Genetic and clinical heterogeneity of permanent neonatal diabetes mellitus: a single tertiary centre experience
ConclusionsPNDM is a heterogenous disease with variable genotypes and clinical phenotypes among Egyptian patients.EIF2AK3, INS,ABCC8, and KCNJ11 mutations were the commonest causes of PNDM in the study cohort. All patients with KATP channel mutations were effectively treated with glyburide, reflecting the fact that genetic testing for patients with NDM is not only important for diagnosis but also for treatment plan and prognosis. (Source: Acta Diabetologica)
Source: Acta Diabetologica - December 1, 2021 Category: Endocrinology Source Type: research
Vibrio alginolyticus Triggers Inflammatory Response in Mouse Peritoneal Macrophages via Activation of NLRP3 Inflammasome
In this study, an in vitro model of mouse peritoneal macrophages infected with V. alginolyticus was established. qPCR results revealed that V. alginolyticus induced the transcription levels of various cytokines, including IL-1β, IL-12, IL-18, TNF-α, IL-17, IL-6, IFN-γ, and IL-10, and the secretion level of IL-1β is the most significant. Inhibition assays with Ac-YVAD-CHO (a caspase-1 inhibitor) and Z-VAD-FMK (a pan-caspase inhibitor) were conducted to determine whether caspase-1 or caspase-11 is involved in V. alginolyticus-triggered IL-1β secretion. Results showed that IL-1β secretion was partly inhibited by Ac-YVAD...
Source: Frontiers in cellular and infection microbiology - November 16, 2021 Category: Microbiology Source Type: research
Correlates of Insulin Selection as a First-Line Pharmacological Treatment for Gestational Diabetes
Conclusion Women of Hispanic ethnicity and women with no insurance were less likely to receive insulin and more likely to receive oral antidiabetic medication for GDM pharmacotherapy, while management by endocrinology was associated with higher odds of insulin prescription.This finding deserves more investigation to understand if differences are due to patient choice or a health disparity in the choice of pharmacologic agent for A2GDM.
Key Points
[...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | ...
Source: American Journal of Perinatology - November 10, 2021 Category: Perinatology & Neonatology Authors: Palatnik, Anna Harrison, Rachel K. Thakkar, Madhuli Y. Walker, Rebekah J. Egede, Leonard E. Tags: Original Article Source Type: research
Early Diagnosis of Prediabetes Among Pregnant Women that Develop Gestational Diabetes Mellitus and Its Influence on Perinatal Outcomes
Conclusion: Women identified as having early impaired glucose tolerance consistent with prediabetes that subsequently develop gestational diabetes are more likely to be prescribed insulin treatment and may be at increased risk of adverse neonatal outcomes leading to NICU admission than women with negative first trimester diabetes screening. Future studies should focus on whether different methods of early treatment and/or intervention improve perinatal outcomes.
[...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor , NY 10001 New York, USAArticle in Thieme eJournals: Table of contents | Abstract (Sou...
Source: American Journal of Perinatology - October 28, 2021 Category: Perinatology & Neonatology Authors: Wilkie, Gianna Delpapa, Ellen Leftwich, Heidi K Tags: Original Article Source Type: research
Genetic and clinical heterogeneity of permanent neonatal diabetes mellitus: a single tertiary centre experience
ConclusionsPNDM is a heterogenous disease with variable genotypes and clinical phenotypes among Egyptian patients.EIF2AK3, INS,ABCC8, and KCNJ11 mutations were the commonest causes of PNDM in the study cohort. All patients with KATP channel mutations were effectively treated with glyburide, reflecting the fact that genetic testing for patients with NDM is not only important for diagnosis but also for treatment plan and prognosis. (Source: Acta Diabetologica)
Source: Acta Diabetologica - October 24, 2021 Category: Endocrinology Source Type: research
Glycemic control and neonatal outcomes in women with gestational diabetes mellitus treated using glyburide, metformin, or insulin: a pairwise and network meta-analysis
We aimed to assess the comparative efficiency and safety of the use of glyburide, metformin, and insulin in gestational diabetes mellitus (GDM). (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - October 12, 2021 Category: Endocrinology Authors: Dan-Qing Yu, Guan-Xin Xu, Xin-Yuan Teng, Jing-Wei Xu, Liang-Fang Tang, Chun Feng, Jin-Peng Rao, Min Jin and Li-Quan Wang Tags: Research Source Type: research
"Changing Patterns in Medication Prescription for Gestational Diabetes During a Time of Guideline Change in the USA: A Cross-sectional Study"
CONCLUSIONS: Insulin followed by metformin has replaced glyburide as the most common pharmacotherapy for GDM among a privately insured U.S. population during a time period of evolving professional guidelines. Further evaluation of the relative effectiveness and safety of metformin compared with insulin is needed.PMID:34605130 | DOI:10.1111/1471-0528.16960 (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - October 4, 2021 Category: OBGYN Authors: Kartik K Venkatesh ChienWei Chiang Wendy Camelo Castillo Ashley N Battarbee Macarius Donneyong Lorie M Harper Maged Costantine George Saade Erika F Werner Kim A Boggess Mark B Landon Source Type: research
"Changing Patterns in Medication Prescription for Gestational Diabetes During a Time of Guideline Change in the USA: A Cross-sectional Study"
