Gastroesophageal reflux disease in a patient with BMI 30kg/m2 and previous endoscopic vertical gastroplasty: Indication for a one anastomosis gastric bypass.
PMID: 30683273 [PubMed - as supplied by publisher] (Source: Cirugia eEspanola)
Source: Cirugia eEspanola - January 22, 2019 Category: Surgery Authors: Ruiz-Tovar J, Carbajo MA, Jimenez JM, Ortiz-de-Solorzano J, Castro MJ Tags: Cir Esp Source Type: research

Systematic Endoscopy 5  Years After Sleeve Gastrectomy Results in a High Rate of Barrett’s Esophagus: Results of a Multicenter Study
AbstractBackgroundRecent evidence has indicated an increased risk of Barrett ’s esophagus (BE) in the long term after sleeve gastrectomy (SG).AimThe aim of the study is to investigate the spectrum of gastroesophageal reflux disease (GERD) symptoms as well as the prevalence of BE, at minimum 5  years after SG in patients who underwent SG in different bariatric centers of two countries: France and Italy.Patients and MethodsFive high volume outpatient centers dedicated to bariatric surgery that routinely perform upper GI endoscopy before any bariatric procedures were invited to participate in the study. From Januar...
Source: Obesity Surgery - January 21, 2019 Category: Surgery Source Type: research

Do patients with gastroesophageal reflux disease and somatoform tendencies benefit from antireflux surgery?
Abstract BACKGROUND: The clinical presentation of gastroesophageal reflux disease (GERD) shows a large symptom variation also in different intensities among patients. As several studies have shown, there is a large overlap in the symptomatic spectrum between proven GERD and other disorders such as dyspepsia, functional heartburn and/or somatoform disorders. AIM: To prospectively evaluate the GERD patients with and without somatoform disorders before and after laparoscopic antireflux surgery. METHODS: In a tertiary referral center for foregut surgery over a period of 3 years patients with GERD, qualifying...
Source: World Journal of Gastroenterology : WJG - January 21, 2019 Category: Gastroenterology Authors: Fuchs HF, Babic B, Fuchs KH, Breithaupt W, Varga G, Musial F Tags: World J Gastroenterol Source Type: research

The type of dyspepsia is important in the context of patients with irritable bowel syndrome and gastroesophageal reflux disease
Publication date: Available online 19 January 2019Source: Journal of the Formosan Medical AssociationAuthor(s): Rinaldo Pellicano (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - January 20, 2019 Category: General Medicine Source Type: research

Asthma in the older adult.
CONCLUSIONS: The diagnosis and management of asthma in older adults has certain challenges, but if the clinician is aware of them, the morbidity and mortality of this condition can be improved in this growing population. PMID: 30656998 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - January 20, 2019 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Laparoscopic repair of type III/IV giant para-oesophageal herniae with biological prosthesis: a single centre experience
AbstractPurposeRepair of giant paraoesophageal herniae (GPEH) is technically challenging and requires significant experience in advanced foregut surgery. Controversy continues on suture versus mesh cruroplasty with the most recent systematic review and meta-analysis putting the onus on the operating surgeon. Study aim was to review whether the biological prosthesis (non-cross-linked bovine pericardium and porcine dermis) and the technique adopted for patients with GPEH had an influence on clinical and radiological recurrences.MethodA retrospective analysis of a prospectively collected data of 60 consecutive patients with c...
Source: Hernia - January 19, 2019 Category: Sports Medicine Source Type: research

The type of dyspepsia is important in the context of patients with irritable bowel syndrome and gastroesophageal reflux disease.
PMID: 30670341 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - January 19, 2019 Category: General Medicine Authors: Pellicano R Tags: J Formos Med Assoc Source Type: research

Validation of the Korean Version of the Gastroesophageal Reflux Disease Questionnaire for the Diagnosis of Gastroesophageal Reflux Disease.
Conclusion: The Korean version of GerdQ is a useful complementary tool in the diagnosis of GERD. PMID: 30646480 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - January 18, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Gender-specific Effect of Micronutrient on Non-erosive Reflux Disease and Erosive Esophagitis.
Conclusions: While many dietary micronutrients reduced NERD, they had no effect on erosive esophagitis. The effect of micronutrient on NERD was more prominent in women than men. PMID: 30646479 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - January 18, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

