Infrarenal Aortic Aneurysm in a Patient with Remote History of Liver Transplant with Aorto-Hepatic Conduit
A 72-year-old male with a past medical history of hypertension, peripheral artery disease, and cadaveric liver transplant twenty-seven years prior for hepatitis C induced liver failure was found to have an asymptomatic ten cm infrarenal abdominal aortic aneurysm (AAA) during a CT scan for evaluation of genitourinary symptoms (Image A, Video 1). Notably, the Dacron aorto-hepatic conduit used for the transplant came off mid-aneurysm, making any method of repair especially challenging (Image B/Cover). (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - May 3, 2024 Category: Surgery Authors: Moira A. McGevna, Anne Pierce, James Y. Lu, Aryan Borole, Kristen Lee, William E. Beckerman Source Type: research
Multicentre Experience with Novel Bidirectional Double Cuffed Inner Branches for Complex Endovascular Aortic Repair
This study aimed to report the initial experience with a novel bidirectional double cuff inner branch design for incorporation of renal and mesenteric arteries in patients undergoing fenestrated and branched endovascular aortic repair (F/BEVAR). (Source: European Journal of Vascular and Endovascular Surgery)
Source: European Journal of Vascular and Endovascular Surgery - May 3, 2024 Category: Surgery Authors: M árton Berczeli, Tilo Kölbel, Nikolaos Tsilimparis, Angelos Karelis, Gustavo S. Oderich, Giuseppe Panuccio, Fiona Rohlffs, Björn Sonesson, Nuno V. Dias Source Type: research
Tensile strength of adhesives in peripheral nerve anastomoses: an in vitro biomechanical evaluation of four different neurorrhaphies
ConclusionWithin the limitations of an in vitro study the adhesive-based neurorrhaphy technique with VIVO and Histoacryl have the biomechanical potential to offer alternatives to sutured neuroanastomosis because of their stability, and faster handling. Further in vivo studies are required to evaluate functional outcomes and confirm safety. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - May 3, 2024 Category: Research Source Type: research
Post-dissection Thoraco-abdominal Aortic Aneurysm Managed with Fenestrated or Branched Endovascular Aortic Repair
CONCLUSION: Fenestrated or branched endovascular repairs in patients with PD-TAAA showed high technical success, with acceptable early mortality and MAE rates. The SCI rate was > 10%, despite CSFD use and staged procedures. Almost one-half of patients needed an unscheduled re-intervention within 24 months after f/bEVAR.PMID:38697255 | DOI:10.1016/j.ejvs.2024.04.041 (Source: PubMed: Eur J Vasc Endovasc ...)
Source: PubMed: Eur J Vasc Endovasc ... - May 2, 2024 Category: Surgery Authors: Filippo Gorgatti Petroula Nana Giuseppe Panuccio Fiona Rohlffs Jos é I Torrealba Tilo K ölbel Source Type: research
Personal protective equipment for preventing asbestos exposure in workers
CONCLUSIONS: Where the outside asbestos concentration is below 0.1 f/cm3, SARS and PAPRs likely reduce exposure to below the proposed OEL of 0.01 f/cm3. For outside concentrations up to 10 f/cm3, all respirators may reduce exposure below the current OEL, but only SAR also below the proposed OEL. In band 5 (10 to < 100 f/cm3), full-face filtering masks may not reduce asbestos exposure below either OEL, SARs likely reduce exposure below both OELs, and there were no data for PAPRs. In band 6 (100 f/cm3 to < 1000 f/cm3), PAPRs may not reduce exposure below either OEL, and there were no data for full-face filtering masks ...
