Correction to: Short-Term Symptomatic Relief in Gastroesophageal Reflux Disease: A Comparative Study of Esomeprazole and Vonoprazan
The original version of the article unfortunately contained percentage errors in second and third paragraphs of GerdQ Score section. Below is the corrected version. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - May 16, 2019 Category: Gastroenterology Source Type: research

Clinical Aspects of Thickeners for Pediatric Gastroesophageal Reflux and Oropharyngeal Dysphagia
AbstractPurpose of ReviewThe purpose of this review is to discuss current knowledge and recent findings regarding clinical aspects of thickeners for pediatric gastroesophageal reflux and oropharyngeal dysphagia. We review evidence for thickener efficacy, discuss types of thickeners, practical considerations when using various thickeners, and risks and benefits of thickener use in pediatrics.Recent FindingsThickeners are effective in decreasing regurgitation and improving swallowing mechanics and can often be used empirically for the treatment of infants and young children. Adverse effects have been reported, but with caref...
Source: Current Gastroenterology Reports - May 16, 2019 Category: Gastroenterology Source Type: research

N-doped carbon dots with tunable emission for multifaceted application: solvatochromism, moisture sensing, pH sensing, and solid state multicolor lighting
Publication date: Available online 13 May 2019Source: Sensors and Actuators B: ChemicalAuthor(s): Md Moniruzzaman, Jongsung KimAbstractNovel N-doped green-emitting carbon dots (N-GCDs) that were responsive to various external stimuli and had high quantum yields (QYs) for multifaceted applications were synthesized from β-resorcylic acid and ethylenediamine using a hydrothermal process followed by a reflux method. The QYs of the N-GCDs were in the range of 17.36%–48.4% and were associated with different photoluminescent color emission in different solvents. Interestingly, the as-synthesized N-GCDs exhibited strict...
Source: Sensors and Actuators B: Chemical - May 15, 2019 Category: Chemistry Source Type: research

The Impact of the American Academy of Pediatrics Brief Resolved Unexplained Event Guidelines on Gastrointestinal Testing and Prescribing Practices
To determine if hospitalization, testing, diagnosis, and management of suspected gastroesophageal reflux, and follow-up visits decreased since introduction of American Academy of Pediatrics guidelines for brief resolved unexplained events (BRUEs). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 15, 2019 Category: Pediatrics Authors: Daniel R. Duncan, Amanda S. Growdon, Enju Liu, Kara Larson, Madeline Gonzalez, Kerri Norris, Rachel L. Rosen Tags: Original Article Source Type: research

Modified inspiratory muscle training (m-IMT) as promising treatment for gastro-oesophageal reflux disease (GERD).
ale M Abstract BACKGROUND: Gastro-oesophageal reflux disease (GERD) is one of the most common diseases, but is still a challenge to cure. Different medical treatments are used, first of all Proton pump inhibitors (PPIs), however these are sometimes ineffective and long-term intake can lead to underestimated complications. Recently, some studies investigated the role of inspiratory muscle training (IMT) in the medical treatment of GERD. It seems that IMT is able to increase the pressure generated by the lower oesophageal sphincter (LES), reduce spontaneous releases of LES, acid exposure, use of PPIs, and improve sy...
Source: Acta Otorrinolaringologica Espanola - May 15, 2019 Category: ENT & OMF Authors: Moffa A, Oliveto G, Matteo FD, Baptista P, Cárdenas A, Cassano M, Casale M Tags: Acta Otorrinolaringol Esp Source Type: research

Prospects to the formation and control of potential dimer impurity E of pantoprazole sodium sesquihydrate
Publication date: Available online 1 March 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Arun Kumar Awasthi, Lalit Kumar, Punit Tripathi, Madhava Golla, Cirandur Suresh Reddy, Pramod KumarAbstractPantoprazole sodium, a substituted benzimidazole derivative, is an irreversible proton pump inhibitor which is primarily used for the treatment of duodenal ulcers, gastric ulcers, and gastroesophageal reflux disease (GERD). The monographs of European Pharmacopoeia (Ph. Eur.) and United States Pharmacopoeia (USP) specify six impurities, viz.; impurities A, B, C, D, E and F, respectively for its active pharmaceutical ingr...
Source: Journal of Pharmaceutical Analysis - May 14, 2019 Category: Drugs & Pharmacology Source Type: research

