Left Transthoracic Approach for Magnetic Sphincter Augmentation Device LINX Implantation
Publication date: October 2019Source: The Annals of Thoracic Surgery, Volume 108, Issue 4Author(s): Saleh A. Alnasser, Hai V. Salfity, Jacob A. Klapper, Matthew G. HartwigMagnetic sphincter augmentation with the LINX Reflux Management System (Torax Medical, St. Paul, MN) is a recently introduced surgical option with comparable therapeutic efficacy for medically refractory gastroesophageal reflux disease. An appropriately sized LINX device is usually placed around the gastroesophageal junction through a laparoscopic approach. In general, redo abdominal surgeries are technically challenging, with a higher risk of associated ...
Source: The Annals of Thoracic Surgery - September 20, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

Epidemiology of idiopathic pulmonary fibrosis: a population-based study in primary care
AbstractIdiopathic pulmonary fibrosis (IPF) is a chronic disease with unknown etiology and poor prognosis. Little is known about the epidemiology of this disease; most of the studies are limited by small and restricted cohort studies. We aim to investigate the epidemiology of IPF in the Italian primary care setting using the Health Search Database (HSD) between January 2002 and June 2017. In an attempt to define cases of IPF we adopted iterative combinations of International Classification of Diseases Ninth Revision (ICD-9-CM) and other clinical investigations according to three different operational Algorithms. Incidence ...
Source: Internal and Emergency Medicine - September 20, 2019 Category: Emergency Medicine Source Type: research

“Reflux esophagitis, functional and non-functional”
Publication date: Available online 17 September 2019Source: Best Practice & Research Clinical GastroenterologyAuthor(s): Serhat BorABSTRACT:The pathogenesis of gastroesophageal reflux disease has been explained by acid-peptic model. However, related with the progress of the diagnostic modalities, another phenotypical group of patients were defined and called “functional disorders of the esophagus”. These patients are important because diagnosis is particularly difficult, co-morbid disorders especially psychiatric diseases are common, proton pump inhibitor response is low, and surgical results are very poor....
Source: Best Practice and Research Clinical Gastroenterology - September 19, 2019 Category: Gastroenterology Source Type: research

42 - A Multicentre, Prospective, Observational Study of Diabetes Self-Management and Behavioural Change in Newly Referred Patients to Diabetes Education Centres
Publication date: October 2019Source: Canadian Journal of Diabetes, Volume 43, Issue 7, SupplementAuthor(s): James M. Bowen, Robert B. Hopkins, LIFENG Xie, Gord Blackhouse, Daria J. O’reilly (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - September 19, 2019 Category: Endocrinology Source Type: research

The Role of Gastroesophageal Reflux in Patients with Acquired Tracheal Stenosis
(Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - September 19, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Benny Weksler Source Type: research

Commentary: The role of gastroesophageal reflux in patients with acquired tracheal stenosis
Gastroesophageal reflux (GERD) has been associated with several pulmonary and airway pathologies, including asthma, subglottic stenosis, pulmonary fibrosis, and bronchiolitis obliterans in patients who had a lung transplantation. Surgical treatment of GERD improves survival in patients with pulmonary fibrosis,1 improves lung allograft function,2 and decreases the need for steroids in patients with asthma.3 Idiopathic tracheal stenosis appears to be associated with GERD,4 and the treatment of GERD might improve outcomes. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - September 19, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Benny Weksler Tags: Commentary Source Type: research

Gastric cancer and gastrin: on the interaction of Helicobacter pylori gastritis and acid inhibitory induced hypergastrinemia.
Authors: Waldum HL, Rehfeld JF Abstract Gastric cancer, a disease with a reduced frequency for decades, now appears to be on the rise again in young Americans. The epidemiology of gastric cancer differs between tumors in the cardia and those of the more distal parts of the stomach. The tumors are divided into the intestinal type showing glandular growth pattern and the diffuse type with a different pattern. The latter often expresses neuroendocrine and more specifically ECL-cell markers suggesting that they originate from the ECL cell, the target cell for the antral hormone, gastrin. Helicobacter pylori gastritis i...
Source: Scandinavian Journal of Gastroenterology - September 18, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Mucosal impedance testing: A new diagnostic testing in gastroesophageal reflux disease.
In conclusion, endoscopic MIT measurement can differentiate esophageal disorders instantly during endoscopy. It may not only serve as an important tool in diagnosing of GERD but also help guide therapy in clinically difficult situations as a surrogate to predict the treatment response. PMID: 31542333 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - September 18, 2019 Category: General Medicine Authors: Lei WY, Vaezi MF, Naik RD, Chen CL Tags: J Formos Med Assoc Source Type: research

