Short-Term Symptomatic Relief in Gastroesophageal Reflux Disease: A Comparative Study of Esomeprazole and Vonoprazan
ConclusionsThere were no substantial differences in the symptom relief between the two groups at any time point in this short-term study. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - November 10, 2018 Category: Gastroenterology Source Type: research

Covering the Cover
A US multicenter study develops a clinical model to estimate the pretest probability of abnormal acid reflux during pH monitoring in patients with refractory heartburn or suspected extraesophageal reflux symptoms who failed proton pump inhibitor therapy. (Source: Gastroenterology)
Source: Gastroenterology - November 9, 2018 Category: Gastroenterology Authors: Andrew T. Chan, Christopher S. Williams Tags: Covering the Cover Source Type: research

An Ethanolic Extract of Allium hookeri Root Alleviates Reflux Esophagitis and Modulates NF- κB Signaling.
An Ethanolic Extract of Allium hookeri Root Alleviates Reflux Esophagitis and Modulates NF-κB Signaling. Evid Based Complement Alternat Med. 2018;2018:1834681 Authors: Nan L, Nam HH, Choo BK, Park JC, Kim DG, Lee JH, Moon KH Abstract Reflux esophagitis (RE) is a kind of gastroesophageal reflux disease, of which an esophageal inflammatory lesion is caused by the contents of the stomach and duodenum flowing back into the esophagus. Allium hookeri is a plant possessing both nutritional and medicinal properties. In our study, we investigated the inhibition effect of inflammation of A. hookeri root ex...
Source: Evidence-based Complementary and Alternative Medicine - November 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Attitude and Knowledge of Saudi community pharmacists towards Use of Proton Pump Inhibitors
ConclusionCommunity pharmacists in Saudi Arabia usually recommend and prescribe PPIs to their patients. Most of them have some knowledge on PPIs indications and side effects. Managing OTC PPI use in the community pharmacy setting is necessary to promote both patient and medication safety. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - November 8, 2018 Category: Drugs & Pharmacology Source Type: research

Sex-specific airway hyperreactivity and sex-specific transcriptome remodeling in neonatal piglets challenged with intra-airway acid.
Abstract Acute airway acidification is a potent stimulus of sensory nerves and occurs commonly with gastroesophageal reflux disease, cystic fibrosis and asthma. In infants and adults, airway acidification can acutely precipitate asthma-like symptoms, and treatment resistant asthma can be associated with gastroesophageal reflux disease. Airway protective behaviors, such as mucus secretion and airway smooth muscle contraction, are often exaggerated in asthma. These behaviors are manifested through activation of neural circuits. In some populations, the neural response to acid might be particularly important. For exa...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - November 8, 2018 Category: Cytology Authors: Reznikov LR, Liao YJ, Gu T, Davis KM, Kuan SP, Atanasova KR, Dadural JS, Collins EN, Guevara MV, Vogt K Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Preoperative gastric residual volumes in fasted patients measured by bedside ultrasound: a prospective observational study
The purpose of this prospective observational study was to measure gastric volumes in fasted patients using bedside gastric ultrasound. Patients presenting for non-emergency surgery underwent a gastric antrum assessment, using the two-diameter and free-trace methods to determine antral cross-sectional area (CSA). Gastric residual volume (GRV) was calculated using a validated formula. Univariate and multivariable analyses were performed to examine any potential relationships between ‘at risk’ GRVs (>100 ml) and patient factors. Two hundred and twenty-two successful scans were performed; of these 110 patients ...
Source: Anaesthesia and Intensive Care - November 7, 2018 Category: Anesthesiology Source Type: research

The Relationship Between Hiatal Hernia and Cricopharyngeus Muscle Dysfunction
AbstractAlthough the precise etiology of cricopharyngeus muscle (CPM) dysfunction (CPMD) is uncertain, many have hypothesized that a hypertrophied CPM may develop as a protective compensation against gastroesophageal reflux disease (GERD). The purpose of this investigation was to evaluate the association between CPMD and the presence of hiatal hernia (HH) in an attempt to elucidate the potential etiology of CPMD. The charts of individuals who underwent video fluoroscopic esophagrams between 01/01/14 and 10/30/16 were reviewed from an electronic database. A group of 50 subjects with reported HH were identified and age- and ...
Source: Dysphagia - November 7, 2018 Category: Speech-Language Pathology Source Type: research