Healthcare burden among individuals with Angelman syndrome: Findings from the Angelman Syndrome Natural History Study
ConclusionsThis study shows that individuals with AS have high HRU/STU, and apart from a few differences, HRU/STU was similar across molecular etiology. These results reflect usage in younger individuals and studies that describe HRU/STU in older individuals are needed. (Source: Molecular Genetics & Genomic Medicine)
Source: Molecular Genetics & Genomic Medicine - May 14, 2019 Category: Genetics & Stem Cells Authors: Nasreen Khan, Raquel Cabo, Wen ‐Hann Tan, Regina Tayag, Lynne M. Bird Tags: ORIGINAL ARTICLE Source Type: research

Alteration of the esophageal microbiota in Barrett's esophagus and esophageal adenocarcinoma.
Abstract The incidence of esophageal adenocarcinoma (EAC) has increased in recent decades, and its 5-year survival rate is less than 20%. As a well-established precursor, patients with Barrett's esophagus (BE) have a persistent risk of progression to EAC. Many researchers have already identified some factors that may contribute to the development of BE and EAC, and the identified risks include gastroesophageal reflux (GER), male sex, older age, central obesity, tobacco smoking, Helicobacter pylori (H. pylori) eradication, and the administration of proton pump inhibitors (PPIs) and antibiotics. The human gut harbor...
Source: World Journal of Gastroenterology : WJG - May 14, 2019 Category: Gastroenterology Authors: Lv J, Guo L, Liu JJ, Zhao HP, Zhang J, Wang JH Tags: World J Gastroenterol Source Type: research

Per-oral endoscopic myotomy for esophageal diverticula with or without esophageal motility disorders
ConclusionsIn the case of MED and esophageal motility disorder, POEM permitted treatment of the underlying cause of the diverticulum, achieving favorable early clinical outcomes. In the absence of motility disorder, POEM was feasible with promising early outcomes, and could be a valid alternative to surgical diverticulectomy in selected patients. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - May 11, 2019 Category: Gastroenterology Source Type: research

Pathogenesis and Cells of Origin of Barrett's Esophagus
In patients with Barrett ’s esophagus (BE), metaplastic columnar mucosa, containing epithelial cells with gastric and intestinal features, replaces esophageal squamous mucosa damaged by gastroesophageal reflux disease. This condition is estimated to affect 5.6% of adults in the United States, and is a major risk factor fo r esophageal adenocarcinoma. Despite the prevalence and importance of BE, its pathogenesis is incompletely understood and there are disagreements over the cells of origin. We review mechanisms of BE pathogenesis, including transdifferentiation and transcommitment, and discuss potential cells of orig...
Source: Gastroenterology - May 10, 2019 Category: Gastroenterology Authors: Jianwen Que, Katherine S. Garman, Rhonda F. Souza, Stuart Jon Spechler Source Type: research

Malnutrition in idiopathic pulmonary fibrosis: the great forgotten comorbidity!
The publication by Torrisi et al. [1] in the European Respiratory Journal evaluated the ability of comorbidities to improve the prediction of survival of idiopathic pulmonary fibrosis (IPF) patients. These variables are in addition to those in the best validated Gender-Age-Physiology (GAP) multivariable prediction model for mortality in IPF. The authors have added to the four parameters (age, sex, forced vital capacity per cent predicted and diffusing capacity of the lung for carbon monoxide per cent predicted) of the GAP model [2] comorbidities such as gastro-oesophageal reflux, pulmonary hypertension, lung cancer, valvul...
Source: European Respiratory Journal - May 9, 2019 Category: Respiratory Medicine Authors: Jouneau, S., Lederlin, M., Vernhet, L., Thibault, R. Tags: Original Articles: Correspondence Source Type: research

