Gestational diabetes: Implications for fetal growth, intervention timing, and treatment options
Curr Opin Pharmacol. 2021 Jul 13;60:1-10. doi: 10.1016/j.coph.2021.06.003. Online ahead of print.ABSTRACTMaternal gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy, which can adversely affect the short- and long-term health of mothers and newborns. In recent years, several studies have revealed the early impact of maternal hyperglycemia on fetal growth trajectory and birth weight abnormalities in GDM-exposed pregnancies. However, an intense debate continues regarding the mode and optimal timing of diagnosis and treatment of this condition. The purpose of this review is to prov...
Source: Current Opinion in Pharmacology - July 19, 2021 Category: Drugs & Pharmacology Authors: Maria Mirabelli Eusebio Chiefari Vera Tocci Emanuela Greco Daniela Foti Antonio Brunetti Source Type: research

Gestational diabetes: Implications for fetal growth, intervention timing, and treatment options
Curr Opin Pharmacol. 2021 Jul 13;60:1-10. doi: 10.1016/j.coph.2021.06.003. Online ahead of print.ABSTRACTMaternal gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy, which can adversely affect the short- and long-term health of mothers and newborns. In recent years, several studies have revealed the early impact of maternal hyperglycemia on fetal growth trajectory and birth weight abnormalities in GDM-exposed pregnancies. However, an intense debate continues regarding the mode and optimal timing of diagnosis and treatment of this condition. The purpose of this review is to prov...
Source: Current Opinion in Pharmacology - July 19, 2021 Category: Drugs & Pharmacology Authors: Maria Mirabelli Eusebio Chiefari Vera Tocci Emanuela Greco Daniela Foti Antonio Brunetti Source Type: research

Gestational diabetes: Implications for fetal growth, intervention timing, and treatment options
Curr Opin Pharmacol. 2021 Jul 13;60:1-10. doi: 10.1016/j.coph.2021.06.003. Online ahead of print.ABSTRACTMaternal gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy, which can adversely affect the short- and long-term health of mothers and newborns. In recent years, several studies have revealed the early impact of maternal hyperglycemia on fetal growth trajectory and birth weight abnormalities in GDM-exposed pregnancies. However, an intense debate continues regarding the mode and optimal timing of diagnosis and treatment of this condition. The purpose of this review is to prov...
Source: Current Opinion in Pharmacology - July 19, 2021 Category: Drugs & Pharmacology Authors: Maria Mirabelli Eusebio Chiefari Vera Tocci Emanuela Greco Daniela Foti Antonio Brunetti Source Type: research

Gestational diabetes: Implications for fetal growth, intervention timing, and treatment options
Curr Opin Pharmacol. 2021 Jul 13;60:1-10. doi: 10.1016/j.coph.2021.06.003. Online ahead of print.ABSTRACTMaternal gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy, which can adversely affect the short- and long-term health of mothers and newborns. In recent years, several studies have revealed the early impact of maternal hyperglycemia on fetal growth trajectory and birth weight abnormalities in GDM-exposed pregnancies. However, an intense debate continues regarding the mode and optimal timing of diagnosis and treatment of this condition. The purpose of this review is to prov...
Source: Current Opinion in Pharmacology - July 19, 2021 Category: Drugs & Pharmacology Authors: Maria Mirabelli Eusebio Chiefari Vera Tocci Emanuela Greco Daniela Foti Antonio Brunetti Source Type: research

Effectiveness of antidiabetic agents for treatment of gestational diabetes: A methodological quality assessment of meta ‐analyses and network meta‐analysis
ConclusionsThis review study of available literature shows that metformin can be a superior option in most neonatal and maternal adverse pregnancy outcomes in women with gestational diabetes mellitus; the results need to be further updated by including future more qualified studies. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - June 24, 2021 Category: Endocrinology Authors: Razieh Bidhendi Yarandi, Mina Amiri, Fahimeh Ramezani Tehrani, Samira Behboudi ‐Gandevani Tags: Original Article Source Type: research

Study of the correlation between the noncanonical pathway of pyroptosis and idiopathic inflammatory myopathy
CONCLUSION: Our results suggest that the noncanonical pathway of pyroptosis may be involved in the pathogenesis of IIM, and glyburide and BBG exert certain intervention effects on its pathogenesis.PMID:34116285 | DOI:10.1016/j.intimp.2021.107810 (Source: International Immunopharmacology)
Source: International Immunopharmacology - June 11, 2021 Category: Allergy & Immunology Authors: Miao Ma Kexia Chai Rui Deng Source Type: research

Effectiveness of anti ‐diabetic agents for treatment of gestational diabetes: A methodological quality assessment of meta‐analyses and network meta‐analysis
ConclusionsThis review study of available literature shows that metformin can be a superior option in most neonatal and maternal adverse pregnancy outcomes in women with GDM; results need to be further updated by including future more qualified studies. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 27, 2021 Category: Endocrinology Authors: Razieh Bidhendi Yarandi, Mina Amiri, Fahimeh Ramezani Tehrani, Samira Behboudi ‐Gandevani Tags: ORIGINAL ARTICLE Source Type: research

