Enteral plasma supports brain repair in newborn pigs after birth asphyxia
We present a new clinically relevant animal model of moderate birth asphyxia inducing structural and functional brain damage. The components in plasma that support brain repair remain to be identified but may represent a therapeutic potential for infants and animals after birth asphyxia.PMID:38677626 | DOI:10.1016/j.bbi.2024.04.032 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 27, 2024 Category: Neurology Authors: Gemma Chavarria Ventura Nadiya Dyshliuk Oksana Dmytriyeva Mads Jacob Bagi Nordsten Maria Mathilde Haugaard Line Iadsatian Christiansen Thomas Thymann Per Torp Sangild Stanislava Pankratova Source Type: research
miR-194-3p regulates epithelial-mesenchymal transition in embryonic epicardial cells via p120/ β-catenin signaling
In conclusion, miR-194-3p directly targets p120-catenin and modulates its expression, which in turn alters β-catenin expression, critically influencing the EMT process in the embryonic epicardial cells via the cell adhesion mechanism.PMID:38676398 | DOI:10.3724/abbs.2024051 (Source: Acta Biochimica et Biophysica Sinica)
Source: Acta Biochimica et Biophysica Sinica - April 27, 2024 Category: Biochemistry Authors: Tianhua Xiong Dinghui Wang Huiping Yang Bin Liu Yingrui Li Wenlong Yu Jing Wang Qiang She Source Type: research
Preparation of modified chitosan-based nano-TiO < sub > 2 < /sub > -nisin composite packaging film and preservation mechanism applied to chilled pork
Int J Biol Macromol. 2024 Apr 25:131873. doi: 10.1016/j.ijbiomac.2024.131873. Online ahead of print.ABSTRACTHere, we developed a nano-TiO2-nisin-modified chitosan composite packaging film and investigated its properties and antibacterial activity, as well as its effect on chilled pork preservation time. The results indicated that the preservation time of chilled pork coated with a nano-TiO2-nisin-modified chitosan film (including 0.7 g/L nano-TiO2, irradiated with ultraviolet light for 40 min, and dried for 6 h) followed by modified atmosphere packaging (50% CO2 + 50% N2) increased from 7 to 20 days at 4 °C. Both nano-TiO...
Source: International Journal of Biological Macromolecules - April 27, 2024 Category: Biochemistry Authors: Ruonan Yan Mingxue Liu Xiaoqun Zeng Qiwei Du Zhen Wu Yuxing Guo Maolin Tu Daodong Pan Source Type: research
Enteral plasma supports brain repair in newborn pigs after birth asphyxia
We present a new clinically relevant animal model of moderate birth asphyxia inducing structural and functional brain damage. The components in plasma that support brain repair remain to be identified but may represent a therapeutic potential for infants and animals after birth asphyxia.PMID:38677626 | DOI:10.1016/j.bbi.2024.04.032 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 27, 2024 Category: Neurology Authors: Gemma Chavarria Ventura Nadiya Dyshliuk Oksana Dmytriyeva Mads Jacob Bagi Nordsten Maria Mathilde Haugaard Line Iadsatian Christiansen Thomas Thymann Per Torp Sangild Stanislava Pankratova Source Type: research
Role of intracranial bone marrow mesenchymal stem cells in stroke recovery: A focus on post-stroke inflammation and mitochondrial transfer
Brain Res. 2024 Apr 25;1837:148964. doi: 10.1016/j.brainres.2024.148964. Online ahead of print.ABSTRACTStem cell therapy has become a hot research topic in the medical field in recent years, with enormous potential for treating a variety of diseases. In particular, bone marrow mesenchymal stem cells (BMSCs) have wide-ranging applications in the treatment of ischemic stroke, autoimmune diseases, tissue repair, and difficult-to-treat diseases. BMSCs can differentiate into multiple cell types and exhibit strong immunomodulatory properties. Although BMSCs can regulate the inflammatory response activated after stroke, the mecha...
Source: Brain Research - April 27, 2024 Category: Neurology Authors: Jiang Ming Yidong Liao Wenxue Song Zili Wang Junshuan Cui Longcai He Guangtang Chen Kaya Xu Source Type: research
Shift from Pro- to Anti-Inflammatory Phase in Pelvic Floor Muscles at Postpartum Matches Histological Signs of Regeneration in Multiparous Rabbits
Conclusions: A shift from the pro- to anti-inflammatory phase in the bulbospongiosus and pubococcygeus muscles of multiparous rabbits matches with centralized myonuclei, suggesting the ongoing regeneration of muscles.PMID:38674321 | PMC:PMC11052351 | DOI:10.3390/medicina60040675 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Esteban Rodr íguez-Benítez Kenia L ópez-García Nicte Xelhuantzi Dora Luz Corona-Quintanilla Francisco Castel án Margarita Mart ínez-Gómez Source Type: research
Introduction to Amniotic Membranes in Maxillofacial Surgery-A Scoping Review
Conclusions: Amniotic membranes offer a versatile and effective option in maxillofacial surgery, promoting wound healing, reducing inflammation, and providing a scaffold for tissue regeneration. Further research, including randomized trials and comparative studies, is warranted to validate the efficacy and optimize the utilization of HAM in clinical practice.PMID:38674309 | PMC:PMC11051762 | DOI:10.3390/medicina60040663 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Grzegorz Dawiec Wojciech Niemczyk Rafa ł Wiench Stanis ław Niemczyk Dariusz Skaba Source Type: research
Socioeconomic and Other Risk Factors for Retear after Arthroscopic Surgery for Nontraumatic Rotator Cuff Tear
Conclusions: Age, initial tear size, and symptom duration significantly affect retear risk after arthroscopic rotator cuff repair. Occupation and type of medical insurance were also risk factors for retear. Socioeconomically vulnerable patients may be at a greater risk of retear. Proactive efforts are required to expand early access to medical care.PMID:38674286 | PMC:PMC11052191 | DOI:10.3390/medicina60040640 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Jung Sub Lee Kuen Tak Suh Won Chul Shin Jung Yun Bae Tae Sik Goh Sung Won Jung Min-Hyeok Choi Suk-Woong Kang Source Type: research
Descriptive Analysis of Outcomes After Onlay Ventral Hernia Repair in Obese Patients
CONCLUSION: Obesity is a risk factor for poor outcomes after VHR. We developed a protocol for obese patients with large defects involving a modified onlay technique which demonstrates comparable results to other VHR techniques in obese patients.PMID:38676337 | DOI:10.1177/00031348241241706 (Source: The American Surgeon)
Source: The American Surgeon - April 27, 2024 Category: Surgery Authors: Carolyn P Smullin Rivfka S Shenoy Kevin J Blair Charles F Chandler Source Type: research
Sex Comparative Analysis on Branched and Fenestrated Endovascular Aortic Arch Repair Outcomes
CONCLUSION: Both sexes presented similar outcomes after f/b-Arch. Appropriate patient selection may decrease the effect of sex in f/b-Arch outcomes.PMID:38677467 | DOI:10.1016/j.ejvs.2024.04.030 (Source: PubMed: Eur J Vasc Endovasc ...)
