Risk of hypoglycemia by anthropometric measurements in neonates of mothers with diabetes
Conclusion: BirthweightZ-score was associated with the risk of neonatal hypoglycemia in neonates from mothers treated for gestational diabetes. The risk of neonatal hypoglycemia was increased for both extreme birthweightZ-scores, regardless of maternal treatment. Small for gestational age neonates of diabetic mothers require special attention for the risk of neonatal hypoglycemia.What is Known:• Macrosomia in neonates of diabetic women is a risk factor for neonatal hypoglycemia, with an over-risk for asymmetric macrosomia. Few retrospective studies have assessed the risk for neonatal hypoglycemia among small for gestatio...
Source: European Journal of Pediatrics - July 4, 2022 Category: Pediatrics Source Type: research
Hypoxanthine is a pharmacodynamic marker of ischemic brain edema modified by glibenclamide
Cell Rep Med. 2022 Jun 9:100654. doi: 10.1016/j.xcrm.2022.100654. Online ahead of print.ABSTRACTBrain edema after a large stroke causes significant morbidity and mortality. Here, we seek to identify pharmacodynamic markers of edema that are modified by intravenous (i.v.) glibenclamide (glyburide; BIIB093) treatment. Using metabolomic profiling of 399 plasma samples from patients enrolled in the phase 2 Glyburide Advantage in Malignant Edema and Stroke (GAMES)-RP trial, 152 analytes are measured using liquid chromatography-tandem mass spectrometry. Associations with midline shift (MLS) and the matrix metalloproteinase-9 (MM...
Source: Cancer Control - June 14, 2022 Category: Cancer & Oncology Authors: Hannah J Irvine Animesh Acharjee Zoe Wolcott Zsuzsanna Ament H E Hinson Bradley J Molyneaux J Marc Simard Kevin N Sheth W Taylor Kimberly Source Type: research
Potassium Channels Contributes to Apelin-induced Vasodilation in Rat Thoracic Aorta
CONCLUSION: In conclusion, our findings suggest that BKCa, IKCa, Kv, KATP, Kir, and K2P channels are involved in the vasorelaxant effect mechanisms of apelin in the rat thoracic aorta.PMID:35578855 | DOI:10.2174/0929866529666220516141317 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - May 17, 2022 Category: Biochemistry Authors: Serdar Sahinturk Sadettin Demirel Naciye Isbil Fadil Ozyener Source Type: research
Potassium Channels Contributes to Apelin-induced Vasodilation in Rat Thoracic Aorta
CONCLUSION: In conclusion, our findings suggest that BKCa, IKCa, Kv, KATP, Kir, and K2P channels are involved in the vasorelaxant effect mechanisms of apelin in the rat thoracic aorta.PMID:35578855 | DOI:10.2174/0929866529666220516141317 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - May 17, 2022 Category: Biochemistry Authors: Serdar Sahinturk Sadettin Demirel Naciye Isbil Fadil Ozyener Source Type: research
Potassium Channels Contributes to Apelin-induced Vasodilation in Rat Thoracic Aorta
CONCLUSION: In conclusion, our findings suggest that BKCa, IKCa, Kv, KATP, Kir, and K2P channels are involved in the vasorelaxant effect mechanisms of apelin in the rat thoracic aorta.PMID:35578855 | DOI:10.2174/0929866529666220516141317 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - May 17, 2022 Category: Biochemistry Authors: Serdar Sahinturk Sadettin Demirel Naciye Isbil Fadil Ozyener Source Type: research
Potassium Channels Contributes to Apelin-induced Vasodilation in Rat Thoracic Aorta
CONCLUSION: In conclusion, our findings suggest that BKCa, IKCa, Kv, KATP, Kir, and K2P channels are involved in the vasorelaxant effect mechanisms of apelin in the rat thoracic aorta.PMID:35578855 | DOI:10.2174/0929866529666220516141317 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - May 17, 2022 Category: Biochemistry Authors: Serdar Sahinturk Sadettin Demirel Naciye Isbil Fadil Ozyener Source Type: research
Potassium Channels Contributes to Apelin-induced Vasodilation in Rat Thoracic Aorta
CONCLUSION: In conclusion, our findings suggest that BKCa, IKCa, Kv, KATP, Kir, and K2P channels are involved in the vasorelaxant effect mechanisms of apelin in the rat thoracic aorta.PMID:35578855 | DOI:10.2174/0929866529666220516141317 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - May 17, 2022 Category: Biochemistry Authors: Serdar Sahinturk Sadettin Demirel Naciye Isbil Fadil Ozyener Source Type: research
