The HSP40 family chaperone isoform DNAJB6b prevents neuronal cells from tau aggregation
Alzheimer ’s disease (AD) is the most common neurodegenerative disorder with clinical presentations of progressive cognitive and memory deterioration. The pathologic hallmarks of AD include tau neurofibrillary ... (Source: BMC Biology)
Source: BMC Biology - December 18, 2023 Category: Biology Authors: Ya-Lan Chang, Chan-Chih Yang, Yun-Yu Huang, Yi-An Chen, Chia-Wei Yang, Chia-Yu Liao, Hsun Li, Ching-Shyi Wu, Chin-Hsien Lin and Shu-Chun Teng Tags: Research article Source Type: research
Biomechanical stimulation promotes blood vessel growth despite VEGFR-2 inhibition
Angiogenesis, or the growth of new vasculature from existing blood vessels, is widely considered a primary hallmark of cancer progression. When a tumor is small, diffusion is sufficient to receive essential nu... (Source: BMC Biology)
Source: BMC Biology - December 10, 2023 Category: Biology Authors: Bronte Miller Johnson, Allison McKenzie Johnson, Michael Heim, Molly Buckley, Bryan Mortimer, Joel L. Berry and Mary Kathryn Sewell-Loftin Tags: Research article Source Type: research
New chromosome-scale genomes provide insights into marine adaptations of sea snakes (Hydrophis: Elapidae)
Sea snakes underwent a complete transition from land to sea within the last ~ 15 million years, yet they remain a conspicuous gap in molecular studies of marine adaptation in vertebrates. (Source: BMC Biology)
Source: BMC Biology - December 8, 2023 Category: Biology Authors: Alastair J. Ludington, Jillian M. Hammond, James Breen, Ira W. Deveson and Kate L. Sanders Tags: Research article Source Type: research
Follicular fluid C3a-peptide promotes oocyte maturation through F-actin aggregation
Immature cumulus-oocyte complexes are retrieved to obtain mature oocytes by in vitro maturation (IVM), a laboratory tool in reproductive medicine to obtain mature oocytes. Unfortunately, the efficiency of IVM ... (Source: BMC Biology)
Source: BMC Biology - December 8, 2023 Category: Biology Authors: Ye Yang, Chun Zhao, Beili Chen, Xiaoning Yu, Yuxi Zhou, Danyu Ni, Xiaolan Zhang, Junqiang Zhang, Xiufeng Ling, Zhiguo Zhang and Ran Huo Tags: Research article Source Type: research
Imputation strategies for genomic prediction using nanopore sequencing
Genomic prediction describes the use of SNP genotypes to predict complex traits and has been widely applied in humans and agricultural species. Genotyping-by-sequencing, a method which uses low-coverage sequen... (Source: BMC Biology)
Source: BMC Biology - December 8, 2023 Category: Biology Authors: H. J. Lamb, L. T. Nguyen, J. P. Copley, B. N. Engle, B. J. Hayes and E. M. Ross Tags: Research article Source Type: research
Geroprotector drugs and exercise: friends or foes on healthy longevity?
