The midgut epithelium of mosquitoes adjusts cell proliferation and endoreplication to respond to physiological challenges
Hematophagous mosquitoes transmit many pathogens that cause human diseases. Pathogen acquisition and transmission occur when female mosquitoes blood feed to acquire nutrients for reproduction. The midgut epith... (Source: BMC Biology)
Source: BMC Biology - January 29, 2024 Category: Biology Authors: M. L. Taracena-Agarwal, B. Hixson, S. Nandakumar, A. P. Girard-Mejia, R. Y. Chen, L. Huot, N. Padilla and N. Buchon Tags: Research article Source Type: research
A computational model of circRNA-associated diseases based on a graph neural network: prediction and case studies for follow-up experimental validation
Circular RNAs (circRNAs) have been confirmed to play a vital role in the occurrence and development of diseases. Exploring the relationship between circRNAs and diseases is of far-reaching significance for stu... (Source: BMC Biology)
Source: BMC Biology - January 29, 2024 Category: Biology Authors: Mengting Niu, Chunyu Wang, Zhanguo Zhang and Quan Zou Tags: Research article Source Type: research
Analysis of five near-complete genome assemblies of the tomato pathogen Cladosporium fulvum uncovers additional accessory chromosomes and structural variations induced by transposable elements effecting the loss of avirulence genes
Fungal plant pathogens have dynamic genomes that allow them to rapidly adapt to adverse conditions and overcome host resistance. One way by which this dynamic genome plasticity is expressed is through effector... (Source: BMC Biology)
Source: BMC Biology - January 29, 2024 Category: Biology Authors: Alex Z. Zaccaron and Ioannis Stergiopoulos Tags: Research article Source Type: research
Dimensions of genome dynamics in fungal pathogens: from fundamentals to applications
Fungi are ubiquitous in most ecosystems and are at the origin of serious pathogen outbreaks in humans and crops. Investigation of pathogen genomes over the past decade led to a paradigm shift of our understanding... (Source: BMC Biology)
Source: BMC Biology - January 26, 2024 Category: Biology Authors: Daniel Croll Tags: Comment Source Type: research
Two decades of population genomics: will we ever agree on bacterial species?
We have never known more about the genetic variation that characterizes life on earth, which is stored in ever-growing databases, many of which are publicly accessible. Yet, an accessible database does not mea... (Source: BMC Biology)
Source: BMC Biology - January 26, 2024 Category: Biology Authors: William P. Hanage Tags: Comment Source Type: research
Organellar electrophysiology: DNA nanodevices charging at the unmeasured
Organellar ion channels are regulators of key processes of cellular homeostasis as well as being involved in diseases including cancer, neurological disorders and virus infection. Individual organelle-level el... (Source: BMC Biology)
Source: BMC Biology - January 26, 2024 Category: Biology Authors: Senthil Arumugam Tags: Comment Source Type: research
The temporal association of CapZ with early endosomes regulates endosomal trafficking and viral entry into host cells
Many viruses enter host cells by hijacking endosomal trafficking. CapZ, a canonical actin capping protein, participates in endosomal trafficking, yet its precise role in endocytosis and virus infection remains... (Source: BMC Biology)
Source: BMC Biology - January 25, 2024 Category: Biology Authors: Huazhang Zhu, Dawei Wang, Zuodong Ye, Lihong Huang, Wenjie Wei, Kui Ming Chan, Rongxin Zhang, Liang Zhang and Jianbo Yue Tags: Research article Source Type: research
A high-performance computational workflow to accelerate GATK SNP detection across a 25-genome dataset
Single-nucleotide polymorphisms (SNPs) are the most widely used form of molecular genetic variation studies. As reference genomes and resequencing data sets expand exponentially, tools must be in place to call... (Source: BMC Biology)
Source: BMC Biology - January 25, 2024 Category: Biology Authors: Yong Zhou, Nagarajan Kathiresan, Zhichao Yu, Luis F. Rivera, Yujian Yang, Manjula Thimma, Keerthana Manickam, Dmytro Chebotarov, Ramil Mauleon, Kapeel Chougule, Sharon Wei, Tingting Gao, Carl D. Green, Andrea Zuccolo, Weibo Xie, Doreen Ware & hellip; Tags: Methodology article Source Type: research