Preoperative Endoscopic and Radiologic Evaluation of Bariatric Patients: What Do They Add?
AbstractBackgroundPreoperative esophagogastroduodenoscopy (EGD) and barium swallow (BS) are commonly performed for evaluation in bariatric surgery patients. The routine use of these modalities has been controversial.MethodsA retrospective review of a prospectively maintained database was performed to include primary bariatric surgery patients between March 2013 and August 2016.ResultsTwo hundred nine patients were included. All the patients underwent preoperative EGD and BS. The mean age was 43.12  years and BMI 46.4 kg/m2. Reflux symptoms were present in 58.5% of patients. Preoperative EGD revealed abnormalities...
Source: Journal of Gastrointestinal Surgery - May 9, 2019 Category: Surgery Source Type: research

Per-oral endoscopic myotomy for esophageal diverticula with or without esophageal motility disorders.
CONCLUSIONS: In the case of MED and esophageal motility disorder, POEM permitted treatment of the underlying cause of the diverticulum, achieving favorable early clinical outcomes. In the absence of motility disorder, POEM was feasible with promising early outcomes, and could be a valid alternative to surgical diverticulectomy in selected patients. PMID: 31080116 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - May 9, 2019 Category: Research Authors: Orlandini B, Barret M, Guillaumot MA, Léandri C, Leblanc S, Prat F, Chaussade S Tags: Clin Res Hepatol Gastroenterol Source Type: research

Chronic stress augments esophageal inflammation, and alters the expression of transient receptor potential vanilloid  1 and protease‑activated receptor 2 in a murine model.
Chronic stress augments esophageal inflammation, and alters the expression of transient receptor potential vanilloid 1 and protease‑activated receptor 2 in a murine model. Mol Med Rep. 2019 Apr 25;: Authors: Wulamu W, Yisireyili M, Aili A, Takeshita K, Alimujiang A, Aipire A, Li Y, Jiang Y, Aizezi M, Li Z, Abudureyimu K Abstract Stress is a pivotal factor for inflammation, reactive oxygen species (ROS) production and formation of visceral hypersensitivity (VH) in the process of gastroesophageal reflux disease (GERD). In the present study, the effects of stress on esophageal inflammation, oxidati...
Source: Molecular Medicine Reports - May 8, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Prevalence of gastroesophageal reflux and risk factors for erosive esophagitis in obese patients considered for bariatric surgery
Gastroesophageal reflux disease (GERD) is common in obese individuals. Prospective studies investigating validated GERD questionnaires and clinical parameters at identifying erosive esophagitis (EE) in this population are limited. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - May 7, 2019 Category: Gastroenterology Authors: Ala I. Sharara, Luma Basma O. Rustom, Halim Bou Daher, Hussein H. Rimmani, Rani H. Shayto, Mohamad Minhem, Yervant Ichkhanian, Hanaa Aridi, Amr Al-Abbas, Yasser Shaib, Ramzi Alami, Bassem Safadi Tags: Alimentary Tract Source Type: research

The role of body mass index in determining clinical and quality of life outcomes after laparoscopic anti-reflux surgery
AbstractBackgroundCurrent literature is conflicted regarding the efficacy of laparoscopic anti-reflux surgery (LARS) among obese patients complaining of pathologic reflux or otherwise symptomatic hiatal hernias. Controlling for other factors, this study examined the influence of preoperative body mass index (BMI) on clinical and subjective quality of life (QOL) outcomes following LARS.MethodsPatients who underwent LARS between February 2012 and April 2018 were subdivided into four BMI stratified categories according to CDC definitions: normal (18.5 to  
Source: Surgical Endoscopy - May 6, 2019 Category: Surgery Source Type: research

Gastroesophageal reflux and serum biomarkers in systemic sclerosis –associated interstitial lung disease: comment on the article by Elhai et al
Arthritis&Rheumatology, EarlyView. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 6, 2019 Category: Rheumatology Authors: Sergey Moiseev, Antonina Sosnovskaya, Fatima Chotchaeva, Elena Shchegoleva, Pavel Novikov Tags: Letters Source Type: research

