Glyburide Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Probable Treatment Targets for Diabetic Retinopathy Based on an Integrated Proteomic and Genomic Analysis
CONCLUSIONS: The bioinformatics pipeline described here identifies FDA-approved drugs that can be used for new alternative indications. These theoretical candidate drugs should be validated with experimental studies.TRANSLATIONAL RELEVANCE: Our study suggests possible drugs for DR treatment based on an integrated proteomics and genomics pipeline. This approach can potentially expedite the drug discovery process by identifying already-approved drugs that might be used for new indications.PMID:36745438 | DOI:10.1167/tvst.12.2.8 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - February 6, 2023 Category: Genetics & Stem Cells Authors: Anddre Osmar Valdivia Ye He Xinjun Ren Dejia Wen Lijie Dong Hossein Nazari Xiaorong Li Source Type: research

Molecules, Vol. 28, Pages 746: Signal Suppression in LC-ESI-MS/MS from Concomitant Medications and Its Impact on Quantitative Studies: An Example Using Metformin and Glyburide
This study provided an example model to illustrate the possible effect of clinical drug combination on LC-MS/MS drug quantitative analysis and investigated the effective methods to solve this problem. (Source: Molecules)
Source: Molecules - January 11, 2023 Category: Chemistry Authors: Liu Jiang Lu Zhang Liu Huang Zhong Tags: Article Source Type: research

[ASAP] The Rat Continuous Intestine Model Predicts the Impact of Particle Size and Transporters on the Oral Absorption of Glyburide
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.2c00597 (Source: Molecular Pharmaceutics)
Source: Molecular Pharmaceutics - December 21, 2022 Category: Drugs & Pharmacology Authors: Swati Nagar, Casey Radice, Robert Tuohy, Raymond Stevens, Dale Bennyhoff, and Ken Korzekwa Source Type: research

[ < sup > 11 < /sup > C]glyburide PET imaging for quantitative determination of the importance of Organic Anion-Transporting Polypeptide transporter function in the human liver and whole-body
Biomed Pharmacother. 2022 Dec;156:113994. doi: 10.1016/j.biopha.2022.113994. Epub 2022 Nov 9.ABSTRACTOrganic Anion-Transporting Polypeptides (OATPs) are known to control the liver uptake of many drugs. Non-hepatic expression of OATPs has been reported although functional importance for whole-body pharmacokinetics (WBPK) remains unknown. Glyburide is a well described substrate of several hepatic and non-hepatic OATPs. Dynamic whole-body positron emission tomography (DWB-PET) with [11C]glyburide was performed in humans for determination of the importance of OATPs for liver uptake and WBPK. Seven healthy male subjects (24.7 �...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 22, 2022 Category: Drugs & Pharmacology Authors: Sol ène Marie Louise Breuil Zacharias Chalampalakis Laurent Becquemont C éline Verstuyft Anne-Lise Lecoq Fabien Caill é Philippe Gervais Vincent Lebon Claude Comtat Michel Bottlaender Nicolas Tournier Source Type: research

Incidence of gestational diabetes diagnosed on the 100g glucose tolerance test in pregnancies with a 50g glucose challenge test result of 200mg/dL or greater.
Conclusion: A GCT result of ≥200mg/dL has a positive predictive value of 81% for diagnosis of GDM by GTT in a contemporary US population, with a median inter-test interval of 14 days between GCT and GTT. However, those diagnosed by GCT alone were as likely as those diagnosed by GTT to require medication for glycemic control, including insulin, suggesting that requiring a GTT may result in under-diagnosis and delayed treatment of GDM. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor , NY 10001 New York, USAArticle in Thieme eJournals: Table of contents | Abstract (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - August 23, 2022 Category: Perinatology & Neonatology Authors: Lord, Megan Grace Agee, Robert L Sood, Nikki Clark, Melissa Johnson, Isaiah M Tags: SMFM Fellowship Series Article Source Type: research

Incidence of Gestational Diabetes Diagnosed on the 100-G Glucose Tolerance Test in Pregnancies with a 50-G Glucose Challenge Test Result of 200 mg/dL or Greater
Conclusion A GCT result of ≥200 mg/dL has a PPV of 81% for diagnosis of GDM by GTT in a contemporary U.S. population, with a median intertest interval of 14 days between GCT and GTT. However, those diagnosed by GCT alone were as likely as those diagnosed by GTT to require medication for glycemic control, including insulin, suggesting that requiring a GTT may result in underdiagnosis and delayed treatment of GDM. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: A...
Source: American Journal of Perinatology - August 23, 2022 Category: Perinatology & Neonatology Authors: Lord, Megan G. Agee, Robert L. Sood, Nikki Clark, Melissa Johnson, Isaiah M. Tags: SMFM Fellows Research Series Source Type: research

Convergence of Fructose-Induced NLRP3 Activation with Oxidative Stress and ER Stress Leading to Hepatic Steatosis
AbstractHigh fructose flux enhances hepatocellular triglyceride accumulation (hepatic steatosis), which is a prime trigger in the emergence of hepatic ailments. Nevertheless, the pathophysiology underlying the process is not completely understood. Emerging evidences have revealed the inputs from multiple cues including inflammation, oxidative stress, and endoplasmic reticulum (ER) stress in the development of hepatic steatosis. Here, we substantiated the role of NLRP3 inflammasome and its convergence with oxidative and ER stress leading to hepatic steatosis under high fructose diet feeding. Male SD rats were fed on 60% hig...
Source: Inflammation - August 9, 2022 Category: Allergy & Immunology Source Type: research

Comparison of neonatal and maternal outcomes of anti-diabetic drugs in the treatment of gestational diabetes mellitus: Findings from Bayesian network meta-analysis
J Family Med Prim Care. 2022 May;11(5):1610-1618. doi: 10.4103/jfmpc.jfmpc_1319_21. Epub 2022 May 14.ABSTRACTThe safety and efficacy of different anti-diabetic drugs are not clear because of the lack of sufficiently powered clinical trials. This network meta-analysis was conducted to compare the efficacy and safety of three anti-diabetic drugs (insulin, glyburide, and metformin), and rank them as per their efficiency to control glucose levels, pregnancy, and neonatal outcomes. The study design is a systematic review, meta-analysis, and network meta-analysis. After a systematic search of existing databases, 34 randomized co...
Source: Primary Care - July 8, 2022 Category: Primary Care Authors: Mandar K Shah Mihika A Shah Sharan D Shah Parshwa K Shah Kaushal Patel Mamta Gupta Source Type: research

The inflammasome pathway: A key player in ocular surface and anterior segment diseases
Inflammasomes are multicomplex molecular regulators with an emerging importance in regulating ocular surface and anterior segment health and disease. Key components found in the eye include NF- κB, NLRP3, NLRC4, NLRP6, ASC, IL-1β, IL-18, and caspase-1. The role of NLRP1, NLRC4, AIM2, and NLRP3 inflammasomes in the pathogenesis of infectious ulcers, DED, uveitis, glaucoma, corneal edema, and other diseases is being studied with many developments. Attenuation of these diseases has been exp lored by blocking various molecules along the inflammasome pathway with agents like NAC, polydatin, calcitriol, glyburide, YVAD, and di...
Source: Survey of Ophthalmology - July 4, 2022 Category: Opthalmology Authors: Jordan T. Mandell, Juan Pablo de Rivero Vaccari, Alfonso L. Sabater, Anat Galor Tags: Review article Source Type: research