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Effect of asiaticoside on systolic blood pressure and relaxation of isolated thoracic aorta of rats
CONCLUSION: Asiaticoside induces thoracic aorta relaxation by mediating high-conductance calcium-activated potassium channel opening, promoting nitric oxide release from endothelial cells and regulating Ca2+ influx and outflow, thereby reducing systolic blood pressure in rats.PMID:38597444 | PMC:PMC11006695 | DOI:10.12122/j.issn.1673-4254.2024.03.14 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: G Lu H Sun Z Sun L Liu L Wang N Zhang Y Wang Y He J Ji X Li P Kang B Tang Source Type: research

Effect of asiaticoside on systolic blood pressure and relaxation of isolated thoracic aorta of rats
CONCLUSION: Asiaticoside induces thoracic aorta relaxation by mediating high-conductance calcium-activated potassium channel opening, promoting nitric oxide release from endothelial cells and regulating Ca2+ influx and outflow, thereby reducing systolic blood pressure in rats.PMID:38597444 | DOI:10.12122/j.issn.1673-4254.2024.03.14 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: G Lu H Sun Z Sun L Liu L Wang N Zhang Y Wang Y He J Ji X Li P Kang B Tang Source Type: research

A loss-of-function mutation in KCNJ11 causing sulfonylurea-sensitive diabetes in early adult life
Conclusions/interpretationOur data support the increasing evidence that individuals with mild loss-of-function KATP channel mutations may develop insulin deficiency in early adulthood and even frank diabetes in middle age. In this case, the patient may have had hyperinsulinism that escaped detection in early life. Our results support the importance of functional analysis of KATP channel mutations in cases of atypical diabetes.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - March 24, 2024 Category: Endocrinology Source Type: research

Encyclopaedic Review of Glipizide Pre-clinical and Clinical Status
In conclusion, glipizide has shown promising therapeutic efficacy across a variety of disorders. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - February 26, 2024 Category: Drugs & Pharmacology Authors: Mohammad, Saad Mahmood, Tarique Shamim, Arshiya Ahsan, Farogh Shariq, Mohammad Parveen, Saba Waseem, Rufaida Singh, Aditya Tags: Review Source Type: research

A loss-of-function mutation in KCNJ11 causing sulfonylurea-sensitive diabetes in early adult life
Conclusions/interpretationOur data support the increasing evidence that individuals with mild loss-of-function KATP channel mutations may develop insulin deficiency in early adulthood and even frank diabetes in middle age. In this case, the patient may have had hyperinsulinism that escaped detection in early life. Our results support the importance of functional analysis of KATP channel mutations in cases of atypical diabetes.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - February 17, 2024 Category: Endocrinology Source Type: research

Patient In-Use Stability Testing of FDA-Approved Metformin Combination Products for N-Nitrosamine Impurity
In conclusion, in-use stability study provides quality and safety risk assessment of drug products where nitroso impurities are detected in the probable condition of use.PMID:38267707 | DOI:10.1208/s12249-023-02724-3 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - January 24, 2024 Category: Drugs & Pharmacology Authors: Sathish Dharani Eman M Mohamed Ziyaur Rahman Mansoor A Khan Source Type: research

Successful Prediction of Fetal Exposure to Dual BCRP/P-gp Drug Substrates Using the Efflux Ratio-Relative Expression Factor Approach and PBPK M & amp;S
Clin Pharmacol Ther. 2023 Dec 20. doi: 10.1002/cpt.3157. Online ahead of print.ABSTRACTTo inform fetal drug safety, it is important to determine or predict fetal drug exposure throughout pregnancy. The former is not possible in the 1st or 2nd trimester. In contrast, at the time of birth, fetal drug exposure, relative to maternal exposure, can be estimated as Kp,uu (unbound fetal umbilical venous [UV] plasma AUC/unbound maternal plasma [MP] AUC), provided the observed UV/MP values, spanning the dosing interval, are available from multiple maternal-fetal dyads. However, this fetal Kp,uu cannot be extrapolated to other drugs....
Source: Clinical Pharmacology and Therapeutics - December 21, 2023 Category: Drugs & Pharmacology Authors: Ankit Balhara Mengyue Yin Jashvant D Unadkat Source Type: research