Taurine attenuates activation of hepatic stellate cells by inhibiting autophagy and inducing ferroptosis
CONCLUSION: Taurine exerts therapeutic effects on liver fibrosis via mechanisms that involve inhibition of autophagy and trigger of ferroptosis and ferritinophagy in HSCs to eliminate aHSCs.PMID:38681990 | PMC:PMC11045481 | DOI:10.3748/wjg.v30.i15.2143 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 29, 2024 Category: Gastroenterology Authors: Sen Li Qian-Jun Ren Can-Hao Xie Yang Cui Li-Tao Xu Yi-Dan Wang Su Li Xing-Qiu Liang Bin Wen Ming-Kun Liang Xiao-Fang Zhao Source Type: research
Secretome of adipose derived-mesenchymal stem cells reduces the < em > Vibrio cholerae < /em > attachment to Caco-2 cells and subsequent inflammatory responses
CONCLUSION: The secretome of AD-MSCs can play a critical role in inhibiting bacterial colonization, and subsequent inflammatory responses, and maintaining the integrity of the epithelial barrier. The secretome may be effective in the prevention of hypovolemic shock.PMID:38682070 | PMC:PMC11055443 | DOI:10.18502/ijm.v16i1.14875 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - April 29, 2024 Category: Microbiology Authors: Alireza Moulazade Sara Soudi Bita Bakhshi Source Type: research
The TP53-activated E3 ligase RNF144B is a tumour suppressor that prevents genomic instability
CONCLUSIONS: Supported by clinical data, our study suggests that RNF144B plays a pivotal role in maintaining genomic stability during tumor suppression.PMID:38685100 | DOI:10.1186/s13046-024-03045-4 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - April 29, 2024 Category: Genetics & Stem Cells Authors: Etna Abad J érémy Sandoz Gerard Romero Ivan Zadra Julia Urgel-Solas Pablo Borredat Savvas Kourtis Laura Ortet Carlos M Mart ínez Donate Weghorn Sara Sdelci Ana Janic Source Type: research
Taurine attenuates activation of hepatic stellate cells by inhibiting autophagy and inducing ferroptosis
CONCLUSION: Taurine exerts therapeutic effects on liver fibrosis via mechanisms that involve inhibition of autophagy and trigger of ferroptosis and ferritinophagy in HSCs to eliminate aHSCs.PMID:38681990 | PMC:PMC11045481 | DOI:10.3748/wjg.v30.i15.2143 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 29, 2024 Category: Gastroenterology Authors: Sen Li Qian-Jun Ren Can-Hao Xie Yang Cui Li-Tao Xu Yi-Dan Wang Su Li Xing-Qiu Liang Bin Wen Ming-Kun Liang Xiao-Fang Zhao Source Type: research
ABCG2-Expressing Clonal Repopulating Endothelial Cells Serve to Form and Maintain Blood Vessels
CONCLUSIONS: These results are the first to establish that a single prospective marker identifies CRECs in mice and human individuals, which holds promise to provide new cell therapies for repair of damaged vessels in patients with endothelial dysfunction.PMID:38682338 | DOI:10.1161/CIRCULATIONAHA.122.061833 (Source: Circulation)
Source: Circulation - April 29, 2024 Category: Cardiology Authors: Yang Lin Chang-Hyun Gil Kimihiko Banno Masataka Yokoyama Matthew Wingo Ellen Go Nutan Prasain Ying Liu Takashi Hato Hisamichi Naito Taku Wakabayashi Musia Sominskaia Meng Gao Kevin Chen Fuqiang Geng Jesus Maria Gomez Salinero Sisi Chen W Christopher Shell Source Type: research
A new mechanism in negative pressure wound therapy: interleukin-17 alters chromatin accessibility profiling
In this study, skin wound-healing models were established, with administration of NPWT. Vimentin, collagen I, and MMP9 of skin tissues were detected by immunofluorescence (IF). Gene expression analysis of skin wound tissues was performed by RNA-sequencing (RNA-seq). Protein expression was assayed by a western blotting or IF assay, and mRNA levels were quantified by quantitative PCR. Chromatin accessibility profiles of fibroblasts following NPWT or IL-17 exposure were analyzed by ATAC-seq. In rat wound-healing models, NPWT promoted wound repair by promoting re-epithelialization, extracellular matrix (ECM) synthesis and prol...
Source: Am J Physiol Cell Ph... - April 29, 2024 Category: Cytology Authors: Shuao Xiao Wenxuan Wang Congying Zhao Pan Ren Liwei Dong Hao Zhang Fuxin Ma Xueyong Li Yongqian Bian Source Type: research
A new mechanism in negative pressure wound therapy: interleukin-17 alters chromatin accessibility profiling
In this study, skin wound-healing models were established, with administration of NPWT. Vimentin, collagen I, and MMP9 of skin tissues were detected by immunofluorescence (IF). Gene expression analysis of skin wound tissues was performed by RNA-sequencing (RNA-seq). Protein expression was assayed by a western blotting or IF assay, and mRNA levels were quantified by quantitative PCR. Chromatin accessibility profiles of fibroblasts following NPWT or IL-17 exposure were analyzed by ATAC-seq. In rat wound-healing models, NPWT promoted wound repair by promoting re-epithelialization, extracellular matrix (ECM) synthesis and prol...
