Incidence of Gestational Diabetes Diagnosed on the 100-G Glucose Tolerance Test in Pregnancies with a 50-G Glucose Challenge Test Result of 200 mg/dL or Greater
Conclusion A GCT result of ≥200 mg/dL has a PPV of 81% for diagnosis of GDM by GTT in a contemporary U.S. population, with a median intertest interval of 14 days between GCT and GTT. However, those diagnosed by GCT alone were as likely as those diagnosed by GTT to require medication for glycemic control, including insulin, suggesting that requiring a GTT may result in underdiagnosis and delayed treatment of GDM.
Key Points
[...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: A...
Source: American Journal of Perinatology - August 23, 2022 Category: Perinatology & Neonatology Authors: Lord, Megan G. Agee, Robert L. Sood, Nikki Clark, Melissa Johnson, Isaiah M. Tags: SMFM Fellows Research Series Source Type: research
Convergence of Fructose-Induced NLRP3 Activation with Oxidative Stress and ER Stress Leading to Hepatic Steatosis
AbstractHigh fructose flux enhances hepatocellular triglyceride accumulation (hepatic steatosis), which is a prime trigger in the emergence of hepatic ailments. Nevertheless, the pathophysiology underlying the process is not completely understood. Emerging evidences have revealed the inputs from multiple cues including inflammation, oxidative stress, and endoplasmic reticulum (ER) stress in the development of hepatic steatosis. Here, we substantiated the role of NLRP3 inflammasome and its convergence with oxidative and ER stress leading to hepatic steatosis under high fructose diet feeding. Male SD rats were fed on 60% hig...
Source: Inflammation - August 9, 2022 Category: Allergy & Immunology Source Type: research
Comparison of neonatal and maternal outcomes of anti-diabetic drugs in the treatment of gestational diabetes mellitus: Findings from Bayesian network meta-analysis
J Family Med Prim Care. 2022 May;11(5):1610-1618. doi: 10.4103/jfmpc.jfmpc_1319_21. Epub 2022 May 14.ABSTRACTThe safety and efficacy of different anti-diabetic drugs are not clear because of the lack of sufficiently powered clinical trials. This network meta-analysis was conducted to compare the efficacy and safety of three anti-diabetic drugs (insulin, glyburide, and metformin), and rank them as per their efficiency to control glucose levels, pregnancy, and neonatal outcomes. The study design is a systematic review, meta-analysis, and network meta-analysis. After a systematic search of existing databases, 34 randomized co...
Source: Primary Care - July 8, 2022 Category: Primary Care Authors: Mandar K Shah Mihika A Shah Sharan D Shah Parshwa K Shah Kaushal Patel Mamta Gupta Source Type: research
Comparison of neonatal and maternal outcomes of anti-diabetic drugs in the treatment of gestational diabetes mellitus: Findings from Bayesian network meta-analysis
J Family Med Prim Care. 2022 May;11(5):1610-1618. doi: 10.4103/jfmpc.jfmpc_1319_21. Epub 2022 May 14.ABSTRACTThe safety and efficacy of different anti-diabetic drugs are not clear because of the lack of sufficiently powered clinical trials. This network meta-analysis was conducted to compare the efficacy and safety of three anti-diabetic drugs (insulin, glyburide, and metformin), and rank them as per their efficiency to control glucose levels, pregnancy, and neonatal outcomes. The study design is a systematic review, meta-analysis, and network meta-analysis. After a systematic search of existing databases, 34 randomized co...
Source: Primary Care - July 8, 2022 Category: Primary Care Authors: Mandar K Shah Mihika A Shah Sharan D Shah Parshwa K Shah Kaushal Patel Mamta Gupta Source Type: research
Comparison of neonatal and maternal outcomes of anti-diabetic drugs in the treatment of gestational diabetes mellitus: Findings from Bayesian network meta-analysis
J Family Med Prim Care. 2022 May;11(5):1610-1618. doi: 10.4103/jfmpc.jfmpc_1319_21. Epub 2022 May 14.ABSTRACTThe safety and efficacy of different anti-diabetic drugs are not clear because of the lack of sufficiently powered clinical trials. This network meta-analysis was conducted to compare the efficacy and safety of three anti-diabetic drugs (insulin, glyburide, and metformin), and rank them as per their efficiency to control glucose levels, pregnancy, and neonatal outcomes. The study design is a systematic review, meta-analysis, and network meta-analysis. After a systematic search of existing databases, 34 randomized co...
Source: Primary Care - July 8, 2022 Category: Primary Care Authors: Mandar K Shah Mihika A Shah Sharan D Shah Parshwa K Shah Kaushal Patel Mamta Gupta Source Type: research
Comparison of neonatal and maternal outcomes of anti-diabetic drugs in the treatment of gestational diabetes mellitus: Findings from Bayesian network meta-analysis
J Family Med Prim Care. 2022 May;11(5):1610-1618. doi: 10.4103/jfmpc.jfmpc_1319_21. Epub 2022 May 14.ABSTRACTThe safety and efficacy of different anti-diabetic drugs are not clear because of the lack of sufficiently powered clinical trials. This network meta-analysis was conducted to compare the efficacy and safety of three anti-diabetic drugs (insulin, glyburide, and metformin), and rank them as per their efficiency to control glucose levels, pregnancy, and neonatal outcomes. The study design is a systematic review, meta-analysis, and network meta-analysis. After a systematic search of existing databases, 34 randomized co...