Potassium Channels Contributes to Apelin-induced Vasodilation in Rat Thoracic Aorta
CONCLUSION: In conclusion, our findings suggest that BKCa, IKCa, Kv, KATP, Kir, and K2P channels are involved in the vasorelaxant effect mechanisms of apelin in the rat thoracic aorta.PMID:35578855 | DOI:10.2174/0929866529666220516141317 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - May 17, 2022 Category: Biochemistry Authors: Serdar Sahinturk Sadettin Demirel Naciye Isbil Fadil Ozyener Source Type: research
Potassium Channels Contributes to Apelin-induced Vasodilation in Rat Thoracic Aorta
CONCLUSION: In conclusion, our findings suggest that BKCa, IKCa, Kv, KATP, Kir, and K2P channels are involved in the vasorelaxant effect mechanisms of apelin in the rat thoracic aorta.PMID:35578855 | DOI:10.2174/0929866529666220516141317 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - May 17, 2022 Category: Biochemistry Authors: Serdar Sahinturk Sadettin Demirel Naciye Isbil Fadil Ozyener Source Type: research
Potassium Channels Contributes to Apelin-induced Vasodilation in Rat Thoracic Aorta
CONCLUSION: In conclusion, our findings suggest that BKCa, IKCa, Kv, KATP, Kir, and K2P channels are involved in the vasorelaxant effect mechanisms of apelin in the rat thoracic aorta.PMID:35578855 | DOI:10.2174/0929866529666220516141317 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - May 17, 2022 Category: Biochemistry Authors: Serdar Sahinturk Sadettin Demirel Naciye Isbil Fadil Ozyener Source Type: research
Potassium Channels Contributes to Apelin-induced Vasodilation in Rat Thoracic Aorta
CONCLUSION: In conclusion, our findings suggest that BKCa, IKCa, Kv, KATP, Kir, and K2P channels are involved in the vasorelaxant effect mechanisms of apelin in the rat thoracic aorta.PMID:35578855 | DOI:10.2174/0929866529666220516141317 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - May 17, 2022 Category: Biochemistry Authors: Serdar Sahinturk Sadettin Demirel Naciye Isbil Fadil Ozyener Source Type: research
Potassium Channels Contributes to Apelin-induced Vasodilation in Rat Thoracic Aorta
CONCLUSION: In conclusion, our findings suggest that BKCa, IKCa, Kv, KATP, Kir, and K2P channels are involved in the vasorelaxant effect mechanisms of apelin in the rat thoracic aorta.PMID:35578855 | DOI:10.2174/0929866529666220516141317 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - May 17, 2022 Category: Biochemistry Authors: Serdar Sahinturk Sadettin Demirel Naciye Isbil Fadil Ozyener Source Type: research
Potassium Channels Contributes to Apelin-induced Vasodilation in Rat Thoracic Aorta
CONCLUSION: In conclusion, our findings suggest that BKCa, IKCa, Kv, KATP, Kir, and K2P channels are involved in the vasorelaxant effect mechanisms of apelin in the rat thoracic aorta.PMID:35578855 | DOI:10.2174/0929866529666220516141317 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - May 17, 2022 Category: Biochemistry Authors: Serdar Sahinturk Sadettin Demirel Naciye Isbil Fadil Ozyener Source Type: research
Brain Targeting, Antioxidant Polymeric Nanoparticles for Stroke Drug Delivery and Therapy
This study develops nanoparticles (NPs) consisting of a reactive oxygen species (ROS)-reactive polymer and further engineers them for targeted drug delivery to the ischemic brain through ligand-mediated interaction and thrombin-triggered shrinkability. It is demonstrated that the resulting NPs can efficiently deliver glyburide to the brain for effective stroke treatment. AbstractIschemic stroke is a leading cause of death and disability and remains without effective treatment options. Improved treatment of stroke requires efficient delivery of multimodal therapy to ischemic brain tissue with high specificity. Here, this ar...
Source: Small - March 20, 2022 Category: Nanotechnology Authors: Haoan Wu,
Bin Peng,
Farrah S. Mohammed,
Xingchun Gao,
Zhenpeng Qin,
Kevin N. Sheth,
Jiangbing Zhou,
Zhaozhong Jiang Tags: Research Article Source Type: research