Source: Cochrane Database of Systematic Reviews - May 2, 2024 Category: General Medicine Authors: Lea Belackova Jos H Verbeek Jan L Hoving Henk F van der Molen Diana Gagliardi Stefania Curti Carel Tj Hulshof Paul Tj Scheepers Source Type: research
Iliac artery endofibrosis: diagnostic dilemna and treatment options
CONCLUSION: Correct diagnosis is essential in the treatment of EIAE. A complete and multidisciplinary pathway should be followed to distinguish vascular from non-vascular causes. Correct lesion localization is crucial and besides CTA or MRA, more sophisticated techniques such as dynamic angiography or intravascular ultrasound might be needed.PMID:38693887 | DOI:10.1080/00015458.2024.2348234 (Source: Acta Chirurgica Belgica)
Source: Acta Chirurgica Belgica - May 2, 2024 Category: Surgery Authors: K VanLangenhove Uijtterhaegen G Moreels N Randon C Vermassen F Source Type: research
Impaired LAIR-1-mediated immune control due to collagen degradation in fibrosis
J Autoimmun. 2024 May 1;146:103219. doi: 10.1016/j.jaut.2024.103219. Online ahead of print.ABSTRACTTissue repair is disturbed in fibrotic diseases like systemic sclerosis (SSc), where the deposition of large amounts of extracellular matrix components such as collagen interferes with organ function. LAIR-1 is an inhibitory collagen receptor highly expressed on tissue immune cells. We questioned whether in SSc, impaired LAIR-1-collagen interaction is contributing to the ongoing inflammation and fibrosis. We found that SSc patients do not have an intrinsic defect in LAIR-1 expression or function. Instead, fibroblasts from hea...
Source: Journal of Autoimmunity - May 2, 2024 Category: Allergy & Immunology Authors: Tiago Carvalheiro Wioleta Marut M In ês Pascoal Ramos Samuel Garc ía Devan Fleury Alsya J Affandi Aniek S Meijers Barbara Giovannone Ralph G Tieland Eline Elshof Andrea Ottria Marta Cossu Matthew L Meizlish Tineke Veenendaal Meera Ramanujam Miguel E Mor Source Type: research
ST2 levels and neurodegenerative diseases: is this a significant relation?
Ann Med Surg (Lond). 2024 Mar 12;86(5):2812-2817. doi: 10.1097/MS9.0000000000001939. eCollection 2024 May.ABSTRACTInterleukin-33 (IL-33), belonging to the interleukin-1 cytokine family, has a decoy receptor soluble ST2 (sST2). IL-33 is found in oligodendrocytes and astrocytes and is involved in central nervous system healing and repair, whereas ST2 is found in microglia and astrocytes. Some studies have found a link between changes in the IL-33/ST2 pathway and neurodegenerative disorders. This review article investigates the relationship between the interleukin-33 (IL-33)/ST2 pathway and neurodegenerative disorders. It was...
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Himanshu Arora Binish Javed L V Simhachalam Kutikuppala Mayuri Chaurasia Kaarvi Khullar Shreevikaa Kannan Varshitha Golla Source Type: research
Comprehensive Genomic Characterization in Ovarian Low-Grade and chemosensitive and chemoresistant High-Grade Serous Carcinomas
CONCLUSIONS: These results suggest that very low TMB and MYC, CCNE1 and AKT2 gains in SOC patients may be biomarkers related to platinum treatment efficacy. Thorough genomic characterization of SOCs prior to treatment might lead to more specific platinum-based chemotherapy therapy strategies.PMID:38697030 | DOI:10.1159/000538948 (Source: Oncology)
Source: Oncology - May 2, 2024 Category: Cancer & Oncology Authors: Carolina Jaliffa Uwe Rogel Indrani Sen Gad Singer Source Type: research
Pancreatic stellate cells: Key players in pancreatic health and diseases (Review)
Mol Med Rep. 2024 Jul;30(1):109. doi: 10.3892/mmr.2024.13233. Epub 2024 May 2.ABSTRACTAs a pluripotent cell, activated pancreatic stellate cells (PSCs) can differentiate into various pancreatic parenchymal cells and participate in the secretion of extracellular matrix and the repair of pancreatic damage. Additionally, PSCs characteristics allow them to contribute to pancreatic inflammation and carcinogenesis. Moreover, a detailed study of the pathogenesis of activated PSCs in pancreatic disease can offer promise for the development of innovative therapeutic strategies and improved patient prognoses. Therefore, the present ...
Source: Molecular Medicine Reports - May 2, 2024 Category: Molecular Biology Authors: Zhengfeng Wang Shi Dong Wence Zhou Source Type: research
Features of the DNA Escherichia coli RecN interaction revealed by fluorescence microscopy and single-molecule methods
Biochem Biophys Res Commun. 2024 Apr 25;716:150009. doi: 10.1016/j.bbrc.2024.150009. Online ahead of print.ABSTRACTThe SOS response is a condition that occurs in bacterial cells after DNA damage. In this state, the bacterium is able to reсover the integrity of its genome. Due to the increased level of mutagenesis in cells during the repair of DNA double-strand breaks, the SOS response is also an important mechanism for bacterial adaptation to the antibiotics. One of the key proteins of the SOS response is the SMC-like protein RecN, which helps the RecA recombinase to find a homologous DNA template for repair. In this work...