Concept of histone deacetylases in cancer: Reflections on esophageal carcinogenesis and treatment.
Abstract Esophageal cancer (EC) presents a high mortality rate, mainly due to its aggressive nature. Squamous cell carcinoma is the most common histological type worldwide, though, a continuous increase in esophageal adenocarcinomas has been noted in the past decades. Common risk factors associated with EC include smoking, alcohol consumption, gastroesophageal reflux disease, Barrett's esophagus and obesity. In an effort to overcome chemotherapy resistance in oncology, it was discovered that histone acetylation/deacetylation equilibrium is altered in carcinogenesis, leading to changes in chromatin structure and al...
Source: World Journal of Gastroenterology : WJG - November 7, 2018 Category: Gastroenterology Authors: Schizas D, Mastoraki A, Naar L, Spartalis E, Tsilimigras DI, Karachaliou GS, Bagias G, Moris D Tags: World J Gastroenterol Source Type: research

Basal lower esophageal sphincter pressure in gastroesophageal reflux disease: An ignored metric in high-resolution esophageal manometry
AbstractManometry and 24-h pH interpretation have seldom been studied. Our aim was to study these parameters as gold standard in reflux disease and to identify predictors of pathological acid reflux. Retrospective case record review of all patients with reflux disease evaluated using endoscopy, manometry, and 24-h pH testing from 2010 to 2016. Patients were categorized using Johnson-DeMeester score into two groups —group I (score> 14.7, normal study) and group II (
Source: Indian Journal of Gastroenterology - November 6, 2018 Category: Gastroenterology Source Type: research

Medications With Depression as an Adverse Effect
To the Editor In a cross-sectional survey study, Dr Qato and colleagues found that the use of prescription medications with depression as a potential adverse effect was common. However, the authors did not take into account that most of the drugs described are used to treat conditions already linked to an increased risk of depressive symptoms. Although they investigated the relationship between hypertension and depression, they did not account for the association of depressive symptoms with pain (and subsequent use of pain killers), gastroesophageal reflux disorder (and subsequent use of gastrointestinal agents), or atopic...
Source: JAMA - November 6, 2018 Category: General Medicine Source Type: research

Failed Sleeve Gastrectomy: Single Anastomosis Duodenoileal Bypass or Roux-en-Y Gastric Bypass? A Multicenter Cohort Study
AbstractBackgroundSleeve gastrectomy (SG) has become the most performed bariatric procedure to induce weight loss worldwide. Unfortunately, a significant portion of patients show insufficient weight loss or weight regain after a few years.ObjectiveTo investigate the effectiveness of the single anastomosis duodenoileal (SADI) bypass versus the Roux-en-Y gastric bypass (RYGB) on health outcomes in morbid obese patients who had undergone SG previously, with up to 2  years of follow-up.MethodsFrom 2007 to 2017, 140 patients received revisional laparoscopic surgery after SG in four specialized Dutch bariatric hospitals. Da...
Source: Obesity Surgery - November 6, 2018 Category: Surgery Source Type: research

Avoiding routine postoperative voiding cystourethrogram: Predicting radiologic success for endoscopically treated vesicoureteral reflux.
CONCLUSIONS: We objectively demonstrated that IMM was a poor predictor of radiologic success and should be used with caution. In addition, the performance of a combined prediction model was inferior to the presence of a PUM alone. As such, selective use of postoperative VCUG may be guided solely by the presence of a PUM. PMID: 30407152 [PubMed - as supplied by publisher] (Source: Canadian Urological Association Journal)
Source: Canadian Urological Association Journal - November 5, 2018 Category: Urology & Nephrology Authors: Wang PZT, Abdelhalim A, Walia A, Wehbi E, Dave S, Khoury A Tags: Can Urol Assoc J Source Type: research