Source: Primary Care - July 8, 2022 Category: Primary Care Authors: Mandar K Shah Mihika A Shah Sharan D Shah Parshwa K Shah Kaushal Patel Mamta Gupta Source Type: research
The inflammasome pathway: A key player in ocular surface and anterior segment diseases
Inflammasomes are multicomplex molecular regulators with an emerging importance in regulating ocular surface and anterior segment health and disease. Key components found in the eye include NF- κB, NLRP3, NLRC4, NLRP6, ASC, IL-1β, IL-18, and caspase-1. The role of NLRP1, NLRC4, AIM2, and NLRP3 inflammasomes in the pathogenesis of infectious ulcers, DED, uveitis, glaucoma, corneal edema, and other diseases is being studied with many developments. Attenuation of these diseases has been exp lored by blocking various molecules along the inflammasome pathway with agents like NAC, polydatin, calcitriol, glyburide, YVAD, and di...
Source: Survey of Ophthalmology - July 4, 2022 Category: Opthalmology Authors: Jordan T. Mandell, Juan Pablo de Rivero Vaccari, Alfonso L. Sabater, Anat Galor Tags: Review article Source Type: research
Risk of hypoglycemia by anthropometric measurements in neonates of mothers with diabetes
Conclusion: BirthweightZ-score was associated with the risk of neonatal hypoglycemia in neonates from mothers treated for gestational diabetes. The risk of neonatal hypoglycemia was increased for both extreme birthweightZ-scores, regardless of maternal treatment. Small for gestational age neonates of diabetic mothers require special attention for the risk of neonatal hypoglycemia.What is Known:• Macrosomia in neonates of diabetic women is a risk factor for neonatal hypoglycemia, with an over-risk for asymmetric macrosomia. Few retrospective studies have assessed the risk for neonatal hypoglycemia among small for gestatio...
Source: European Journal of Pediatrics - July 4, 2022 Category: Pediatrics Source Type: research
Hypoxanthine is a pharmacodynamic marker of ischemic brain edema modified by glibenclamide
Cell Rep Med. 2022 Jun 9:100654. doi: 10.1016/j.xcrm.2022.100654. Online ahead of print.ABSTRACTBrain edema after a large stroke causes significant morbidity and mortality. Here, we seek to identify pharmacodynamic markers of edema that are modified by intravenous (i.v.) glibenclamide (glyburide; BIIB093) treatment. Using metabolomic profiling of 399 plasma samples from patients enrolled in the phase 2 Glyburide Advantage in Malignant Edema and Stroke (GAMES)-RP trial, 152 analytes are measured using liquid chromatography-tandem mass spectrometry. Associations with midline shift (MLS) and the matrix metalloproteinase-9 (MM...
Source: Cancer Control - June 14, 2022 Category: Cancer & Oncology Authors: Hannah J Irvine Animesh Acharjee Zoe Wolcott Zsuzsanna Ament H E Hinson Bradley J Molyneaux J Marc Simard Kevin N Sheth W Taylor Kimberly Source Type: research
Potassium Channels Contributes to Apelin-induced Vasodilation in Rat Thoracic Aorta
CONCLUSION: In conclusion, our findings suggest that BKCa, IKCa, Kv, KATP, Kir, and K2P channels are involved in the vasorelaxant effect mechanisms of apelin in the rat thoracic aorta.PMID:35578855 | DOI:10.2174/0929866529666220516141317 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - May 17, 2022 Category: Biochemistry Authors: Serdar Sahinturk Sadettin Demirel Naciye Isbil Fadil Ozyener Source Type: research
Potassium Channels Contributes to Apelin-induced Vasodilation in Rat Thoracic Aorta
CONCLUSION: In conclusion, our findings suggest that BKCa, IKCa, Kv, KATP, Kir, and K2P channels are involved in the vasorelaxant effect mechanisms of apelin in the rat thoracic aorta.PMID:35578855 | DOI:10.2174/0929866529666220516141317 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - May 17, 2022 Category: Biochemistry Authors: Serdar Sahinturk Sadettin Demirel Naciye Isbil Fadil Ozyener Source Type: research
Potassium Channels Contributes to Apelin-induced Vasodilation in Rat Thoracic Aorta
CONCLUSION: In conclusion, our findings suggest that BKCa, IKCa, Kv, KATP, Kir, and K2P channels are involved in the vasorelaxant effect mechanisms of apelin in the rat thoracic aorta.PMID:35578855 | DOI:10.2174/0929866529666220516141317 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - May 17, 2022 Category: Biochemistry Authors: Serdar Sahinturk Sadettin Demirel Naciye Isbil Fadil Ozyener Source Type: research
Potassium Channels Contributes to Apelin-induced Vasodilation in Rat Thoracic Aorta
CONCLUSION: In conclusion, our findings suggest that BKCa, IKCa, Kv, KATP, Kir, and K2P channels are involved in the vasorelaxant effect mechanisms of apelin in the rat thoracic aorta.PMID:35578855 | DOI:10.2174/0929866529666220516141317 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - May 17, 2022 Category: Biochemistry Authors: Serdar Sahinturk Sadettin Demirel Naciye Isbil Fadil Ozyener Source Type: research
Potassium Channels Contributes to Apelin-induced Vasodilation in Rat Thoracic Aorta
CONCLUSION: In conclusion, our findings suggest that BKCa, IKCa, Kv, KATP, Kir, and K2P channels are involved in the vasorelaxant effect mechanisms of apelin in the rat thoracic aorta.PMID:35578855 | DOI:10.2174/0929866529666220516141317 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - May 17, 2022 Category: Biochemistry Authors: Serdar Sahinturk Sadettin Demirel Naciye Isbil Fadil Ozyener Source Type: research