Source: Cell Research - May 2, 2024 Category: Cytology Authors: Viktoria D Roshektaeva Aleksandr A Alekseev Alexey D Vedyaykin Viktor A Vinnik Dmitrii M Baitin Irina V Bakhlanova Georgii E Pobegalov Mikhail A Khodorkovskii Natalia E Morozova Source Type: research
Dulaglutide restores endothelial progenitor cell levels in diabetic mice and mitigates high glucose-induced endothelial injury through SIRT1-mediated mitochondrial fission
This study investigates dulaglutide's effects on peripheral blood levels of CD34+ and CD133+ cells in a mouse model of lower limb ischemia and its protective mechanisms against high-glucose-induced damage in endothelial cells. Results demonstrated that dulaglutide significantly improves blood flow, reduces tissue damage and inflammation in ischemic limbs, and enhances glycemic control. Furthermore, dulaglutide alleviated high-glucose-induced endothelial cell damage, evident from improved tube formation, reduced reactive oxygen species accumulation, and restored endothelial junction integrity. Mechanistically, dulaglutide m...
Source: Cell Research - May 2, 2024 Category: Cytology Authors: Xi Mei Yao Li Jinlin Wu Lumiu Liao Di Lu Ping Qiu Hui-Lan Yang Ming-Wei Tang Xin-Ying Liang Dongfang Liu Source Type: research
Human umbilical cord mesenchymal stem cells promote steroid-induced osteonecrosis of the femoral head repair by improving microvascular endothelial cell function
Aging (Albany NY). 2024 Apr 29;16. doi: 10.18632/aging.205794. Online ahead of print.ABSTRACTRecently, there has been growing interest in using cell therapy through core decompression (CD) to treat osteonecrosis of the femoral head (ONFH). Our study aimed to investigate the effectiveness and mechanism of human umbilical cord mesenchymal stem cells (hUCMSCs) in treating steroid-induced ONFH. We constructed a steroid-induced ONFH rabbit model as well as dexamethasone (Dex)-treated bone microvascular endothelial cells (BMECs) model of human femoral head. We injected hUCMSCs into the rabbit femoral head via CD. The effects of ...
Source: Aging - May 2, 2024 Category: Biomedical Science Authors: Junwen Chen Wenyi Jin Changheng Zhong Wenxiang Cai Liangkun Huang Jianlin Zhou Hao Peng Source Type: research
Dynamic injectable tissue adhesives with strong adhesion and rapid self-healing for regeneration of large muscle injury
Biomaterials. 2024 Apr 26;309:122597. doi: 10.1016/j.biomaterials.2024.122597. Online ahead of print.ABSTRACTWounds often necessitate the use of instructive biomaterials to facilitate effective healing. Yet, consistently filling the wound and retaining the material in place presents notable challenges. Here, we develop a new class of injectable tissue adhesives by leveraging the dynamic crosslinking chemistry of Schiff base reactions. These adhesives demonstrate outstanding mechanical properties, especially in regard to stretchability and self-healing capacity, and biodegradability. Furthermore, they also form robust adhes...
Source: Biomaterials - May 2, 2024 Category: Materials Science Authors: Sungmin Nam Junzhe Lou Sangmin Lee Jan-Marc Kartenbender David J Mooney Source Type: research
A biomechanical analysis of novel endovascular implants for aortic valve replacement and ascending aortic repair
This study proposes a novel linked diamond-shaped implant (LD). To evaluate the safety and effectiveness of this new implant, finite element simulation models were created to assess the risks of endoleak, migration, and vascular wall rupture under annulus displacement load. After the SZ, SD, and LD implants were grafted in virtual release method, all the implants can cover tear-entry located in the ascending aorta, but space distance (δ) which exposed to blood was 14.5, 13.1, and 7.4 mm, respectively; the maximum areas of contact gap was 76.5, 51.5 and 6.3 mm2; the maximum migration distance (ΔL1) were 1.27, 1.06, and 0....
Source: Computer Methods in Biomechanics and Biomedical Engineering - May 2, 2024 Category: Biomedical Engineering Authors: Hui Zuo Wentao Feng Jingbo Wu Tong Gao Yubo Fan Source Type: research