High-resolution Manometry Findings During Solid Swallows Correlate With Delayed Reflux Clearance and Acid Exposure Time in Non-erosive Reflux Disease Patients.
Conclusion: HRM during solid swallows reveals motor abnormalities, undetected during liquid swallows, which might be involved in delaying reflux and acid clearance in patients with GERD. PMID: 30646477 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - January 18, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Are Diet and Micronutrients Effective in Treating Gastroesophageal Reflux Disease Especially in Women?
Authors: Kim JS, Kim BW PMID: 30646473 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - January 18, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Proton Pump Inhibitor Ameliorates Taste Disturbance among Patients with Laryngopharyngeal Reflux: A Randomized Controlled Study.
In conclusion, PPI could ameliorate hypogeusia by improving bitter, salty, and sour tastes among patients with LPR. PMID: 30643081 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - January 17, 2019 Category: Research Authors: Suzuki M, Yokota M, Matsumoto T, Nakayama M, Takemura M, Kanemitsu Y, Niimi A, Nakamura Y, Murakami S Tags: Tohoku J Exp Med Source Type: research

Twenty-four-hour oesophageal pH studies in rural Eastern Cape Province, South Africa.
CONCLUSIONS: Baseline oesophageal pH is not significantly affected by the increased numbers of non-acid gastro-oesophageal reflux events reported in this community. If there is a pathogenic effect of non-acid reflux in the Eastern Cape, it does not appear to be mediated through raised oesophageal pH. PMID: 30645964 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 17, 2019 Category: African Health Tags: S Afr Med J Source Type: research

Peroral endoscopic myotomy and fundoplication: a novel NOTES procedure
Conclusion POEM + F may help mitigate the post-POEM incidence of GER and serve as a minimally invasive endoscopic alternative to a laparoscopic Heller-Dor procedure. This is the largest case series of peroral natural orifice transluminal endoscopic surgery without laparoscopic assistance in the human foregut. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Endoscopy)
Source: Endoscopy - January 17, 2019 Category: Gastroenterology Authors: Inoue, Haruhiro Ueno, Akiko Shimamura, Yuto Manolakis, Anastassios Sharma, Ashish Kono, Shin Nishimoto, Masayuki Sumi, Kazuya Ikeda, Haruo Goda, Kenichi Onimaru, Manabu Yamaguchi, Noriko Itoh, Hiroaki Tags: Innovations and brief communications Source Type: research

Gastroesophageal reflux symptoms and microscopic esophagitis in a cohort of consecutive patients affected by atrophic body gastritis: a pilot study.
CONCLUSIONS: These data showed that GERD is present in a quarter of ABG patients, suggesting that hypochlorhydria not exclude per se arising of oesophageal symptoms. In ABG we found that ME is a frequent finding but its clinical relevance remains to be investigated with further studies. PMID: 30638085 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - January 16, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Acute Esophageal Necrosis: A View in the Dark
Acute esophageal necrosis (AEN), also known as Gurvits syndrome, black esophagus, or acute necrotizing esophagitis, is a rare clinical entity and an unusual reason for upper gastrointestinal bleeding. It is typically described in critically ill patients with multiple medical conditions, arising from a combination of ischemic insult to the esophageal mucosa due to low-flow vascular states, corrosive injury caused by reflux of acid and pepsin, and decreased function of the mucosal barrier systems and reparative mechanisms as occurs in malnourished and debilitated physical states. Patients with AEN tend to be older men, as me...
Source: Case Reports in Gastroenterology - January 16, 2019 Category: Gastroenterology Source Type: research

Identification of clinical parameters to increase the diagnostic yield of the non-emergent upper gastrointestinal series in pediatric outpatients
ConclusionThe yield of routine upper GI series in children with nonspecific symptoms, such as abdominal pain and vomiting, and no surgical history is low. Diagnostic yield was improved in older children and in those complaining of dysphagia and/or foreign body sensation. Routine upper GI series should be avoided in clinically well children with symptoms only of uncomplicated GER and no significant GI history. In children with a history of dysphagia and/or foreign body sensation, an esophagram/barium swallow can suffice. (Source: Pediatric Radiology)
Source: Pediatric Radiology - January 16, 2019 Category: Radiology Source Type: research

