Islet Autoantibody Type-Specific Titer Thresholds Improve Stratification of Risk of Progression to Type 1 Diabetes in Children
CONCLUSIONSThis study defined islet autoantibody type-specific titer thresholds that significantly improved type 1 diabetes risk stratification in children. (Source: Diabetes Care)
Source: Diabetes Care - November 10, 2021 Category: Endocrinology Source Type: research
Changes in the Prevalence of Symptoms of Depression, Loneliness, and Insomnia in U.S. Older Adults With Type 2 Diabetes During the COVID-19 Pandemic: The Look AHEAD Study
CONCLUSIONSThe prevalence of mild or greater depressive symptoms in older adults with diabetes was more than 1.6 times higher during COVID-19 than before the pandemic. (Source: Diabetes Care)
Source: Diabetes Care - November 9, 2021 Category: Endocrinology Source Type: research
Characteristics of Workplace Psychosocial Resources and Risk of Diabetes: A Prospective Cohort Study
CONCLUSIONSA favorable culture of collaboration, support from colleagues, leadership quality, and organizational procedural justice are associated with a lower risk of employees developing type 2 diabetes than in those without such favorable workplace psychosocial resources. (Source: Diabetes Care)
Source: Diabetes Care - November 5, 2021 Category: Endocrinology Source Type: research
Emotional Correlates of the COVID-19 Pandemic in Individuals With and Without Diabetes
CONCLUSIONSIn this naturalistic observational study, participants with type 2 diabetes reported more depression, lower resilience, and significantly more COVID-19 risk factors and medical comorbidities than participants without diabetes. Overall, our participants demonstrated worse depression and anxiety symptoms during compared with before the pandemic. (Source: Diabetes Care)
Source: Diabetes Care - November 5, 2021 Category: Endocrinology Source Type: research
Hypoglycemic and Hyperglycemic Crises Among U.S. Adults With Diabetes and End-stage Kidney Disease: Population-Based Study, 2013 –2017
CONCLUSIONSIn this nationwide study of patients with diabetes/ESKD, hypoglycemic crises were threefold more common than hyperglycemic crises, greatly exceeding national reports in nondialysis patients with chronic kidney disease. Young, Black, and female patients were disproportionately affected. (Source: Diabetes Care)
Source: Diabetes Care - November 5, 2021 Category: Endocrinology Source Type: research
Body Fat Distribution, Cardiometabolic Traits, and Risk of Major Lower-Extremity Arterial Disease in Postmenopausal Women
CONCLUSIONSAmong U.S. postmenopausal women, a positive association of upper-body fat with risk of LEAD appeared to be attributable to traditional risk factors, especially insulin resistance. Lower-body fat was inversely associated with risk of LEAD beyond known risk factors. (Source: Diabetes Care)
Source: Diabetes Care - November 3, 2021 Category: Endocrinology Source Type: research
Relationships of Changes in Physical Activity and Sedentary Behavior With Changes in Physical Fitness and Cardiometabolic Risk Profile in Individuals With Type 2 Diabetes: The Italian Diabetes and Exercise Study 2 (IDES_2)
CONCLUSIONSEven modest increments in MVPA may have a clinically meaningful impact, and reallocating SED-time to LPA may also contribute to improved outcomes, possibly by increasing total energy expenditure. (Source: Diabetes Care)
Source: Diabetes Care - November 2, 2021 Category: Endocrinology Source Type: research
Diabetic Peripheral Neuropathy and Urological Complications in Type 1 Diabetes: Findings From the Epidemiology of Diabetes Interventions and Complications Study
CONCLUSIONSIn long-standing T1D, DPN is associated with the later development of urological complications in men. (Source: Diabetes Care)
Source: Diabetes Care - November 2, 2021 Category: Endocrinology Source Type: research
The Impact of Racial and Ethnic Health Disparities in Diabetes Management on Clinical Outcomes: A Reinforcement Learning Analysis of Health Inequity Among Youth and Young Adults in the SEARCH for Diabetes in Youth Study
CONCLUSIONSMathematically modeling an equalized distribution of T1D self-management tools and technology accounted for part of but not all disparities in glycemic control between non-White and White YYA, underscoring the complexity of race and ethnicity-based health inequity. (Source: Diabetes Care)
Source: Diabetes Care - November 2, 2021 Category: Endocrinology Source Type: research
Remission of Type 2 Diabetes Following a Short-term Intensive Intervention With Insulin Glargine, Sitagliptin, and Metformin: Results of an Open-label Randomized Parallel-Design Trial
CONCLUSIONSAlthough our primary outcome was not statistically significant, the tested approach deserves further study with further optimization of its components. (Source: Diabetes Care)
Source: Diabetes Care - November 2, 2021 Category: Endocrinology Source Type: research
Empagliflozin Improves Insulin Sensitivity of the Hypothalamus in Humans With Prediabetes: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Trial
CONCLUSIONSOur results corroborate insulin resistance of the hypothalamus in humans with prediabetes. Treatment with empagliflozin for 8 weeks was able to restore hypothalamic insulin sensitivity, a favorable response that could contribute to the beneficial effects of SGLT2 inhibitors. Our findings position SGLT2 inhibition as the first pharmacological approach to reverse brain insulin resistance, with potential benefits for adiposity and whole-body metabolism. (Source: Diabetes Care)
Source: Diabetes Care - October 29, 2021 Category: Endocrinology Source Type: research
Cluster Analysis of Cardiovascular Phenotypes in Patients With Type 2 Diabetes and Established Atherosclerotic Cardiovascular Disease: A Potential Approach to Precision Medicine
CONCLUSIONSIn patients with T2DM and ASCVD, cluster analysis identified four clinically distinct groups. Further cardiovascular phenotyping is warranted to inform patient care and optimize clinical trial designs. (Source: Diabetes Care)
Source: Diabetes Care - October 29, 2021 Category: Endocrinology Source Type: research
Traveling Across Time Zones With Type 1 Diabetes: A Pilot Study Comparing Insulin Degludec With Insulin Glargine U100
CONCLUSIONSIn adults with type 1 diabetes using MDI of insulin and traveling across multiple time zones, glycemic outcomes were similar comparing insulin degludec and glargine U100. (Source: Diabetes Care)
Source: Diabetes Care - October 28, 2021 Category: Endocrinology Source Type: research
Risk of Incident Dementia According to Glycemic Status and Comorbidities of Hyperglycemia: A Nationwide Population-Based Cohort Study
CONCLUSIONSMild degrees of hyperglycemia and presence of comorbidities were associated with incident dementia. Intervention during the prodromal stage of a chronic disease (e.g., prediabetes) could be considered for dementia prevention. (Source: Diabetes Care)
Source: Diabetes Care - October 28, 2021 Category: Endocrinology Source Type: research
High-Normal Protein Intake Is Not Associated With Faster Renal Function Deterioration in Patients With Type 2 Diabetes: A Prospective Analysis in the DIALECT Cohort
CONCLUSIONSIn patients with T2D, unrestricted dietary protein intake was not associated with an increased hazard of renal function deterioration. Therefore, substituting carbohydrates with dietary protein is not contraindicated as a part of T2D management, although it may have a positive effect on body weight while minimizing loss of muscle mass. (Source: Diabetes Care)
Source: Diabetes Care - October 28, 2021 Category: Endocrinology Source Type: research