Polymorphisms of the BARX1 and ADAMTS17 locus genes in individuals with gastroesophageal reflux disease.
Conclusion: : This is a study investigating the potential correlation between 2 BARX1 and ADAMTS17 polymorphisms and the development of GERD, showing a considerable association between both polymorphisms and the disease. This finding suggests that esophageal differentiation or altered regulation on microfibrils in the cell environment could be implicated as possible mechanisms in the pathogenesis of GERD. PMID: 31048564 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - May 4, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

What Is the Best Operation for Proximal Gastric Cancer and Distal Esophageal Cancer?
This article summarizes the available evidence on this topic, and highlights specific areas for further research. PMID: 31047035 [PubMed - in process] (Source: The Surgical Clinics of North America)
Source: The Surgical Clinics of North America - May 4, 2019 Category: Surgery Authors: Mazer LM, Poultsides GA Tags: Surg Clin North Am Source Type: research

Bilateral duplex collecting system with bilateral vesicoureteral reflux: a case report
ConclusionsA bilateral duplex collecting system with refluxing upper pole moiety ureter is a very rare entity. The diagnosis should be suspected when exploring any flank pain with recurrent urinary tract infections to avoid subsequent renal impairment. Furthermore, this case shows how some common symptoms may lead to finding an unexpected urinary tract abnormality. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - May 4, 2019 Category: General Medicine Source Type: research

Gastroesophageal reflux and antacid therapy in IPF: analysis from the Australia IPF Registry
Gastroesophageal reflux disease (GORD) is highly prevalent in idiopathic pulmonary fibrosis (IPF) and may play a role in its pathogenesis. Recent IPF treatment guidelines suggest that all patients with IPF be ... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - May 3, 2019 Category: Respiratory Medicine Authors: Helen E. Jo, Tamera J. Corte, Ian Glaspole, Christopher Grainge, Peter M. A. Hopkins, Yuben Moodley, Paul N. Reynolds, Sally Chapman, E. Haydn Walters, Christopher Zappala, Heather Allan, Gregory J. Keir, Wendy A. Cooper, Annabelle M. Mahar, Samantha Elli Tags: Research article Source Type: research

Transoral incisionless fundoplication with EsophyX for gastroesophageal reflux disease: clinical efficacy is maintained up to 10 years
Conclusions Transoral incisionless fundoplication with EsophyX is an effective therapeutic option for symptomatic gastroesophageal reflux disease patients, with Hill grades I – II or hiatal hernia 
Source: Endoscopy International Open - May 2, 2019 Category: Gastroenterology Authors: Testoni, Pier Alberto Testoni, Sabrina Distefano, Giovanni Mazzoleni, Giorgia Fanti, Lorella Passaretti, Sandro Tags: Original article Source Type: research

Relationship between esophageal motility and severity of gastroesophageal reflux disease according to the Los Angeles classification
We examined 124 patients with GERD from January 2016 to June 2018. The LA classification of each patient was determined by endoscopy. HRM was performed by the intraluminal water infusion method. HRM and 24-hour esophageal pH monitoring parameters of the patients were studied and statistically compared. On HRM examination, GERD symptoms were found to be associated with worsened distal contractile integral (DCI), ineffective esophageal motility (IEM), peristalsis break (PB), lower esophageal sphincter (LES) pressure, and the 4-second integrated relaxation pressure (IRP4s) of LES pressure along with the grade of LA classific...
Source: Medicine - May 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Immobilization of Cu(II) on MWCNTs@L-His as a new high efficient reusable catalyst for the synthesis of pyrido[2,3-d:5,6-d′]dipyrimidine derivatives
Publication date: Available online 29 April 2019Source: Journal of Organometallic ChemistryAuthor(s): Hakimeh Saeidiroshan, Leila MoradiAbstractIn this research, a new heterogeneous organometallic catalyst was prepared through Cu(II) Immobilization on l-Histidine Functionalized multi-walled carbon nanotubes (MWCNTs@L-His/Cu(II)). Catalyst was prepared using a simple method and characterized by Fourier transform infrared (FTIR), scanning electron microscopy (SEM), Transmission electron microscopy (TEM), energy dispersive spectroscopy (EDS), thermal analysis (TGA), inductively coupled plasma optical emission spectrometry (IC...
Source: Journal of Organometallic Chemistry - May 1, 2019 Category: Chemistry Source Type: research

