Use of chitin:DNA ratio to assess growth form in fungal cells
Dimorphism, the ability to switch between a ‘yeast-like’ and a hyphal growth form, is an important feature of certain fungi, including important plant and human pathogens. The switch to hyphal growth is often ... (Source: BMC Biology)
Source: BMC Biology - January 17, 2024 Category: Biology Authors: Andrea Kov ács-Simon and Helen N. Fones Tags: Methodology article Source Type: research
TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest
SARS-CoV-2 infection depends on the host cell factors angiotensin-converting enzyme 2, ACE2, and the transmembrane serinprotease 2, TMPRSS2. Potential inhibitors of these proteins would be ideal targets agains... (Source: BMC Biology)
Source: BMC Biology - January 8, 2024 Category: Biology Authors: Alessio De Magis, Philipp Schult, Antonia Sch önleber, Rebecca Linke, Kerstin U. Ludwig, Beate M. Kümmerer and Katrin Paeschke Tags: Research article Source Type: research
Morphology-based deep learning enables accurate detection of senescence in mesenchymal stem cell cultures
Cell senescence is a sign of aging and plays a significant role in the pathogenesis of age-related disorders. For cell therapy, senescence may compromise the quality and efficacy of cells, posing potential saf... (Source: BMC Biology)
Source: BMC Biology - January 2, 2024 Category: Biology Authors: Liangge He, Mingzhu Li, Xinglie Wang, Xiaoyan Wu, Guanghui Yue, Tianfu Wang, Yan Zhou, Baiying Lei and Guangqian Zhou Tags: Research article Source Type: research
Deciphering the roles of subcellular distribution and interactions involving the MEF2 binding region, the ankyrin repeat binding motif and the catalytic site of HDAC4 in Drosophila neuronal morphogenesis
Dysregulation of nucleocytoplasmic shuttling of histone deacetylase 4 (HDAC4) is associated with several neurodevelopmental and neurodegenerative disorders. Consequently, understanding the roles of nuclear and... (Source: BMC Biology)
Source: BMC Biology - January 2, 2024 Category: Biology Authors: Wei Jun Tan, Hannah R. Hawley, Sarah J. Wilson and Helen L. Fitzsimons Tags: Research article Source Type: research
DisoFLAG: accurate prediction of protein intrinsic disorder and its functions using graph-based interaction protein language model
Intrinsically disordered proteins and regions (IDPs/IDRs) are functionally important proteins and regions that exist as highly dynamic conformations under natural physiological conditions. IDPs/IDRs exhibit a ... (Source: BMC Biology)
Source: BMC Biology - January 2, 2024 Category: Biology Authors: Yihe Pang and Bin Liu Tags: Methodology article Source Type: research
Asymmetric and parallel subgenome selection co-shape common carp domestication
The common carp (Cyprinus carpio) might best represent the domesticated allopolyploid animals. Although subgenome divergence which is well-known to be a key to allopolyploid domestication has been comprehensively... (Source: BMC Biology)
Source: BMC Biology - January 2, 2024 Category: Biology Authors: Min Wang, Xinxin Li, Chongnv Wang, Ming Zou, Jing Yang, Xiang-dong Li and Baocheng Guo Tags: Research article Source Type: research
Evolution beyond DNA: epigenetic drivers for evolutionary change?
Epigenetics has been a buzzword in science for many years, but 20 years ago, the idea that epigenetic gene regulation could be a driver in evolutionary processes was only a mischievous glint in a Lamarckian eye. ... (Source: BMC Biology)
Source: BMC Biology - December 29, 2023 Category: Biology Authors: Peter Sarkies Tags: Comment Source Type: research
Lessons in immune adaptations to hypoxia revealed by comparative and evolutionary physiology
Recent findings from comparative and evolutionary physiologists reveal novel insights into the regulation of inflammation and immune function under conditions of chronic-sustained and intermittent hypoxia. Com... (Source: BMC Biology)
Source: BMC Biology - December 29, 2023 Category: Biology Authors: Erica C. Heinrich and Michael S. Tift Tags: Comment Source Type: research
Single-sample network modeling on omics data
Modeling networks for single samples can facilitate discoveries in biology that go beyond those found when analyzing an “aggregate” network, i.e., one that merges information across all the samples in an omics... (Source: BMC Biology)
Source: BMC Biology - December 29, 2023 Category: Biology Authors: Margherita De Marzio, Kimberly Glass and Marieke L. Kuijjer Tags: Comment Source Type: research
A muscle exercise research revolution powered by -omics at single cell and nucleus resolution
In the last few years, single cell and single nucleus RNA-sequencing technologies have been leveraged in exercised adult skeletal muscle to reveal complex cell type-specific regulation of muscle plasticity. Ex... (Source: BMC Biology)
Source: BMC Biology - December 29, 2023 Category: Biology Authors: Kevin A. Murach and Charlotte A. Peterson Tags: Comment Source Type: research
How much do we know about the function of mammalian genes?
The last two decades have seen impressive advances in functional genomics, but we are still a long way from understanding the complexity of gene function. Here, we pose questions on how much is currently known ab... (Source: BMC Biology)
Source: BMC Biology - December 29, 2023 Category: Biology Authors: Lydia Teboul, Yann H érault, Sara Wells and Guillaume Pavlovic Tags: Comment Source Type: research
Selection on the promoter regions plays an important role in complex traits during duck domestication
Identifying the key factors that underlie complex traits during domestication is a great challenge for evolutionary and biological studies. In addition to the protein-coding region differences caused by varian... (Source: BMC Biology)
Source: BMC Biology - December 21, 2023 Category: Biology Authors: Zhong-Tao Yin, Xiao-Qin Li, Yun-Xiao Sun, Jacqueline Smith, Maxwell Hincke, Ning Yang and Zhuo-Cheng Hou Tags: Research article Source Type: research
Identifying disease-related microbes based on multi-scale variational graph autoencoder embedding Wasserstein distance
Enormous clinical and biomedical researches have demonstrated that microbes are crucial to human health. Identifying associations between microbes and diseases can not only reveal potential disease mechanisms,... (Source: BMC Biology)
Source: BMC Biology - December 20, 2023 Category: Biology Authors: Huan Zhu, Hongxia Hao and Liang Yu Tags: Research article Source Type: research
Functional characterization of four opsins and two G alpha subtypes co-expressed in the molluscan rhabdomeric photoreceptor
Rhabdomeric photoreceptors of eyes in the terrestrial slug Limax are the typical invertebrate-type but unique in that three visual opsins (Gq-coupled rhodopsin, xenopsin, Opn5A) and one retinochrome, all belongin... (Source: BMC Biology)
Source: BMC Biology - December 18, 2023 Category: Biology Authors: Ryota Matsuo, Mitsumasa Koyanagi, Tomohiro Sugihara, Taishi Shirata, Takashi Nagata, Keiichi Inoue, Yuko Matsuo and Akihisa Terakita Tags: Research article Source Type: research
GPRC5C regulates the composition of cilia in the olfactory system
Olfactory sensory neurons detect odourants via multiple long cilia that protrude from their dendritic endings. The G protein-coupled receptor GPRC5C was identified as part of the olfactory ciliary membrane pro... (Source: BMC Biology)
Source: BMC Biology - December 18, 2023 Category: Biology Authors: Sneha Bhat, Andr é Dietz, Katja Senf, Sandor Nietzsche, Yoshio Hirabayashi, Martin Westermann and Eva Maria Neuhaus Tags: Research article Source Type: research