Reduction in Gastroesophageal Reflux Disease Symptoms Is Associated with Miso Soup Intake in a Population-Based Cross-Sectional Study: The Nagahama Study.
Authors: Mano F, Ikeda K, Sato T, Nakayama T, Tanaka D, Joo E, Takahashi Y, Kosugi S, Sekine A, Tabara Y, Matsuda F, Inagaki N, Nagahama Study Group Abstract Dietary habits and lifestyles are considered to affect the frequency of epigastric symptoms. In our previous study, we found that three amino acids in Japanese broth promoted gastric emptying. We hypothesized that a higher consumption of miso soup which was mainly composed of Japanese broth and miso paste would be associated with a lower frequency of epigastric symptoms. We conducted a cross-sectional study of the association between frequency of miso soup int...
Source: Journal of Nutritional Science and Vitaminology - November 3, 2018 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Gastroesophageal Reflux—Is It Uncommon in Indian Patients With Decompensated Liver Cirrhosis?
Publication date: Available online 5 October 2018Source: Journal of Clinical and Experimental HepatologyAuthor(s): Uday Sanglodkar, Mayank Jain, M.J. Alexander, Jayanthi VenkataramanAbstractThe prevalence of reflux symptoms among Indian patients with decompensated cirrhosis is not known. We prospectively collected data using a predesigned questionnaire. Out of 200 patients recruited in the study, only 9.5% had reflux symptoms. None of the risk factors like smoking, alcohol and tobacco use; sex; age and severity of ascites correlated with patient symptoms. The present study highlights that GERD symptoms are infrequent among...
Source: Journal of Clinical and Experimental Hepatology - November 2, 2018 Category: Gastroenterology Source Type: research

Dual Delayed-Release Dexlansoprazole for Healing and Maintenance of Healed Erosive Esophagitis: A Safety Study in Adolescents
ConclusionsDexlansoprazole is safe and efficacious for healing EE and maintenance of healed EE in adolescents. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - November 2, 2018 Category: Gastroenterology Source Type: research

Clinical Validity and Reliability of the Malay Language Translations of Gastroesophageal Reflux Disease Questionnaire and Quality of Life in Reflux and Dyspepsia Questionnaire in a Primary Care Setting
Conclusions: GERDQ-M and QOLRAD-M are valid and reliable tools applicable in a primary care setting.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - November 1, 2018 Category: Gastroenterology Source Type: research

Proton Pump Inhibitor –Refractory Gastroesophageal Reflux Disease
This article reviews the definition, mechanisms, and management options for PPI-refractory GERD. (Source: Medical Clinics of North America)
Source: Medical Clinics of North America - November 1, 2018 Category: Primary Care Authors: Rena Yadlapati, Kelli DeLay Source Type: research

Remission of Barrett's Esophagus after Sleeve Gastrectomy, A Case Study
Background: Barrett's Esophagus (BE),common in individuals with gastroesophageal reflux disease (GERD), pre-disposes the affected individual to the potential development of intestinal metaplasia, dysplasia and esophageal adenocarcinoma. Due to physiologic changes incurred post Laparoscopic Sleeve Gastrectomy (LSG), there is an increased risk of BE development, or progression in patients with active GERD. Because of this, many surgeons consider a patient who has BE to be contraindicated for LSG surgery. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - November 1, 2018 Category: Surgery Authors: Stephanie Therrien, Daniel Jones Source Type: research

Minimally invasive conversion of sleeve gastrectomy to Roux-en-Y Gastric Bypass for Intractable Gastroesophageal Reflux Disease: Short Term Outcome
Background: Sleeve gastrectomy (SG) is considered definitive surgery for weight loss due to excellent short-term results. GERD has been reported to have a post-operative incidence between 3-50% and management remains controversial. This case series demonstrates our experience with intractable GERD management after SG with conversion of SG to Roux-en-Y gastric bypass (RYGB). (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - November 1, 2018 Category: Surgery Authors: Daniel G Davis, Lauren Kastner, Steven Leeds Source Type: research

Impact of bariatric surgery in anti-reflux medication use in patients with asthma and GERD
Background: There is an association between asthma and GERD (1). Although bariatric surgery has shown to reduce medication use in both comorbidities separately, there is limited research done in a population who have both asthma and GERD. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - November 1, 2018 Category: Surgery Authors: Gerardo G Davalos, Dana D Portenier, Hui-Jie Lee, Jennifer Ingram, Daniel D Guerron Source Type: research

Routine Hiatal Dissection and Repair Does Not Improve Short-Term Reflux After Vertical Sleeve Gastrectomy
Background: Gastroesophageal reflux disease (GERD) can be exacerbated or incited by VSG, potentially even leading to Barrett's esophagus. There is limited data regarding the impact of selective versus routine hiatal dissection and repair on GERD after VSG. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - November 1, 2018 Category: Surgery Authors: Mohan K Mallipeddi, Emma Gillette, Harveen K Sekhon, Desmond Huynh, Miguel A Burch, Scott A Cunneen, Edward H Phillips, Daniel Shouhed Source Type: research

