Treatment techniques for rectovaginal fistulas after low rectal resection for deep endometriosis
AbstractEndometriosis is a benign gynecologic affection that may lead to major surgeries, such as colorectal resections. Rectovaginal fistulas (RVF) are among the possible complications. When they occur, it is necessary to adapt the repair surgery as best as possible to limit their functional consequences. This video shows three different techniques for correcting RVF after rectal resection for endometriosis, with a combination of perineal surgery and laparoscopy: a mucosal flap, a transanal transection and single stapled anastomosis (TTSS) and a pull through.Supplementary file1 (MP4 469658 KB) (Source: Techniques in Coloproctology)
Source: Techniques in Coloproctology - April 29, 2024 Category: Surgery Source Type: research
The impact of developmental stage, tissue type, and sex on DNA double-strand break repair in < i > Drosophila melanogaster < /i >
This study describes the impact of development, tissue-specific cycling profile, and, in some cases, sex on DSB repair outcomes, underscoring the complexity of repair in multicellular organisms. (Source: PLoS Genetics)
Source: PLoS Genetics - April 29, 2024 Category: Genetics & Stem Cells Authors: Elizabeth L. Graham Source Type: research
Enhancing nerve regeneration in infraorbital nerve injury rat model: effects of vitamin B complex and photobiomodulation
AbstractOrofacial nerve injuries may result in temporary or long-term loss of sensory function and decreased quality of life in patients. B vitamins are required for DNA synthesis and the repair and maintenance of phospholipids. In particular, vitamins B1, B6, and B12 are essential for neuronal function. Deficiency in vitamin B complex (VBC) has been linked to increased oxidative stress, inflammation and demyelination. Photobiomodulation (PBM) has antioxidant activity and is neuroprotective. In addition, a growing literature attests to the positive effects of PBM on nerve repair. To assess the effect of PBM and VBC on rege...
Source: Lasers in Medical Science - April 29, 2024 Category: Laser Surgery Source Type: research
Molecules, Vol. 29, Pages 2050: Application of Deferoxamine in Tissue Regeneration Attributed to Promoted Angiogenesis
Ran Zhang
Deferoxamine, an iron chelator used to treat diseases caused by excess iron, has had a Food and Drug Administration-approved status for many years. A large number of studies have confirmed that deferoxamine can reduce inflammatory response and promote angiogenesis. Blood vessels play a crucial role in sustaining vital life by facilitating the delivery of immune cells, oxygen, and nutrients, as well as eliminating waste products generated during cellular metabolism. Dysfunction in blood vessels may contribute significantly to the development of life-threatening diseases. Anti-angiogenesis therapy and pro-ang...
Source: Molecules - April 29, 2024 Category: Chemistry Authors: Haijun Shen Yane Ma Yi Qiao Chun Zhang Jialing Chen Ran Zhang Tags: Review Source Type: research
Intestinal Fatty Acid Binding Protein as a Predictor of Early Mesenteric Injury Preceding Clinical Presentation: A Case Report
Diagnosing non-occlusive mesenteric ischaemia (NOMI) in patients is complicated, due to poor signs and symptoms and non-specific laboratory tests, leading to high mortality. This case study presents a rare case of a patient who developed mesenteric ischaemia after an emergency thoracic endovascular aneurysm repair (TEVAR) for a type B aortic dissection (TBAD) and peri-operative cardiogenic shock. Study outcomes revealed that intestinal fatty acid binding protein (I-FABP) identified early mucosal damage 2 days before clinical presentation. (Source: EJVES Extra)
Source: EJVES Extra - April 29, 2024 Category: Surgery Authors: Annet A.M. Duivenvoorden, Flores M. Metz, Robin Wijenbergh, Hanne C.R. Verberght, Annemarie A.J.H.M. van Bijnen, Steven W.M. Olde Damink, Robert H. Geelkerken, Kaatje Lenaerts, Tim Lubbers Tags: Case Report Source Type: research
The Limb Girdle Muscular Dystrophy Health Index (LGMD-HI)
Limb girdle muscular dystrophy (LGMD) is a genetically diverse group of rare, autosomal muscular dystrophies caused by mutations in genes encoding proteins that are needed for muscle maintenance, repair and normal function [1,2]. Using next-generation sequencing (NGS), more than 30 subtypes of LGMD at different autosomal loci have been identified in LGMD [2]. Since 2018 these have been categorized with the nomenclature “LGMD D” for autosomal dominant and “LGMD R” for autosomal recessive mutations [3]. (Source: Neuromuscular Disorders)
Source: Neuromuscular Disorders - April 29, 2024 Category: Neurology Authors: Joy A. Stouffer, Kameron Bates, Leroy R. Thacker, Chad Heatwole, Nicholas E. Johnson Source Type: research
Comment on Left Ventricular Dysfunction Following Repair of Ventricular Septal Defects in Infants
(Source: Mammalian Genome)
Source: Mammalian Genome - April 28, 2024 Category: Genetics & Stem Cells Source Type: research
Subchondral bone fatigue injury in the parasagittal condylar grooves of the third metacarpal bone in thoroughbred racehorses elevates site-specific strain concentration
