Prescribing patterns and outcomes among patients treated for gestational diabetes mellitus
This study aimed to identify the most commonly prescribed agents for treating GDM, along with the maternal and fetal outcomes associated with their use. Electronic medical records were used to identify the medications prescribed for GDM at a large health system. Data were collected comparing medication failure rate, maternal weight gain, and incidence of fetal macrosomia, neonatal hypoglycemia, and premature delivery between the agents used. Of the 368 patients who met the inclusion criteria, 76.9% were initiated on glyburide, 13.6% were initiated on metformin, 8.2% were initiated on insulin, and 1.4% were initiated on a c...
Source: Baylor University Medical Center Proceedings - March 9, 2022 Category: Universities & Medical Training Authors: Heather Hay Delaney Ivy Kiumars Zolfaghari Source Type: research

Prescribing patterns and outcomes among patients treated for gestational diabetes mellitus
This study aimed to identify the most commonly prescribed agents for treating GDM, along with the maternal and fetal outcomes associated with their use. Electronic medical records were used to identify the medications prescribed for GDM at a large health system. Data were collected comparing medication failure rate, maternal weight gain, and incidence of fetal macrosomia, neonatal hypoglycemia, and premature delivery between the agents used. Of the 368 patients who met the inclusion criteria, 76.9% were initiated on glyburide, 13.6% were initiated on metformin, 8.2% were initiated on insulin, and 1.4% were initiated on a c...
Source: Baylor University Medical Center Proceedings - March 9, 2022 Category: Universities & Medical Training Authors: Heather Hay Delaney Ivy Kiumars Zolfaghari Source Type: research

Prescribing patterns and outcomes among patients treated for gestational diabetes mellitus
This study aimed to identify the most commonly prescribed agents for treating GDM, along with the maternal and fetal outcomes associated with their use. Electronic medical records were used to identify the medications prescribed for GDM at a large health system. Data were collected comparing medication failure rate, maternal weight gain, and incidence of fetal macrosomia, neonatal hypoglycemia, and premature delivery between the agents used. Of the 368 patients who met the inclusion criteria, 76.9% were initiated on glyburide, 13.6% were initiated on metformin, 8.2% were initiated on insulin, and 1.4% were initiated on a c...
Source: Baylor University Medical Center Proceedings - March 9, 2022 Category: Universities & Medical Training Authors: Heather Hay Delaney Ivy Kiumars Zolfaghari Source Type: research

Prescribing patterns and outcomes among patients treated for gestational diabetes mellitus
This study aimed to identify the most commonly prescribed agents for treating GDM, along with the maternal and fetal outcomes associated with their use. Electronic medical records were used to identify the medications prescribed for GDM at a large health system. Data were collected comparing medication failure rate, maternal weight gain, and incidence of fetal macrosomia, neonatal hypoglycemia, and premature delivery between the agents used. Of the 368 patients who met the inclusion criteria, 76.9% were initiated on glyburide, 13.6% were initiated on metformin, 8.2% were initiated on insulin, and 1.4% were initiated on a c...
Source: Baylor University Medical Center Proceedings - March 9, 2022 Category: Universities & Medical Training Authors: Heather Hay Delaney Ivy Kiumars Zolfaghari Source Type: research

< em > CASP < /em > orter: A Novel Inducible Human CASP1/NALP3/ASC Inflammasome Biosensor
CONCLUSION: We have established a cell-based CASP1/NLRP3 inflammasome model, utilizing a fluorescence biosensor as readout for qualitatively observing and quantitatively determining the activation of caspase 1 and NLRP3 inflammasomes in living cells and easily define the inhibitory effect of inhibitors with high efficacy.PMID:35221708 | PMC:PMC8865862 | DOI:10.2147/JIR.S333725 (Source: Cell Research)
Source: Cell Research - February 28, 2022 Category: Cytology Authors: Chan Zou Jordan A Beard Guoping Yang William E Evans Erik J Bonten Source Type: research

Kv7.4 Channels Regulate Potassium Permeability in Neuronal Mitochondria
In conclusion, these findings provide the first experimental evidence for the expression of Kv7.4 channels and their contribution in regulating K+ permeability of neuronal mitochondria.PMID:35085542 | DOI:10.1016/j.bcp.2022.114931 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - January 27, 2022 Category: Drugs & Pharmacology Authors: Gianluca Paventi Maria Virginia Soldovieri Ilenio Servettini Vincenzo Barrese Francesco Miceli Maria Jos è Sisalli Paolo Ambrosino Ilaria Mosca Iolanda Vinciguerra Lara Testai Antonella Scorziello Gennaro Raimo Vincenzo Calderone Salvatore Passarella Mau Source Type: research

Kv7.4 Channels Regulate Potassium Permeability in Neuronal Mitochondria
In conclusion, these findings provide the first experimental evidence for the expression of Kv7.4 channels and their contribution in regulating K+ permeability of neuronal mitochondria.PMID:35085542 | DOI:10.1016/j.bcp.2022.114931 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - January 27, 2022 Category: Drugs & Pharmacology Authors: Gianluca Paventi Maria Virginia Soldovieri Ilenio Servettini Vincenzo Barrese Francesco Miceli Maria Jos è Sisalli Paolo Ambrosino Ilaria Mosca Iolanda Vinciguerra Lara Testai Antonella Scorziello Gennaro Raimo Vincenzo Calderone Salvatore Passarella Mau Source Type: research