The chromosome-scale genome assembly for the West Nile vector Culex quinquefasciatus uncovers patterns of genome evolution in mosquitoes
Understanding genome organization and evolution is important for species involved in transmission of human diseases, such as mosquitoes. Anophelinae and Culicinae subfamilies of mosquitoes show striking differ... (Source: BMC Biology)
Source: BMC Biology - January 25, 2024 Category: Biology Authors: Sergei S. Ryazansky, Chujia Chen, Mark Potters, Anastasia N. Naumenko, Varvara Lukyanchikova, Reem A. Masri, Ilya I. Brusentsov, Dmitriy A. Karagodin, Andrey A. Yurchenko, Vitor L. dos Anjos, Yuki Haba, Noah H. Rose, Jinna Hoffman, Rong Guo, Theresa Menna Tags: Research article Source Type: research
Quantifying the proportion of different cell types in the human cortex using DNA methylation profiles
Due to interindividual variation in the cellular composition of the human cortex, it is essential that covariates that capture these differences are included in epigenome-wide association studies using bulk ti... (Source: BMC Biology)
Source: BMC Biology - January 25, 2024 Category: Biology Authors: Eilis Hannon, Emma L. Dempster, Jonathan P. Davies, Barry Chioza, Georgina E. T. Blake, Joe Burrage, Stefania Policicchio, Alice Franklin, Emma M. Walker, Rosemary A. Bamford, Leonard C. Schalkwyk and Jonathan Mill Tags: Research article Source Type: research
Differentiated genomic footprints suggest isolation and long-distance migration of Hmong-Mien populations
The underrepresentation of Hmong-Mien (HM) people in Asian genomic studies has hindered our comprehensive understanding of the full landscape of their evolutionary history and complex trait architecture. South... (Source: BMC Biology)
Source: BMC Biology - January 25, 2024 Category: Biology Authors: Guanglin He, Peixin Wang, Jing Chen, Yan Liu, Yuntao Sun, Rong Hu, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Junbao Yang, Zhiyong Wang, Libing Yun, Liping Hu, Jiangwei Yan, Shengjie Nie, Lanhai Wei & hellip; Tags: Research article Source Type: research
Application of multiple sgRNAs boosts efficiency of CRISPR/Cas9-mediated gene targeting in Arabidopsis
Precise gene targeting (GT) is a powerful tool for heritable precision genome engineering, enabling knock-in or replacement of the endogenous sequence via homologous recombination. We recently established a CR... (Source: BMC Biology)
Source: BMC Biology - January 17, 2024 Category: Biology Authors: Jing Li, Dali Kong, Yongping Ke, Wenjie Zeng and Daisuke Miki Tags: Research article Source Type: research
The accumulation of modular serine protease mediated by a novel circRNA sponging miRNA increases Aedes aegypti immunity to fungus
Mosquitoes transmit many infectious diseases that affect human health. The fungus Beauveria bassiana is a biological pesticide that is pathogenic to mosquitoes but harmless to the environment. (Source: BMC Biology)
Source: BMC Biology - January 17, 2024 Category: Biology Authors: Tengfei Lu, Yannan Ji, Mengmeng Chang, Xiaoming Zhang, Yanhong Wang and Zhen Zou Tags: Research article Source Type: research
IGT/LAZY genes are differentially influenced by light and required for light-induced change to organ angle
Plants adjust their growth orientations primarily in response to light and gravity signals. Considering that the gravity vector is fixed and the angle of light incidence is constantly changing, plants must som... (Source: BMC Biology)
Source: BMC Biology - January 17, 2024 Category: Biology Authors: Jessica Marie Waite and Christopher Dardick Tags: Research article Source Type: research
A chromosome-level genome for the nudibranch gastropod Berghia stephanieae helps parse clade-specific gene expression in novel and conserved phenotypes
How novel phenotypes originate from conserved genes, processes, and tissues remains a major question in biology. Research that sets out to answer this question often focuses on the conserved genes and processe... (Source: BMC Biology)
Source: BMC Biology - January 17, 2024 Category: Biology Authors: Jessica A. Goodheart, Robin A. Rio, Neville F. Taraporevala, Rose A. Fiorenza, Seth R. Barnes, Kevin Morrill, Mark Allan C. Jacob, Carl Whitesel, Park Masterson, Grant O. Batzel, Hereroa T. Johnston, M. Desmond Ramirez, Paul S. Katz and Deirdre C. Lyons Tags: Research article Source Type: research
