Removal of a partial genomic duplication restores synaptic transmission and behavior in the MyosinVA mutant mouse Flailer
Copy number variations, and particularly duplications of genomic regions, have been strongly associated with various neurodegenerative conditions including autism spectrum disorder (ASD). These genetic variati... (Source: BMC Biology)
Source: BMC Biology - November 14, 2023 Category: Biology Authors: Fernando J. Bustos, Swarna Pandian, Henny Haensgen, Jian-Ping Zhao, Haley Strouf, Matthias Heidenreich, Lukasz Swiech, Benjamin E. Deverman, Viviana Gradinaru, Feng Zhang and Martha Constantine-Paton Tags: Research article Source Type: research
Neuromolecular responses in disrupted mutualistic cleaning interactions under future environmental conditions
Mutualistic interactions, which constitute some of the most advantageous interactions among fish species, are highly vulnerable to environmental changes. A key mutualistic interaction is the cleaning service r... (Source: BMC Biology)
Source: BMC Biology - November 14, 2023 Category: Biology Authors: S. Ram írez-Calero, J. R. Paula, E. Otjacques, T. Ravasi, R. Rosa and C. Schunter Tags: Research article Source Type: research
Circulating cell-free DNA fragmentation is a stepwise and conserved process linked to apoptosis
Circulating cell-free DNA (cfDNA) is a pool of short DNA fragments mainly released from apoptotic hematopoietic cells. Nevertheless, the precise physiological process governing the DNA fragmentation and molecu... (Source: BMC Biology)
Source: BMC Biology - November 13, 2023 Category: Biology Authors: Dandan Zhu, Haihong Wang, Wei Wu, Shuaipeng Geng, Guolin Zhong, Yunfei Li, Han Guo, Guanghui Long, Qingqi Ren, Yi Luan, Chaohui Duan, Bing Wei, Jie Ma, Shiyong Li, Jun Zhou and Mao Mao Tags: Research article Source Type: research
Expression profiles of the autism-related SHANK proteins in the human brain
SHANKs are major scaffolding proteins at postsynaptic densities (PSDs) in the central nervous system. Mutations in all three family members have been associated with neurodevelopmental disorders such as autism... (Source: BMC Biology)
Source: BMC Biology - November 13, 2023 Category: Biology Authors: Sarah Woelfle, Maria T. Pedro, Jan Wagner, Michael Sch ön and Tobias M. Boeckers Tags: Research article Source Type: research
A systematic scientometric review of paternal inheritance of acquired metabolic traits
The concept of the inheritance of acquired traits, a foundational principle of Lamarck ’s evolutionary theory, has garnered renewed attention in recent years. Evidence for this phenomenon remained limited for d... (Source: BMC Biology)
Source: BMC Biology - November 13, 2023 Category: Biology Authors: Lu ís Crisóstomo, Pedro F. Oliveira and Marco G. Alves Tags: Research article Source Type: research
A systematic review of the development and application of home cage monitoring in laboratory mice and rats
Traditionally, in biomedical animal research, laboratory rodents are individually examined in test apparatuses outside of their home cages at selected time points. However, the outcome of such tests can be inf... (Source: BMC Biology)
Source: BMC Biology - November 13, 2023 Category: Biology Authors: Pia Kahnau, Paul Mieske, Jenny Wilzopolski, Otto Kalliokoski, Silvia Mandillo, Sabine M. H ölter, Vootele Voikar, Adriana Amfim, Sylvia Badurek, Aleksandra Bartelik, Angela Caruso, Maša Čater, Elodie Ey, Elisabetta Golini, Anne Jaap, Dragan Hrncic & he Tags: Research article Source Type: research
Chronic high-sugar diet in adulthood protects Caenorhabditis elegans from 6-OHDA-induced dopaminergic neurodegeneration
Diets high in saturated fat and sugar, termed “Western diets,” have been associated with several negative health outcomes, including increased risk for neurodegenerative disease. Parkinson’s disease (PD) is th... (Source: BMC Biology)
Source: BMC Biology - November 10, 2023 Category: Biology Authors: Katherine S. Morton, Jessica H. Hartman, Nathan Heffernan, Ian T. Ryde, Isabel W. Kenny-Ganzert, Lingfeng Meng, David R. Sherwood and Joel N. Meyer Tags: Research article Source Type: research
Transcription dosage compensation does not occur in Down syndrome