Trends in pharmacotherapy selection for gestational diabetes mellitus in a Medicaid population, 2007 to 2019
We examined changes in initiation of insulin, metformin, and glyburide between 2007 and 2019 among Tennessee Medicaid (TennCare) recipients who received pharmacotherapy for GDM. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 23, 2021 Category: OBGYN Authors: Amelie Pham, Andrew Spieker, Andrew Wiese, Kayla C. Johnson, Sharon Phillips Margaret adgent, Carlos Grijalva, Sarah S. Osmundson Tags: Poster Session IV Source Type: research

Genetic and clinical heterogeneity of permanent neonatal diabetes mellitus: a single tertiary centre experience
ConclusionsPNDM is a heterogenous disease with variable genotypes and clinical phenotypes among Egyptian patients.EIF2AK3, INS,ABCC8, and KCNJ11 mutations were the commonest causes of PNDM in the study cohort. All patients with KATP channel mutations were effectively treated with glyburide, reflecting the fact that genetic testing for patients with NDM is not only important for diagnosis but also for treatment plan and prognosis. (Source: Acta Diabetologica)
Source: Acta Diabetologica - December 1, 2021 Category: Endocrinology Source Type: research

Vibrio alginolyticus Triggers Inflammatory Response in Mouse Peritoneal Macrophages via Activation of NLRP3 Inflammasome
In this study, an in vitro model of mouse peritoneal macrophages infected with V. alginolyticus was established. qPCR results revealed that V. alginolyticus induced the transcription levels of various cytokines, including IL-1β, IL-12, IL-18, TNF-α, IL-17, IL-6, IFN-γ, and IL-10, and the secretion level of IL-1β is the most significant. Inhibition assays with Ac-YVAD-CHO (a caspase-1 inhibitor) and Z-VAD-FMK (a pan-caspase inhibitor) were conducted to determine whether caspase-1 or caspase-11 is involved in V. alginolyticus-triggered IL-1β secretion. Results showed that IL-1β secretion was partly inhibited by Ac-YVAD...
Source: Frontiers in cellular and infection microbiology - November 16, 2021 Category: Microbiology Source Type: research

Correlates of Insulin Selection as a First-Line Pharmacological Treatment for Gestational Diabetes
Conclusion Women of Hispanic ethnicity and women with no insurance were less likely to receive insulin and more likely to receive oral antidiabetic medication for GDM pharmacotherapy, while management by endocrinology was associated with higher odds of insulin prescription.This finding deserves more investigation to understand if differences are due to patient choice or a health disparity in the choice of pharmacologic agent for A2GDM. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  ...
Source: American Journal of Perinatology - November 10, 2021 Category: Perinatology & Neonatology Authors: Palatnik, Anna Harrison, Rachel K. Thakkar, Madhuli Y. Walker, Rebekah J. Egede, Leonard E. Tags: Original Article Source Type: research

Early Diagnosis of Prediabetes Among Pregnant Women that Develop Gestational Diabetes Mellitus and Its Influence on Perinatal Outcomes
Conclusion: Women identified as having early impaired glucose tolerance consistent with prediabetes that subsequently develop gestational diabetes are more likely to be prescribed insulin treatment and may be at increased risk of adverse neonatal outcomes leading to NICU admission than women with negative first trimester diabetes screening. Future studies should focus on whether different methods of early treatment and/or intervention improve perinatal outcomes. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor , NY 10001 New York, USAArticle in Thieme eJournals: Table of contents  |  Abstract (Sou...
Source: American Journal of Perinatology - October 28, 2021 Category: Perinatology & Neonatology Authors: Wilkie, Gianna Delpapa, Ellen Leftwich, Heidi K Tags: Original Article Source Type: research

Genetic and clinical heterogeneity of permanent neonatal diabetes mellitus: a single tertiary centre experience
ConclusionsPNDM is a heterogenous disease with variable genotypes and clinical phenotypes among Egyptian patients.EIF2AK3, INS,ABCC8, and KCNJ11 mutations were the commonest causes of PNDM in the study cohort. All patients with KATP channel mutations were effectively treated with glyburide, reflecting the fact that genetic testing for patients with NDM is not only important for diagnosis but also for treatment plan and prognosis. (Source: Acta Diabetologica)
Source: Acta Diabetologica - October 24, 2021 Category: Endocrinology Source Type: research

Glycemic control and neonatal outcomes in women with gestational diabetes mellitus treated using glyburide, metformin, or insulin: a pairwise and network meta-analysis
We aimed to assess the comparative efficiency and safety of the use of glyburide, metformin, and insulin in gestational diabetes mellitus (GDM). (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - October 12, 2021 Category: Endocrinology Authors: Dan-Qing Yu, Guan-Xin Xu, Xin-Yuan Teng, Jing-Wei Xu, Liang-Fang Tang, Chun Feng, Jin-Peng Rao, Min Jin and Li-Quan Wang Tags: Research Source Type: research

"Changing Patterns in Medication Prescription for Gestational Diabetes During a Time of Guideline Change in the USA: A Cross-sectional Study"
CONCLUSIONS: Insulin followed by metformin has replaced glyburide as the most common pharmacotherapy for GDM among a privately insured U.S. population during a time period of evolving professional guidelines. Further evaluation of the relative effectiveness and safety of metformin compared with insulin is needed.PMID:34605130 | DOI:10.1111/1471-0528.16960 (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - October 4, 2021 Category: OBGYN Authors: Kartik K Venkatesh ChienWei Chiang Wendy Camelo Castillo Ashley N Battarbee Macarius Donneyong Lorie M Harper Maged Costantine George Saade Erika F Werner Kim A Boggess Mark B Landon Source Type: research