H2AX: A key player in DNA damage response and a promising target for cancer therapy
Biomed Pharmacother. 2024 Apr 29;175:116663. doi: 10.1016/j.biopha.2024.116663. Online ahead of print.ABSTRACTCancer is caused by a complex interaction of factors that interrupt the normal growth and division of cells. At the center of this process is the intricate relationship between DNA damage and the cellular mechanisms responsible for maintaining genomic stability. When DNA damage is not repaired, it can cause genetic mutations that contribute to the initiation and progression of cancer. On the other hand, the DNA damage response system, which involves the phosphorylation of the histone variant H2AX (γH2AX), is cruci...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 30, 2024 Category: Drugs & Pharmacology Authors: Kirti S Prabhu Shilpa Kuttikrishnan Nuha Ahamad Ummu Habeeba Zahwa Mariyam Muhammad Suleman Ajaz A Bhat Shahab Uddin Source Type: research
Periodontal granulation tissue - To remove or not to remove, that is the question
J Periodontal Res. 2024 Apr 30. doi: 10.1111/jre.13261. Online ahead of print.ABSTRACTFormation of granulation tissue is a fundamental phase in periodontal wound healing with subsequent maturation leading to regeneration or repair. However, persistently inflamed granulation tissue presents in osseous defects as a result of periodontitis and is routinely disrupted and discarded with non-surgical and surgical therapy to facilitate wound healing or improve chances of regeneration. Histological assessment suggests that granulation tissue from periodontitis-affected sites is effectively a chronic inflammatory tissue resulting f...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Ye Han Sam Luigi Nibali Mandeep Ghuman Source Type: research
The role of innate lymphoid cells in systemic lupus erythematosus
Cytokine. 2024 Apr 28;179:156623. doi: 10.1016/j.cyto.2024.156623. Online ahead of print.ABSTRACTSystemic lupus erythematosus (SLE) is a connective tissue disorder that affects various body systems. Both the innate and adaptive immunity contribute to the onset and progression of SLE. The main mechanism of SLE is an excessive immune response of immune cells to autoantigens, which leads to systemic inflammation and inflammation-induced organ damage. Notably, a subset of innate immune cells known as innate lymphoid cells (ILCs) has recently emerged. ILCs are pivotal in the early stages of infection; participate in immune resp...
Source: Cytokine - April 30, 2024 Category: Molecular Biology Authors: Yong Chen Xiaotian Gu Kunyu Cao Miao Tu Wan Liu Jiyu Ju Source Type: research
Fabrication of MXene-Based Shape Memory Hydrogel and Its Application in Skin Wound Repair
Soft Matter, 2024, Accepted Manuscript DOI: 10.1039/D4SM00157E, PaperJingchuan Hu, Jun Xie, Tao Peng, Qingwen Shi, Chen Pan, Haiying Tan, Jiuxiao Sun Wound dressings can generally finish hemostasis and provide temporary protection after skin damage. Herein, MXene-based hydrogel was prepared from MXene, gelatin, poly(ethylene glycol) diacrylate (PEGDA) and N,N'-Methylenebis(acrylamide) (HEAA) to prepare... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Soft Matter latest articles)
Source: RSC - Soft Matter latest articles - April 30, 2024 Category: Chemistry Authors: Jingchuan Hu Source Type: research
Challenging repair of the left subclavian vein in a pediatric patient
AbstractThis is a case involving a 3-year-old child who presented with an iatrogenic left subclavian/innominate vein lesion, leading to severe bleeding and intravascular catheter rupture during its removal. We successfully performed a very challenging and minimally invasive repair of the vein, along with the removal of the catheter entrapped in the innominate vein. (Source: Updates in Surgery)
Source: Updates in Surgery - April 30, 2024 Category: Surgery Source Type: research
Managing ischemic and necrotic incarcerated femoral hernia contents and their risk factors
ConclusionOpen tension-free repair was the most commonly used surgical methods for emergency incarcerated femoral hernia patients. Ischemia and necrosis of hernia contents will increase bowel resection rate and prolong operation and hospital stay. Long incarceration time is an independent risk factor for ischemia and necrosis of hernia contents. (Source: Hernia)
Source: Hernia - April 30, 2024 Category: Sports Medicine Source Type: research
Efficacy and Safety of Neoadjuvant Subcutaneous Envafolimab in dMMR/MSI-H Locally Advanced Colon Cancer
ConclusionsEnvafolimab yielded promising surgical outcomes and safety in dMMR/MSI-H locally advanced colon cancer, representing a promising treatment modality for this population. (Source: Targeted Oncology)
Source: Targeted Oncology - April 30, 2024 Category: Cancer & Oncology Source Type: research