The increase in DNA copy number in Down syndrome (DS; caused by trisomy 21) has led to the DNA dosage hypothesis, which posits that the level of gene expression is proportional to the gene ’s DNA copy number. Y... (Source: BMC Biology)
Source: BMC Biology - November 10, 2023 Category: Biology Authors: Samuel Hunter, Jo Hendrix, Justin Freeman, Robin D. Dowell and Mary A. Allen Tags: Research article Source Type: research
Integrative single-cell RNA-seq analysis of vascularized cerebral organoids
Cerebral organoids are three-dimensional in vitro cultured brains that mimic the function and structure of the human brain. One of the major challenges for cerebral organoids is the lack of functional vasculat... (Source: BMC Biology)
Source: BMC Biology - November 9, 2023 Category: Biology Authors: Yuya Sato, Toru Asahi and Kosuke Kataoka Tags: Research article Source Type: research
Changing turn-over rates regulate abundance of tryptophan, GS biosynthesis, IAA transport and photosynthesis proteins in Arabidopsis growth defense transitions
Shifts in dynamic equilibria of the abundance of cellular molecules in plant-pathogen interactions need further exploration. We induced PTI in optimally growing Arabidopsis thaliana seedlings for 16 h, returning ... (Source: BMC Biology)
Source: BMC Biology - November 9, 2023 Category: Biology Authors: Mohammad Abukhalaf, Carsten Proksch, Domenika Thieme, J örg Ziegler and Wolfgang Hoehenwarter Tags: Research article Source Type: research
Engineered domain-inlaid Nme2Cas9 adenine base editors with increased on-target DNA editing and targeting scope
Nme2ABE8e has been constructed and characterized as a compact, accurate adenine base editor with a less restrictive dinucleotide protospacer-adjacent motif (PAM: N4CC) but low editing efficiency at challenging... (Source: BMC Biology)
Source: BMC Biology - November 9, 2023 Category: Biology Authors: Ding Zhao, Xun Gao, Jiale Zhou, Jinze Li, Yuqiang Qian, Di Wang, Wenchao Niu, Tao Zhang, Mingyang Hu, Haoyang Xiong, Liangxue Lai and Zhanjun Li Tags: Research article Source Type: research
Deep transcriptome profiling reveals limited conservation of A-to-I RNA editing in Xenopus
Xenopus has served as a valuable model system for biomedical research over the past decades. Notably, ADAR was first detected in frog oocytes and embryos as an activity that unwinds RNA duplexes. However, the sco... (Source: BMC Biology)
Source: BMC Biology - November 9, 2023 Category: Biology Authors: Tram Anh Nguyen, Jia Wei Joel Heng, Yan Ting Ng, Rui Sun, Shira Fisher, Gokce Oguz, Pornchai Kaewsapsak, Shifeng Xue, Bruno Reversade, Adaikalavan Ramasamy, Eli Eisenberg and Meng How Tan Tags: Research article Source Type: research
High-resolution open-top axially swept light sheet microscopy
Open-top light-sheet microscopy (OT-LSM) is a specialized microscopic technique for the high-throughput cellular imaging of optically cleared, large-sized specimens, such as the brain. Despite the development ... (Source: BMC Biology)
Source: BMC Biology - November 8, 2023 Category: Biology Authors: Soohyun Park, Myeongsu Na, Sunghoe Chang and Ki Hean Kim Tags: Research article Source Type: research
Comprehensive mapping of exon junction complex binding sites reveals universal EJC deposition in Drosophila
The exon junction complex (EJC) is involved in most steps of the mRNA life cycle, ranging from splicing to nonsense-mediated mRNA decay (NMD). It is assembled by the splicing machinery onto mRNA in a sequence-... (Source: BMC Biology)
Source: BMC Biology - November 7, 2023 Category: Biology Authors: Luc ía Morillo, Toni Paternina, Quentin Alasseur, Auguste Genovesio, Schraga Schwartz and Hervé Le Hir Tags: Research article Source Type: research
Location and timing govern tripartite interactions of fungal phytopathogens and host in the stem canker species complex
Leptosphaeria maculans “brassicae” (Lmb) and Leptosphaeria biglobosa “brassicae” (Lbb) make up a species complex involved in the stem canker (blackleg) disease of rapeseed (Brassica napus). They coinfect rapeseed... (Source: BMC Biology)
Source: BMC Biology - November 7, 2023 Category: Biology Authors: Elise J. Gay, No émie Jacques, Nicolas Lapalu, Corinne Cruaud, Valerie Laval, Marie-Hélène Balesdent and Thierry Rouxel Tags: Research article Source Type: research