J Mech Behav Biomed Mater. 2024 Apr 24;155:106561. doi: 10.1016/j.jmbbm.2024.106561. Online ahead of print.ABSTRACTCondylar stress fracture of the distal end of the third metacarpal/metatarsal (MC3/MT3) bones is a major cause of Thoroughbred racehorse injury and euthanasia worldwide. Functional adaptation to exercise and fatigue damage lead to structural changes in the subchondral bone that include increased modeling (resulting in sclerotic bone tissue) and targeted remodeling repair (resulting in focal resorption spaces in the parasagittal groove). Whether these focal structural changes, as detectable by standing computed...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 28, 2024 Category: Materials Science Authors: Soroush Irandoust R Christopher Whitton Peter Muir Corinne R Henak Source Type: research
Pold4 subunit of replicative polymerase δ promotes fork slowing at broken templates
In conclusion, the Pold4 subunit of Polδ has roles in the PARP1-Polε exonuclease-mediated fork reversal, contributing to the suppression of DSBs.PMID:38678695 | DOI:10.1016/j.dnarep.2024.103688 (Source: DNA Repair)
Source: DNA Repair - April 28, 2024 Category: Genetics & Stem Cells Authors: Kota Kojima Hiromori Ohkubo Ryotaro Kawasumi Kouji Hirota Source Type: research
Enhancing sciatic nerve regeneration with osteopontin-loaded acellular nerve allografts in rats: Effects on macrophage polarization
In conclusion, the study suggested that ANA loaded with 2 nM OPN effectively repaired transected sciatic nerves in rats, potentially through enhancing axonal sprouting and exerting anti-inflammatory effects.PMID:38678741 | DOI:10.1016/j.tice.2024.102379 (Source: Tissue and Cell)
Source: Tissue and Cell - April 28, 2024 Category: Cytology Authors: Shukur Wasman Smail Shang Ziyad Abdulqadir Lana Sardar Saleh Alalem Taban Kamal Rasheed Zhikal Omar Khudhur Abdullah Faqiyazdin Ahmed Mzury Harem Khdir Awla Mohammad B Ghayour Arash Abdolmaleki Source Type: research
Subchondral bone fatigue injury in the parasagittal condylar grooves of the third metacarpal bone in thoroughbred racehorses elevates site-specific strain concentration
J Mech Behav Biomed Mater. 2024 Apr 24;155:106561. doi: 10.1016/j.jmbbm.2024.106561. Online ahead of print.ABSTRACTCondylar stress fracture of the distal end of the third metacarpal/metatarsal (MC3/MT3) bones is a major cause of Thoroughbred racehorse injury and euthanasia worldwide. Functional adaptation to exercise and fatigue damage lead to structural changes in the subchondral bone that include increased modeling (resulting in sclerotic bone tissue) and targeted remodeling repair (resulting in focal resorption spaces in the parasagittal groove). Whether these focal structural changes, as detectable by standing computed...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 28, 2024 Category: Materials Science Authors: Soroush Irandoust R Christopher Whitton Peter Muir Corinne R Henak Source Type: research
Pold4 subunit of replicative polymerase δ promotes fork slowing at broken templates
In conclusion, the Pold4 subunit of Polδ has roles in the PARP1-Polε exonuclease-mediated fork reversal, contributing to the suppression of DSBs.PMID:38678695 | DOI:10.1016/j.dnarep.2024.103688 (Source: DNA Repair)
Source: DNA Repair - April 28, 2024 Category: Genetics & Stem Cells Authors: Kota Kojima Hiromori Ohkubo Ryotaro Kawasumi Kouji Hirota Source Type: research
Enhancing sciatic nerve regeneration with osteopontin-loaded acellular nerve allografts in rats: Effects on macrophage polarization
In conclusion, the study suggested that ANA loaded with 2 nM OPN effectively repaired transected sciatic nerves in rats, potentially through enhancing axonal sprouting and exerting anti-inflammatory effects.PMID:38678741 | DOI:10.1016/j.tice.2024.102379 (Source: Tissue and Cell)
Source: Tissue and Cell - April 28, 2024 Category: Cytology Authors: Shukur Wasman Smail Shang Ziyad Abdulqadir Lana Sardar Saleh Alalem Taban Kamal Rasheed Zhikal Omar Khudhur Abdullah Faqiyazdin Ahmed Mzury Harem Khdir Awla Mohammad B Ghayour Arash Abdolmaleki Source Type: research
Subchondral bone fatigue injury in the parasagittal condylar grooves of the third metacarpal bone in thoroughbred racehorses elevates site-specific strain concentration
J Mech Behav Biomed Mater. 2024 Apr 24;155:106561. doi: 10.1016/j.jmbbm.2024.106561. Online ahead of print.ABSTRACTCondylar stress fracture of the distal end of the third metacarpal/metatarsal (MC3/MT3) bones is a major cause of Thoroughbred racehorse injury and euthanasia worldwide. Functional adaptation to exercise and fatigue damage lead to structural changes in the subchondral bone that include increased modeling (resulting in sclerotic bone tissue) and targeted remodeling repair (resulting in focal resorption spaces in the parasagittal groove). Whether these focal structural changes, as detectable by standing computed...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 28, 2024 Category: Materials Science Authors: Soroush Irandoust R Christopher Whitton Peter Muir Corinne R Henak Source Type: research
Construction of hyaluronic acid-functionalized magnolol nanoparticles for ulcerative colitis treatment
This study introduces a novel nanoparticle (NPs) formulation based on Mag, functionalized with hyaluronic acid (HA) for targeted UC therapy. Bovine serum albumin (BSA) was modified with 2-thiamine hydrochloride to synthesize BSA·SH. Thiol-ene click reaction with Mag led to the formation of BSA·SH-Mag NPs, which were further modified with HA through dehydration condensation, regular spherical inflammation-targeting HA-BSA·SH-Mag nanoparticles with a charge of -23.6 mV and a particle size of 403 ± 4 nm were formed. In vitro studies revealed significant macrophage targeting and enhanced uptake by colon epithelial cells. O...
Source: International Journal of Biological Macromolecules - April 28, 2024 Category: Biochemistry Authors: Yanfei Li Tao Chen Lihang Chen Di Wu Jiangning Hu Source Type: research