Comparison between endoscopic and laparoscopic evaluation of hiatus hernia in patients undergoing weight loss surgery
Background: Currently, the advantages of pre-operative upper endoscopy in patients undergoing weight loss surgery remains controversial. Data suggests that patients with obesity have a high incidence of gastro-oesophageal reflux, oesophagitis and hiatus hernia (HH). Upper endoscopy findings may play an important role in operative planning. Currently, little evidence exists regarding the diagnostic sensitivity of upper endoscopy in detecting hiatus hernia. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - November 1, 2018 Category: Surgery Authors: Sabin J Warner-Smith, M Surg Pimlico Source Type: research

The Effect of Laparoscopic Sleeve Gastrectomy on Gastroesophageal Reflux Disease
Background: Gastroesophageal reflux disease (GERD) is a common condition in adults, affecting both quality of life and risk of developing esophageal cancer. Laparoscopic sleeve gastrectomy (LSG) has become a popular option for patients seeking operative management of morbid obesity, however it is unclear whether it may potentially worsen GERD symptoms. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - November 1, 2018 Category: Surgery Authors: Christina Poa, Collin Creange, Matthew J Pergamo, Christine J Ren-Fielding, George Fielding, Bradley F Schwack Source Type: research

Magnetic Sphincter Augmentation for Refractory Reflux Following Laparoscopic Sleeve Gastrectomy
Background: GERD can occur de novo in up to 30% of patients after Sleeve Gastrectomy (LSG). Most patients are successfully managed with lifestyle modifications and medical therapy. However, GERD refractory to medical therapy is difficult to manage with many patients requiring conversion Laparoscopic Roux En Y Gastric Bypass (LRYGB). Recently, Magnetic Sphincter Augmentation (MSA) has been proposed as a less morbid alternative for the relief of GERD. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - November 1, 2018 Category: Surgery Authors: Ryan D Horsley, Gordian U Ndubizu, Anthony Petrick Source Type: research

Laparoscopic Repair of Congenital Diaphragm Hernia with Gastric Bypass
Background: We are presenting a 35 year old patient with morbid obesity as well as symptoms of severe gastroesophageal reflux disease who, with preoperative imaging, was diagnosed with a large paraesophageal hernia. He underwent laparoscopic repair of the hernia as well as gastric bypass and was found at the time of surgery to have a large primary diaphragmatic hernia instead of a paraesophageal hernia. The defect did not appear to be either a Morgagni or Bochdalek hernia as it was centrally located in the diaphragm, just lateral to the left crus. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - November 1, 2018 Category: Surgery Authors: Kellen Hayes, Philip R Schauer Source Type: research

Type 3 Hiatal hernia complicating a mediogastric stenosis after gastric banding: cure of hiatal hernia and revision to Roux en Y Gastric Bypass
We present the case of a 54-year-old woman with a residual BMI of 35.4 kg/m2 after failure of gastric banding. She complained of persistent Gastro-Esophageal Reflux Disease (GERD) and dysphagia despite removal of the gastric band 3 years before. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - November 1, 2018 Category: Surgery Authors: Maud Robert, Arnaud Pasquer Source Type: research

Laparosocpic Nissen fundoplication with the excluded stomach for Recalcitrant GERD after a Roux en Y gastric bypass
Background: The patient is a 63 y/o white female who had undergone a roux en y gastric bypass 10 years prior. Patient had excellent weight loss, however the patient had significant reflux which was managed with PPI's. The patient 3 years ago underwent a lenthening of the roux limb for presumed bile reflux, however the patient continued to complain of significant reflux. She was then referred to us. The patient underwent a manometry which demonstrated good esophageal motility. Her impedence probe was significant for non acid reflux which was abnormal for total number of reflux episodes both supine and recumbent and associat...
Source: Surgery for Obesity and Related Diseases - November 1, 2018 Category: Surgery Authors: Rana Pullatt, Karl T Byrne, Benjamin White, Diana Axiotis, Molly Jones, Shelby Allen, Nina M Crowley Source Type: research

Roux-en-Y Gastric Bypass after Failed Lower Esophageal Sphincter Magnetic Augmentation Procedure
We present a video of a 49y/o female with a failed lower esophageal sphincter magnetic augmentation (LESM). The patient presented after referral to the bariatric practice after developing recurrent GERD (HRQL=13, on PPI), intermittent dysphagia, regurgitation and weight gain (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - November 1, 2018 Category: Surgery Authors: Darren Tishler, Andrea Stone, Beata Lobel, Pavlos K Papasavas Tags: Tuesday, November 13th1:30 pm--3:00 pm Source Type: research

