Impact of Early Life Factors on Metabolic Phenotypes of Obesity in Preschool Children
CONCLUSIONSEarly life factors, such as maternal obesity and accelerated BMI growth rate between 6 and 24 months, were related not only to MHO but also to MUO. Children with these early life factors should be given interventions for weight control to prevent metabolic abnormalities. (Source: Diabetes Care)
Source: Diabetes Care - March 16, 2023 Category: Endocrinology Source Type: research
Abatacept for Delay of Type 1 Diabetes Progression in Stage 1 Relatives at Risk: A Randomized, Double-Masked, Controlled Trial
CONCLUSIONSAlthough abatacept treatment for 1 year did not significantly delay progression to glucose intolerance in at-risk individuals, it impacted immune cell subsets and preserved insulin secretion, suggesting that costimulation blockade may modify progression of type 1 diabetes. (Source: Diabetes Care)
Source: Diabetes Care - March 15, 2023 Category: Endocrinology Source Type: research
Potential and Pitfalls of ChatGPT and Natural-Language Artificial Intelligence Models for Diabetes Education
Diabetes self-management and education (DSME) is an integral part of diabetes care and has been shown to improve glycemic control, reduce complications, and increase quality of life (1). The traditional model in which clinicians and diabetes educators share responsibility for patient education faces challenges such as reduced access to care during the pandemic and a shortage of trained educators. (Source: Diabetes Care)
Source: Diabetes Care - March 15, 2023 Category: Endocrinology Source Type: research
Novel Once-Weekly Basal Insulin Fc Achieved Similar Glycemic Control With a Safety Profile Comparable to Insulin Degludec in Patients With Type 1 Diabetes
CONCLUSIONSOnce-weekly BIF demonstrated noninferior glycemic control to once-daily degludec (treatment difference: 0.17% favoring degludec) and no difference in hypoglycemia or other safety findings in patients with T1D. (Source: Diabetes Care)
Source: Diabetes Care - March 15, 2023 Category: Endocrinology Source Type: research
Biomarker Changes Associated With Both Dulaglutide and Cardiovascular Events in the REWIND Randomized Controlled Trial: A Nested Case-Control Post Hoc Analysis
CONCLUSIONSDulaglutide was associated with a reduced 2-year rise from baseline of NT-proBNP and GDF-15. Higher rises of these biomarkers were also associated with MACE. (Source: Diabetes Care)
Source: Diabetes Care - March 10, 2023 Category: Endocrinology Source Type: research
Evaluation of the Clinical Impact of Dapagliflozin Discontinuation as Adjunctive Therapy for Patients With Type 1 Diabetes After Indication Withdrawal: A Two-Center Retrospective Study
Instituto de Salud Carlos III, Madrid, SpainCM22/00217 (Source: Diabetes Care)
Source: Diabetes Care - March 8, 2023 Category: Endocrinology Source Type: research
Incidence of LADA and Type 2 Diabetes in Relation to Tobacco Use and Genetic Susceptibility to Type 2 Diabetes and Related Traits: Findings From a Swedish Case-Control Study and the Norwegian HUNT Study
CONCLUSIONSTobacco use may confer a higher risk of LADA in individuals with genetic susceptibility to T2D and insulin resistance, whereas genetic susceptibility does not seem to influence the increased T2D incidence associated with tobacco use. (Source: Diabetes Care)
Source: Diabetes Care - March 3, 2023 Category: Endocrinology Source Type: research
Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study
CONCLUSIONSIron intake may alter the risk of IA in children with high-risk HLA haplogenotypes. (Source: Diabetes Care)
Source: Diabetes Care - March 3, 2023 Category: Endocrinology Source Type: research
Tirzepatide Reduces Appetite, Energy Intake, and Fat Mass in People With Type 2 Diabetes
CONCLUSIONSDifferences in energy intake during ad libitum lunch were not sufficient to explain the different weight outcomes. Further evaluation is needed to assess mechanistic differences related to tirzepatide actions on 24-h energy intake, substrate utilization, and energy expenditure. (Source: Diabetes Care)
Source: Diabetes Care - March 1, 2023 Category: Endocrinology Source Type: research
Distinct Mechanisms Responsible for the Increase in Glucose Production and Ketone Formation Caused by Empagliflozin in T2DM Patients
CONCLUSIONSThe decrease in plasma insulin and increase in plasma glucagon concentration caused by empagliflozin is responsible for the increase in plasma FFA concentration and ketone production. The increase in EGP caused by empagliflozin is independent of the change in plasma insulin or glucagon concentrations and is likely explained by the increase in NE turnover. (Source: Diabetes Care)
Source: Diabetes Care - March 1, 2023 Category: Endocrinology Source Type: research
An Integrated Digital Health Care Platform for Diabetes Management With AI-Based Dietary Management: 48-Week Results From a Randomized Controlled Trial
CONCLUSIONSAmong adults with T2D, use of an integrated digital health care platform with AI-driven dietary management resulted in better glycemia and more weight loss. (Source: Diabetes Care)
Source: Diabetes Care - February 23, 2023 Category: Endocrinology Source Type: research
Physical Activity and Insulin Sensitivity Independently Attenuate the Effect of FTO rs9939609 on Obesity
CONCLUSIONSGreater PA and IS independently reduced the effect of rs9939609 on obesity. These effects might be mediated through altered expression ofFTO in skeletal muscle. Our results indicated that PA and/or other means of increasing insulin sensitivity could counteractFTO-related genetic predisposition to obesity. (Source: Diabetes Care)
Source: Diabetes Care - February 21, 2023 Category: Endocrinology Source Type: research
Noninvasive Hypoglycemia Detection in People With Diabetes Using Smartwatch Data
CONCLUSIONSOur approach may allow for noninvasive hypoglycemia detection using wearables in people with diabetes and thus complement existing methods for hypoglycemia detection and warning. (Source: Diabetes Care)
Source: Diabetes Care - February 17, 2023 Category: Endocrinology Source Type: research
Association and Interaction of Genetics and Area-Level Socioeconomic Factors on the Prevalence of Type 2 Diabetes and Obesity
CONCLUSIONSGenetic and socioeconomic factors significantly interact to increase risk of T2D and obesity. Favorable area-level socioeconomic status was associated with an almost 50% lower T2D prevalence in those with high genetic risk. (Source: Diabetes Care)
Source: Diabetes Care - February 14, 2023 Category: Endocrinology Source Type: research
Erratum. 2. Classification and diagnosis of diabetes: Standards of Care in Diabetes —2023 . Diabetes Care 2023;46(Suppl. 1):S19–S40
In Table 2.3 of the article cited above, the hypertension risk factor was incorrectly defined as “≥140/90 mmHg or on therapy for hypertension”; this has been corrected to “≥130/80 or on therapy for hypertension.” More information on updated hypertension guideline recommendations can be found in Section 10 ofStandards of Care in Diabetes —2023, “Cardiovascular Disease and Risk Management” (https://doi.org/10.2337/dc23-S010). (Source: Diabetes Care)
Source: Diabetes Care - February 1, 2023 Category: Endocrinology Source Type: research
