Vitamin D receptor activation reduces hepatic inflammation via enhancing macrophage autophagy in cholestatic mice
Am J Pathol. 2023 Dec 15:S0002-9440(23)00462-5. doi: 10.1016/j.ajpath.2023.11.016. Online ahead of print.ABSTRACTMacrophage autophagy dysfunction aggravates liver injury by activating inflammasomes, which can cleave pro-IL-1β to its active, secreted form. Here, to determine whether the vitamin D (VD)/ VD receptor (VDR) axis could upregulate macrophage autophagy function to inhibit the activation of inflammasome-dependent IL-1β during cholestasis. Paricalcitol (PAL, VDR agonist) was intraperitoneally injected into bile duct ligated (BDL) mice for 5 days. Research found that upregulation of VDR expression by PAL reduced li...
Source: The American Journal of Pathology - December 17, 2023 Category: Pathology Authors: Tianfu Wen Jing Xie Liman Ma Zhiqing Hao Weiwei Zhang Tingyao Wu Lihua Li Source Type: research
Vitamin D receptor activation reduces hepatic inflammation via enhancing macrophage autophagy in cholestatic mice
Am J Pathol. 2023 Dec 15:S0002-9440(23)00462-5. doi: 10.1016/j.ajpath.2023.11.016. Online ahead of print.ABSTRACTMacrophage autophagy dysfunction aggravates liver injury by activating inflammasomes, which can cleave pro-IL-1β to its active, secreted form. Here, to determine whether the vitamin D (VD)/ VD receptor (VDR) axis could upregulate macrophage autophagy function to inhibit the activation of inflammasome-dependent IL-1β during cholestasis. Paricalcitol (PAL, VDR agonist) was intraperitoneally injected into bile duct ligated (BDL) mice for 5 days. Research found that upregulation of VDR expression by PAL reduced li...
Source: Am J Pathol - December 17, 2023 Category: Pathology Authors: Tianfu Wen Jing Xie Liman Ma Zhiqing Hao Weiwei Zhang Tingyao Wu Lihua Li Source Type: research
Vitamin D receptor activation reduces hepatic inflammation via enhancing macrophage autophagy in cholestatic mice
Am J Pathol. 2023 Dec 15:S0002-9440(23)00462-5. doi: 10.1016/j.ajpath.2023.11.016. Online ahead of print.ABSTRACTMacrophage autophagy dysfunction aggravates liver injury by activating inflammasomes, which can cleave pro-IL-1β to its active, secreted form. Here, to determine whether the vitamin D (VD)/ VD receptor (VDR) axis could upregulate macrophage autophagy function to inhibit the activation of inflammasome-dependent IL-1β during cholestasis. Paricalcitol (PAL, VDR agonist) was intraperitoneally injected into bile duct ligated (BDL) mice for 5 days. Research found that upregulation of VDR expression by PAL reduced li...
Source: The American Journal of Pathology - December 17, 2023 Category: Pathology Authors: Tianfu Wen Jing Xie Liman Ma Zhiqing Hao Weiwei Zhang Tingyao Wu Lihua Li Source Type: research
Vitamin D receptor activation reduces hepatic inflammation via enhancing macrophage autophagy in cholestatic mice
Am J Pathol. 2023 Dec 15:S0002-9440(23)00462-5. doi: 10.1016/j.ajpath.2023.11.016. Online ahead of print.ABSTRACTMacrophage autophagy dysfunction aggravates liver injury by activating inflammasomes, which can cleave pro-IL-1β to its active, secreted form. Here, to determine whether the vitamin D (VD)/ VD receptor (VDR) axis could upregulate macrophage autophagy function to inhibit the activation of inflammasome-dependent IL-1β during cholestasis. Paricalcitol (PAL, VDR agonist) was intraperitoneally injected into bile duct ligated (BDL) mice for 5 days. Research found that upregulation of VDR expression by PAL reduced li...
