The BAF chromatin remodeling complex licenses planarian stem cells access to ectodermal and mesodermal cell fates
The flatworm planarian, Schmidtea mediterranea, has a large population of adult stem cells (ASCs) that replace any cell type during tissue turnover or regeneration. How planarian ASCs (called neoblasts) manage se... (Source: BMC Biology)
Source: BMC Biology - October 20, 2023 Category: Biology Authors: Mallory Wiggans, Shu Jun Zhu, Alyssa M. Molinaro and Bret J. Pearson Tags: Research article Source Type: research
Expression and splicing mediate distinct biological signals
Through alternative splicing, most human genes produce multiple isoforms in a cell-, tissue-, and disease-specific manner. Numerous studies show that alternative splicing is essential for development, diseases... (Source: BMC Biology)
Source: BMC Biology - October 20, 2023 Category: Biology Authors: S øren Helweg Dam, Lars Rønn Olsen and Kristoffer Vitting-Seerup Tags: Research article Source Type: research
Nuclear lncRNA NORSF reduces E2 release in granulosa cells by sponging the endogenous small activating RNA miR-339
Functioning as a competing endogenous RNA (ceRNA) is the main action mechanism of most cytoplasmic lncRNAs. However, it is not known whether this mechanism of action also exists in the nucleus. (Source: BMC Biology)
Source: BMC Biology - October 20, 2023 Category: Biology Authors: Miaomiao Wang, Yang Wang, Liu Yang, Xing Du and Qifa Li Tags: Research article Source Type: research
Single-nucleus transcriptome inventory of giant panda reveals cellular basis for fitness optimization under low metabolism
Energy homeostasis is essential for the adaptation of animals to their environment and some wild animals keep low metabolism adaptive to their low-nutrient dietary supply. Giant panda is such a typical low-met... (Source: BMC Biology)
Source: BMC Biology - October 20, 2023 Category: Biology Authors: Shangchen Yang, Tianming Lan, Rongping Wei, Ling Zhang, Lin Lin, Hanyu Du, Yunting Huang, Guiquan Zhang, Shan Huang, Minhui Shi, Chengdong Wang, Qing Wang, Rengui Li, Lei Han, Dan Tang, Haimeng Li & hellip; Tags: Research article Source Type: research
Single-cell Mayo Map (scMayoMap): an easy-to-use tool for cell type annotation in single-cell RNA-sequencing data analysis
Single-cell RNA-sequencing (scRNA-seq) has become a widely used tool for both basic and translational biomedical research. In scRNA-seq data analysis, cell type annotation is an essential but challenging step.... (Source: BMC Biology)
Source: BMC Biology - October 20, 2023 Category: Biology Authors: Lu Yang, Yan Er Ng, Haipeng Sun, Ying Li, Lucas C. S. Chini, Nathan K. LeBrasseur, Jun Chen and Xu Zhang Tags: Research article Source Type: research
The composition of piRNA clusters in Drosophila melanogaster deviates from expectations under the trap model
It is widely assumed that the invasion of a transposable element (TE) in mammals and invertebrates is stopped when a copy of the TE jumps into a piRNA cluster (i.e., the trap model). However, recent works, whi... (Source: BMC Biology)
Source: BMC Biology - October 20, 2023 Category: Biology Authors: Filip Wierzbicki and Robert Kofler Tags: Research article Source Type: research
Metabolic shift toward ketosis in asocial cavefish increases social-like affinity
Social affinity and collective behavior are nearly ubiquitous in the animal kingdom, but many lineages feature evolutionarily asocial species. These solitary species may have evolved to conserve energy in food... (Source: BMC Biology)
Source: BMC Biology - October 16, 2023 Category: Biology Authors: Motoko Iwashita, Amity Tran, Marianne Garcia, Jia Cashon, Devanne Burbano, Vanessa Salgado, Malia Hasegawa, Rhoada Balmilero-Unciano, Kaylah Politan, Miki Wong, Ryan W. Y. Lee and Masato Yoshizawa Tags: Research article Source Type: research
Characterization of essential eggshell proteins from Aedes aegypti mosquitoes
Up to 40% of the world population live in areas where mosquitoes capable of transmitting the dengue virus, including Aedes aegypti, coexist with humans. Understanding how mosquito egg development and oviposition ... (Source: BMC Biology)