Genotype tailored treatment of mild symptomatic acid reflux in children with uncontrolled asthma (GenARA): Rationale and methods
Asthma causes enormous suffering and cost for children in the US and around the world [1 –3]. Co-morbid gastroesophageal reflux disease (GERD) makes asthma management more difficult due to increased symptoms. Proton pump inhibitor (PPI) drugs are effective at improving to GERD symptoms, however they have demonstrated only modest and variable effects on asthma control in the setting of co-morbid GERD. Importantly, PPI metabolism and efficacy depend on CYP2C19 genotype. The Genotype Tailored Treatment of Symptomatic Acid Reflux in Children with Uncontrolled Asthma (GenARA) study is a randomized, double-blind, placebo-c...
Source: Contemporary Clinical Trials - January 16, 2019 Category: Radiology Authors: Monica Tang, Kathryn V. Blake, John J. Lima, Edward B. Mougey, James Franciosi, Stephan Schmidt, Md Jobayer Hossain, Marjan Cobbaert, Bernard M. Fischer, Jason E. Lang Source Type: research

Matrix association region/scaffold attachment region: the crucial player in defining the positions of chromosome breaks mediated by bile acid-induced apoptosis in nasopharyngeal epithelial cells
It has been found that chronic rhinosinusitis (CRS) increases the risk of developing nasopharyngeal carcinoma (NPC). CRS can be caused by gastro-oesophageal reflux (GOR) that may reach nasopharynx. The major c... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - January 15, 2019 Category: Genetics & Stem Cells Authors: Sang-Nee Tan and Sai-Peng Sim Tags: Research article Source Type: research

Tracheobronchomalacia and Excessive Dynamic Airway Collapse: Medical and Surgical Treatment
Semin Respir Crit Care Med 2018; 39: 667-673 DOI: 10.1055/s-0038-1676571Excessive central airway collapse (ECAC) is characterized by excessive narrowing of the airway lumen during exhalation leading to dyspnea, cough, mucostasis, recurrent respiratory infections, and poor quality of life. Tracheobronchomalacia and excessive dynamic airway collapse are heterogeneous entities of ECAC and are characterized by a diverse nonspecific symptom profile. Although the pathophysiology of airway mechanics as well as morphology in both entities is different, current evidence so far shows no practical benefit in making such distinction s...
Source: Seminars in Respiratory and Critical Care Medicine - January 14, 2019 Category: Respiratory Medicine Authors: Kheir, Fayez Majid, Adnan Tags: Review Article Source Type: research

Dexlansoprazole is Effective in Relieving Heartburn during the Fasting Month of Ramadan
Conclusion: Dexlansoprazole is effective in the treatment of heartburn during Ramadan. Clinicaltrials.gov number: NCT03079050.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - January 13, 2019 Category: Gastroenterology Source Type: research

Insulin Resistance in Gastroesophageal Reflux Disease.
Authors: Budiyani L, Purnamasari D, Simadibrata M, Abdullah M Abstract Insulin resistance is the disturbance of glucose regulation characterized by higher insulin level. In clinical context, insulin resistance can manifest as abnormalities that are related with cardiovascular event risk, known as metabolic syndrome. Several studies had reported that insulin resistance was associated with erosive esophagitis in patients with gastroesophageal reflux disease (GERD). PMID: 30631000 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - January 13, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Symptoms and Upper Gastrointestinal Mucosal Injury Associated with Bisphosphonate Therapy.
This study investigated symptoms and upper gastrointestinal mucosal injury associated with oral bisphosphonates. Methods Symptoms were evaluated using the F-scale questionnaire, and esophageal mucosal injury and gastroduodenal ulceration were assessed by endoscopy. Patients were stratified by the type of bisphosphonate (alendronate, risedronate, or minodronate), treatment schedule (once weekly or every four weeks), and the concomitant use of other medications (antithrombotic agents, nonsteroidal anti-inflammatory drugs [NSAIDs], or acid suppressants). Patients The subjects included 221 patients treated with oral bisphospho...
Source: Internal Medicine - January 12, 2019 Category: Internal Medicine Tags: Intern Med Source Type: research