Extract of Plantago asiatica L. Seeds Ameliorates Hypertension in Spontaneously Hypertensive Rats by Inhibition of Angiotensin Converting Enzyme
In this study, we investigated the antihypertensive effect and underlying mechanisms of P. asiatica L. seeds extract (PASE) in spontaneously hypertensive rat (SHR). Male SHRs were treated with 2.5 mg/kg of fosinopril (FOS) and 400 mg/kg of PASE orally per day for once or 12 weeks. SHR or Wistar-Kyoto rats (WKY) receiving vehicle (distilled water) was used as control. The results demonstrated systolic, diastolic, and mean blood pressures (SBP, DBP, and MBP) were significantly lowered after single and long-term intragastric administration of PASE. The cardiac and aortic index and collagen accumulation were improved in the PA...
Source: Frontiers in Pharmacology - April 30, 2019 Category: Drugs & Pharmacology Source Type: research

High-Resolution Manometry Diagnosis of Ineffective Esophageal Motility Is Associated with Higher Reflux Burden
AbstractIntroductionIneffective esophageal motility (IEM) is the most commonly diagnosed abnormality on high-resolution manometry (HRM). However, the clinical significance of IEM and associated reflux burden remains unclear.AimOur primary aim was to compare reflux patterns between IEM versus normal motility on HRM.MethodsHRM and reflux studies in patients with IEM and normal motility were retrospectively reviewed. Esophageal pressure topography parameters, reflux variables, and patient-reported outcome questionnaires were explored.ResultsA total of 239 patients with IEM were explored. Of these, 146 underwent reflux monitor...
Source: Digestive Diseases and Sciences - April 30, 2019 Category: Gastroenterology Source Type: research

Anti-reflux mucosectomy with band ligation in the treatment of refractory gastroesophageal reflux disease
Endoscopy DOI: 10.1055/a-0875-3479 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Endoscopy)
Source: Endoscopy - April 30, 2019 Category: Gastroenterology Authors: Monino, Laurent Gonzalez, Jean-Michel Vitton, Veronique Barthet, Marc Tags: E-Videos Source Type: research

Efficacy and safety of hangeshashinto for treatment of GERD refractory to proton pump inhibitors
AbstractBackgroundProton pump inhibitor (PPI)-refractory gastroesophageal reflux disease (GERD) leads to a clinical decline in the quality of life (QOL). Therefore, new treatment options are needed. We performed a multicenter, randomized, parallel-group exploratory trial to determine the efficacy of hangeshashinto (HST) in patients with PPI-refractory GERD.MethodsWe enrolled 78 patients with PPI-refractory GERD for standard PPI regimens for at least 4  weeks and randomly assigned patients to receive either a combination of usual dose of rabeprazole (10 mg/day) + HST (7.5 g/day; HST group) or a ...
Source: Journal of Gastroenterology - April 29, 2019 Category: Gastroenterology Source Type: research

2007 –2019: a “Third”-Space Odyssey in the Endoscopic Management of Gastrointestinal Tract Diseases
AbstractPurpose of reviewThe main scope of this review article is to introduce readers to the innovative field of third-space endoscopy and offer a closer look at its history, milestones, and procedure spectrum while discussing ongoing and future challenges arising from its increasing adoption worldwide.Recent findingsOver the past few years, third-space endoscopy has been utilized in various diagnostic and interventional procedures performed throughout the gastrointestinal tract: obliteration of Zenker ’s diverticulum, myotomy for achalasia, gastroparesis or Hirschsprung’s disease, biopsy or removal of subepit...
Source: Current Treatment Options in Gastroenterology - April 29, 2019 Category: Gastroenterology Source Type: research