Source: Am J Pathol - December 17, 2023 Category: Pathology Authors: Tianfu Wen Jing Xie Liman Ma Zhiqing Hao Weiwei Zhang Tingyao Wu Lihua Li Source Type: research
Vitamin D receptor activation reduces hepatic inflammation via enhancing macrophage autophagy in cholestatic mice
Am J Pathol. 2023 Dec 15:S0002-9440(23)00462-5. doi: 10.1016/j.ajpath.2023.11.016. Online ahead of print.ABSTRACTMacrophage autophagy dysfunction aggravates liver injury by activating inflammasomes, which can cleave pro-IL-1β to its active, secreted form. Here, to determine whether the vitamin D (VD)/ VD receptor (VDR) axis could upregulate macrophage autophagy function to inhibit the activation of inflammasome-dependent IL-1β during cholestasis. Paricalcitol (PAL, VDR agonist) was intraperitoneally injected into bile duct ligated (BDL) mice for 5 days. Research found that upregulation of VDR expression by PAL reduced li...
Source: The American Journal of Pathology - December 17, 2023 Category: Pathology Authors: Tianfu Wen Jing Xie Liman Ma Zhiqing Hao Weiwei Zhang Tingyao Wu Lihua Li Source Type: research
Vitamin D receptor activation reduces hepatic inflammation via enhancing macrophage autophagy in cholestatic mice
Am J Pathol. 2023 Dec 15:S0002-9440(23)00462-5. doi: 10.1016/j.ajpath.2023.11.016. Online ahead of print.ABSTRACTMacrophage autophagy dysfunction aggravates liver injury by activating inflammasomes, which can cleave pro-IL-1β to its active, secreted form. Here, to determine whether the vitamin D (VD)/ VD receptor (VDR) axis could upregulate macrophage autophagy function to inhibit the activation of inflammasome-dependent IL-1β during cholestasis. Paricalcitol (PAL, VDR agonist) was intraperitoneally injected into bile duct ligated (BDL) mice for 5 days. Research found that upregulation of VDR expression by PAL reduced li...
Source: Am J Pathol - December 17, 2023 Category: Pathology Authors: Tianfu Wen Jing Xie Liman Ma Zhiqing Hao Weiwei Zhang Tingyao Wu Lihua Li Source Type: research
Vitamin D receptor activation reduces hepatic inflammation via enhancing macrophage autophagy in cholestatic mice
Am J Pathol. 2023 Dec 15:S0002-9440(23)00462-5. doi: 10.1016/j.ajpath.2023.11.016. Online ahead of print.ABSTRACTMacrophage autophagy dysfunction aggravates liver injury by activating inflammasomes, which can cleave pro-IL-1β to its active, secreted form. Here, to determine whether the vitamin D (VD)/ VD receptor (VDR) axis could upregulate macrophage autophagy function to inhibit the activation of inflammasome-dependent IL-1β during cholestasis. Paricalcitol (PAL, VDR agonist) was intraperitoneally injected into bile duct ligated (BDL) mice for 5 days. Research found that upregulation of VDR expression by PAL reduced li...
Source: The American Journal of Pathology - December 17, 2023 Category: Pathology Authors: Tianfu Wen Jing Xie Liman Ma Zhiqing Hao Weiwei Zhang Tingyao Wu Lihua Li Source Type: research
Vitamin D receptor activation reduces hepatic inflammation via enhancing macrophage autophagy in cholestatic mice
Am J Pathol. 2023 Dec 15:S0002-9440(23)00462-5. doi: 10.1016/j.ajpath.2023.11.016. Online ahead of print.ABSTRACTMacrophage autophagy dysfunction aggravates liver injury by activating inflammasomes, which can cleave pro-IL-1β to its active, secreted form. Here, to determine whether the vitamin D (VD)/ VD receptor (VDR) axis could upregulate macrophage autophagy function to inhibit the activation of inflammasome-dependent IL-1β during cholestasis. Paricalcitol (PAL, VDR agonist) was intraperitoneally injected into bile duct ligated (BDL) mice for 5 days. Research found that upregulation of VDR expression by PAL reduced li...