Source: American Journal of Physiology. Cell Physiology - April 29, 2024 Category: Cytology Authors: Shuao Xiao Wenxuan Wang Congying Zhao Pan Ren Liwei Dong Hao Zhang Fuxin Ma Xueyong Li Yongqian Bian Source Type: research
Exploring the roles of non-coding RNAs in liver regeneration
Noncoding RNA Res. 2024 Apr 16;9(3):945-953. doi: 10.1016/j.ncrna.2024.04.003. eCollection 2024 Sep.ABSTRACTLiver regeneration (LR) is a complex process encompassing three distinct phases: priming, proliferation phase and restoration, all influenced by various regulatory factors. After liver damage or partial resection, the liver tissue demonstrates remarkable restorative capacity, driven by cellular proliferation and repair mechanisms. The essential roles of non-coding RNAs (ncRNAs), predominantly microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNA (circRNA), in regulating LR have been vastly studied. Addi...
Source: Cell Research - April 29, 2024 Category: Cytology Authors: Penghui Li Xiao Ma Di Huang Xinyu Gu Source Type: research
Developing a Rehabilitation Guideline (REGUIDE) for Patients Undergoing an Arthroscopic Bankart Repair After Traumatic Anterior Shoulder Dislocation, Focusing on Managing Apprehension: An International Delphi-Based Consensus Study
Journal of Orthopaedic&Sports Physical Therapy,Volume 54, Issue 5, Page 289-301, May 2024. (Source: The Journal of Orthopaedic and Sports Physical Therapy)
Source: The Journal of Orthopaedic and Sports Physical Therapy - April 29, 2024 Category: Physiotherapy Authors: Marianne Larsen van Gastel Theodore Paul van Iersel Eric Danjel Tutuhatunewa Ann M. Cools Michel Pieter Jozef van den Bekerom Karin Marie Christine Hekman Source Type: research
Modulation of the microhomology-mediated end joining pathway suppresses large deletions and enhances homology-directed repair following CRISPR-Cas9-induced DNA breaks
CRISPR-Cas9 genome editing often induces unintended, large genomic rearrangements, posing potential safety risks. However, there are no methods for mitigating these risks. (Source: BMC Biology)
Source: BMC Biology - April 29, 2024 Category: Biology Authors: Baolei Yuan, Chongwei Bi, Yeteng Tian, Jincheng Wang, Yiqing Jin, Khaled Alsayegh, Muhammad Tehseen, Gang Yi, Xuan Zhou, Yanjiao Shao, Fernanda Vargas Romero, Wolfgang Fischle, Juan Carlos Izpisua Belmonte, Samir Hamdan, Yanyi Huang and Mo Li Tags: Research article Source Type: research
Physiology of Nerve Regeneration
Functional recovery after peripheral nerve injuries is disappointing despite surgical advances in nerve repair. This review summarizes the relatively short window of opportunity for successful nerve regeneration due to the decline in the expression of growth-associated genes and in turn, the decline in regenerative capacity of the injured neurons and the support provided by the denervated Schwann cells, and the atrophy of denervated muscles. Brief, low-frequency electrical stimulation and post-injury exercise regimes ameliorate these deficits in animal models and patients, but the misdirection of regenerating nerve fibers ...
Source: Hand Clinics - April 29, 2024 Category: Orthopaedics Authors: Tessa Gordon Source Type: research
The History and Evolution of the Open Labral Repair with Capsular Shift for Shoulder Instability
AbstractPurpose of ReviewThe purpose of this review is to describe the evolution of the open labral repair with capsular shift, including the current role of this procedure in the treatment of shoulder instability.Recent FindingsCurrently, a subset of patients – high-level collision/contact sport athletes, patients with significant inferior or multi-directional instability, and individuals with failed arthroscopic Bankart repair without bone loss – may experience benefit from undergoing open Bankart repair with capsular shift. Surgeons performing open stabilization can benefit from instrumentation and anchors developed...
Source: Current Reviews in Musculoskeletal Medicine - April 29, 2024 Category: Orthopaedics Source Type: research
Use of sugammadex in prevention of post-operative urinary retention in minimally invasive hernia surgery
ConclusionThe results of this study reflect the protective role of sugammadex against POUR in minimally invasive IHR cases. (Source: Hernia)
Source: Hernia - April 29, 2024 Category: Sports Medicine Source Type: research
Correction to: Concomitant midline ventral and inguinal hernia repair: can we create an algorithmic approach?
(Source: Hernia)
Source: Hernia - April 29, 2024 Category: Sports Medicine Source Type: research
Determining the value of the abdominal core health quality collaborative to support regulatory decisions
ConclusionsCompared to traditional postmarket studies, use of ACHQC data can result in cost and time savings when used for appropriate regulatory decisions in light of key assumptions. (Source: Hernia)
Source: Hernia - April 29, 2024 Category: Sports Medicine Source Type: research