Esophageal symptoms and their lack of association with high-resolution manometry in systemic sclerosis patients
ConclusionWe observed a high prevalence of esophageal symptoms and of HRM abnormalities. However, there was no clear association between symptomatology and HRM findings. HRM does not seem to accurately predict upper GI symptomatology.ResumenAntecedentesLa afectación esofágica en la esclerosis sistémica causa impacto en la morbimortalidad. La manometría de alta resolución evalúa la afectación esofágica. Nuestro objetivo fue categorizar el trastorno motor esofágico en pacientes con esclerosis sistémica por HRM.MétodosSe realizó un estudio obs...
Source: Reumatologia Clinica - April 28, 2019 Category: Rheumatology Source Type: research

Correlation Between Clinical Signs and High-resolution Manometry Data in Children
Conclusions: With nonspecific clinical signs suggesting an esophageal motility disorder, weight loss was a predictive sign of abnormal HRM results. HRM was well tolerated in pediatric patients, and ineffective esophageal motility appears to be the most frequent motility disorder in our cohort, as already observed in adult patient studies. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - April 26, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Development of a Core Outcome Set for Infant Gastroesophageal Reflux Disease
Conclusions: We developed a COS for infant GERD consisting of 9 items that should minimally be measured in future therapeutic trials to decrease study heterogeneity and ease comparability of results. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - April 26, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

The Cellular Origin of Barrett's Esophagus and Its Stem Cells.
Authors: Xian W, Duleba M, Zhang Y, Yamamoto Y, Ho KY, Crum C, McKeon F Abstract The incidence of esophageal adenocarcinoma is rapidly increasing in Western countries. This is despite the introduction of sophisticated endoscopic techniques and our ability to readily monitor the presumed precursor lesion known as Barrett's esophagus. Preemptive approaches, including radiofrequency ablation (RFA), and photodynamic therapy (PDT) for Barrett's esophagus and dysplasia are achieving dramatic initial results. Although the long-term efficacy of these nonspecific ablative therapies is awaiting longitudinal studies, reports ...
Source: Advances in Experimental Medicine and Biology - April 26, 2019 Category: Research Tags: Adv Exp Med Biol Source Type: research

Effects of Proton Pump Inhibitors on the Gastrointestinal Microbiota in Gastroesophageal Reflux Disease
We examined the association between the PPI usage and the microbiota present in gastric mucosal and fecal samples from GERD patients and healthy controls (HCs) using 16S rRNA gene sequencing. GERD patients taking PPIs were further divided into short-term and long- term PPI user groups. We showed that PPI administration lowered the relative bacterial diversity of the gastric microbiota in GERD patients. Compared to the non-PPI-user and HC groups, higher abundances of Planococcaceae, Oxalobacteraceae, and Sphingomonadaceae were found in the gastric microbiota from the PPI-user group. In addition, the Methylophilus genus was ...
Source: Genomics, Proteomics and Bioinformatics - April 25, 2019 Category: Bioinformatics Source Type: research

Identification and structural characterization of the stress degradation products of omeprazole using Q-TOF-LC-ESI-MS/MS and NMR experiments: evaluation of the toxicity of the degradation products
New J. Chem., 2019, Advance Article DOI: 10.1039/C9NJ00932A, PaperG. Shankar, Roshan M. Borkar, Suresh Udutha, M. Kanakaraju, G. Sai Charan, S. Misra, R. Srinivas Omeprazole (OMP), a prototype proton pump inhibitor used for the treatment of peptic ulcers and gastroesophageal reflux disease (GERD), was subjected to forced degradation studies as per ICH guidelines Q1A (R2). To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - April 25, 2019 Category: Chemistry Authors: G. Shankar Source Type: research

