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Prediction, prevention and management of gastroesophageal reflux after per-oral endoscopic myotomy: An update
World J Gastroenterol. 2024 Mar 7;30(9):1096-1107. doi: 10.3748/wjg.v30.i9.1096.ABSTRACTAchalasia cardia, the most prevalent primary esophageal motility disorder, is predominantly characterized by symptoms of dysphagia and regurgitation. The principal therapeutic approaches for achalasia encompass pneumatic dilatation (PD), Heller's myotomy, and the more recent per-oral endoscopic myotomy (POEM). POEM has been substantiated as a safe and efficacious modality for the management of achalasia. Although POEM demonstrates superior efficacy compared to PD and an efficacy parallel to Heller's myotomy, the incidence of gastroesoph...
Source: World Journal of Gastroenterology - April 5, 2024 Category: Gastroenterology Authors: Zaheer Nabi Pradev Inavolu Nageshwar Reddy Duvvuru Source Type: research

Prediction, prevention and management of gastroesophageal reflux after per-oral endoscopic myotomy: An update
World J Gastroenterol. 2024 Mar 7;30(9):1096-1107. doi: 10.3748/wjg.v30.i9.1096.ABSTRACTAchalasia cardia, the most prevalent primary esophageal motility disorder, is predominantly characterized by symptoms of dysphagia and regurgitation. The principal therapeutic approaches for achalasia encompass pneumatic dilatation (PD), Heller's myotomy, and the more recent per-oral endoscopic myotomy (POEM). POEM has been substantiated as a safe and efficacious modality for the management of achalasia. Although POEM demonstrates superior efficacy compared to PD and an efficacy parallel to Heller's myotomy, the incidence of gastroesoph...
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Zaheer Nabi Pradev Inavolu Nageshwar Reddy Duvvuru Source Type: research

Refining definitions of Barretts oesophagus to improve clinical resource utilisation
Oesophageal adenocarcinoma (OAC) is a devastating disease with an average 5-year survival of around 15%.1 Moreover, rates of OAC have increased substantially in recent decades, adding greatly to the clinical and economic burden of this disease.2 OAC arises out of a metaplastic precursor in which the normal squamous lining of the oesophagus is replaced with columnar, mucin-secreting cells. This is termed Barrett’s oesophagus (BO) and is thought to form as a protective mechanism in response to gastro-oesophageal reflux disease (GORD). The cells that make up this oesophageal metaplasia can take several forms, roughly be...
Source: Gut - April 5, 2024 Category: Gastroenterology Authors: Stachler, M. D., Ain, Q. U. Tags: Gut Commentary Source Type: research

Pancreatic Cancer: Rapid Evidence Review
Am Fam Physician. 2024 Mar;109(3):245-250.ABSTRACTPancreatic cancer is relatively uncommon and carries a poor prognosis because patients often develop signs or symptoms at a late stage of illness. Patients with a family history, especially those with genetic syndromes, are at a significantly increased risk of pancreatic cancer. Modifiable risk factors include smoking, heavy alcohol use, and obesity. Although patients at increased risk should be screened, screening is not recommended for asymptomatic people at average risk. The differential diagnosis for a symptomatic patient is broad, including gastroesophageal reflux dise...
Source: American Family Physician - April 4, 2024 Category: Primary Care Authors: Carl Bryce Merima Bucaj Source Type: research

Pancreatic Cancer: Rapid Evidence Review
Am Fam Physician. 2024 Mar;109(3):245-250.ABSTRACTPancreatic cancer is relatively uncommon and carries a poor prognosis because patients often develop signs or symptoms at a late stage of illness. Patients with a family history, especially those with genetic syndromes, are at a significantly increased risk of pancreatic cancer. Modifiable risk factors include smoking, heavy alcohol use, and obesity. Although patients at increased risk should be screened, screening is not recommended for asymptomatic people at average risk. The differential diagnosis for a symptomatic patient is broad, including gastroesophageal reflux dise...
Source: Pain Physician - April 4, 2024 Category: Anesthesiology Authors: Carl Bryce Merima Bucaj Source Type: research

Comparing Pre- and Post-Operative Findings in Patients Who Underwent Laparoscopic Proximal Gastrectomy With a Double-Flap Technique: A Study on High-Resolution Manometry, Impedance pH Monitoring, and Esophagogastroduodenoscopy Findings
CONCLUSIONS: There is no significant functional difference in HRM and impedance pH monitoring tests after DFT. DFT appears to be useful in preserving LES function following proximal gastrectomy.PMID:38575507 | DOI:10.5230/jgc.2024.24.e1 (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - April 4, 2024 Category: Gastroenterology Authors: Hyun Joo Yoo Jin-Jo Kim Source Type: research

Comparing Pre- and Post-Operative Findings in Patients Who Underwent Laparoscopic Proximal Gastrectomy With a Double-Flap Technique: A Study on High-Resolution Manometry, Impedance pH Monitoring, and Esophagogastroduodenoscopy Findings
CONCLUSIONS: There is no significant functional difference in HRM and impedance pH monitoring tests after DFT. DFT appears to be useful in preserving LES function following proximal gastrectomy.PMID:38575507 | PMC:PMC10995827 | DOI:10.5230/jgc.2024.24.e1 (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - April 4, 2024 Category: Gastroenterology Authors: Hyun Joo Yoo Jin-Jo Kim Source Type: research