Polygenic Prediction of Type 2 Diabetes in Africa
CONCLUSIONSAfrican American –derived PRS enhances polygenic prediction of T2D in continental Africans. Improved representation of non-European populations (including Africans) in GWAS promises to provide better tools for precision medicine interventions in T2D. (Source: Diabetes Care)
Source: Diabetes Care - January 11, 2022 Category: Endocrinology Source Type: research
Beliefs Around Hypoglycemia and Their Impacts on Hypoglycemia Outcomes in Individuals with Type 1 Diabetes and High Risks for Hypoglycemia Despite Using Advanced Diabetes Technologies
CONCLUSIONSDespite the use of advanced diabetes technologies, severe and level 2 hypoglycemia continues to occur in individuals with type 1 diabetes and high hypoglycemia risks. Human factors, including beliefs around hypoglycemia, may continue to impact the effectiveness of glucose self-management. (Source: Diabetes Care)
Source: Diabetes Care - January 11, 2022 Category: Endocrinology Source Type: research
Cost-Related Medication Nonadherence in Adults With Diabetes in the United States: The National Health Interview Survey 2013 –2018
CONCLUSIONSIn the U.S., one in six nonelderly and one in 14 elderly adults with diabetes reported CRN. Removing financial barriers to accessing medications may improve medication adherence among these patients, with the potential to improve their outcomes. (Source: Diabetes Care)
Source: Diabetes Care - January 11, 2022 Category: Endocrinology Source Type: research
Interplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial
CONCLUSIONSConcurrently high endogenous melatonin and carbohydrate intake, as typical for late eating, impairs glucose tolerance, especially inMTNR1B G-risk allele carriers, attributable to insulin secretion defects. (Source: Diabetes Care)
Source: Diabetes Care - January 11, 2022 Category: Endocrinology Source Type: research
Diabetes Distress in Young Adults With Youth-Onset Type 2 Diabetes: TODAY2 Study Results
CONCLUSIONSFuture research should identify modifiable factors associated with high diabetes distress in young adults with youth-onset type 2 diabetes that may inform distress interventions with this medically vulnerable group. (Source: Diabetes Care)
Source: Diabetes Care - January 11, 2022 Category: Endocrinology Source Type: research
Erratum. 11. Chronic Kidney Disease and Risk Management: Standards of Medical Care in Diabetes —2022 . Diabetes Care 2022;45(Suppl. 1): S175–S184
In the article cited above, Recommendation 11.3c stated “In patients with chronic kidney disease who are at increased risk for cardiovascular events or chronic kidney disease progression and are unable to use a sodium–glucose cotransporter 2 inhibitor, a nonsteroidal mineralocorticoid receptor antagonist (finerenone) is recommended to reduce chronic kidney disease progression and cardiovascular events.” The correct text is “In patients with chronic kidney disease who are at increased risk for cardiovascular events or chronic kidney disease progression or are unable to use a sodium–glucose cotransporter 2 inhibito...
Source: Diabetes Care - December 29, 2021 Category: Endocrinology Source Type: research
Glycemic Control and Risk of Sepsis and Subsequent Mortality in Type 2 Diabetes
CONCLUSIONSIn a nationwide cohort of individuals with type 2 diabetes, we found a U-shaped association between HbA1c and sepsis and a fourfold increased risk of death among those developing sepsis. (Source: Diabetes Care)
Source: Diabetes Care - December 28, 2021 Category: Endocrinology Source Type: research
Effect of Fenofibrate Therapy on Laser Treatment for Diabetic Retinopathy: A Meta-Analysis of Randomized Controlled Trials
Diabetic eye disease (retinopathy and maculopathy) remains a leading cause of blindness and impaired vision, and it is also the only major cause that is increasing in most regions of the world (1). While good control of blood glucose and blood pressure modestly reduces the risk and progression of microvascular disease, these approaches can be difficult to achieve, require monitoring, and may have undesired side effects. Fenofibrate is an inexpensive lipid-modifying agent that activates the peroxisome proliferator –activated receptor α, thereby lowering circulating triglycerides and modestly raising HDL cholesterol. A hy...