Source: BMC Biology - October 13, 2023 Category: Biology Authors: Jun Isoe, Carter J. Simington, Max E. Oscherwitz, Alyssa J. Peterson, Alberto A. Rasc ón Jr., Brooke B. Massani, Roger L. Miesfeld and Michael A. Riehle Tags: Research article Source Type: research
Genomic analysis reveals limited hybridization among three giraffe species in Kenya
In the speciation continuum, the strength of reproductive isolation varies, and species boundaries are blurred by gene flow. Interbreeding among giraffe (Giraffa spp.) in captivity is known, and anecdotal reports... (Source: BMC Biology)
Source: BMC Biology - October 13, 2023 Category: Biology Authors: Raphael T. F. Coimbra, Sven Winter, Arthur Muneza, Stephanie Fennessy, Moses Otiende, Domnic Mijele, Symon Masiaine, Jenna Stacy-Dawes, Julian Fennessy and Axel Janke Tags: Research article Source Type: research
The neck as a keystone structure in avian macroevolution and mosaicism
The origin of birds from non-avian theropod dinosaur ancestors required a comprehensive restructuring of the body plan to enable the evolution of powered flight. One of the proposed key mechanisms that allowed... (Source: BMC Biology)
Source: BMC Biology - October 13, 2023 Category: Biology Authors: Ryan D. Marek and Ryan N. Felice Tags: Research article Source Type: research
Cont-ID: detection of sample cross-contamination in viral metagenomic data
High-throughput sequencing (HTS) technologies completed by the bioinformatic analysis of the generated data are becoming an important detection technique for virus diagnostics. They have the potential to repla... (Source: BMC Biology)
Source: BMC Biology - October 13, 2023 Category: Biology Authors: Johan Rollin, Wei Rong and S ébastien Massart Tags: Software Source Type: research
Nr4a1 marks a distinctive ILC2 activation subset in the mouse inflammatory lung
Group 2 innate lymphoid cells (ILC2s) are critical sources of type 2 cytokines and represent one of the major tissue-resident lymphoid cells in the mouse lung. However, the molecular mechanisms underlying ILC2... (Source: BMC Biology)
Source: BMC Biology - October 13, 2023 Category: Biology Authors: Shasha Xu, Yu Zhang, Xingjie Liu, Huisheng Liu, Xinya Zou, Linlin Zhang, Jing Wang, Zhiwei Zhang, Xiang Xu, Mingxia Li, Kairui Li, Shuyue Shi, Ying Zhang, Zhichao Miao, Jie Zha and Yong Yu Tags: Research article Source Type: research
Reanalysis of a μ opioid receptor crystal structure reveals a covalent adduct with BU72
The first crystal structure of the active μ opioid receptor (μOR) exhibited several unexplained features. The ligand BU72 exhibited many extreme deviations from ideal geometry, along with unexplained electron ... (Source: BMC Biology)
Source: BMC Biology - October 10, 2023 Category: Biology Authors: Thomas A. Munro Tags: Research article Source Type: research
Distinct hybridization modes in wide- and narrow-ranged lineages of Causonis (Vitaceae)
Explaining contrasting patterns of distribution between related species is crucial for understanding the dynamics of biodiversity. Despite instances where hybridization and whole genome duplication (WGD) can y... (Source: BMC Biology)
Source: BMC Biology - October 9, 2023 Category: Biology Authors: Jinren Yu, Hong Zhao, Yanting Niu, Yichen You, Russell L. Barrett, Rindra Manasoa Ranaivoson, Romer Narindra Rabarijaona, Gaurav Parmar, Langxing Yuan, Xiaofeng Jin, Pan Li, Jianhua Li, Jun Wen, Zhiduan Chen and Limin Lu Tags: Research article Source Type: research
Independent wing reductions and losses among stick and leaf insects (Phasmatodea), supported by new Cretaceous fossils in amber
Phasmatodea (stick and leaf insects) play a central role on the debate regarding wing reduction and loss, and its wings are putative reacquisition from secondarily wingless ancestors based solely on extant spe... (Source: BMC Biology)
Source: BMC Biology - October 9, 2023 Category: Biology Authors: Hongru Yang, Michael S. Engel, Chungkun Shih, Fan Song, Yisheng Zhao, Dong Ren and Taiping Gao Tags: Research article Source Type: research
