Skeletal muscle niche, at the crossroad of cell/cell communications
Curr Top Dev Biol. 2024;158:203-220. doi: 10.1016/bs.ctdb.2024.01.012. Epub 2024 Feb 5.ABSTRACTSkeletal muscle is composed of a variety of tissue and non-tissue resident cells that participate in homeostasis. In particular, the muscle stem cell niche is a dynamic system, requiring direct and indirect communications between cells, involving local and remote cues. Interactions within the niche must happen in a timely manner for the maintenance or recovery of the homeostatic niche. For instance, after an injury, pro-myogenic cues delivered too early will impact on muscle stem cell proliferation, delaying the repair process. W...
Source: Current Topics in Developmental Biology - April 26, 2024 Category: Biology Authors: Marine Theret B énédicte Chazaud Source Type: research
Perioperative steroid injection in elbow arthroscopy
Acta Orthop Belg. 2024 Mar;90(1):67-71. doi: 10.52628/90.1.12493.ABSTRACTThe goal of the present study was to evaluate the incidence of infection after perioperative intra-articular steroid injection during elbow arthroscopy. Starting from May 2019, we prospectively included all patients that underwent an elbow arthroscopy for various indications. All patients received preoperative antibiotics intravenously and a corticosteroid injection immediately after portal closure. Patients who needed ligamentous repair and aged below 18 years old were excluded. Final follow up of all patients was 3 months. In total, 108 elbow arthro...
Source: Acta Orthopaedica - April 26, 2024 Category: Orthopaedics Authors: M Vanderstappen L VAN Melkebeke J Duerinckx P Caekebeke Source Type: research
Perioperative steroid injection in elbow arthroscopy
Acta Orthop Belg. 2024 Mar;90(1):67-71. doi: 10.52628/90.1.12493.ABSTRACTThe goal of the present study was to evaluate the incidence of infection after perioperative intra-articular steroid injection during elbow arthroscopy. Starting from May 2019, we prospectively included all patients that underwent an elbow arthroscopy for various indications. All patients received preoperative antibiotics intravenously and a corticosteroid injection immediately after portal closure. Patients who needed ligamentous repair and aged below 18 years old were excluded. Final follow up of all patients was 3 months. In total, 108 elbow arthro...
Source: Acta Orthopaedica Belgica - April 26, 2024 Category: Orthopaedics Authors: M Vanderstappen L VAN Melkebeke J Duerinckx P Caekebeke Source Type: research
The Effect of Lower Limb Alignment on Tibiofemoral Joint Contact Biomechanics after Medial Meniscus Posterior Root Repair: A Finite-Element Analysis
DISCUSSION: Greater PCPs and areas of LCP elevation in varus knees may reduce the clinical effectiveness of root repair in delaying or preventing the development of tibiofemoral osteoarthritis.PMID:38669669 | DOI:10.5435/JAAOS-D-23-00702 (Source: The Journal of the American Academy of Orthopaedic Surgeons)
Source: The Journal of the American Academy of Orthopaedic Surgeons - April 26, 2024 Category: Orthopaedics Authors: Alexander N Berk William M Cregar Shangcheng Wang Nahir A Habet Anna Maria Ifarraguerri David P Trofa Dana P Piasecki James E Fleischli Bryan M Saltzman Source Type: research
Inflammasome Molecular Insights in Autoimmune Diseases
Curr Issues Mol Biol. 2024 Apr 18;46(4):3502-3532. doi: 10.3390/cimb46040220.ABSTRACTAutoimmune diseases (AIDs) emerge due to an irregular immune response towards self- and non-self-antigens. Inflammation commonly accompanies these conditions, with inflammatory factors and inflammasomes playing pivotal roles in their progression. Key concepts in molecular biology, inflammation, and molecular mimicry are crucial to understanding AID development. Exposure to foreign antigens can cause inflammation, potentially leading to AIDs through molecular mimicry triggered by cross-reactive epitopes. Molecular mimicry emerges as a key m...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Monica Neam țu Veronica Bild Alexandru Vasincu Oana Dana Arcan Delia Bulea Daniela-Carmen Ababei R ăzvan-Nicolae Rusu Ioana Macadan Ana Maria Sciuc ă Andrei Neam țu Source Type: research