Synthesis and characterization of nano acid catalyst derived from rice husk silica and its application for the synthesis of 3,4-dihydropyrimidinones/thiones compounds
Publication date: 5 April 2019Source: Journal of Molecular Structure, Volume 1181Author(s): Jamal Davarpanah, Mohammad Hosein Sayahi, Mahboubeh Ghahremani, Sahar KarkhoeiAbstractIn the present work, the extraction of silica nanoparticles from the rice husk followed by the modification using an acidic ionic liquid containing imidazolium butyl sulfonic acid through a sol-gel method (RH@[SiPrImBuSO3H]Cl) has been investigated. The composition, morphology and structural properties of the synthesized solid acid were analyzed by fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscop...
Source: Journal of Molecular Structure - January 10, 2019 Category: Molecular Biology Source Type: research

Rates of Duodenal Biopsy During Upper Endoscopy Differ Widely Between Providers: Implications for Diagnosis of Celiac Disease
Conclusions: A duodenal biopsy is more likely to be performed in younger patients, females, and for key indications such as weight loss, diarrhea, and anemia. Providers varied widely in the performance of duodenal biopsy. Further study is warranted to better understand the decision to perform duodenal biopsy and to determine the optimal scenarios for its performance. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - January 10, 2019 Category: Gastroenterology Tags: ONLINE ARTICLES: Original Articles Source Type: research

Gastroesophageal Reflux Treatment With Proton Pump Inhibitors in Patients With Hypertension
No abstract available (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - January 10, 2019 Category: Gastroenterology Tags: LETTERS TO THE EDITOR Source Type: research

Oral neuromuscular training relieves hernia-related dysphagia and GERD symptoms as effectively in obese as in non-obese patients.
MK Abstract BACKGROUND: Many physicians insist patients lose weight before their hiatal hernia (HH) condition and related symptoms including intermittent esophageal dysphagia (IED) and gastroesophageal reflux disease (GERD) can be treated, but it is not proven that body mass index (BMI) has an impact on exercise-based treatment of HH-related symptoms. AIMS/OBJECTIVES: To investigate whether BMI has significance on IQoro® neuromuscular training (IQNT) effectiveness in treating HH-related symptoms. MATERIAL AND METHODS: Eighty-six patients with sliding HH and enduring IED and GERD symptoms, despite pr...
Source: Acta Oto-Laryngologica - January 10, 2019 Category: ENT & OMF Authors: Franzen T, Tibbling LI, Hägg MK Tags: Acta Otolaryngol Source Type: research

Commentary: Per oral endoscopic myotomy (POEM): Should it now be considered the first-line therapeutic approach for patients with achalasia?
Why should we be assessing another treatment approach for patients with achalasia? Historically, we have had 2 tried-and-tested treatments for achalasia, 1 endoscopic and 1 surgical, with excellent track records for efficacy and safety. Graded pneumatic dilatation has a well-documented long-term success rate for symptomatic improvement ranging from 82% to 86%, although 25% to 33% of patients will require multiple dilatations within 4 to 5  years.1 Laparoscopic Heller myotomy (LHM) is an elegant and well-tolerated surgical procedure that successfully addresses dysphagia long term in 85% to 95% of patients with type I a...
Source: The Journal of Thoracic and Cardiovascular Surgery - January 10, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Piers R. Boshier, Donald E. Low Tags: Commentary Source Type: research

Direct measurements of collisional Raman line broadening in the S-branch transitions of CO perturbed by CO, N_2, and CO_2
We report direct measurement of collisional line-broadening coefficients associated with rotational Raman transitions of carbon monoxide (CO), obtained using time-resolved picosecond rotational coherent anti-Stokes Raman scattering spectroscopy. The dependencies of the CO self-broadening ... (Source: Applied Optics)
Source: Applied Optics - January 9, 2019 Category: Physics Authors: Paul S. Hsu Hans U. Stauffer Naibo Jiang James R. Gord Sukesh Roy Source Type: research

Activation of EGFR-DNA-PKcs pathway by IGFBP2 protects esophageal adenocarcinoma cells from acidic bile salts-induced DNA damage.
CONCLUSIONS: IGFBP2 protects EAC cells against ABS-induced DNA damage and apoptosis through stabilization and activation of EGFR - DNA-PKcs signaling axis. PMID: 30626422 [PubMed - in process] (Source: Clin Med Res)
Source: Clin Med Res - January 9, 2019 Category: Research Authors: Zhou Z, Lu H, Zhu S, Gomaa A, Chen Z, Yan J, Washington K, El-Rifai W, Dang C, Peng D Tags: J Exp Clin Cancer Res Source Type: research