Source: PubMed: Eur J Vasc Endovasc ... - April 27, 2024 Category: Surgery Authors: Petroula Nana Giuseppe Panuccio Jos é I Torrealba Fiona Rohlffs Konstantinos Spanos Tilo K ölbel Source Type: research
A Core Outcome Set for Intact Abdominal Aortic Aneurysm Repair
CONCLUSION: Six core outcomes are recommended for use as a minimum framework in all future studies and registries of intact open and endovascular AAA repair. Further work to select instruments for quality of life and define instruments for cognitive functioning is needed.PMID:38677466 | DOI:10.1016/j.ejvs.2024.04.029 (Source: PubMed: Eur J Vasc Endovasc ...)
Source: PubMed: Eur J Vasc Endovasc ... - April 27, 2024 Category: Surgery Authors: Matthew Machin Anders Wanhainen Mario D'Oria Mark Koelemaij Stavros Kakkos Matthew Joe Grima Janet T Powell collaborators Source Type: research
The circAno6/miR-296-3p/TLR4 signaling axis mediates the inflammatory response to induce the activation of hepatic stellate cells
CONCLUSION: This study suggests that circAno6 and miR-296-3p/TLR4 may form a regulatory axis and regulate the inflammatory response, which in turn induces HSC activation. Targeting circAno6 may be a potential therapeutic strategy to treat LF.PMID:38677350 | DOI:10.1016/j.gene.2024.148497 (Source: Gene)
Source: Gene - April 27, 2024 Category: Genetics & Stem Cells Authors: Zhen Li Yanzhen Ma Chang Fan Hui Jiang Source Type: research
Therapeutic potential: The role of mesenchymal stem cells from diverse sources and their derived exosomes in diabetic nephropathy
Biomed Pharmacother. 2024 Apr 26;175:116672. doi: 10.1016/j.biopha.2024.116672. Online ahead of print.ABSTRACTDiabetic nephropathy (DN) is one of the most common microvascular complications in diabetic patients, with its incidence continuously increasing in recent years. DN causes renal tissue damage and functional decline, expedites the aging process of the kidneys, and may ultimately progress leading to end-stage renal disease, severely impacting the patient's quality of life and prognosis. Mesenchymal stem cells (MSCs) are highly valued for their multipotent differentiation, paracrine functions, immunomodulatory effects...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 27, 2024 Category: Drugs & Pharmacology Authors: Lixin Liu Yiman Chen Xuan Li Juan Wang Lina Yang Source Type: research
Lung fibroblast-derived extracellular vesicles and soluble factors alleviate elastase-induced lung injury
In conclusion, this study highlights the therapeutic potential of both lung fibroblast-derived EV- and SF-enriched concentrates for the treatment of lung injury and emphysema.PMID:38677537 | DOI:10.1016/j.ejphar.2024.176612 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 27, 2024 Category: Drugs & Pharmacology Authors: Luke van der Koog Myrthe J Boerrigter Iris C Gorter Reinoud Gosens Anika Nagelkerke Source Type: research
A novel LINC02321 promotes cell proliferation and decreases cisplatin sensitivity in bladder cancer by regulating RUVBL2
In this study, A high expression of LINC02321 was found in BC tissues, which was associated with poor prognosis in patients. LINC02321 promoted both proliferation and G1-G0 progression in BC cells, while also inhibited sensitivity to cisplatin. Mechanistically, LINC02321 can bind to RUVBL2 and regulate the expression levels of RUVBL2 protein by affecting its half-life. RUVBL2 is involved in the DNA damage response. The potential of DNA damage repair pathways to exert chemosensitization has been demonstrated in vivo. The rescue experiment demonstrated that RUVBL2 overexpression can markedly abolish the decreased cell prolif...
Source: Translational Oncology - April 27, 2024 Category: Cancer & Oncology Authors: Chuncheng Lu Hongbin Gao Haiyuan Li Ning Luo Shipeng Fan Xi Li Renbin Deng Danpeng He Hui Zhao Source Type: research