Simple Niobium Catalysts Applied in Reflux and Ultrasound-Assisted Systems for Biofuel Synthesis
Using niobium compounds as heterogeneous catalysts in biodiesel production is a promising methodology from economic and environmental viewpoints. However, the application of niobium catalysts still is a challenge due to the high temperatures and pressures for moderate biofuel yields. Therefore, easily handled and applied materials have been developed to optimize biofuel production, which is the goal of this study. Nb2O5 and ammonium niobium oxalate (AmNO) were activated in reflux and ultrasound-assisted system. Nb2O5 showed better activity under reflux, using methanol. The characterizations conclude that the Lewis-acid sit...
Source: Journal of the Brazilian Chemical Society - September 17, 2019 Category: Chemistry Source Type: research

Concomitant endoscopic fundoplication – can it reduce the risk of gastroesophageal reflux following peroral endoscopic myotomy?
Endoscopy DOI: 10.1055/a-1000-8196 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Endoscopy)
Source: Endoscopy - September 17, 2019 Category: Gastroenterology Authors: Bapaye, Amol Dharamsi, Siddharth Jain, Rishabh Basava, Guru Bapaye, Jay A. Pujari, Rajendra Gadhikar, Harshal Tags: E-Videos Source Type: research

108 A Prospective Audit and Review of Proton Pump Inhibitors (PPIs) in Older Adults in a Reablement Unit
ConclusionMost patients on a PPI did not have a clear indication.The majority of inappropriate PPIs were deemed suitable for review and were subsequently dose reduced or discontinued.Some patients were unsuitable for PPI review due to multiple risk factors or ongoing symptoms of reflux.The continued need for PPIs should be assessed regularly and a risk-benefit analysis should be carried out. (Source: Age and Ageing)
Source: Age and Ageing - September 16, 2019 Category: Geriatrics Source Type: research

193 Audit on Inappropriate Prescribing of Proton Pump Inhibitors Amongst Patients over 65 Years in an Acute Rehabilitation Hospital
ConclusionThis audit highlighted the inappropriate prescribing of PPI ’s in the older person. By providing education to Doctors about NICE PPI prescribing guidelines, overall rate of inappropriate prescribing of PPI decreased by 28.4% and accurate dosing of PPI improved by 21.2%. (Source: Age and Ageing)
Source: Age and Ageing - September 16, 2019 Category: Geriatrics Source Type: research

Bariatric Surgery After Previous Antireflux Surgery Without Takedown of the Previous Fundoplication: a Prospective Study
ConclusionBariatric surgery is possible after fundoplication without taking down the fundoplication. It appears to be a viable alternative in patients seeking weight loss surgery after fundoplication, which is currently assumed contraindicated. (Source: Obesity Surgery)
Source: Obesity Surgery - September 16, 2019 Category: Surgery Source Type: research

Management of uncomplicated gastric ulcer in community pharmacy: a pseudo-patient study
ConclusionThe questioning skill of the  community pharmacists in this setting was poor. Few community pharmacists diagnosed the pseudo-patients’ minor ailment correctly. Also, recommendations were mostly inappropriate compared with the standard treatment guideline. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - September 16, 2019 Category: Drugs & Pharmacology Source Type: research

Evaluating the Effect of Oral Gabapentin on the Improvement of Gastrointestinal Symptoms in Patients with Functional Dyspepsia Resistant to Conventional Treatments.
Conclusion: Gabapentin as an adjunctive drug could be more effective in reducing the severity of GI symptoms in patients with dyspepsia, especially neurological symptoms (such as pain, reflux, and indigestion). PMID: 31516891 [PubMed] (Source: Biomed Res)
Source: Biomed Res - September 15, 2019 Category: Research Authors: Shafigh-Ardestani MH, Karami-Horestani M, Emami B, Arjmandpour A Tags: Adv Biomed Res Source Type: research