Efficient Catalytic Conversion of Terminal/ Internal Epoxides to Cyclic Carbonates by Porous Co(II) MOF at Ambient Conditions: Structure Property Correlation and Computational Studies
J. Mater. Chem. A, 2019, Accepted Manuscript DOI: 10.1039/C8TA10631B, PaperBhavesh Parmar, Parth Patel, Renjith S. Pillai, Rukhsana Ilyas Kureshy, Dr. Noorul Hasan Khan, Eringathodi Suresh Mixed ligand three-dimensional neutral porous framework {[Co(OBA)(L)] ·xG}n (CoMOF-1) (H2OBA = 4,4′-Oxybis(benzoic acid); L = (E)-N'-(pyridin-4-ylmethylene) isonicotinohydrazide; G = DMF, EtOH, MeOH, H2O) has been successfully synthesized by hydrothermal and reflux... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - J. Mater. Chem. latest articles)
Source: RSC - J. Mater. Chem. latest articles - January 7, 2019 Category: Chemistry Authors: Bhavesh Parmar Source Type: research

Multiple rapid swallow testing in patients with gastroesophageal reflux disease
We report our single-center experience on MRS testing.ᅟᅟ (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - January 7, 2019 Category: Gastroenterology Source Type: research

Predictors of Hiatal Hernia Recurrence After Laparoscopic Anti-reflux Surgery with Hiatal Hernia Repair: a Prospective Database Analysis
ConclusionsHHR is correlated with large hernia size. Mesh use and patient BMI were not predictors, and no correlation was identified between HHR and presence of GERD symptoms. Recurrence after repair is not uncommon, but is asymptomatic in most cases. Reoperation is rare and mesh is not routinely needed. Large asymptomatic HHs in the elderly often do not require intervention. (Source: Journal of Gastrointestinal Surgery)
Source: Journal of Gastrointestinal Surgery - January 7, 2019 Category: Surgery Source Type: research

Endoscopic foregut surgery and interventions: The future is now. The state-of-the-art and my personal journey.
Abstract In this paper, I reviewed the emerging field of endoscopic surgery and present data supporting the contention that endoscopy can now be used to treat many foregut diseases that have been traditionally treated surgically. Within each topic, the content will progress as follows: "lessons learned", "technical considerations" and "future opportunities". Lessons learned will provide a brief background and update on the most current literature. Technical considerations will include my personal experience, including tips and tricks that I have learned over the years. Finally, future...
Source: World Journal of Gastroenterology : WJG - January 7, 2019 Category: Gastroenterology Authors: Chang KJ Tags: World J Gastroenterol Source Type: research

Epidemiology of Gastroesophageal Junction Adenocarcinoma in Korea.
Authors: Kim JJ Abstract The incidence of gastroesophageal junction adenocarcinoma (GEJAC) in Western countries has increased in recent decades, in addition to a rise in the incidence of esophageal adenocarcinoma (EAC). Gastroesophageal reflux disease (GERD), obesity, smoking, alcohol consumption, and low Helicobacter pylori (HP) infection rate have been nominated as risk factors for such cancers. Among these risk factors, the increased prevalence of GERD and obesity and the decreased prevalence of HP infection are of special interest owing to the currently increasing prevalence of GEJAC in Western countries. Altho...
Source: Journal of Gastric Cancer - January 6, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Evidence-Based Practice Guideline for Surgical Treatment of Gastroesophageal Reflux Disease 2018.
Authors: Seo HS, Choi M, Son SY, Kim MG, Han DS, Lee HH Abstract The prevalence of gastroesophageal reflux disease (GERD) is increasing in Korea, and physicians, including surgeons, have been focusing on its treatment. Indeed, in Korea, medical treatment using a proton pump inhibitor is the mainstream treatment for GERD, while awareness of surgical treatment is limited. Accordingly, to promote the understanding of surgical treatment for GERD, the Korean Anti-Reflux Surgery Study Group published the Evidence-Based Practice Guideline for the Surgical Treatment of GERD. The guideline consists of 2 sections: fundamenta...
Source: Journal of Gastric Cancer - January 6, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Comparison of double-flap and OrVil techniques of laparoscopy-assisted proximal gastrectomy in preventing gastroesophageal reflux: a retrospective cohort study.
Abstract BACKGROUND: Laparoscopy-assisted proximal gastrectomy (LAPG) with esophagogastrostomy using the double-flap technique has been reported to rarely cause gastroesophageal reflux. However, quantitative evaluation of the reflux has hardly been performed. The aim of this study was to clarify the superiority of the double-flap technique of LAPG with esophagogastrostomy compared with the OrVil technique in terms of preventing gastroesophageal reflux. METHODS: A total of 40 and 51 patients who underwent LAPG with esophagogastrostomy using the double-flap and OrVil techniques, respectively, for upper one-thir...
Source: Hand Surgery - January 5, 2019 Category: Surgery Authors: Hosoda K, Washio M, Mieno H, Moriya H, Ema A, Ushiku H, Watanabe M, Yamashita K Tags: Langenbecks Arch Surg Source Type: research