When should endoscopy and 24h pH-test be done before bariatric surgery?
Background: The presence of gastroesophageal reflux disease (GERD) has an impact on the choice and outcomes of bariatric surgery. However, GERD diagnosis based solely on clinical evaluation has been proven to yield poor results in individuals with and without obesity. We studied the factors associated with abnormal 24h pH-test and the impact on diagnostic approach in patients with severe obesity. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - November 1, 2018 Category: Surgery Authors: Guilherme Mazzini, Daniel Navarini, Guilherme M Campos, Jad Khoraki, Fabio R Bar ão, Carlos A Madalosso, Richard R Gurski Source Type: research

Gastroesophageal reflux (gerd): a major factor in highly labile steroid-dependent asthma
In the setting of severe asthma with difficult to control symptoms, it is crucial to evaluate for other diagnoses and comorbidities in order to optimize management. In the case presented, sub-optimally treated GERD was identified as the driving force causing severe asthma symptoms. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: A. Meyer, S. Gupta, N. Rabinovitch, P. Hauk, J. Abbott Tags: M210 Source Type: research

Adverse drug reaction to all proton pump inhibitors except esomeprazole in medically complex pediatric patient
Proton-pump inhibitors (PPIs) are commonly used for treatment of gastroesophageal reflux disease (GERD). PPIs have a favourable safety profile; however, immediate and delayed hypersensitivity reactions have been described. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: L. Duan, S. Jeimy, S. Silver, J. Upton Tags: M056 Source Type: research

Prevalence of elevated exhaled nitric oxide in patients with chronic cough in a community setting
Physicians are frequently tasked with treating chronic cough (lasting longer than 8 weeks). Among patients who do not smoke cigarettes, the three primary etiologies of chronic cough are postnasal-drip syndrome, gastroesophageal reflux disease, and atypical asthma, which combined account for 92% of chronic cough. The measurement of exhaled nitric oxide in patients with chronic cough can identify patients who will likely improve with inhaled steroids versus those who will likely not, thereby mitigating the need for a trial of corticosteroids. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: W. Smith, W. Smith, L. Webb Tags: P112 Source Type: research

#12 Proposed randomised controlled feasibility trial of a novel polyvinylideneflouride (PVDF) mesh (Dynamesh ®-HIATUS) cruroplasty versus suture-only repair of large hiatus hernia: the DYNAMIC Study (oral presentation)
Background: Gastro-oesophageal reflux disease (GORD) is a significant health problem affecting up to 25% of adults. Keyhole surgical treatment of chronic GORD has become an alternative to medical treatment over the past 20 years. However, patients with large hiatus hernias more than 5cm in size appear to have poorer results with recurrence in up to half of the patients. The use of mesh reinforcement has been considered to improve this, as this has been efficacious in other hernia repairs. However, with hiatal hernia repair there have been concerns about risks of mesh erosion and infection, and results to date have been equ...
Source: International Journal of Surgery - November 1, 2018 Category: Surgery Authors: S. Toh, B. Knight, C. Fogg, E. Baddesley, A. Higginson, R. Beable, S. Babu, E. Hawes, M. Moon, J. Shoebridge, P. Meredith, M. Amos-Lyons, P. May-Miller Source Type: research

Lymphocytic gastritis induced by pembrolizumab in a patient with metastatic melanoma
We present the case of a 44-year-old man with advanced melanoma and recurrent lung metastases who developed symptoms of dyspepsia and gastroesophageal reflux disease after 1 month of therapy with pembrolizumab. Gastric biopsy showed histologic features consistent with lymphocytic gastritis, which was absent on a biopsy 2 months before initiation of therapy. Lymphocytic infiltrates likely secondary to increased autoimmunity after use of immunotherapy have been observed in the colon; however, such histologic findings in the upper gastrointestinal tract have yet to be described. Here, we present a case of lymphocytic gastriti...
Source: Melanoma Research - October 31, 2018 Category: Cancer & Oncology Tags: SHORT COMMUNICATIONS Source Type: research