Role of Filamin A in Growth and Migration of Breast Cancer-Review
Curr Issues Mol Biol. 2024 Apr 17;46(4):3408-3423. doi: 10.3390/cimb46040214.ABSTRACTDespite ongoing research in the field of breast cancer, the morbidity rates indicate that the disease remains a significant challenge. While patients with primary tumors have relatively high survival rates, these chances significantly decrease once metastasis begins. Thus, exploring alternative approaches, such as targeting proteins overexpressed in malignancies, remains significant. Filamin A (FLNa), an actin-binding protein (ABP), is involved in various cellular processes, including cell migration, adhesion, proliferation, and DNA repair...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Patryk Zawadka Wioletta Zieli ńska Maciej Gagat Magdalena Izdebska Source Type: research
Muscle stem cell dysfunction in rhabdomyosarcoma and muscular dystrophy
Curr Top Dev Biol. 2024;158:83-121. doi: 10.1016/bs.ctdb.2024.01.019. Epub 2024 Feb 19.ABSTRACTMuscle stem cells (MuSCs) are crucial to the repair and homeostasis of mature skeletal muscle. MuSC dysfunction and dysregulation of the myogenic program can contribute to the development of pathology ranging from cancers like rhabdomyosarcoma (RMS) or muscle degenerative diseases such as Duchenne muscular dystrophy (DMD). Both diseases exhibit dysregulation at nearly all steps of myogenesis. For instance, MuSC self-renewal processes are altered. In RMS, this leads to the creation of tumor propagating cells. In DMD, impaired asym...
Source: Current Topics in Developmental Biology - April 26, 2024 Category: Biology Authors: Rebecca Robertson Shulei Li Romina L Filippelli Natasha C Chang Source Type: research
Circadian timing of satellite cell function and muscle regeneration
Curr Top Dev Biol. 2024;158:307-339. doi: 10.1016/bs.ctdb.2024.01.017. Epub 2024 Apr 9.ABSTRACTRecent research has highlighted an important role for the molecular circadian machinery in the regulation of tissue-specific function and stress responses. Indeed, disruption of circadian function, which is pervasive in modern society, is linked to accelerated aging, obesity, and type 2 diabetes. Furthermore, evidence supporting the importance of the circadian clock within both the mature muscle tissue and satellite cells to regulate the maintenance of muscle mass and repair capacity in response injury has recently emerged. Here,...
Source: Current Topics in Developmental Biology - April 26, 2024 Category: Biology Authors: Pei Zhu Clara B Peek Source Type: research
Epigenetic integration of signaling from the regenerative environment
Curr Top Dev Biol. 2024;158:341-374. doi: 10.1016/bs.ctdb.2024.02.003. Epub 2024 Feb 19.ABSTRACTSkeletal muscle has an extraordinary capacity to regenerate itself after injury due to the presence of tissue-resident muscle stem cells. While these muscle stem cells are the primary contributor to the regenerated myofibers, the process occurs in a regenerative microenvironment where multiple different cell types act in a coordinated manner to clear the damaged myofibers and restore tissue homeostasis. In this regenerative environment, immune cells play a well-characterized role in initiating repair by establishing an inflammat...
Source: Current Topics in Developmental Biology - April 26, 2024 Category: Biology Authors: Perla Geara F Jeffrey Dilworth Source Type: research
Skeletal muscle niche, at the crossroad of cell/cell communications
Curr Top Dev Biol. 2024;158:203-220. doi: 10.1016/bs.ctdb.2024.01.012. Epub 2024 Feb 5.ABSTRACTSkeletal muscle is composed of a variety of tissue and non-tissue resident cells that participate in homeostasis. In particular, the muscle stem cell niche is a dynamic system, requiring direct and indirect communications between cells, involving local and remote cues. Interactions within the niche must happen in a timely manner for the maintenance or recovery of the homeostatic niche. For instance, after an injury, pro-myogenic cues delivered too early will impact on muscle stem cell proliferation, delaying the repair process. W...