Dor versus Toupet fundoplication after Laparoscopic Heller Myotomy: Systematic review and Bayesian meta-analysis of randomized controlled trials.
Abstract Laparoscopic Heller Myotomy (LHM) with partial fundoplication has become the treatment of choice for esophageal achalasia. However, the choice of the partial fundoplication is debated. The aim of this study was to compare outcomes for Dor and Toupet fundoplication after LHM. A systematic search of randomized controlled trials comparing Dor and Toupet fundoplication was performed using PubMed, EMBASE and Web of Science. Three studies met the inclusion criteria. Overall, 174 patients were included in the analysis. The postoperative abnormal acid reflux [pooled Risk Ratio 0.98 (95% HPD 0.54-1.80)] and dyspha...
Source: Asian Journal of Surgery - April 25, 2019 Category: Surgery Authors: Aiolfi A, Tornese S, Bonitta G, Cavalli M, Rausa E, Micheletto G, Campanelli G, Bona D Tags: Asian J Surg Source Type: research

The Effect of Gastric Helicobacter pylori Colonization on Nasal Functions.
tar B, Uyar Y Abstract The aim of this study is to investigate the effect of gastric Helicobacter pylori colonization on nasal functions. The study enrolled patients (n = 100) who underwent endoscopy for gastroesophageal reflux disease. Patients with laryngopharyngeal reflux (LPR) were identified by Reflux Symptom Index (RSI) and Reflux Finding Score (RFS). Patients were divided into 2 groups: LPR (+) (n = 64) H pylori (+), RSI> 13, RFS> 7; LPR (-) (n = 36) H pylori (+), RSI
Source: Ear, Nose and Throat Journal - April 24, 2019 Category: ENT & OMF Authors: Kumral TL, Gökden Y, Saltürk Z, Berkiten G, Yıldırım G, Ataç E, Tutar B, Uyar Y Tags: Ear Nose Throat J Source Type: research

Thirty Years of Minimally Invasive Surgery in Children: Analysis of Meta-Analyses
Conclusion In the available MAs, the advantages of MIS seem to outnumber the disadvantages. However, for some types of procedures, MIS may have considerable disadvantages. More randomized controlled trials are required to confirm the advantage of MIS for most procedures. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - April 23, 2019 Category: Surgery Authors: Schukfeh, Nagoud Kuebler, Joachim F. Dingemann, Jens Ure, Benno M. Tags: Original Article Source Type: research

Visceral fat thickness of erosive and non-erosive reflux disease subjects in Indonesia's tertiary referral hospital
ConclusionVisceral fat thickness as measured by ultrasonography has no significant difference between NERD and ERD. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - April 21, 2019 Category: Endocrinology Source Type: research

Benefit of Laparoendoscopic Repair of Hiatal Hernia in the Presence of Aberrant Left Hepatic Artery.
Conclusion: The laparoendoscopic technique of hiatal hernia repair, using extracorporeal arthroscopic sliding knots and concomitant transoral incisionless fundoplication, is safe, preserves an ALHA, and allows proper surgical techniques in a confined operative field. PMID: 30996584 [PubMed - in process] (Source: JSLS : Journal of the Society of Laparoendoscopic Surgeons)
Source: JSLS : Journal of the Society of Laparoendoscopic Surgeons - April 20, 2019 Category: Surgery Tags: JSLS Source Type: research

Analyzing the effect of laparoscopy duration time on peroperative gastroesophageal reflux
Conclusion: Esophageal pH values decreased and continued to remain low following IAP increase and TP in this experimental rat model. Prolonged laparoscopic procedures can particularly lead to GER that requires instant recognition and rapid and appropriate intervention. PMID: 30997979 [PubMed - as supplied by publisher] (Source: Turkish Journal of Medical Sciences)
Source: Turkish Journal of Medical Sciences - April 19, 2019 Category: General Medicine Tags: Turk J Med Sci Source Type: research

Esophageal schwannomas: A rarity beneath benign esophageal tumors a case report
ConclusionThe knowledge about a new case, impacts in obtaining more information about the clinical course and surgical treatment of this tumor. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - April 19, 2019 Category: Surgery Source Type: research

Laparoscopic Heller Myotomy: A Fundoplication Is Necessary to Control Gastroesophageal Reflux
Journal of Laparoendoscopic&Advanced Surgical Techniques, Ahead of Print. (Source: Journal of Laparoendoscopic)
Source: Journal of Laparoendoscopic - April 19, 2019 Category: Surgery Authors: Marco Di Corpo Timothy M. Farrell Marco G. Patti Source Type: research

