A bacterial cellulose/polyvinyl alcohol/nitro graphene oxide double layer network hydrogel efficiency antibacterial and promotes wound healing
In this study, graphene oxide (GO) was chemically modified utilizing concentrated nitric acid to produce a nitrated graphene oxide derivative (NGO) with enhanced oxidation level, improved dispersibility, and increased antibacterial activity. A double-layer composite hydrogel material (BC/PVA/NGO) with a core-shell structure was fabricated by utilizing bacterial cellulose (BC) and polyvinyl alcohol (PVA) binary composite hydrogel scaffold as the inner network template, and hydrophilic polymer (PVA) loaded with antibacterial material (NGO) as the outer network. The fabrication process involved physical crosslinking based on ...
Source: International Journal of Biological Macromolecules - May 1, 2024 Category: Biochemistry Authors: Shen Song Xiaoyuan Liu Ling Ding Zhao Liu Mohamed Aamer Abubaker Yaqiang Xu Ji Zhang Source Type: research
Effect of neurosurgical residency programs on neurosurgical patient outcomes in a single health care system: a cohort study
CONCLUSION: Hospitals with neurosurgical residents had longer operative times with similar to better outcomes. Most, but not all, of the differences between hospitals with and without residency programs were explained by hospital-level variables rather than direct effects of residents.PMID:38692681 | DOI:10.1503/cjs.008522 (Source: Canadian Journal of Surgery)
Source: Canadian Journal of Surgery - May 1, 2024 Category: Surgery Authors: Shervin Taslimi Susan B Brogly Wenbin Li Jillian Rodger Ekkehard M Kasper Douglas J Cook Ron Levy Source Type: research
Laparoscopic vs robotic inguinal hernia repair: a comparison of learning curves and skill transference in general surgery residents
CONCLUSION: The robotic platform may be a more effective teaching tool with a higher degree of entrustability indicated by the higher mean resident participation. We observed a greater degree of skill transference from laparoscopy to the robot, indicated by a higher degree of correlation between the resident's prior laparoscopic experience and the percent console time in robotic cases. There was minimal correlation between residents' prior robotic experience and their participation in laparoscopic cases. Our findings suggest that the learning curve for the robot may be shorter as prior robotic experience had a much stronge...
Source: Hand Surgery - May 1, 2024 Category: Surgery Authors: Kristen M Quinn Louis T Runge Claire Griffiths Hannah Harris Heidi Pieper Michael Meara Ben Poulose Vimal Narula David Renton Courtney Collins Alan Harzman Syed Husain Source Type: research
Long-term results of arthroscopic capsulolabral revision repair for failed anterior shoulder instability repair using suture anchors at a minimum of 10 years follow-up
CONCLUSION: Long-term follow-up after ACRR shows predictable results, with a high degree of patient satisfaction, good to excellent patient-reported outcome scores and minimal radiological degenerative changes. However, with an average recurrence rate of 19.3% after 11.86 years, the redislocation rate appears high. With careful patient selection, recurrence rates can be significantly reduced.PMID:38693287 | DOI:10.1007/s00402-024-05304-7 (Source: Hand Surgery)
Source: Hand Surgery - May 1, 2024 Category: Surgery Authors: Mohamed Aboalata Johannes Plath Hani Eltair Stephan Vogt Andreas B Imhoff Source Type: research
Necrotizing Fasciitis after Panniculectomy Caused by < em > Finegoldia magna < /em >
We present a case of a 54-year-old woman with a complex medical history who developed necrotizing fasciitis 9 days after panniculectomy and epigastric hernia repair. Microbiological examination revealed Finegoldia magna as the causative agent, a rare pathogen in necrotizing fasciitis. Patients undergoing body contouring may be at increased risk of developing necrotizing fasciitis; therefore, increased attention should be paid to this differential diagnosis in case of postoperative signs of infection. This case report highlights the pivotal importance of early recognition, prompt surgical intervention, and comprehensive med...
Source: Hand Surgery - May 1, 2024 Category: Surgery Authors: David Breidung Sarina Delavari Ioannis-Fivos Megas Bert Reichert Moritz Billner Source Type: research
Microsatellite Instability, Mismatch Repair, and Tumor Mutation Burden in Lung Cancer
Surg Pathol Clin. 2024 Jun;17(2):295-305. doi: 10.1016/j.path.2023.11.011. Epub 2023 Dec 20.ABSTRACTSince US Food and Drug Administration approval of programmed death ligand 1 (PD-L1) as the first companion diagnostic for immune checkpoint inhibitors (ICIs) in non-small cell lung cancer, many patients have experienced increased overall survival. To improve selection of ICI responders versus nonresponders, microsatellite instability/mismatch repair deficiency (MSI/MMR) and tumor mutation burden (TMB) came into play. Clinical data show PD-L1, MSI/MMR, and TMB are independent predictive immunotherapy biomarkers. Harmonization...
