Sebaceous Neoplasm With Defective DNA Mismatch Repair
A woman in her 70s presented with a cutaneous lesion composed of a mixture of basaloid cells and sebocytes arranged in lobules, most consistent with a sebaceous adenoma (Figure 1). Immunohistochemistry for mismatch repair genes showed loss of nuclear expression of MSH2 and MSH6 in the tumor cells. Representative images are depicted in Figure 2. Microsatellite instability testing showed instability in all of the 7 informative markers analyzed, indicative of defective DNA mismatch repair function within the tumor. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - May 1, 2024 Category: Internal Medicine Authors: Burak Tekin, Sounak Gupta, Lori A. Erickson Tags: Path to patient image quiz Source Type: research
A Multifunctional Herb ‐Derived Glycopeptide Hydrogel for Chronic Wound Healing
This research aimed to build a herb-derived versatile glycopeptide hydrogel as a promising dressing to promote chronic wound repair. AbstractChronic wounds constitute an increasingly prevalent global healthcare issue, characterized by recurring bacterial infections, pronounced oxidative stress, compromised functionality of immune cells, unrelenting inflammatory reactions, and deficits in angiogenesis. In response to these multifaceted challenges, the study introduced a stimulus-responsive glycopeptide hydrogel constructed by oxidizedBletilla striata polysaccharide (OBSP), gallic acid-grafted ε-Polylysine (PLY-GA), and pae...
Source: Small - April 30, 2024 Category: Nanotechnology Authors: Xinyi Zhang,
Ye Wu,
Heng Gong,
Yan Xiong,
Yu Chen,
Lin Li,
Biao Zhi,
Saiqun Lv,
Tao Peng,
Hui Zhang Tags: Research Article Source Type: research
Interposition of acellular amniotic membrane at the tendon to bone interface would be better for healing than overlaying above the tendon to bone junction in the repair of rotator cuff injury
CONCLUSION: In the RC repair model, AAM enhanced regeneration of the tendon to bone junction. This regeneration was more effective when the AAM was intervened at the tendon to bone interface than overlaid above the tendon to bone junction.PMID:38688817 | DOI:10.1016/j.cjtee.2024.04.001 (Source: Chinese Journal of Traumatology)
Source: Chinese Journal of Traumatology - April 30, 2024 Category: Orthopaedics Authors: Jiang-Tao Wang Chun-Bao Li Jia-Ting Zhang Ming-Yang An Gang Zhao Yu-Jie Liu Source Type: research
The effect of traction force on eyelid blood perfusion during closure of defects
CONCLUSIONS: Eyelid tissue seems to respond to traction in a non-linear fashion, where the initial force results in the greatest eyelid stretching and reduction in blood perfusion. The results provide information on the effects of a large force for direct closure of large eyelid defects. Considering how quickly perfusion approaches zero, the high success rate of eyelid reconstruction surgery is likely a testament to the extensive vascularization of the periocular region.PMID:38687914 | DOI:10.1080/01676830.2024.2335999 (Source: Orbit)
Source: Orbit - April 30, 2024 Category: Opthalmology Authors: Jens N ääv Ottosson Johanna V Berggren Kajsa Tenland Elin Bohman Rafi Sheikh Malin Malmsj ö Aboma Merdasa Source Type: research
Meta-analysis of the Efficacy of Photodynamic Therapy (PDT) in the Treatment of Peri-implantitis
CONCLUSION: Compared to other non-surgical treatments, PDT treatment has significant advantages in reducing peri-implant probing depth and bleeding in patients with peri-implantitis. These results suggest that PDT may be a more effective non-surgical option for reducing probing depth and bleeding in patients with peri-implantitis. Of course, future studies with larger sample sizes and longer follow-up periods are needed to confirm these findings.PMID:38687855 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 30, 2024 Category: Complementary Medicine Authors: Shuangxi Liu Binping Wang Zhuogeng Chen Hui Mo Min Lin Xieshan Huang Source Type: research
The emerging role of deubiquitylating enzyme USP21 as a potential therapeutic target in cancer
Bioorg Chem. 2024 Apr 25;147:107400. doi: 10.1016/j.bioorg.2024.107400. Online ahead of print.ABSTRACTAlthough certain members of the Ubiquitin-specific peptidases (USPs) have been recognized as promising therapeutic targets for various diseases, research progress regarding USP21 has been relatively sluggish in its early stages. USP21 is a crucial member of the USPs subfamily, involved in diverse cellular processes such as apoptosis, DNA repair, and signal transduction. Research findings from the past decade demonstrate that USP21 mediates the deubiquitination of multiple well-known target proteins associated with critical...