Regioselective hydroxylation pathway of tenatoprazole to produce human metabolites by Bacillus megaterium CYP102A1
In conclusion, an enzymatic synthesis of 5’-OH tenatoprazole, a major human metabolite of tenatoprazole, was developed by using mutants of CYP102A1 from Bacillus megaterium as a biocatalyst and tenatoprazole as a substrate.Graphical abstract (Source: Process Biochemistry)
Source: Process Biochemistry - September 15, 2019 Category: Biochemistry Source Type: research

Esophageal pH-impedance monitoring in children: position paper on indications, methodology and interpretation by the SIGENP working group
Multichannel intraluminal impedance pH (MII-pH) monitoring currently represents the gold standard diagnostic technique for the detection of gastro-esophageal reflux (GER), since it allows to quantify and characterize all reflux events and their possible relation with symptoms. Over the last ten years, thanks to its strengths and along with the publication of several clinical studies, its worldwide use has gradually increased, particularly in infants and children. Nevertheless, factors such as the limited pediatric reference values and limited therapeutic options still weaken its current clinical impact. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 13, 2019 Category: Gastroenterology Authors: Paolo Quitadamo, Renato Tambucci, Valentina Mancini, Fernanda Cristofori, Mariella Baldassarre, Licia Pensabene, Ruggiero Francavilla, Giovanni Di Nardo, Tamara Caldaro, Paolo Rossi, Saverio Mallardo, Elena Maggiora, Annamaria Staiano, Francesco Cresi, Si Tags: Position Paper Source Type: research

Is the stomach a way to one's heart? Gastric autonomic activity and AF susceptibility in gastro ‐esophageal reflux disease
This article is protected by copyright. All rights reserved. (Source: Journal of Cardiovascular Electrophysiology)
Source: Journal of Cardiovascular Electrophysiology - September 13, 2019 Category: Cardiology Authors: Varun Malik, Dennis H Lau, Dominik Linz, Melissa E. Middeldorp, Prashanthan Sanders Tags: EDITORIAL – INVITED Source Type: research

Development of scores assessing the refluxogenic potential of diet of patients with laryngopharyngeal reflux
ConclusionREDS, RESDI and GRES are proposed as objective scores for assessing the refluxogenic potential of F&B composing a dish or the overall diet of LPR patients. Future studies are needed to study the correlation between these scores and the development of LPR according to impedance –pH study. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - September 12, 2019 Category: ENT & OMF Source Type: research

Gastroesophageal Reflux Disease and Atrial fibrillation: Insight from Autonomic Cardiogastric Neural Interaction
In this study, we investigated the effects of acid reflux on the intrinsic cardiac autonomic nervous system, atrial/ventricular electrophysiology, and AF inducibility.MethodsEighteen rabbits were randomized into three groups: acid reflux (group 1, n = 6), control (group 2, n = 6), and acid reflux with periesophageal vagal blockade (group 3, n = 6). Atrial and ventricular effective refractory periods (ERPs) and AF inducibility were checked at baseline and then hourly until 5 hours after the experiment.ResultsThree hours after the experiment, atrial ERP prolongation was noted in groups 2 and 3 (P
Source: Journal of Cardiovascular Electrophysiology - September 12, 2019 Category: Cardiology Authors: Ting ‐Chun Huang, Li‐Wei Lo, Shinya Yamada, Yu‐Hui Chou, Wei‐Lun Lin, Shih‐Lin Chang, Yenn‐Jiang Lin, Shin‐Huei Liu, Wen‐Han Cheng, Tsung‐Ying Tsai, Ping‐Yen Liu, Shih‐Ann Chen Tags: ORIGINAL ‐ EXPERIMENTAL Source Type: research