Can Freehand Elastosonography Be an Alternative to Renal Scintigraphy in Pediatric Vesicoureteral Reflux Cases?
Conclusion In this study, we could not find any significant difference in term of tissue tension values (ST and SI) measured by freehand elastosonography between renal units with and without scar formation in renal scan. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - October 31, 2018 Category: Surgery Authors: Karabulut, Bilge Bayram, Gulsah Oztorun, Can Ihsan Ozcift, Burak Tiryaki, Tu ğrul Hüseyin Tags: Original Article Source Type: research

ACVIM consensus statement: Support for rational administration of gastrointestinal protectants to dogs and cats
This report offers a consensus opinion on the rational administration of GI protectants to dogs and cats, with an emphasis on proton pump inhibitors (PPIs), histamine type ‐2 receptor antagonists (H2RAs), misoprostol, and sucralfate. These medications decrease gastric acidity or promote mucosal protective mechanisms, transforming the management of dyspepsia, peptic ulceration, and gastroesophageal reflux disease. In contrast to guidelines that have been established in people for the optimal treatment of gastroduodenal ulcers and gastroesophageal reflux disease, effective clinical dosages of antisecretory drugs have not b...
Source: Journal of Veterinary Internal Medicine - October 31, 2018 Category: Veterinary Research Authors: Stanley L. Marks, Peter H. Kook, Mark G. Papich, M. Katherine Tolbert, Michael D. Willard Tags: CONSENSUS STATEMENT Source Type: research

Laparoscopic placement of the linx® system in management of severe reflux after sleeve gastrectomy
ConclusionThe LINX® system may be used as an alternative to RYGB conversion in managing refractory post-SG reflux. (Source: The American Journal of Surgery)
Source: The American Journal of Surgery - October 30, 2018 Category: Surgery Source Type: research

Endosheath ultrathin transnasal endoscopy is a cost-effective method for screening for Barrett ’s esophagus in patients with GERD symptoms
In this study, we determined the cost-utility of uTNE in a high-risk subgroup compared with no screening or screening with standard endoscopy (SE). (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - October 29, 2018 Category: Gastroenterology Authors: Judith Honing, Wietske Kievit, Jan Bookelaar, Yonne Peters, Prasad G. Iyer, Peter D. Siersema Source Type: research

The diagnostic value of GerdQ in subjects with atypical symptoms of gastro-esophageal reflux disease.
CONCLUSIONS: GerdQ has a diagnostic value in an unselected population presenting with typical and/or atypical symptoms of GERD, but a low sensitivity for diagnosis of GERDpH was found in subjects with predominant symptoms such as cough, dysphagia and globus. PMID: 30353750 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - October 27, 2018 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Pneumomediastinum as a complication of esophageal intramural pseudodiverticulosis.
We report esophageal intramural pseudodiverticulosis (EIPD) as a cause of dysphagia that is less known by physicians and it is rarely described in the literature. EIPD is characterized by multiple, segmental or diffuse, flask-like outpouchings in the esophageal wall corresponding to dilated and inflamed excretory ducts of the submucosal esophageal glands. The underlying etiology remains unclear. Esophageal strictures, esophageal candidiasis and gastroesophageal reflux disease are often associated. The diagnosis can be made by upper gastrointestinal endoscopy, but barium esophagography is the modality of choice. Complicatio...
Source: Acta Gastro-Enterologica Belgica - October 25, 2018 Category: Gastroenterology Tags: Acta Gastroenterol Belg Source Type: research

A Multifaceted Intervention to Reduce Pediatric Acid-Suppressant Prescriptions for Gastroesophageal Reflux: What Have We Learned?
Conclusion: This multifaceted implementation strategy did not lead to a significant difference in acid-suppressant prescriptions by tertiary care clinicians of whom the majority was familiar with the gastroesophageal reflux disease guideline. Future studies should clarify, which implementation strategies are most effective in reducing inappropriate prescribing of acid suppressants for children. Uniform registration of prescriptions and indications in a national database will enable monitoring of the intervention effect. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - October 25, 2018 Category: Gastroenterology Tags: Original Article: Gastroenterology Source Type: research

Early Infant Risk Factors for Pediatric Eosinophilic Esophagitis
Conclusions: Acid-blocking medications and antibiotics during infancy were associated with later diagnosis of EoE. Erythema toxicum neonatorum, an eosinophilic immune phenomenon, was strongly associated with EoE. Identifying early infant risk factors for EoE may help to risk stratify the need for endoscopy. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - October 25, 2018 Category: Gastroenterology Tags: Original Article: Gastroenterology: Eosinophilic GI Disease Source Type: research