Source: The American Journal of Pathology - December 17, 2023 Category: Pathology Authors: Tianfu Wen Jing Xie Liman Ma Zhiqing Hao Weiwei Zhang Tingyao Wu Lihua Li Source Type: research
Vitamin D receptor activation reduces hepatic inflammation via enhancing macrophage autophagy in cholestatic mice
Am J Pathol. 2023 Dec 15:S0002-9440(23)00462-5. doi: 10.1016/j.ajpath.2023.11.016. Online ahead of print.ABSTRACTMacrophage autophagy dysfunction aggravates liver injury by activating inflammasomes, which can cleave pro-IL-1β to its active, secreted form. Here, to determine whether the vitamin D (VD)/ VD receptor (VDR) axis could upregulate macrophage autophagy function to inhibit the activation of inflammasome-dependent IL-1β during cholestasis. Paricalcitol (PAL, VDR agonist) was intraperitoneally injected into bile duct ligated (BDL) mice for 5 days. Research found that upregulation of VDR expression by PAL reduced li...
Source: Am J Pathol - December 17, 2023 Category: Pathology Authors: Tianfu Wen Jing Xie Liman Ma Zhiqing Hao Weiwei Zhang Tingyao Wu Lihua Li Source Type: research
Vitamin D Receptor Activation Reduces Hepatic Inflammation via Enhancing Macrophage Autophagy in Cholestatic Mice
Am J Pathol. 2023 Dec 15:S0002-9440(23)00462-5. doi: 10.1016/j.ajpath.2023.11.016. Online ahead of print.ABSTRACTMacrophage autophagy dysfunction aggravates liver injury by activating inflammasomes, which can cleave pro-IL-1β to its active, secreted form. Here, whether the vitamin D/vitamin D receptor (VDR) axis could up-regulate macrophage autophagy function to inhibit the activation of inflammasome-dependent IL-1β during cholestasis was investigated. Paricalcitol (PAL; VDR agonist) was intraperitoneally injected into bile duct-ligated mice for 5 days. Research found that up-regulation of VDR expression by PAL reduced l...
Source: The American Journal of Pathology - December 17, 2023 Category: Pathology Authors: Tianfu Wen Jing Xie Liman Ma Zhiqing Hao Weiwei Zhang Tingyao Wu Lihua Li Source Type: research
Vitamin D Receptor Activation Reduces Hepatic Inflammation via Enhancing Macrophage Autophagy in Cholestatic Mice
Am J Pathol. 2023 Dec 15:S0002-9440(23)00462-5. doi: 10.1016/j.ajpath.2023.11.016. Online ahead of print.ABSTRACTMacrophage autophagy dysfunction aggravates liver injury by activating inflammasomes, which can cleave pro-IL-1β to its active, secreted form. Here, whether the vitamin D/vitamin D receptor (VDR) axis could up-regulate macrophage autophagy function to inhibit the activation of inflammasome-dependent IL-1β during cholestasis was investigated. Paricalcitol (PAL; VDR agonist) was intraperitoneally injected into bile duct-ligated mice for 5 days. Research found that up-regulation of VDR expression by PAL reduced l...
Source: Am J Pathol - December 17, 2023 Category: Pathology Authors: Tianfu Wen Jing Xie Liman Ma Zhiqing Hao Weiwei Zhang Tingyao Wu Lihua Li Source Type: research
Vitamin D Receptor Activation Reduces Hepatic Inflammation via Enhancing Macrophage Autophagy in Cholestatic Mice
Am J Pathol. 2023 Dec 15:S0002-9440(23)00462-5. doi: 10.1016/j.ajpath.2023.11.016. Online ahead of print.ABSTRACTMacrophage autophagy dysfunction aggravates liver injury by activating inflammasomes, which can cleave pro-IL-1β to its active, secreted form. Here, whether the vitamin D/vitamin D receptor (VDR) axis could up-regulate macrophage autophagy function to inhibit the activation of inflammasome-dependent IL-1β during cholestasis was investigated. Paricalcitol (PAL; VDR agonist) was intraperitoneally injected into bile duct-ligated mice for 5 days. Research found that up-regulation of VDR expression by PAL reduced l...