Increase in lumbar kyphosis and spinal inclination, declining back muscle strength, and sarcopenia are risk factors for onset of GERD: a 5-year prospective longitudinal cohort study
The objective was to identify risk factors for new development of gastroesophageal reflux disease (GERD) 5  years later in a prospective longitudinal cohort study.MethodsA total of 178 subjects (male 72, female 106, mean age 68  years) without GERD in 2013 were examined for GERD in 2018. A Frequency Scale for Symptoms of GERD score ≥ 8 was used for diagnosis of GERD. Body mass index, spinal alignment, muscle strength, physical ability, number of oral drugs per day, sarcopenia, and frailty determined in 2013 and 2018 w ere compared between the GERD(+) and GERD(−) groups in 2018. Aggravation of lumb...
Source: European Spine Journal - September 10, 2019 Category: Orthopaedics Source Type: research

Magnetic Sphincter Augmentation Superior to Proton Pump Inhibitors for Regurgitation in a 1-year Randomized Trial
Regurgitative gastroesophageal reflux disease (GERD) refractive to medical treatment is common and caused by mechanical failure of the anti-reflux barrier. We compared the effects of magnetic sphincter augmentation (MSA) with those of proton-pump inhibitors (PPIs) in a randomized trial. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 10, 2019 Category: Gastroenterology Authors: Reginald Bell, John Lipham, Brian E. Louie, Valerie Williams, James Luketich, Michael Hill, William Richards, Christy Dunst, Dan Lister, Lauren McDowell-Jacobs, Patrick Reardon, Karen Woods, Jon Gould, F. Paul Buckley, Shanu Kothari, Leena Khaitan, C. Dan Source Type: research

Role and safety of fundoplication in esophageal disease and dysmotility syndromes.
Authors: Bakhos CT, Petrov RV, Parkman HP, Malik Z, Abbas AE Abstract Gastroesophageal reflux disease (GERD) is quite prevalent worldwide, especially in the western hemisphere. The pathophysiology of GERD is complex, involving an incompetent esophagogastric junction (EGJ) as an anti-reflux barrier, as well as other co-morbid conditions such as gastroparesis, hiatal herniation or hyper acid secretion. Esophageal dysmotility is also frequently encountered in GERD, further contributing to the disease in the form of fragmented peristalsis, ineffective esophageal motility (IEM) or the more severe aperistalsis. The latte...
Source: Journal of Thoracic Disease - September 7, 2019 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

The role of diet in the development and management of gastroesophageal reflux disease: why we feel the burn.
Authors: Newberry C, Lynch K Abstract Gastroesophageal reflux disease (GERD) is a common esophageal disorder that is characterized by troublesome symptoms associated with increased esophageal acid exposure. Cornerstones of therapy include acid suppressive agents like proton pump inhibitors (PPI) and lifestyle modifications including dietary therapy, although the latter is not well defined. As concerns regarding long term PPI use continue to be explored, patients and providers are becoming increasingly interested in the role of diet in disease management. The following is a review of dietary therapy for GERD with an...
Source: Journal of Thoracic Disease - September 7, 2019 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Associations of the microbiome and esophageal disease.
Authors: Okereke I, Hamilton C, Wenholz A, Jala V, Giang T, Reynolds S, Miller A, Pyles R Abstract The incidence of esophageal diseases such as esophageal adenocarcinoma (EAC) and gastroesophageal reflux disease (GERD) have been increasing over the last 40 years. The esophageal microbiome appears to have a role in the development of some disease processes, and could also serve as markers of early diseases of the esophagus. A literature review was performed examining the role of the microbiome in the development of esophageal disease. In addition, the results of several studies and experiments were included in the r...
Source: Journal of Thoracic Disease - September 7, 2019 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Gastroesophageal reflux disease, obesity and laparoscopic sleeve gastrectomy: The burning questions.
Abstract Obesity is a global health epidemic with considerable economic burden. Surgical solutions have become increasingly popular following technical advances leading to sustained efficacy and reduced risk. Sleeve gastrectomy accounts for almost half of all bariatric surgeries worldwide but concerns regarding its relationship with gastroesophageal reflux disease (GERD) has been a topic of debate. GERD, including erosive esophagitis, is highly prevalent in the obese population. The role of pre-operative endoscopy in bariatric surgery has been controversial. Two schools of thought exist on the matter, one that bel...
Source: World Journal of Gastroenterology - September 7, 2019 Category: Gastroenterology Authors: Bou Daher H, Sharara AI Tags: World J Gastroenterol Source Type: research