Comparison of Insulin, Metformin, and Glyburide on Perinatal Complications of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis
Conclusions: This review suggests that metformin can decrease the incidence of perinatal complications, and it should be considered as a generally safe alternative to insulin.Gynecol Obstet Invest (Source: Gynecologic and Obstetric Investigation)
Source: Gynecologic and Obstetric Investigation - May 12, 2021 Category: OBGYN Source Type: research

Cancers, Vol. 13, Pages 2344: Photosensitizing Medications and Skin Cancer: A Comprehensive Review
unyoung Cho (1) The incidence of skin cancer is increasing in the United States (US) despite scientific advances in our understanding of skin cancer risk factors and treatments. In vitro and in vivo studies have provided evidence that suggests that certain photosensitizing medications (PSMs) increase skin cancer risk. This review summarizes current epidemiological evidence on the association between common PSMs and skin cancer. (2) A comprehensive literature search was conducted to identify meta-analyses, observational studies and clinical trials that report on skin cancer events in PSM users. The associated risks of k...
Source: Cancers - May 12, 2021 Category: Cancer & Oncology Authors: Elisabeth A. George Navya Baranwal Jae H. Kang Abrar A. Qureshi Aaron M. Drucker Eunyoung Cho Tags: Review Source Type: research

siGCD: a web server to explore survival interaction of genes, cells and drugs in human cancers
Brief Bioinform. 2021 Apr 5:bbab058. doi: 10.1093/bib/bbab058. Online ahead of print.ABSTRACTIt is pivotal and remains challenge for cancer precision treatment to identify the survival outcome interactions between genes, cells and drugs. Here, we present siGCD, a web-based tool for analysis and visualization of the survival interaction of Genes, Cells and Drugs in human cancers. siGCD utilizes the cancer heterogeneity to simulate the manipulated gene expression, cell infiltration and drug treatment, which overcomes the data and experimental limitations. To illustrate the performance of siGCD, we identified the survival int...
Source: Briefings in Bioinformatics - April 6, 2021 Category: Bioinformatics Authors: XiuLiang Cui Lu Han Yang Liu Ying Li Wen Sun Bin Song Wenxia Zhou Yongxiang Zhang Hongyang Wang Source Type: research

siGCD: a web server to explore survival interaction of genes, cells and drugs in human cancers
Brief Bioinform. 2021 Apr 5:bbab058. doi: 10.1093/bib/bbab058. Online ahead of print.ABSTRACTIt is pivotal and remains challenge for cancer precision treatment to identify the survival outcome interactions between genes, cells and drugs. Here, we present siGCD, a web-based tool for analysis and visualization of the survival interaction of Genes, Cells and Drugs in human cancers. siGCD utilizes the cancer heterogeneity to simulate the manipulated gene expression, cell infiltration and drug treatment, which overcomes the data and experimental limitations. To illustrate the performance of siGCD, we identified the survival int...
Source: Briefings in Bioinformatics - April 6, 2021 Category: Bioinformatics Authors: XiuLiang Cui Lu Han Yang Liu Ying Li Wen Sun Bin Song Wenxia Zhou Yongxiang Zhang Hongyang Wang Source Type: research

siGCD: a web server to explore survival interaction of genes, cells and drugs in human cancers
Brief Bioinform. 2021 Apr 5:bbab058. doi: 10.1093/bib/bbab058. Online ahead of print.ABSTRACTIt is pivotal and remains challenge for cancer precision treatment to identify the survival outcome interactions between genes, cells and drugs. Here, we present siGCD, a web-based tool for analysis and visualization of the survival interaction of Genes, Cells and Drugs in human cancers. siGCD utilizes the cancer heterogeneity to simulate the manipulated gene expression, cell infiltration and drug treatment, which overcomes the data and experimental limitations. To illustrate the performance of siGCD, we identified the survival int...
Source: Briefings in Bioinformatics - April 6, 2021 Category: Bioinformatics Authors: XiuLiang Cui Lu Han Yang Liu Ying Li Wen Sun Bin Song Wenxia Zhou Yongxiang Zhang Hongyang Wang Source Type: research

BIIB093 (intravenous glibenclamide) for the prevention of severe cerebral edema
CONCLUSION: Studies analyzing the GAMES-Pilot and GAMES-PR trials suggest that glibenclamide has a moderate, however, measurable effect on intermediate biomarkers and clinical endpoints. Meaningful conclusions are limited by the small sample size of patients studied.PMID:33767884 | PMC:PMC7982107 | DOI:10.25259/SNI_933_2020 (Source: Surgical Neurology International)
Source: Surgical Neurology International - March 26, 2021 Category: Neurosurgery Authors: Daniel W Griepp Jason Lee Christina M Moawad Cyrus Davati Juliana Runnels Brian Fiani Source Type: research