Improvements in Awareness and Testing Have Led to a Threefold Increase Over 10 Years in the Identification of Monogenic Diabetes in the U.K.
CONCLUSIONSSince 2009, referral rates and case diagnosis have increased threefold. This is likely to be the consequence of tNGS, GDN education, and use of the MODY calculator. (Source: Diabetes Care)
Source: Diabetes Care - January 21, 2022 Category: Endocrinology Source Type: research
Advanced Glycation End Products Predict Loss of Renal Function and High-Risk Chronic Kidney Disease in Type 2 Diabetes
CONCLUSIONSThese data provide further support for a causal role of AGEs in diabetic nephropathy independently of glycemic control and suggest utility of the composite AGE panel in predicting long-term decline in renal function. (Source: Diabetes Care)
Source: Diabetes Care - January 20, 2022 Category: Endocrinology Source Type: research
Medication Use Among U.S. Adults After Bariatric Surgery: A Population-Based Analysis of NHANES 2015 –2018
Bariatric surgery for patients with morbid obesity results in greater improvements in weight loss and type 2 diabetes outcomes compared with nonsurgical interventions (1). However, individuals with prior morbid obesity who had bariatric surgery can have altered drug absorption, distribution, and metabolism (2). The cumulative effect of bariatric surgery on medication use patterns has not been systematically investigated to improve postsurgery patient care. Using National Health and Nutrition Examination Survey (NHANES) data from 2015 to 2018, we identified and compared medication use in adults who had bariatric surgery wit...
Source: Diabetes Care - January 19, 2022 Category: Endocrinology Source Type: research
Contrast Pattern Mining With the T1D Exchange Clinic Registry Reveals Complex Phenotypic Factors and Comorbidity Patterns Associated With Familial Versus Sporadic Type 1 Diabetes
Scant attention has been paid to evaluating differences in the prevalence of comorbidities and diabetes-related complications in familial versus sporadic type 1 diabetes (1). Knowledge gains in this area could advance the development of risk prediction tools and tailored interventions for preventing or delaying onset of comorbidities or diabetes-related complications in high-risk patient subgroups. (Source: Diabetes Care)
Source: Diabetes Care - January 19, 2022 Category: Endocrinology Source Type: research
Inflammation, Hyperglycemia, and Adverse Outcomes in Individuals With Diabetes Mellitus Hospitalized for COVID-19
CONCLUSIONSOur findings suggest that the association between DM and outcomes in COVID-19 is largely mediated by hyperinflammation as assessed by suPAR levels, while the impact of hyperglycemia is independent of inflammation. (Source: Diabetes Care)
Source: Diabetes Care - January 19, 2022 Category: Endocrinology Source Type: research
The Gut Microbiome of Adults With Type 1 Diabetes and Its Association With the Host Glycemic Control
CONCLUSIONSWe identified a distinct gut microbial signature in adults with longstanding T1D and associations between microbial taxa, metabolic pathways, and glycemic control indices. Additional mechanistic studies are needed to identify the role of these bacteria for potential therapeutic strategies. (Source: Diabetes Care)
Source: Diabetes Care - January 19, 2022 Category: Endocrinology Source Type: research
Gender Differences in Strategies to Prevent Physical Activity –Related Hypoglycemia in Patients With Type 1 Diabetes: A BETTER Study
The objectives of this study were to determine and compare the most common strategies (type and frequency) used to prevent PA-related hypoglycemia and to compare the most common barriers to PA between self-identified men and women. (Source: Diabetes Care)
Source: Diabetes Care - January 19, 2022 Category: Endocrinology Source Type: research
Risk of Developing Type 2 Diabetes in Individuals With a Psychiatric Disorder: A Nationwide Register-Based Cohort Study
CONCLUSIONSWe found that the IR of type 2 diabetes was higher in individuals with a psychiatric disorder compared with individuals without a psychiatric disorder and particularly high in the younger people with a psychiatric disorder. New studies into the prevention and early detection of type 2 diabetes in these groups are warranted. (Source: Diabetes Care)
Source: Diabetes Care - January 18, 2022 Category: Endocrinology Source Type: research
Hypoglycemia Subtypes in Type 1 Diabetes: An Exploration of the Hypoglycemia Fear Survey-II
CONCLUSIONSThis is the first study to define clusters of hypoglycemia experience by worry, behaviors, and cognitive barriers to hypoglycemia avoidance. The resulting subtypes may be important in understanding and treating problematic hypoglycemia. (Source: Diabetes Care)
Source: Diabetes Care - January 18, 2022 Category: Endocrinology Source Type: research
Heterogeneity of DKA Incidence and Age-Specific Clinical Characteristics in Children Diagnosed With Type 1 Diabetes in the TEDDY Study
CONCLUSIONSDKA at onset in TEDDY is uncommon, especially for FDRs. For those without familial risk, metabolic monitoring continues to provide a primary benefit of reduced DKA but requires regular follow-up. Clinical and laboratory features vary by age at onset, adding to the heterogeneity of type 1 diabetes. (Source: Diabetes Care)
Source: Diabetes Care - January 18, 2022 Category: Endocrinology Source Type: research
Three Sides to the Story: Adherence Trajectories During the First Year of SGLT2 Inhibitor Therapy Among Medicare Beneficiaries
CONCLUSIONSIn a large population of older patients with type 2 diabetes, 45% were highly adherent during the first year of SGLT2i treatment. Female sex and Black race/ethnicity were most strongly associated with low adherence. (Source: Diabetes Care)
Source: Diabetes Care - January 18, 2022 Category: Endocrinology Source Type: research
Economic Disparities Among Pediatric Diabetic Ketoacidosis Readmissions in the U.S.
This study assessed whether there was a variation in readmissions in the pediatric population with DKA by household income in the U.S. (Source: Diabetes Care)
Source: Diabetes Care - January 18, 2022 Category: Endocrinology Source Type: research
Prediction of Major Adverse Cardiovascular Events From Retinal, Clinical, and Genomic Data in Individuals With Type 2 Diabetes: A Population Cohort Study
CONCLUSIONSRetinal parameters alone and in combination with genome-wide CHD PRS have independent and incremental prognostic value compared with traditional CV risk assessment in type 2 diabetes. (Source: Diabetes Care)
Source: Diabetes Care - January 18, 2022 Category: Endocrinology Source Type: research
Improving the Prediction of Type 1 Diabetes Across Ancestries
Prediction of type 1 diabetes (T1D) is essential for disease prevention and early interventional therapies. Genetic risk score (GRS) models developed to predict T1D have largely been determined using Eurocentric populations and applied to all individuals, regardless of race, ethnicity, or ancestry (1). Recent T1D incidence data suggest significant increases of new cases in Black, Hispanic, and Asian/Pacific Islander populations, emphasizing the need for personalized assessment strategies (2). Here, we demonstrate that a frequently used GRS model fails to recognize T1D in individuals of African descent (AFR); however, these...
Source: Diabetes Care - January 18, 2022 Category: Endocrinology Source Type: research
HbA 1c Reduction in Dulaglutide-Treated Patients Irrespective of Duration of Diabetes, Microvascular Disease, and BMI: A Post Hoc Analysis From the REWIND Trial
CONCLUSIONSDulaglutide 1.5-mg treatment was statistically associated with a long-lasting decrease in HbA1c over 72 months, irrespective of baseline duration of diabetes, microvascular disease, and BMI. (Source: Diabetes Care)
Source: Diabetes Care - January 18, 2022 Category: Endocrinology Source Type: research