Oesophageal intramural pseudodiverticulosis: a rare endoscopic finding.
This report highlights the occurrence of this rare and benign cause of dysphagia in Nigeria. Funding: None declared. PMID: 31481816 [PubMed - in process] (Source: Ghana Medical Journal)
Source: Ghana Medical Journal - September 6, 2019 Category: African Health Tags: Ghana Med J Source Type: research

Neuroendocrine cell hyperplasia of infancy: An unusual cause of unresolving tachypnea in infancy
A 6-month-old full-term male patient was born uneventfully through vaginal delivery. At the age of 3 months, he began experiencing unresolving dry cough and poor feeding. During respiratory auscultation, tachypnea without adventitious breath sounds was noted. Chest radiograph (CxR) based from the latest admission revealed ground-glass opacity (GGO) and hyperinflation in bilateral lung fields (Supplement Fig.). Meanwhile, echocardiogram showed a patent foramen ovale, while esophagogram was negative for tracheoesophageal fistula or gastroesophageal reflux. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - September 6, 2019 Category: Perinatology & Neonatology Authors: Sui-Ling Liao, Shen-Hao Lai Tags: Letter to the Editor Source Type: research

Short-Term and Long-Term Outcomes of Paraesophageal Hernia Repair
The assessment of outcome after paraesophageal repair is difficult and complex. There is a wide range of reported outcomes that are not consistently defined. The focus of this article is on short-term ( ≤5 years) and long-term (>5  year) outcomes after laparoscopic paraesophageal repair and reviews key patient-reported outcomes (gastroesophageal reflux disease [GERD]–related and non–GERD-related symptoms), radiologic recurrence, additional therapy, and objective measurements. Overall, patients reported an excellent impro vement in their quality of life after repair that remains durable. Recurren...
Source: Thoracic Surgery Clinics - September 6, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Anne-Sophie Laliberte, Brian E. Louie Source Type: research

Management of Paraesophageal Hernia in the Morbidly Obese Patient
Gastroesophageal reflux disease (GERD) is common in the morbidly obese population, and hiatal hernias are encountered in 20% to 52% of patients. Primary surgical repair of hiatal hernias, in particular the paraesophageal type, is associated with a higher recurrence rate in obese patients. Concomitant weight loss surgery may be advisable. Combined sleeve gastrectomy and paraesophageal hiatal hernia repair is feasible but can induce or worsen preexisting GERD. A Roux-en-Y gastric bypass offers advantages of more pronounced excess weight loss and better symptom control, albeit with a potentially higher rate of morbidity compa...
Source: Thoracic Surgery Clinics - September 6, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Charles T. Bakhos, Shrey P. Patel, Roman V. Petrov, Abbas E. Abbas Source Type: research

Non-canonical Wnt Signaling through Ryk Regulates the Generation of Somatostatin- and Parvalbumin-Expressing Cortical Interneurons
Publication date: 4 September 2019Source: Neuron, Volume 103, Issue 5Author(s): Melissa G. McKenzie, Lucy V. Cobbs, Patrick D. Dummer, Timothy J. Petros, Michael M. Halford, Steven A. Stacker, Yimin Zou, Gord J. Fishell, Edmund AuSummaryGABAergic interneurons have many important functions in cortical circuitry, a reflection of their cell diversity. The developmental origins of this diversity are poorly understood. Here, we identify rostral-caudal regionality in Wnt exposure within the interneuron progenitor zone delineating the specification of the two main interneuron subclasses. Caudally situated medial ganglionic eminen...
Source: Neuron - September 5, 2019 Category: Neuroscience Source Type: research

