Dysregulation of innate immune signaling in animal models of spinal muscular atrophy
Spinal muscular atrophy (SMA) is a devastating neuromuscular disease caused by hypomorphic loss of function in the survival motor neuron (SMN) protein. SMA presents across a broad spectrum of disease severity.... (Source: BMC Biology)
Source: BMC Biology - April 25, 2024 Category: Biology Authors: Eric L. Garcia, Rebecca E. Steiner, Amanda C. Raimer, Laura E. Herring, A. Gregory Matera and Ashlyn M. Spring Tags: Research article Source Type: research
Meta-analysis of the human upper respiratory tract microbiome reveals robust taxonomic associations with health and disease
The human upper respiratory tract (URT) microbiome, like the gut microbiome, varies across individuals and between health and disease states. However, study-to-study heterogeneity in reported case –control resu... (Source: BMC Biology)
Source: BMC Biology - April 23, 2024 Category: Biology Authors: Nick Quinn-Bohmann, Jose A. Freixas-Coutin, Jin Seo, Ruth Simmons, Christian Diener and Sean M. Gibbons Tags: Research article Source Type: research
Hypoxia exposure blunts angiogenic signaling and upregulates the antioxidant system in endothelial cells derived from elephant seals
Elephant seals exhibit extreme hypoxemic tolerance derived from repetitive hypoxia/reoxygenation episodes they experience during diving bouts. Real-time assessment of the molecular changes underlying protectio... (Source: BMC Biology)
Source: BMC Biology - April 23, 2024 Category: Biology Authors: Kaitlin N. Allen, Julia Mar ía Torres-Velarde, Juan Manuel Vazquez, Diana D. Moreno-Santillán, Peter H. Sudmant and José Pablo Vázquez-Medina Tags: Research article Source Type: research
Pangenome analysis reveals transposon-driven genome evolution in cotton
Transposable elements (TEs) have a profound influence on the trajectory of plant evolution, driving genome expansion and catalyzing phenotypic diversification. The pangenome, a comprehensive genetic pool encom... (Source: BMC Biology)
Source: BMC Biology - April 23, 2024 Category: Biology Authors: Xin He, Zhengyang Qi, Zhenping Liu, Xing Chang, Xianlong Zhang, Jianying Li and Maojun Wang Tags: Research article Source Type: research
Recognition of nonself is necessary to activate Drosophila ’s immune response against an insect parasite
Innate immune responses can be activated by pathogen-associated molecular patterns (PAMPs), danger signals released by damaged tissues, or the absence of self-molecules that inhibit immunity. As PAMPs are typi... (Source: BMC Biology)
Source: BMC Biology - April 22, 2024 Category: Biology Authors: Alexandre B. Leit ão, Ramesh Arunkumar, Jonathan P. Day, Nancy Hanna, Aarathi Devi, Matthew P. Hayes and Francis M. Jiggins Tags: Research article Source Type: research
Fast and accurate variant identification tool for sequencing-based studies
Accurate identification of genetic variants, such as point mutations and insertions/deletions (indels), is crucial for various genetic studies into epidemic tracking, population genetics, and disease diagnosis... (Source: BMC Biology)
Source: BMC Biology - April 22, 2024 Category: Biology Authors: Jeffry M. Gaston, Eric J. Alm and An-Ni Zhang Tags: Research article Source Type: research
Listeria-vectored cervical cancer vaccine candidate strains reduce MDSCs via the JAK-STAT signaling pathway
Immunosuppressive status is prevalent in cancer patients and increases the complexity of tumor immunotherapy. It has been found that Listeria-vectored tumor vaccines had the potential ability of two-side regulato... (Source: BMC Biology)
Source: BMC Biology - April 19, 2024 Category: Biology Authors: Yunwen Zhang, Yao Lei, Qian Ou, Mengdie Chen, Sicheng Tian, Jing Tang, Ruidan Li, Qian Liang, Zhaobin Chen and Chuan Wang Tags: Research article Source Type: research
Prediction of blood –brain barrier penetrating peptides based on data augmentation with Augur
The blood –brain barrier serves as a critical interface between the bloodstream and brain tissue, mainly composed of pericytes, neurons, endothelial cells, and tightly connected basal membranes. It plays a pivo... (Source: BMC Biology)