CONCLUSIONS: Insulin followed by metformin has replaced glyburide as the most common pharmacotherapy for GDM among a privately insured U.S. population during a time period of evolving professional guidelines. Further evaluation of the relative effectiveness and safety of metformin compared with insulin is needed.PMID:34605130 | DOI:10.1111/1471-0528.16960 (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - October 4, 2021 Category: OBGYN Authors: Kartik K Venkatesh ChienWei Chiang Wendy Camelo Castillo Ashley N Battarbee Macarius Donneyong Lorie M Harper Maged Costantine George Saade Erika F Werner Kim A Boggess Mark B Landon Source Type: research
"Changing Patterns in Medication Prescription for Gestational Diabetes During a Time of Guideline Change in the USA: A Cross-sectional Study"
CONCLUSIONS: Insulin followed by metformin has replaced glyburide as the most common pharmacotherapy for GDM among a privately insured U.S. population during a time period of evolving professional guidelines. Further evaluation of the relative effectiveness and safety of metformin compared with insulin is needed.PMID:34605130 | DOI:10.1111/1471-0528.16960 (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - October 4, 2021 Category: OBGYN Authors: Kartik K Venkatesh ChienWei Chiang Wendy Camelo Castillo Ashley N Battarbee Macarius Donneyong Lorie M Harper Maged Costantine George Saade Erika F Werner Kim A Boggess Mark B Landon Source Type: research
Effects of Different Glucose-Lowering Measures on Maternal and Infant Outcomes in Pregnant Women with Gestational Diabetes: A Network Meta-analysis
ConclusionMetformin is a potentially superior choice for GDM treatment because it is associated with minimal incidences of multiple adverse pregnancy outcome indicators and does not lead to high values of certain adverse outcome indices. Other hypoglycemic agent or diet groups exhibit high incidences of certain adverse outcomes. Therefore, when selecting a GDM treatment strategy, the efficacies and risks of different treatment programs should be evaluated according to the scenario in hand. (Source: Diabetes Therapy)
Source: Diabetes Therapy - September 4, 2021 Category: Endocrinology Source Type: research
Angiotensin-Converting Enzyme Inhibitors Used Concomitantly with Insulin Secretagogues and the Risk of Serious Hypoglycemia
Clin Pharmacol Ther. 2021 Jul 27. doi: 10.1002/cpt.2377. Online ahead of print.ABSTRACTSerious hypoglycemia is a major adverse event associated with insulin secretagogues. Previous studies have suggested a potential relationship between angiotensin-converting enzyme inhibitors (ACEIs) used with sulfonylureas and serious hypoglycemia, and widely used drug compendia warn of this potential drug-drug interaction. We investigated the association between serious hypoglycemia and concomitant use of ACEIs in patients receiving insulin secretagogues, using the self-controlled case series design and Medicaid claims data from 5 US st...
Source: Clinical Pharmacology and Therapeutics - July 27, 2021 Category: Drugs & Pharmacology Authors: Young Hee Nam Colleen M Brensinger Warren B Bilker James H Flory Charles E Leonard Sean Hennessy Source Type: research
Angiotensin-Converting Enzyme Inhibitors Used Concomitantly with Insulin Secretagogues and the Risk of Serious Hypoglycemia
Clin Pharmacol Ther. 2021 Jul 27. doi: 10.1002/cpt.2377. Online ahead of print.ABSTRACTSerious hypoglycemia is a major adverse event associated with insulin secretagogues. Previous studies have suggested a potential relationship between angiotensin-converting enzyme inhibitors (ACEIs) used with sulfonylureas and serious hypoglycemia, and widely used drug compendia warn of this potential drug-drug interaction. We investigated the association between serious hypoglycemia and concomitant use of ACEIs in patients receiving insulin secretagogues, using the self-controlled case series design and Medicaid claims data from 5 US st...
Source: Clinical Pharmacology and Therapeutics - July 27, 2021 Category: Drugs & Pharmacology Authors: Young Hee Nam Colleen M Brensinger Warren B Bilker James H Flory Charles E Leonard Sean Hennessy Source Type: research
Gestational diabetes: Implications for fetal growth, intervention timing, and treatment options
Curr Opin Pharmacol. 2021 Jul 13;60:1-10. doi: 10.1016/j.coph.2021.06.003. Online ahead of print.ABSTRACTMaternal gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy, which can adversely affect the short- and long-term health of mothers and newborns. In recent years, several studies have revealed the early impact of maternal hyperglycemia on fetal growth trajectory and birth weight abnormalities in GDM-exposed pregnancies. However, an intense debate continues regarding the mode and optimal timing of diagnosis and treatment of this condition. The purpose of this review is to prov...
Source: Current Opinion in Pharmacology - July 19, 2021 Category: Drugs & Pharmacology Authors: Maria Mirabelli Eusebio Chiefari Vera Tocci Emanuela Greco Daniela Foti Antonio Brunetti Source Type: research
Gestational diabetes: Implications for fetal growth, intervention timing, and treatment options
Curr Opin Pharmacol. 2021 Jul 13;60:1-10. doi: 10.1016/j.coph.2021.06.003. Online ahead of print.ABSTRACTMaternal gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy, which can adversely affect the short- and long-term health of mothers and newborns. In recent years, several studies have revealed the early impact of maternal hyperglycemia on fetal growth trajectory and birth weight abnormalities in GDM-exposed pregnancies. However, an intense debate continues regarding the mode and optimal timing of diagnosis and treatment of this condition. The purpose of this review is to prov...
Source: Current Opinion in Pharmacology - July 19, 2021 Category: Drugs & Pharmacology Authors: Maria Mirabelli Eusebio Chiefari Vera Tocci Emanuela Greco Daniela Foti Antonio Brunetti Source Type: research