Effect of Acid Suppression on Peripheral T-Lymphocyte Subsets and Immunohistochemical Esophageal Mucosal Changes in Patients With Gastroesophageal Reflux Disease
Background and Aims: Gastroesophageal reflux disease (GERD) is a common prevalent disease. We aimed to assess the dynamic changes in the peripheral T lymphocytes and lymphocytes infiltrating the esophageal mucosa after treatment with proton-pump inhibitor (PPI) in patients with GERD. Patients and Methods: A total of 200 patients who presented with upper GIT symptoms were included in this prospective study. All patients were subjected to full history taking, clinical examination, and complete blood count. Upper endoscopy was performed to detect the grade of GERD, followed by 4 quadrant biopsies before and 1 month after...
Source: Journal of Clinical Gastroenterology - September 5, 2019 Category: Gastroenterology Tags: ONLINE ARTICLES: Original Articles Source Type: research

Impact Of Fundoplication For Gastroesophageal Reflux In The Outcome Of Benign Tracheal Stenosis
This study focuses on the impact of anti-reflux surgery in the outcome of tracheal stenosis. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - September 5, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Edno Tales Bianchi, Paulo Francisco Guerreiro Cardoso, Helio Minamoto, Benoit Jacques Bibas, Michele Salati, Paulo Manuel Pego-Fernandes Source Type: research

[TECHNIQUES] Use of Bioelectronics in the Gastrointestinal Tract
Gastrointestinal (GI) motility disorders are major contributing factors to functional GI diseases that account for>40% of patients seen in gastroenterology clinics and affect>20% of the general population. The autonomic and enteric nervous systems and the muscles within the luminal GI tract have key roles in motility. In health, this complex integrated system works seamlessly to transport liquid, solid, and gas through the GI tract. However, major and minor motility disorders occur when these systems fail. Common functional GI motility disorders include dysphagia, gastroesophageal reflux disease, functional dyspepsia...
Source: Cold Spring Harbor perspectives in medicine - September 3, 2019 Category: Research Authors: Miller, L., Farajidavar, A., Vegesna, A. Tags: Bioelectronic Medicine TECHNIQUES Source Type: research

Per-oral endoscopic myotomy and gastroesophageal reflux: Where do we stand after a decade of “POETRY”?
AbstractPer-oral endoscopic myotomy (POEM) was introduced nearly a decade ago. Since then, the literature on its safety and efficacy has been ever increasing. Initial studies focused solely on the feasibility and efficacy of this procedure in patients with idiopathic achalasia. Subsequent studies analyzed the incidence of gastroesophageal reflux disease (GERD) in addition to the efficacy of POEM. These studies depict a high incidence of GERD after POEM. However, vast majority of these studies lacked a comprehensive evaluation of GERD after POEM. Consequently, it is difficult to provide a true estimate of the incidence of G...
Source: Indian Journal of Gastroenterology - September 2, 2019 Category: Gastroenterology Source Type: research

Barrett Esophagus
Barrett esophagus is a metaplastic change in the lining of the distal esophageal epithelium, characterized by replacement of the normal squamous epithelium by specialized intestinal metaplasia. The presence of Barrett esophagus increases the risk of esophageal adenocarcinoma several-fold. Esophageal adenocarcinoma is a malignancy with rapidly rising incidence and persistently poor outcomes when diagnosed after the onset of symptoms. Risk factors for Barrett esophagus include chronic gastroesophageal reflux, central obesity, white race, male gender, older age, smoking, and a family history of Barrett esophagus or esophageal...
Source: Mayo Clinic Proceedings - September 1, 2019 Category: Internal Medicine Authors: Prasad G. Iyer, Vivek Kaul Tags: Thematic review on gastroenterological diseases Source Type: research

[A Difficult-to-Treat Asthma Bronchiale Is Not Necessarily a Severe Asthma].
Abstract A Difficult-to-Treat Asthma Bronchiale Is Not Necessarily a Severe Asthma Abstract. New biologicals offer the opportunity for treatment of 'difficult-to-treat' asthma. Before prescribing these medications, each 'difficult-to-treat' asthma bronchiale has to be checked for factors aggravating asthma control (e.g. insufficient inhalation technique and adherence, persistent allergen exposure) and asthma-related comorbidities (e.g. rhinosinusitis, gastro-esophageal reflux disease or obstructive sleep apnea) rendering the asthma 'controlled'. Asthma phenotyping s essential for the understanding of different tre...
Source: Praxis - September 1, 2019 Category: General Medicine Authors: Nussbaumer-Ochsner Y Tags: Praxis (Bern 1994) Source Type: research