Source: BMC Biology - April 19, 2024 Category: Biology Authors: Zhi-Feng Gu, Yu-Duo Hao, Tian-Yu Wang, Pei-Ling Cai, Yang Zhang, Ke-Jun Deng, Hao Lin and Hao Lv Tags: Research article Source Type: research
Genomic insights into the seawater adaptation in Cyprinidae
Cyprinidae, the largest fish family, encompasses approximately 367 genera and 3006 species. While they exhibit remarkable adaptability to diverse aquatic environments, it is exceptionally rare to find them in ... (Source: BMC Biology)
Source: BMC Biology - April 19, 2024 Category: Biology Authors: Ying Wang, Xuejing Zhang, Jing Wang, Cheng Wang, Fei Xiong, Yuting Qian, Minghui Meng, Min Zhou, Wenjun Chen, Zufa Ding, Dan Yu, Yang Liu, Yumei Chang, Shunping He and Liandong Yang Tags: Research article Source Type: research
GATA3 functions downstream of BRCA1 to promote DNA damage repair and suppress dedifferentiation in breast cancer
Inadequate DNA damage repair promotes aberrant differentiation of mammary epithelial cells. Mammary luminal cell fate is mainly determined by a few transcription factors including GATA3. We previously reported... (Source: BMC Biology)
Source: BMC Biology - April 16, 2024 Category: Biology Authors: Xuejie Wang, Feng Bai, Xiong Liu, Bin Peng, Xingzhi Xu, Hongquan Zhang, Li Fu, Wei-Guo Zhu, Bin Wang and Xin-Hai Pei Tags: Research article Source Type: research
Nuclear lamina component KAKU4 regulates chromatin states and transcriptional regulation in the Arabidopsis genome
The nuclear lamina links the nuclear membrane to chromosomes and plays a crucial role in regulating chromatin states and gene expression. However, current knowledge of nuclear lamina in plants is limited compa... (Source: BMC Biology)
Source: BMC Biology - April 12, 2024 Category: Biology Authors: Yaxin Cao, Hengyu Yan, Minghao Sheng, Yue Liu, Xinyue Yu, Zhongqiu Li, Wenying Xu and Zhen Su Tags: Research article Source Type: research
A network of transcription factors in complex with a regulating cell cycle cyclin orchestrates fungal oxidative stress responses
Response to oxidative stress is universal in almost all organisms and the mitochondrial membrane protein, BbOhmm, negatively affects oxidative stress responses and virulence in the insect fungal pathogen, Beauver... (Source: BMC Biology)
Source: BMC Biology - April 12, 2024 Category: Biology Authors: Yanze Kan, Zhangjiang He, Nemat O. Keyhani, Ning Li, Shuaishuai Huang, Xin Zhao, Pengfei Liu, Fanqin Zeng, Min Li, Zhibing Luo and Yongjun Zhang Tags: Research article Source Type: research
Chromosome-level genome assembly of Hippophae tibetana provides insights into high-altitude adaptation and flavonoid biosynthesis
As an endemic shrub of the Qinghai-Tibetan Plateau (QTP), the distribution of Hippophae tibetana Schlecht. ranges between 2800 and 5200 m above sea level. As the most basal branch of the Hippophae genus, H. tibet... (Source: BMC Biology)
Source: BMC Biology - April 12, 2024 Category: Biology Authors: Guoyun Zhang, Yating Song, Ning Chen, Jihua Wei, Jianguo Zhang and Caiyun He Tags: Research article Source Type: research
Targeting of REST with rationally-designed small molecule compounds exhibits synergetic therapeutic potential in human glioblastoma cells
Glioblastoma (GBM) is an aggressive brain cancer associated with poor prognosis, intrinsic heterogeneity, plasticity, and therapy resistance. In some GBMs, cell proliferation is fueled by a transcriptional reg... (Source: BMC Biology)
Source: BMC Biology - April 12, 2024 Category: Biology Authors: Svetlana B. Panina, Joshua V. Schweer, Qian Zhang, Gaurav Raina, Haley A. Hardtke, Seungjin Kim, Wanjie Yang, Dionicio Siegel and Y. Jessie Zhang Tags: Research article Source Type: research
A cilia-bound unconventional secretory pathway for Drosophila odorant receptors
Post-translational transport is a vital process which ensures that each protein reaches its site of function. Though most do so via an ordered ER-to-Golgi route, an increasing number of proteins are now shown ... (Source: BMC Biology)
Source: BMC Biology - April 12, 2024 Category: Biology Authors: Najat Dzaki and Mattias Alenius Tags: Research article Source Type: research
