Comment on Celis-Morales et al. Type 2 Diabetes, Glycemic Control, and Their Association With Dementia and Its Major Subtypes: Findings From the Swedish National Diabetes Register. Diabetes Care 2022;45:634 –641

The risk for Alzheimer disease was lower in patients with type 2 diabetes than in control subjects (hazard ratio 0.94 [95% CI 0.90, 0.99]) but might result in patients with type 2 diabetes dying earlier than control subjects, which was observed by Celis-Morales et al. (1) in a real-world prospective cohort with a large sample of individuals with type 2 diabetes and 7-year follow-up. We recommend that authors incorporate the death event as a competing risk in the Cox regression, which might clarify whether or to what extent type 2 diabetes contributes to the incident Alzheimer disease.
Source: Diabetes Care - Category: Endocrinology Source Type: research