Source: Diabetes Care - December 28, 2021 Category: Endocrinology Source Type: research
Response to Comment on Liu et al. Incidence of Type 1 Diabetes May Be Underestimated in the Chinese Population: Evidence From 21.7 Million People Between 2007 and 2017. Diabetes Care 2021;44:2503 –2509
We thank Weng et al. (1) for their interest in our article regarding the incidence of type 1 diabetes (T1D) in the Chinese population (2). Such epidemiologic data are important from clinical practice and policy perspectives, while comprehensive population-based estimates of T1D incidence rates and trends are still limited in China (3–5). (Source: Diabetes Care)
Source: Diabetes Care - December 28, 2021 Category: Endocrinology Source Type: research
Response to Comment on Shih et al. Increased Incidence of Pediatric Type 1 Diabetes With Novel Association With Coxsackievirus A Species in Young Children but Declined Incidence in Adolescents in Taiwan. Diabetes Care 2021;44:1579 –1585
We appreciate the comments from Dr. Yen and Dr. Wei (1). Here is our response to their concerns. First, we agree that the yearly positive isolation numbers of enterovirus (EV) serotypes from 2001 to 2015 from the nationwide laboratory surveillance system of the Taiwan Centers for Disease Control show no decreasing trend (2). This laboratory surveillance system selected some patients with respiratory tract infections or hand, foot, and mouth disease to perform viral isolation and reported the most common circulating viruses in Taiwan, but the isolation numbers of EV did not reflect the EV incidence of the general population...
Source: Diabetes Care - December 28, 2021 Category: Endocrinology Source Type: research
Comment on Liu et al. Incidence of Type 1 Diabetes May Be Underestimated in the Chinese Population: Evidence From 21.7 Million People Between 2007 and 2017. Diabetes Care 2021;44:2503 –2509
We read the article by Dr. Liu et al. (1) with great interest and thank the authors for their reference to our study (2). As academic physicians of type 1 diabetes (T1D), we welcome discussion to further our collective understanding of the disease to work toward positive outcomes for patients and better inform policy-setting in public health. (Source: Diabetes Care)
Source: Diabetes Care - December 28, 2021 Category: Endocrinology Source Type: research
The Noble and Often Nobel Role Played by Insulin-Focused Research in Modern Medicine
Since diabetes was first described over 3,000 years ago, clinicians and scientists alike have sought ever improving treatments en route to a cure. As we approach the 100th anniversary of insulin ’s first therapeutic use, this article will recount the glorious history associated with research surrounding insulin’s isolation, purification, cloning, and subsequent modification. The discovery path we will relate tells the story of many relentless and passionate investigators pursuing ground -breaking research. The fruits of their labor include several Nobel Prizes, new technology, and, more importantly, ever improving trea...
Source: Diabetes Care - December 28, 2021 Category: Endocrinology Source Type: research
Issues and Events
(Source: Diabetes Care)
Source: Diabetes Care - December 28, 2021 Category: Endocrinology Source Type: research
Response to Comment on Hamblin et al. Capillary Ketone Concentrations at the Time of Colonoscopy: A Cross-Sectional Study With Implications for SGLT2 Inhibitor –Treated Type 2 Diabetes. Diabetes Care 2021;44:e124–e126
We thank Dr. Thiruvenkatarajan et al. (1) for their interest in our article (2). In developing the reference interval for blood ketone concentrations, we used the widely cited approved recommendation from the International Federation of Clinical Chemistry (IFCC) Expert Panel for dealing with nonparametric data by using the central 95% of the data set (3). We have strong concerns that referencing an opinion piece published in theWikiJournal of Medicine should form the basis for departing from this internationally accepted methodology for establishing reference intervals. (Source: Diabetes Care)
Source: Diabetes Care - December 28, 2021 Category: Endocrinology Source Type: research
The Life and Times of Dr. Robert Sherwin, One of the Greatest of Great Diabetes Investigators
I did not know Dr. Sherwin until 1975, when I began my fellowship in endocrinology at Yale University. However, I later learned of Bob ’s lovely family, which consisted of his mother (Frieda Sherwin) and father (Harold Sherwin) as well as his very accomplished brother, Dr. Paul Sherwin (an English professor at City College in New York City). Bob had many outstanding accomplishments as a trainee prior to his time at Yale. Perhaps his greatest accomplishment was as a star on his high school baseball team, which won the city championship in Yankee Stadium. As he is a Yankees fan, I have no doubt that this was Bob’s most o...
Source: Diabetes Care - December 28, 2021 Category: Endocrinology Source Type: research