Source: Current Topics in Developmental Biology - April 26, 2024 Category: Biology Authors: Marine Theret B énédicte Chazaud Source Type: research
Navigating translational control of gene expression in satellite cells
Curr Top Dev Biol. 2024;158:253-277. doi: 10.1016/bs.ctdb.2024.02.013. Epub 2024 Mar 19.ABSTRACTSatellite cells, named for their satellite position around the sarcolemma of the myofibre, are responsible for skeletal muscle regeneration. Satellite cells normally reside in a quiescent state, but rapidly activate the myogenic program and the cell cycle in response to injury. Translational control of gene expression has emerged as an important regulator of satellite cell activity. Quiescent satellite cells maintain low levels of protein synthesis and selectively translate specific mRNAs to conserve limited energy. Activated sa...
Source: Current Topics in Developmental Biology - April 26, 2024 Category: Biology Authors: Holly Jiogo Colin Crist Source Type: research
Decoding the forces that shape muscle stem cell function
Curr Top Dev Biol. 2024;158:279-306. doi: 10.1016/bs.ctdb.2024.02.009. Epub 2024 Mar 5.ABSTRACTSkeletal muscle is a force-producing organ composed of muscle tissues, connective tissues, blood vessels, and nerves, all working in synergy to enable movement and provide support to the body. While robust biomechanical descriptions of skeletal muscle force production at the body or tissue level exist, little is known about force application on microstructures within the muscles, such as cells. Among various cell types, skeletal muscle stem cells reside in the muscle tissue environment and play a crucial role in driving the self-...
Source: Current Topics in Developmental Biology - April 26, 2024 Category: Biology Authors: Jo Nguyen Penney M Gilbert Source Type: research
Muscle stem cell niche dynamics during muscle homeostasis and regeneration
Curr Top Dev Biol. 2024;158:151-177. doi: 10.1016/bs.ctdb.2024.02.008. Epub 2024 Mar 23.ABSTRACTThe process of skeletal muscle regeneration involves a coordinated interplay of specific cellular and molecular interactions within the injury site. This review provides an overview of the cellular and molecular components in regenerating skeletal muscle, focusing on how these cells or molecules in the niche regulate muscle stem cell functions. Dysfunctions of muscle stem cell-to-niche cell communications during aging and disease will also be discussed. A better understanding of how niche cells coordinate with muscle stem cells ...
Source: Current Topics in Developmental Biology - April 26, 2024 Category: Biology Authors: Yishu Yin Gary J He Shenyuan Hu Erin H Y Tse Tom H Cheung Source Type: research
Genomic stress and impaired DNA repair in Alzheimer disease
DNA Repair (Amst). 2024 Apr 11;139:103678. doi: 10.1016/j.dnarep.2024.103678. Online ahead of print.ABSTRACTAlzheimer disease (AD) is the most prominent form of dementia and has received considerable attention due to its growing burden on economic, healthcare and basic societal infrastructures. The two major neuropathological hallmarks of AD, i.e., extracellular amyloid beta (Aβ) peptide plaques and intracellular hyperphosphorylated Tau neurofibrillary tangles, have been the focus of much research, with an eye on understanding underlying disease mechanisms and identifying novel therapeutic avenues. One often overlooked as...
Source: DNA Repair - April 26, 2024 Category: Genetics & Stem Cells Authors: Jolien Neven Luidy Kazuo Issayama Ilse Dewachter David M Wilson Source Type: research
Perioperative steroid injection in elbow arthroscopy
Acta Orthop Belg. 2024 Mar;90(1):67-71. doi: 10.52628/90.1.12493.ABSTRACTThe goal of the present study was to evaluate the incidence of infection after perioperative intra-articular steroid injection during elbow arthroscopy. Starting from May 2019, we prospectively included all patients that underwent an elbow arthroscopy for various indications. All patients received preoperative antibiotics intravenously and a corticosteroid injection immediately after portal closure. Patients who needed ligamentous repair and aged below 18 years old were excluded. Final follow up of all patients was 3 months. In total, 108 elbow arthro...
Source: Acta Orthopaedica - April 26, 2024 Category: Orthopaedics Authors: M Vanderstappen L VAN Melkebeke J Duerinckx P Caekebeke Source Type: research