Source: The American Journal of Pathology - December 17, 2023 Category: Pathology Authors: Tianfu Wen Jing Xie Liman Ma Zhiqing Hao Weiwei Zhang Tingyao Wu Lihua Li Source Type: research
Vitamin D Receptor Activation Reduces Hepatic Inflammation via Enhancing Macrophage Autophagy in Cholestatic Mice
Am J Pathol. 2023 Dec 15:S0002-9440(23)00462-5. doi: 10.1016/j.ajpath.2023.11.016. Online ahead of print.ABSTRACTMacrophage autophagy dysfunction aggravates liver injury by activating inflammasomes, which can cleave pro-IL-1β to its active, secreted form. Here, whether the vitamin D/vitamin D receptor (VDR) axis could up-regulate macrophage autophagy function to inhibit the activation of inflammasome-dependent IL-1β during cholestasis was investigated. Paricalcitol (PAL; VDR agonist) was intraperitoneally injected into bile duct-ligated mice for 5 days. Research found that up-regulation of VDR expression by PAL reduced l...
Source: Am J Pathol - December 17, 2023 Category: Pathology Authors: Tianfu Wen Jing Xie Liman Ma Zhiqing Hao Weiwei Zhang Tingyao Wu Lihua Li Source Type: research
Vitamin D Receptor Activation Reduces Hepatic Inflammation via Enhancing Macrophage Autophagy in Cholestatic Mice
Am J Pathol. 2023 Dec 15:S0002-9440(23)00462-5. doi: 10.1016/j.ajpath.2023.11.016. Online ahead of print.ABSTRACTMacrophage autophagy dysfunction aggravates liver injury by activating inflammasomes, which can cleave pro-IL-1β to its active, secreted form. Here, whether the vitamin D/vitamin D receptor (VDR) axis could up-regulate macrophage autophagy function to inhibit the activation of inflammasome-dependent IL-1β during cholestasis was investigated. Paricalcitol (PAL; VDR agonist) was intraperitoneally injected into bile duct-ligated mice for 5 days. Research found that up-regulation of VDR expression by PAL reduced l...
Source: The American Journal of Pathology - December 17, 2023 Category: Pathology Authors: Tianfu Wen Jing Xie Liman Ma Zhiqing Hao Weiwei Zhang Tingyao Wu Lihua Li Source Type: research
Vitamin D Receptor Activation Reduces Hepatic Inflammation via Enhancing Macrophage Autophagy in Cholestatic Mice
Am J Pathol. 2023 Dec 15:S0002-9440(23)00462-5. doi: 10.1016/j.ajpath.2023.11.016. Online ahead of print.ABSTRACTMacrophage autophagy dysfunction aggravates liver injury by activating inflammasomes, which can cleave pro-IL-1β to its active, secreted form. Here, whether the vitamin D/vitamin D receptor (VDR) axis could up-regulate macrophage autophagy function to inhibit the activation of inflammasome-dependent IL-1β during cholestasis was investigated. Paricalcitol (PAL; VDR agonist) was intraperitoneally injected into bile duct-ligated mice for 5 days. Research found that up-regulation of VDR expression by PAL reduced l...
Source: Am J Pathol - December 17, 2023 Category: Pathology Authors: Tianfu Wen Jing Xie Liman Ma Zhiqing Hao Weiwei Zhang Tingyao Wu Lihua Li Source Type: research