What Constitutes Optimal Management of T1N0 Esophageal Adenocarcinoma?
ConclusionsIn patients with T1aN0 EAC, overall survival with endoscopic eradication therapy is equal to esophagectomy. Given the substantial risk of LNM in patients with submucosal (T1b) EAC, esophagectomy remains the standard of care for surgical candidates. In the case of inoperability or low-risk lesions, endoscopic resection may be considered adequate therapy. Chemotherapy and radiation can be offered as primary therapy for non-surgical candidates with lesions not amenable to endoscopic therapy, but does not have a clear role in the adjuvant setting after either endoscopic or surgical resection. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - January 3, 2019 Category: Cancer & Oncology Source Type: research

What Constitutes Optimal Management of T1N0 Esophageal Adenocarcinoma?
CONCLUSIONS: In patients with T1aN0 EAC, overall survival with endoscopic eradication therapy is equal to esophagectomy. Given the substantial risk of LNM in patients with submucosal (T1b) EAC, esophagectomy remains the standard of care for surgical candidates. In the case of inoperability or low-risk lesions, endoscopic resection may be considered adequate therapy. Chemotherapy and radiation can be offered as primary therapy for non-surgical candidates with lesions not amenable to endoscopic therapy, but does not have a clear role in the adjuvant setting after either endoscopic or surgical resection. PMID: 30607765 [...
Source: Ann Oncol - January 3, 2019 Category: Cancer & Oncology Authors: Ramay FH, Vareedayah AA, Visrodia K, Iyer PG, Wang KK, Eluri S, Shaheen NJ, Reddy R, Martin LW, Greenwald BD, Edwards MA Tags: Ann Surg Oncol Source Type: research

Pepsin in Saliva as a Diagnostic Marker for Gastroesophageal Reflux Disease: A Meta-Analysis.
CONCLUSIONS The meta-analysis showed that pepsin in saliva has moderate diagnostic value for GERD, and is not as helpful as previously thought. PMID: 30596632 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 2, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Etiology analysis of nonspecific chronic cough in children of 5 years and younger
This study aims to analyze the etiology of nonspecific chronic cough in children of 5 years and younger, in order to improve the diagnostic and treatment levels of pediatricians for nonspecific chronic cough in young children. The clinical data of 85 cases of children of 5 years old and below, who suffered from nonspecific chronic cough between the period of January 2015 and August 2016 were retrospectively analyzed. The etiology distribution of 85 cases of children with nonspecific chronic cough were as follows: 27 cases had cough variant asthma (31.8%), 32 cases had upper airway cough syndrome (37.6%), 16 cases had cou...
Source: Medicine - January 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Gastroesophageal Reflux Disease: Pathophysiology, Diagnosis, and Treatment
Gastroesophageal reflux disease (GERD) is a common chronic disorder in industrialized countries. Gastroesophageal reflux disease is one of the most frequent diseases encountered by primary care providers. The primary symptoms of GERD include heartburn, regurgitation, globus sensation, dysphagia, chest pain, and belching. If symptoms are left untreated, a major concern is complications and the potential risk of esophageal adenocarcinoma associated with GERD. With the increasing prevalence and incidence of GERD and the increasing cost of this disease, there is a need for advanced practice registered nurses to understand the ...
Source: Gastroenterology Nursing - January 1, 2019 Category: Nursing Tags: Features Source Type: research