Photodynamic and nitric oxide therapy-based synergistic antimicrobial nanoplatform: an advanced root canal irrigation system for endodontic bacterial infections
The main issues faced during the treatment of apical periodontitis are the management of bacterial infection and the facilitation of the repair of alveolar bone defects to shorten disease duration. Conventiona... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - April 30, 2024 Category: Nanotechnology Authors: Youyun Zeng, Xiangyu Hu, Zhibin Cai, Dongchao Qiu, Ying Ran, Yiqin Ding, Jiayi Shi, Xiaojun Cai and Yihuai Pan Tags: Research Source Type: research
Long-Term Comparison of Esthetic Outcomes Between Hatchet and Transposition Flaps in Facial-Defect Reconstruction
ConclusionsThe hatchet flap had good esthetic outcome for facial reconstruction and could be a valuable option for reconstructing facial defects.Level of Evidence IVThis journal requires that authors assign a level of evidence to each article. For a full description of these evidence-based medicine ratings, please refer to Table of Contents or online Instructions to Authorswww.springer.com/00266. (Source: Aesthetic Plastic Surgery)
Source: Aesthetic Plastic Surgery - April 30, 2024 Category: Cosmetic Surgery Source Type: research
Endoscopic Endonasal Anterior Skull Base Meningoencephalocele and Cerebrospinal Fluid Leak Repair: Our Intraoperative and Postoperative Protocol and Long-term Outcomes
Conclusion This study represents one of the largest long-term analyses of outcomes by a single team. Our specific protocol for the endoscopic endonasal repair of anterior skull base MECs and CSF leaks is safe and effective. These patients should be evaluated and treated for elevated intracranial pressure following the repair. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Journal of Neurological Surgery Part B: Skull Base)
Source: Journal of Neurological Surgery Part B: Skull Base - April 30, 2024 Category: Neurosurgery Authors: Ruiz, Gianna M. Uram, Zach Strelko, Oleksandr Hossain, Adnan Ng, Isaac Patel, Chirag R. Germanwala, Anand V. Tags: Original Article Source Type: research
The effects of NLRP3 inflammasome inhibition or knockout in experimental apical periodontitis induced in mice
ConclusionsNLRP3 inflammasome inhibition or knockout can attenuate the inflammatory events that result in the periapical lesion (AP) formation after pulpal exposure in mice.Clinical relevanceThe NLRP3 inflammasome may be a therapeutic target for AP, and new approaches may verify the impact of its inhibition (through intracanal medications or filling materials) on the bone repair process and treatment success. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - April 30, 2024 Category: Dentistry Source Type: research
Emerging Roles of Spatial Transcriptomics in Liver Research
In conclusion, spatial transcriptomics represents a significant advance in hepatology, promising to enhance our understanding and treatment of liver diseases. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Seminars in Liver Disease)
Source: Seminars in Liver Disease - April 30, 2024 Category: Gastroenterology Authors: Fujiwara, Naoto Kimura, Genki Nakagawa, Hayato Tags: Review Article Source Type: research
Post-dissection Thoraco-abdominal Aortic Aneurysm Managed with Fenestrated or Branched Endovascular Aortic Repair
This study aimed to analyse early and follow up outcomes of f/bEVAR. (Source: European Journal of Vascular and Endovascular Surgery)
Source: European Journal of Vascular and Endovascular Surgery - April 30, 2024 Category: Surgery Authors: Filippo Gorgatti, Petroula Nana, Giuseppe Panuccio, Fiona Rohlffs, Jos é I. Torrealba, Tilo Kölbel Source Type: research
Treating Benign Ovarian Lesions in the Pediatric Population: A Single Institution ’s Retrospective Investigation of Laparoscopy Versus Open Repair
Journal of Laparoendoscopic&Advanced Surgical Techniques, Ahead of Print. (Source: Journal of Laparoendoscopic)
Source: Journal of Laparoendoscopic - April 30, 2024 Category: Surgery Authors: Nicole Chicoine Niloufar Hafezi Victoria Sanchez Victoria Elliott Brian Gray Source Type: research
Unconventional activation of PRKDC by TNF- α: deciphering its crucial role in Th1-mediated inflammation beyond DNA repair as part of the DNA-PK complex
The DNA-dependent protein kinase (DNA-PK) complex comprises a catalytic (PRKDC) and two requisite DNA-binding (Ku70/Ku80) subunits. The role of the complex in repairing double-stranded DNA breaks (DSBs) is est... (Source: Journal of Inflammation)
Source: Journal of Inflammation - April 30, 2024 Category: Allergy & Immunology Authors: Mohamed A. Ghonim, Jihang Ju, Kusma Pyakurel, Salome V. Ibba, Mai M. Abouzeid, Hamada F. Rady, Shigemi Matsuyama, Luis Del Valle and A. Hamid Boulares Tags: Research Source Type: research