Physical activity and several pharmacological approaches individually combat age-associated conditions and extend healthy longevity in model systems. It is tantalizing to extrapolate that combining geroprotect... (Source: BMC Biology)
Source: BMC Biology - December 8, 2023 Category: Biology Authors: Christian J. Elliehausen, Rozalyn M. Anderson, Gary M. Diffee, Timothy W. Rhoads, Dudley W. Lamming, Troy A. Hornberger and Adam R. Konopka Tags: Review Source Type: research
DNA polymerases in precise and predictable CRISPR/Cas9-mediated chromosomal rearrangements
Recent studies have shown that, owning to its cohesive cleavage, Cas9-mediated CRISPR gene editing outcomes at junctions of chromosomal rearrangements or DNA-fragment editing are precise and predictable; howev... (Source: BMC Biology)
Source: BMC Biology - December 8, 2023 Category: Biology Authors: Mohammadreza M. Mehryar, Xin Shi, Jingwei Li and Qiang Wu Tags: Research article Source Type: research
Plasmodium yoelii iron transporter PyDMT1 interacts with host ferritin and is required in full activity for malarial pathogenesis
The rapid reproduction of malaria parasites requires proper iron uptake. However, the process of iron absorption by parasites is rarely studied. Divalent metal transporter (DMT1) is a critical iron transporter... (Source: BMC Biology)
Source: BMC Biology - December 5, 2023 Category: Biology Authors: Mengjiao Zhong and Bing Zhou Tags: Research article Source Type: research
Identification of FtfL as a novel target of berberine in intestinal bacteria
Berberine (BBR) is a commonly used anti-intestinal inflammation drug, and its anti-cancer activity has been found recently. BBR can intervene and control malignant colorectal cancer (CRC) through intestinal mi... (Source: BMC Biology)
Source: BMC Biology - December 5, 2023 Category: Biology Authors: Jinci Yan, Chengli Fang, Gaohua Yang, Jianxu Li, Yanqiang Liu, Lu Zhang, Pengjie Yang, Jingyuan Fang, Yang Gu, Yu Zhang and Weihong Jiang Tags: Research article Source Type: research
FGF-independent MEK1/2 signalling in the developing foetal testis is essential for male germline differentiation in mice
Disrupted germline differentiation or compromised testis development can lead to subfertility or infertility and are strongly associated with testis cancer in humans. In mice, SRY and SOX9 induce expression of Fg... (Source: BMC Biology)
Source: BMC Biology - December 5, 2023 Category: Biology Authors: Rheannon O. Bl ücher, Rachel S. Lim, Ellen G. Jarred, Matthew E. Ritchie and Patrick S. Western Tags: Research article Source Type: research
Diversity across organisational scale emerges through dispersal ability and speciation dynamics in tropical fish
Biodiversity exists at different levels of organisation: e.g. genetic, individual, population, species, and community. These levels of organisation all exist within the same system, with diversity patterns eme... (Source: BMC Biology)
Source: BMC Biology - December 5, 2023 Category: Biology Authors: Thomas Keggin, Conor Waldock, Alexander Skeels, Oskar Hagen, Camille Albouy, St éphanie Manel and Loïc Pellissier Tags: Research article Source Type: research
Cisplatin exposure alters tRNA-derived small RNAs but does not affect epimutations in C. elegans
The individual lifestyle and environment of an organism can influence its phenotype and potentially the phenotype of its offspring. The different genetic and non-genetic components of the inheritance system an... (Source: BMC Biology)
Source: BMC Biology - November 29, 2023 Category: Biology Authors: Manon Fallet, Rachel Wilson and Peter Sarkies Tags: Research article Source Type: research
Ovarian ER β cistrome and transcriptome reveal chromatin interaction with LRH-1
Estrogen receptor beta (ER β, Esr2) plays a pivotal role in folliculogenesis and ovulation, yet its exact mechanism of action is mainly uncharacterized. (Source: BMC Biology)
Source: BMC Biology - November 29, 2023 Category: Biology Authors: Madeleine Birgersson, Rajitha Indukuri, Linn éa Lindquist, Lina Stepanauskaite, Qing Luo, Qiaolin Deng, Amena Archer and Cecilia Williams Tags: Research article Source Type: research
Fruit bats adjust their decision-making process according to environmental dynamics
One of the main functions of behavioral plasticity lies in the ability to contend with dynamic environments. Indeed, while numerous studies have shown that animals adapt their behavior to the environment, how ... (Source: BMC Biology)
Source: BMC Biology - November 29, 2023 Category: Biology Authors: Goni Naamani, Nitzan Shahar, Yoav Ger and Yossi Yovel Tags: Research article Source Type: research
Lipid bilayer properties potentially contributed to the evolutionary disappearance of betaine lipids in seed plants
Many organisms rely on mineral nutrients taken directly from the soil or aquatic environment, and therefore, developed mechanisms to cope with the limitation of a given essential nutrient. For example, photosy... (Source: BMC Biology)
Source: BMC Biology - November 28, 2023 Category: Biology Authors: St éphanie Bolik, Alexander Schlaich, Tetiana Mukhina, Alberto Amato, Olivier Bastien, Emanuel Schneck, Bruno Demé and Juliette Jouhet Tags: Research article Source Type: research