Gastroesophageal Reflux Disease: Pathophysiology, Diagnosis, and Treatment
No abstract available (Source: Gastroenterology Nursing)
Source: Gastroenterology Nursing - January 1, 2019 Category: Nursing Tags: CE Tests Source Type: research

Association between tea consumption and gastroesophageal reflux disease: A meta-analysis
Conclusions: There was no significant relationship between tea consumption and the risk of GERD overall. However, in subgroup analysis, tea drinking may increase the risk of GERD in East Asia and decrease in Middle Asia. To clarify the causality between tea intake and GERD, a more precise study design will be needed. (Source: Medicine)
Source: Medicine - January 1, 2019 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Melatonin for the treatment of gastroesophageal reflux disease; protocol for a systematic review and meta-analysis
Conclusion: This study will provide evidence of melatonin or melatonin receptor agonist treatment for GERD. (Source: Medicine)
Source: Medicine - January 1, 2019 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Prevalence of trachoma in the area councils of the Federal Capital Territory, Nigeria: results of six population-based surveys
Volume 25, Issue sup1, 2018, Page 11-17 . (Source: Ophthalmic Epidemiology)
Source: Ophthalmic Epidemiology - December 31, 2018 Category: Opthalmology Authors: Nasiru Muhammad Caleb Mpyet Mohammed Dantani Adamu Adamani William Murtala Muhammad Umar Habila Muazu Uwazoeke Onyebuchi Sunday Isiyaku Rebecca M. Flueckiger Brian K. Chu Rebecca Willis Alex Pavluck Abbas Dalhatu Chris Ogoshi Nicholas Olobio Bruce A. Gord Source Type: research

Prevalence of trachoma in the area councils of the Federal Capital Territory, Nigeria: results of six population-based surveys
Volume 25, Issue sup1, December 2018, Page 11-17 . (Source: Ophthalmic Epidemiology)
Source: Ophthalmic Epidemiology - December 31, 2018 Category: Opthalmology Authors: Nasiru Muhammad Caleb Mpyet Mohammed Dantani Adamu Adamani William Murtala Muhammad Umar Habila Muazu Uwazoeke Onyebuchi Sunday Isiyaku Rebecca M. Flueckiger Brian K. Chu Rebecca Willis Alex Pavluck Abbas Dalhatu Chris Ogoshi Nicholas Olobio Bruce A. Gord Source Type: research

Silent Aspiration in Laryngomalacia?
Laryngomalacia is the most common laryngeal anomaly in infants, with a presentation of inspiratory stridor being nearly ubiquitous. In addition, young children with laryngomalacia can demonstrate feeding difficulty, dysphagia, aspiration, failure to thrive, apnea, cyanosis, and/or obstructive sleep apnea. Managing the balancing act between sucking, breathing, and swallowing is anticipated to carry additional challenge in infants with airway abnormalities, potentially leading to dysphagia, aspiration, and feeding difficulties. Somewhat unsurprisingly, infants with laryngomalacia may cough and choke during feeding, take thei...
Source: JAMA Otolaryngology - Head and Neck Surgery - December 27, 2018 Category: ENT & OMF Source Type: research

Lung Transplantation for Late-Onset Pulmonary Hypertension in a Patient with Congenital Diaphragmatic Hernia
European J Pediatr Surg Rep 2018; 06: e100-e103 DOI: 10.1055/s-0038-1675377Lung hypoplasia and pulmonary hypertension (PH) in association with congenital diaphragmatic hernia (CDH) may cause fatal respiratory failure. Lung transplantation (Ltx) may represent an option for CDH-related end-stage pulmonary failure. The aim of this study is to report a patient with CDH who underwent Ltx or combined heart-lung transplantation (H-Ltx). Our patient was born at 33 weeks of gestation, with a prenatally diagnosed isolated left CDH. Twenty-four hours after birth, she underwent surgical repair of a type D defect (according to the CDH ...
Source: European Journal of Pediatric Surgery Reports - December 26, 2018 Category: Surgery Authors: Iacusso, Chiara Morini, Francesco Capolupo, Irma Dotta, Andrea Sgr ò, Stefania Parisi, Francesco Carotti, Adriano Bagolan, Pietro Tags: Case Report Source Type: research