring Funding for Young People With Type 1 Diabetes: Uptake and Outcomes Over 2 Years, a Population-Based Study
CONCLUSIONSFollowing the national subsidy, CGM use was high and associated with sustained improvement in glycemic control. This information will inform economic analyses and future policy and serve as a model of evaluation diabetes technologies. (Source: Diabetes Care)
Source: Diabetes Care - December 6, 2021 Category: Endocrinology Source Type: research
Cobalamin Intake and Related Biomarkers: Examining Associations With Mortality Risk Among Adults With Type 2 Diabetes in NHANES
CONCLUSIONSSerum and dietary cobalamin were not associated with reduced mortality. Decreased cobalamin sensitivity was significantly associated with all-cause and cardiac mortality, particularly among metformin nonusers. (Source: Diabetes Care)
Source: Diabetes Care - December 3, 2021 Category: Endocrinology Source Type: research
Association of a Healthy Lifestyle With All-Cause and Cause-Specific Mortality Among Individuals With Type 2 Diabetes: A Prospective Study in UK Biobank
CONCLUSIONSA healthy lifestyle was associated with a lower risk of all-cause mortality and mortality due to CVD, cancer, respiratory disease, and digestive disease among individuals with type 2 diabetes. (Source: Diabetes Care)
Source: Diabetes Care - December 2, 2021 Category: Endocrinology Source Type: research
Role of the Gut in the Temporal Changes of β-Cell Function After Gastric Bypass in Individuals With and Without Diabetes Remission
CONCLUSIONSOur data show the time course of changes in β-cell function after RYGB. The improvement in β-cell function after RYGB, but not changes in weight loss or insulin sensitivity, drives diabetes remission. (Source: Diabetes Care)
Source: Diabetes Care - December 2, 2021 Category: Endocrinology Source Type: research
Association Between the ACE Insertion/Deletion Polymorphism and Risk of Lower-Limb Amputation in Patients With Long-Standing Type 1 Diabetes
CONCLUSIONSThis report is the first of an independent association betweenACE D allele and excess LLA risk, mainly minor amputations, in patients with type 1 diabetes. (Source: Diabetes Care)
Source: Diabetes Care - December 1, 2021 Category: Endocrinology Source Type: research
Index60 Identifies Individuals at Appreciable Risk for Stage 3 Among an Autoantibody-Positive Population With Normal 2-Hour Glucose Levels: Implications for Current Staging Criteria of Type 1 Diabetes
CONCLUSIONSIndex60 identifies individuals with characteristics of type 1 diabetes at appreciable risk for progression who would otherwise be missed by 2-h glucose staging criteria. (Source: Diabetes Care)
Source: Diabetes Care - December 1, 2021 Category: Endocrinology Source Type: research
Circulating Metabolites and the Development of Type 2 Diabetes in Chinese Adults
CONCLUSIONSIn Chinese adults, metabolites across diverse pathways were independently associated with T2D risk, providing valuable etiological insights and potential to improve T2D risk prediction. (Source: Diabetes Care)
Source: Diabetes Care - November 30, 2021 Category: Endocrinology Source Type: research
Impact of COVID-19 Vaccination on Glycemia in Individuals With Type 1 and Type 2 Diabetes: Substudy of the COVAC-DM Study
As people with diabetes are considered a high-risk population in the coronavirus disease 2019 (COVID-19) pandemic scenario, they are globally prioritized in COVID-19 vaccine policy. To date, in most industrialized countries, people with diabetes have already been offered the opportunity to receive a vaccine. Nonetheless, concerns exist about vaccine-induced dysglycemia among people living with diabetes, potentially holding them back from getting vaccinated. Immune responses can trigger alterations in insulin sensitivity, potentially increasing insulin requirements due to inflammation, humoral, and cellular immune responses...
Source: Diabetes Care - November 30, 2021 Category: Endocrinology Source Type: research
Evidence That Hypothalamic Gliosis Is Related to Impaired Glucose Homeostasis in Adults With Obesity
CONCLUSIONSFindings support a role for hypothalamic gliosis in the progression of insulin resistance in obesity and thus T2D pathogenesis in humans. (Source: Diabetes Care)
Source: Diabetes Care - November 30, 2021 Category: Endocrinology Source Type: research
Dietary Insulinemic Potential and Risk of Total and Cause-Specific Mortality in the Nurses ’ Health Study and the Health Professionals Follow-up Study
CONCLUSIONSHigher insulinemic potential of diet was associated with increased risk of all-cause, CVD, and cancer mortality. Adopting a diet with low insulinemic potential might be an effective approach to improve overall health and prevent premature death. (Source: Diabetes Care)
Source: Diabetes Care - November 29, 2021 Category: Endocrinology Source Type: research