[The Mysterious Cough - a Case-Based Proposal of Differential Diagnosis].
Abstract The Mysterious Cough - a Case-Based Proposal of Differential Diagnosis Abstract. Cough is a frequent complaint in the general practice. Avoidance of overdiagnosis and underdiagnosis is essential. In case of acute cough or subacute (8 week duration) and normal baseline examination and after cessation of smoking and medication with ACE-I, cough-variant asthma, gastro-esophageal reflux disease and upper airway cough syndrome are the main causes and should be assessed and empirically treated in a systematic manner. PMID: 31480953 [PubMed - in process] (Source: Praxis)
Source: Praxis - September 1, 2019 Category: General Medicine Authors: Wieser S Tags: Praxis (Bern 1994) Source Type: research

Can Chinese T2D patients with BMI 20-32.5 kg/m2 benefit from loop  duodenojejunal bypass with sleeve gastrectomy?
This study investigated the therapeutic outcomes of LDJB-SG and predictors of type 2 diabetes (T2D) remission in Chinese patients with a body mass index (BMI) of 20 to 32.5 kg/m2. SETTING: A university hospital. METHODS: This retrospective study included 28 T2D patients with a BMI of 20 to 32.5 kg/m2 who underwent LDJB-SG. T2DM remission, weight loss, postoperative nutrition status, and complications at 1- and 3-year follow-up were assessed. Remission of T2DM was defined as a fasting blood glucose
Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery - September 1, 2019 Category: Surgery Authors: Lin S, Yang N, Guan W, Liang H Tags: Surg Obes Relat Dis Source Type: research

Characterization of Gender-Related Disparity in Gastroesophageal Reflux Disease: Surgical Perspective from a Rural High-Volume Antireflux Program.
PMID: 31638552 [PubMed - in process] (Source: The American Surgeon)
Source: The American Surgeon - September 1, 2019 Category: Surgery Authors: Fanous M, Jaehne A, Williams S, Lambert A Tags: Am Surg Source Type: research

Laparoendoscopic Single-Site (LESS) versus Robotic "Redo" Hiatal Hernia Repair with Fundoplication: Which Approach Is Better?
This study was undertaken to evaluate the robotic approach versus laparoendoscopic single-site (LESS) approach for redo fundoplications. With an Institutional Review Board approval, 64 patients undergoing LESS (n = 32) or robotic (n = 32) redo antireflux operations were prospectively followed up. Data are presented as median (mean + SD). For LESS versus robotic redo operations, the operative duration was 145 (143 ± 33.5) versus 196 (208 ± 76.7) minutes (P
Source: The American Surgeon - September 1, 2019 Category: Surgery Authors: Giovannetti A, Craigg D, Castro M, Ross S, Sucandy I, Rosemurgy A Tags: Am Surg Source Type: research

Quality of Life before and after Sleeve Gastrectomy in Lebanese Population.
Authors: Alkassis M, Haddad FG, Gharios J, Noun R, Chakhtoura G Abstract Introduction: Obesity is increasing worldwide and in Lebanon with a negative impact on the quality of life. The primary objective of this study is to measure the quality of life in obese subjects before and after bariatric surgery, depending on age, sex, and degree of weight loss. A secondary objective is to determine the impact of bariatric surgery on comorbidities associated with obesity. Materials and methods: Patients undergoing laparoscopic sleeve gastrectomy for BMI ≥ 30 kg/m2 between August 2016 and April 201...
Source: Journal of Obesity - August 31, 2019 Category: Eating Disorders & Weight Management Tags: J Obes Source Type: research