Source: Bioorganic Chemistry - April 30, 2024 Category: Chemistry Authors: Zhen-Yuan Shi Chang-Yun Li Ru-Yi Chen Jin-Jin Shi Yan-Jun Liu Jian-Fei Lu Guan-Jun Yang Jiong Chen Source Type: research
The role of innate lymphoid cells in systemic lupus erythematosus
Cytokine. 2024 Apr 28;179:156623. doi: 10.1016/j.cyto.2024.156623. Online ahead of print.ABSTRACTSystemic lupus erythematosus (SLE) is a connective tissue disorder that affects various body systems. Both the innate and adaptive immunity contribute to the onset and progression of SLE. The main mechanism of SLE is an excessive immune response of immune cells to autoantigens, which leads to systemic inflammation and inflammation-induced organ damage. Notably, a subset of innate immune cells known as innate lymphoid cells (ILCs) has recently emerged. ILCs are pivotal in the early stages of infection; participate in immune resp...
Source: Cytokine - April 30, 2024 Category: Molecular Biology Authors: Yong Chen Xiaotian Gu Kunyu Cao Miao Tu Wan Liu Jiyu Ju Source Type: research
The effect of traction force on eyelid blood perfusion during closure of defects
CONCLUSIONS: Eyelid tissue seems to respond to traction in a non-linear fashion, where the initial force results in the greatest eyelid stretching and reduction in blood perfusion. The results provide information on the effects of a large force for direct closure of large eyelid defects. Considering how quickly perfusion approaches zero, the high success rate of eyelid reconstruction surgery is likely a testament to the extensive vascularization of the periocular region.PMID:38687914 | DOI:10.1080/01676830.2024.2335999 (Source: Orbit)
Source: Orbit - April 30, 2024 Category: Opthalmology Authors: Jens N ääv Ottosson Johanna V Berggren Kajsa Tenland Elin Bohman Rafi Sheikh Malin Malmsj ö Aboma Merdasa Source Type: research
Interposition of acellular amniotic membrane at the tendon to bone interface would be better for healing than overlaying above the tendon to bone junction in the repair of rotator cuff injury
CONCLUSION: In the RC repair model, AAM enhanced regeneration of the tendon to bone junction. This regeneration was more effective when the AAM was intervened at the tendon to bone interface than overlaid above the tendon to bone junction.PMID:38688817 | DOI:10.1016/j.cjtee.2024.04.001 (Source: Chinese Journal of Traumatology)
Source: Chinese Journal of Traumatology - April 30, 2024 Category: Orthopaedics Authors: Jiang-Tao Wang Chun-Bao Li Jia-Ting Zhang Ming-Yang An Gang Zhao Yu-Jie Liu Source Type: research
The Impact of Target Vessel Anatomy and Bridging Stent Geometry on Branched Endovascular Aortic Repair Outcomes
CONCLUSION: Target vessel diameter, bridging length (gap), and horizontal misalignment seemed to be associated with adverse target vessel outcomes. This may be solved with more customised endograft solutions to reduce the negative impact of the latter parameter.PMID:38685310 | DOI:10.1016/j.ejvs.2024.04.028 (Source: PubMed: Eur J Vasc Endovasc ...)
