Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization
Tumors are complex tissues containing collections of phenotypically diverse malignant and nonmalignant cells. We know little of the mechanisms that govern heterogeneity of tumor cells nor of the role heterogen... (Source: BMC Biology)
Source: BMC Biology - April 27, 2023 Category: Biology Authors: Sanjana Rajan, Emily M. Franz, Camille A. McAloney, Tatyana A. Vetter, Maren Cam, Amy C. Gross, Cenny Taslim, Meng Wang, Matthew V. Cannon, Alexander Oles and Ryan D. Roberts Tags: Research article Source Type: research
TRPM4 regulates hilar mossy cell loss in temporal lobe epilepsy
Mossy cells comprise a large fraction of excitatory neurons in the hippocampal dentate gyrus, and their loss is one of the major hallmarks of temporal lobe epilepsy (TLE). The vulnerability of mossy cells in T... (Source: BMC Biology)
Source: BMC Biology - April 26, 2023 Category: Biology Authors: Laura Mundrucz, Ang éla Kecskés, Nóra Henn-Mike, Péter Kóbor, Péter Buzás, Rudi Vennekens and Miklós Kecskés Tags: Research article Source Type: research
Egg-laying by female Aedes aegypti shapes the bacterial communities of breeding sites
Aedes aegypti, the main arboviral mosquito vector, is attracted to human dwellings and makes use of human-generated breeding sites. Past research has shown that bacterial communities associated with such sites un... (Source: BMC Biology)
Source: BMC Biology - April 26, 2023 Category: Biology Authors: Katherine D. Mosquera, Luis Eduardo Mart ínez Villegas, Gabriel Rocha Fernandes, Mariana Rocha David, Rafael Maciel-de-Freitas, Luciano A. Moreira and Marcelo G. Lorenzo Tags: Research article Source Type: research
Prevalence, causes and impact of TP53-loss phenocopying events in human tumors
TP53 is a master tumor suppressor gene, mutated in approximately half of all human cancers. Given the many regulatory roles of the corresponding p53 protein, it is possible to infer loss of p53 activity – which m... (Source: BMC Biology)
Source: BMC Biology - April 24, 2023 Category: Biology Authors: Bruno Fito-Lopez, Marina Salvadores, Miguel-Martin Alvarez and Fran Supek Tags: Research article Source Type: research
m5U-SVM: identification of RNA 5-methyluridine modification sites based on multi-view features of physicochemical features and distributed representation
RNA 5-methyluridine (m5U) modifications are obtained by methylation at the C5 position of uridine catalyzed by pyrimidine methylation transferase, which is related to the development of human diseases. Accurate i... (Source: BMC Biology)
Source: BMC Biology - April 24, 2023 Category: Biology Authors: Chunyan Ao, Xiucai Ye, Tetsuya Sakurai, Quan Zou and Liang Yu Tags: Methodology article Source Type: research