Etiologies associated with chronic cough and its clinical characteristics in school-age children.
Conclusions: The common etiologies of chronic cough in school-age children were UACS, CVA, and PB, while EB and GERD were rare. PMID: 31463138 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - August 31, 2019 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Mid-Term Outcome of Mandibular Distraction Osteogenesis in Pierre Robin Sequence
The aim of the present study was to present a single center's experience with mandibular distraction osteogenesis (MDO) in Pierre Robin sequence (PRS) patients. A retrospective chart review was performed to identify patients with PRS that underwent MDO at our institution from 2003 to 2012. Inclusion criteria were as follows: All pediatric patients with PRS who were not adequately managed with conservative therapy;Those who underwent MDO with internal mandibular distractors;Not previous treatment elsewhere andPatients were followed for ≥3 years. Evaluation included demographic information, postoperative complications, ...
Source: Journal of Craniofacial Surgery - August 30, 2019 Category: Surgery Tags: Original Articles Source Type: research

Z-line alterations and gastroesophageal reflux: an endoscopic population-based prospective cohort study.
Conclusions: In a general community, the only endoscopic alteration to the Z-line definitely linked to longstanding GER symptoms was the presence of obvious tongues of metaplastic columnar epithelium (ZAP II/III). PMID: 31453726 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - August 29, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Modified Sleeve Gastrectomy Combined with Laparoscopic Rossetti Fundoplication and Vascularization Assessment with Indocyanine Green
ConclusionThe modified sleeve gastrectomy combined with laparoscopic Rossetti fundoplication seems to be a safe, effective procedure and a suitable alternative to gastric bypass in obese patients with GERD. (Source: Obesity Surgery)
Source: Obesity Surgery - August 29, 2019 Category: Surgery Source Type: research

Exposure to Bile Leads to the Emergence of Adaptive Signaling Variants in the Opportunistic Pathogen Pseudomonas aeruginosa
The chronic colonisation of the respiratory tract by the opportunistic pathogen Pseudomonas aeruginosa is the primary cause of morbidity and mortality in Cystic Fibrosis (CF) patients. P. aeruginosa has been shown to undergo extensive genomic adaptation facilitating its persistence within the CF lung allowing it to evade the host immune response and outcompete co-colonising residents of the lung microbiota. However, whilst several studies have described the various mutations that frequently arise in clinical isolates of P. aeruginosa, the environmental factors governing the emergence of these genetic variants is less well ...
Source: Frontiers in Microbiology - August 29, 2019 Category: Microbiology Source Type: research

New optically active camphor-derived cyclopalladated complexes with an asymmetric carbon bonded to the metal
Publication date: Available online 27 August 2019Source: Journal of Organometallic ChemistryAuthor(s): Purna Chandra Rao Vasireddy, Gerard C. Dickmu, Angel Ugrinov, Irina P. SmoliakovaAbstractN,N-Dimethylhydrazone of D-camphor 1 was obtained as the single E isomer in 80% yield by treating the enantiopure ketone with N,N-dimethylhydrazine in the presence of an equimolar amount of p-toluenesulfonic acid in ethanol. Direct cyclopalladation of hydrazone 1 was accomplished at the C(3)H2 group using [Pd(MeCN)2Cl2] and NaOAc in MeCN at the reflux temperature. The product of the reaction, dinuclear cyclopalladated complex 2, was i...
Source: Journal of Organometallic Chemistry - August 28, 2019 Category: Chemistry Source Type: research

Is sleeve gastrectomy over-criticized? a single center indian experience with 5 years follow up results
Bariatric surgery has seen a sharp rise in numbers worldwide in the last decade. Being a popular procedure, sleeve gastrectomy(SG) has been widely studied over the years for its efficacy, potential of weight regain, metabolic impact and de novo Gastro-esophageal reflux disease (GERD). (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - August 28, 2019 Category: Surgery Authors: Amrit Manik Nasta, Sharmila Vyas, Madhu Goel, Ramen Goel Tags: Original articles Source Type: research

Is sleeve gastrectomy overcriticized? A single-center Indian experience with 5-year follow-up results
Bariatric surgery has seen a sharp rise in numbers worldwide in the last decade. Being a popular procedure, sleeve gastrectomy (SG) has been widely studied over the years for its efficacy, potential for weight regain, metabolic impact, and de novo gastroesophageal reflux disease (GERD). (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - August 28, 2019 Category: Surgery Authors: Amrit Manik Nasta, Sharmila Vyas, Madhu Goel, Ramen Goel Tags: Original article Source Type: research