Source: PubMed: Eur J Vasc Endovasc ... - April 30, 2024 Category: Surgery Authors: Daniel Becker Laura Sikman Ahmed Ali Carlota F Prendes Jan Stana Nikolaos Tsilimparis Source Type: research
Meta-analysis of the Efficacy of Photodynamic Therapy (PDT) in the Treatment of Peri-implantitis
CONCLUSION: Compared to other non-surgical treatments, PDT treatment has significant advantages in reducing peri-implant probing depth and bleeding in patients with peri-implantitis. These results suggest that PDT may be a more effective non-surgical option for reducing probing depth and bleeding in patients with peri-implantitis. Of course, future studies with larger sample sizes and longer follow-up periods are needed to confirm these findings.PMID:38687855 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 30, 2024 Category: Complementary Medicine Authors: Shuangxi Liu Binping Wang Zhuogeng Chen Hui Mo Min Lin Xieshan Huang Source Type: research
Atherosclerosis Is a Smooth Muscle Cell-Driven Tumor-Like Disease
CONCLUSIONS: Our findings demonstrate that atherosclerosis is an SMC-driven tumor-like disease, advancing our understanding of its pathogenesis and opening prospects for innovative precision molecular strategies aimed at preventing and treating atherosclerotic cardiovascular disease.PMID:38686559 | DOI:10.1161/CIRCULATIONAHA.123.067587 (Source: Atherosclerosis)
Source: Atherosclerosis - April 30, 2024 Category: Cardiology Authors: Huize Pan Sebastian E Ho Chenyi Xue Jian Cui Quinian S Johanson Nadja Sachs Leila S Ross Fang Li Robert A Solomon E Sander Connolly Virendra I Patel Lars Maegdefessel Hanrui Zhang Muredach P Reilly Source Type: research
Atherosclerosis Is a Smooth Muscle Cell-Driven Tumor-Like Disease
CONCLUSIONS: Our findings demonstrate that atherosclerosis is an SMC-driven tumor-like disease, advancing our understanding of its pathogenesis and opening prospects for innovative precision molecular strategies aimed at preventing and treating atherosclerotic cardiovascular disease.PMID:38686559 | DOI:10.1161/CIRCULATIONAHA.123.067587 (Source: Circulation)
Source: Circulation - April 30, 2024 Category: Cardiology Authors: Huize Pan Sebastian E Ho Chenyi Xue Jian Cui Quinian S Johanson Nadja Sachs Leila S Ross Fang Li Robert A Solomon E Sander Connolly Virendra I Patel Lars Maegdefessel Hanrui Zhang Muredach P Reilly Source Type: research
H2AX: A key player in DNA damage response and a promising target for cancer therapy
Biomed Pharmacother. 2024 Apr 29;175:116663. doi: 10.1016/j.biopha.2024.116663. Online ahead of print.ABSTRACTCancer is caused by a complex interaction of factors that interrupt the normal growth and division of cells. At the center of this process is the intricate relationship between DNA damage and the cellular mechanisms responsible for maintaining genomic stability. When DNA damage is not repaired, it can cause genetic mutations that contribute to the initiation and progression of cancer. On the other hand, the DNA damage response system, which involves the phosphorylation of the histone variant H2AX (γH2AX), is cruci...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 30, 2024 Category: Drugs & Pharmacology Authors: Kirti S Prabhu Shilpa Kuttikrishnan Nuha Ahamad Ummu Habeeba Zahwa Mariyam Muhammad Suleman Ajaz A Bhat Shahab Uddin Source Type: research
The emerging role of deubiquitylating enzyme USP21 as a potential therapeutic target in cancer
Bioorg Chem. 2024 Apr 25;147:107400. doi: 10.1016/j.bioorg.2024.107400. Online ahead of print.ABSTRACTAlthough certain members of the Ubiquitin-specific peptidases (USPs) have been recognized as promising therapeutic targets for various diseases, research progress regarding USP21 has been relatively sluggish in its early stages. USP21 is a crucial member of the USPs subfamily, involved in diverse cellular processes such as apoptosis, DNA repair, and signal transduction. Research findings from the past decade demonstrate that USP21 mediates the deubiquitination of multiple well-known target proteins associated with critical...
Source: Bioorganic Chemistry - April 30, 2024 Category: Chemistry Authors: Zhen-Yuan Shi Chang-Yun Li Ru-Yi Chen Jin-Jin Shi Yan-Jun Liu Jian-Fei Lu Guan-Jun Yang Jiong Chen Source Type: research