Potent Acid Suppression with PPIs and P-CABs: What ’s New?
AbstractPurpose of the reviewAcid suppression treatment has revolutionized the management of the acid-related disorders since the introduction of the H2-receptor antagonists (H2-RAs) and the proton pump inhibitors (PPIs). However, there has been increasing identification of needs for improvement in antisecretory therapy, especially in gastroesophageal reflux disease (GERD), the eradication ofHelicobacter pylori (H. pylori), protection from aspirin (ASA) and non-steroidal inflammatory drug (NSAID) injury and the management of upper gastrointestinal (UGI) bleeding. There have also been increasing publications addressing safe...
Source: Current Treatment Options in Gastroenterology - October 25, 2018 Category: Gastroenterology Source Type: research

Comparative study of acid functionalization of carbon nanotube via ultrasonic and reflux mechanism
Publication date: October 2018Source: Journal of Environmental Chemical Engineering, Volume 6, Issue 5Author(s): Lau Yien Jun, N.M. Mubarak, Lau Sie Yon, Chua Han Bing, Mohammad Khalid, E.C. AbdullahAbstractMulti-walled carbon nanotubes (MWCNTs) have a great potential in wide applications due to their extraordinary physical, thermal and mechanical properties. However, the known shortcomings, such as hydrophobic nature, poor solubility and dispersibility in most solvents have impeded the technology to further develop. In the present study, various types of acid functionalized MWNCTs (f-MWCNTs) samples were prepared. The inv...
Source: Journal of Environmental Chemical Engineering - October 24, 2018 Category: Chemistry Source Type: research

Association Between Anxiety and Depression and Gastroesophageal Reflux Disease: Results From a Large Cross-sectional Study.
Conclusion: This cross-sectional study revealed that anxiety and depression levels were significantly higher in subjects with GERD (notably in the NERD) than in controls. PMID: 30347938 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 24, 2018 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Development and Psychometric Assessment of a Self-evaluation Questionnaire for Gastroesophageal Reflux Disease.
This study was conducted to develop an instrument and to determine of the definition of respondent for a patient reported outcomes to assess the efficacy of a treatment used for GERD treatment. Methods: A structural process has developed a self-evaluation questionnaire for GERD (SEQ-GERD); health-related quality of life questionnaire for GERD (GERD-QOL) was translated through cross-cultural validation. Two-week reproducibility was evaluated and construct validity was assessed by correlating the SEQ-GERD with the Patient Assessment of Gastrointestinal Disorders (PAGI-SYM), the reflux disease questionnaire (RDQ), and GER...
Source: Journal of Neurogastroenterology and Motility - October 24, 2018 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Pathophysiology of Potassium-competitive Acid Blocker-refractory Gastroesophageal Reflux and the Potential of Potassium-competitive Acid Blocker Test.
Conclusions: Intra-gastric pH and acid reflux were strongly suppressed by 20-mg vonoprazan. When patients with gastroesophageal reflux disease present symptoms after administration of 20-mg vonoprazan, the possibility of pathophysiologies other than acid reflux should be considered. PMID: 30347936 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 24, 2018 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

The Changing Epidemiology of Gastroesophageal Reflux Disease: Are Patients Getting Younger?
Authors: Yamasaki T, Hemond C, Eisa M, Ganocy S, Fass R Abstract Background/Aims: Gastroesophageal reflux disease (GERD) is a common disease globally with increasing prevalence and consequently greater burden on the Healthcare system. Traditionally, GERD has been considered a disease of middle-aged and older people. Since risk factors for GERD affect a growing number of the adult population, concerns have been raised that increasingly younger people may develop GERD. We aim to determine if the proportion of younger patients has increased among the GERD population. Methods: The incidence of GERD as well as sever...
Source: Journal of Neurogastroenterology and Motility - October 24, 2018 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

It Is Time to Meet the Challenges of the Changing Epidemiology of Gastroesophageal Reflux Disease.
Authors: Kim GH PMID: 30347932 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 24, 2018 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

The effect of dietary carbohydrate on gastroesophageal reflux disease
ConclusionMore acid reflux symptoms are found after high carbohydrate diet. High carbohydrate diet could induce more acid reflux in low esophagus and more reflux symptoms in patients with gastroesophageal reflux disease. (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - October 24, 2018 Category: General Medicine Source Type: research