Source: Clinical Lung Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Oana C Rosca Oana E Vele Source Type: research
Mismatch repair deficiency and abnormal p53 expression has significant predictive value for progesterone resistance and endometrial tumorigenesis in patients with endometrial atypical hyperplasia receiving fertility-preserving treatment
CONCLUSIONS: EAH patients with MMR-d and p53abn have a significantly higher risk of disease relapse and progression. Thus, MMR-d and p53abn may be used as predictive biomarkers of progestin resistance and endometrial tumorigenesis in EAH.PMID:38691985 | DOI:10.1016/j.ygyno.2024.04.013 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 1, 2024 Category: Cancer & Oncology Authors: Hongfa Peng Jingjing Jiang Limeng Li Zengfang Hao Hongguang Lian Hui Du Wei Wang Source Type: research
Bone marrow mesenchymal stem cell-derived exosomes shuttle microRNAs to endometrial stromal fibroblasts that promote tissue proliferation /regeneration/ and inhibit differentiation
CONCLUSION: EVs delivered to tissues by hBMDSCs contain specific miRNAs that prevent terminal differentiation and drive repair and regeneration. Delivery of microRNAs is a novel treatment paradigm with the potential to replace BMDSCs in cell-free regenerative therapies.PMID:38693588 | DOI:10.1186/s13287-024-03716-1 (Source: Cell Research)
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Giulia Bonavina Ramanaiah Mamillapalli Graciela Krikun Yuping Zhou Nimisha Gawde Hugh S Taylor Source Type: research
MSCs promote the efferocytosis of large peritoneal macrophages to eliminate ferroptotic monocytes/macrophages in the injured endometria
CONCLUSION: The data collectively demonstrated first the roles of LPMs via removal of ferroptotic monocytes/macrophages and provided a novel mechanism of MSCs in repairing the endometrial injury.PMID:38693589 | DOI:10.1186/s13287-024-03742-z (Source: Cell Research)
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Jiali Wang Jingman Li Lijie Yin Xiuzhu Wang Yue Dong Guangfeng Zhao Sunan Shen Yayi Hou Source Type: research
FGF10 protects against particulate matter-induced lung injury by inhibiting ferroptosis via Nrf2-dependent signaling
Int Immunopharmacol. 2024 Apr 30;134:112165. doi: 10.1016/j.intimp.2024.112165. Online ahead of print.ABSTRACTParticulate matter (PM) is considered the fundamental component of atmospheric pollutants and is associated with the pathogenesis of many respiratory diseases. Fibroblast growth factor 10 (FGF10) mediates mesenchymal-epithelial signaling and has been linked with the repair process of PM-induced lung injury (PMLI). However, the pathogenic mechanism of PMLI and the specific FGF10 protective mechanism against this injury are still undetermined. PM was administered in vivo into murine airways or in vitro to human bronc...
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Yao Qian Qiangqiang Shi Wanting Zhou Baiqi He Haibo Xu Bin Liu Wanqi Miao Saverio Bellusci Chengshui Chen Nian Dong Source Type: research
Unlocking renal Restoration: Mesaconine from Aconitum plants restore mitochondrial function to halt cell apoptosis in acute kidney injury
This study explored mesaconine, derived from processed Fuzi, as a promising low-toxicity alternative for AKI treatment. In this study, we assessed the protective effects of mesaconine in gentamicin (GM)-induced NRK-52E cells and AKI rat models in vitro and in vivo, respectively. Mesaconine promotes the proliferation of damaged NRK-52E cells and down-regulates intracellular transforming growth factor β1 (TGF-β1) and kidney injury molecule 1 (KIM-1) to promote renal cell repair. Concurrently, mesaconine restored mitochondrial morphology and permeability transition pores, reversed the decrease in mitochondrial membrane pote...
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Yixin Rui Xiumeng Zhang Xinran Min Hongxiao Xie Xiuying Ma Funeng Geng Rong Liu Source Type: research
Necrotizing Fasciitis after Panniculectomy Caused by < em > Finegoldia magna < /em >
We present a case of a 54-year-old woman with a complex medical history who developed necrotizing fasciitis 9 days after panniculectomy and epigastric hernia repair. Microbiological examination revealed Finegoldia magna as the causative agent, a rare pathogen in necrotizing fasciitis. Patients undergoing body contouring may be at increased risk of developing necrotizing fasciitis; therefore, increased attention should be paid to this differential diagnosis in case of postoperative signs of infection. This case report highlights the pivotal importance of early recognition, prompt surgical intervention, and comprehensive med...
Source: Hand Surgery - May 1, 2024 Category: Surgery Authors: David Breidung Sarina Delavari Ioannis-Fivos Megas Bert Reichert Moritz Billner Source Type: research
From ferroptosis to cuproptosis, and calcicoptosis, to find more novel metals-mediated distinct form of regulated cell death
AbstractRegulated cell death (RCD), also known as programmed cell death (PCD), plays a critical role in various biological processes, such as tissue injury/repair, development, and homeostasis. Dysregulation of RCD pathways can lead to the development of many human diseases, such as cancer, neurodegenerative disorders, and cardiovascular diseases. Maintaining proper metal ion homeostasis is critical for human health. However, imbalances in metal levels within cells can result in cytotoxicity and cell death, leading to a variety of diseases and health problems. In recent years, new types of metal overload-induced cell death...
Source: Apoptosis - May 1, 2024 Category: Molecular Biology Source Type: research
Robotic transversus abdominis release (TAR) for ventral hernia repairs is associated with low surgical site occurrence rates and length of stay despite increasing modifiable comorbidities
Conclusion2 + MCMs significantly increase the odds of SSO, specifically in patients who have a history of diabetes and obesity. However, the presence of any number of MCMs was not associated with increased odds of prolonged LOS. (Source: Hernia)
Source: Hernia - May 1, 2024 Category: Sports Medicine Source Type: research
Analysis of postoperative complications of orbital fracture
ConclusionStandardizing surgical techniques and implementing precise auxiliary technologies may reduce the incidence of complications and enhance the operation ’s success rate. (Source: Oral and Maxillofacial Surgery)
Source: Oral and Maxillofacial Surgery - May 1, 2024 Category: ENT & OMF Source Type: research