Laparoscopic Heller Myotomy: A Fundoplication Is Necessary to Control Gastroesophageal Reflux
Journal of Laparoendoscopic&Advanced Surgical Techniques, Ahead of Print. (Source: Journal of Laparoendoscopic and Advanced Surgical Techniques)
Source: Journal of Laparoendoscopic and Advanced Surgical Techniques - April 19, 2019 Category: Surgery Authors: Marco Di Corpo Timothy M. Farrell Marco G. Patti Source Type: research

Gastroesophageal reflux and serum biomarkers in systemic sclerosis ‐related interstitial lung disease. Reply
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 17, 2019 Category: Rheumatology Authors: Muriel Elhai, Anna Maria Hoffmann ‐Vold, Yannick Allanore Tags: Reply to Letter to the Editor Source Type: research

Revision of Sleeve Gastrectomy with Hiatal Repair with Gastropexy for Gastroesophageal Reflux Disease
ConclusionHiatal repair with gastropexy is an acceptable treatment option for GERD after LSG but not very effective because of partial remission of symptoms. (Source: Obesity Surgery)
Source: Obesity Surgery - April 17, 2019 Category: Surgery Source Type: research

Characteristics and Findings of Childhood Urinary Tract Infection in the Last Decade
Conclusions: First UTI in a group of Thai children occurred in approximately equal proportion in boys and girls but boys were younger at diagnosis. Kidney and urinary tract anomalies were detected in half of the children.Urol Int (Source: Urologia Internationalis)
Source: Urologia Internationalis - April 16, 2019 Category: Urology & Nephrology Source Type: research

Juvenile-onset mixed connective tissue disease associated with macrophage activation syndrome: A case with refractory Raynaud’s phenomenon
ConclusionMCTD may present with a myriad of rheumatic manifestations and in association with MAS the diagnosis and management may be challenging. Refractory Raynauds’ phenomenon may remarkably improve on transthoracic sympathectomy. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - April 16, 2019 Category: Rheumatology Source Type: research

Addition of the Aldose Reductase Inhibitor Benzofuroxane Derivative BF-5m to Prolonged and Moderate Exercise Training Enhanced Protection of the Rat Heart From Type-1 Diabetes
Bartolo Ferraro1,2, Maria Donniacuo3, Loredana Sodano3, Franca Ferraraccio4, Rosa Maisto3, Eliana Gulotta5, Gorizio Pieretti6, Michele D’Amico3*, Maria Consiglia Trotta3 and Barbara Rinaldi3 1Institute for Cardiovascular Prevention (IPEK), Ludwig Maximilian University of Munich, Munich, Germany 2DZHK, Partner Site Munich Heart Alliance, Munich, Germany 3Department of Experimental Medicine, Pharmacology Division, University of Campania “L. Vanvitelli”, Naples, Italy 4Department of Clinical, Public and Preventive Medicine, University of Campania “L. Vanvitelli”, Naples, Italy 5Departm...
Source: Frontiers in Pharmacology - April 16, 2019 Category: Drugs & Pharmacology Source Type: research

Sleep Is Compromised in −12° Head Down Tilt Position
Sleep Is Compromised in −12° Head Down Tilt Position Alessa L. Boschert1*, David Elmenhorst2,3, Peter Gauger1, Zhili Li4, Maria T. Garcia-Gutierrez5, Darius Gerlach1, Bernd Johannes1, Jochen Zange1, Andreas Bauer2,6 and Jörn Rittweger1,7 1Department of Muscle and Bone Metabolism, German Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, Germany 2Forschungszentrum Jülich, Institute of Neuroscience and Medicine (INM-2), Jülich, Germany 3Division of Medical Psychology, University of Bonn, Bonn, Germany 4State Key Laboratory of Space Medicine Fundamentals and Application, China ...
Source: Frontiers in Physiology - April 16, 2019 Category: Physiology Source Type: research