Unconventional activation of PRKDC by TNF- α: deciphering its crucial role in Th1-mediated inflammation beyond DNA repair as part of the DNA-PK complex

The DNA-dependent protein kinase (DNA-PK) complex comprises a catalytic (PRKDC) and two requisite DNA-binding (Ku70/Ku80) subunits. The role of the complex in repairing double-stranded DNA breaks (DSBs) is est...

Source: Journal of Inflammation - April 30, 2024 Category: Allergy & Immunology Authors: Mohamed A. Ghonim, Jihang Ju, Kusma Pyakurel, Salome V. Ibba, Mai M. Abouzeid, Hamada F. Rady, Shigemi Matsuyama, Luis Del Valle and A. Hamid Boulares Tags: Research Source Type: research